NOAEL Studies Cosmetic Ingredient

Sodium Metaphosphate NOAEL Studies

INCI: SODIUM METAPHOSPHATE

CAS: 10361-03-2

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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ToxValDB_ECHA_IUCLID 6 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_ECHA_IUCLID NOAEL ~25 mg/kg bw/day Rat oral - reproduction developmental QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaa4ae4b0a7c65d1b525f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/21289/7/9/2?documentUUID=4809115e-3599-48ba-82e2-200926545229; YEAR=2017; ORIGINAL_YEAR=2017; STUDY_GROUP=ECHA IUCLID:15855389:M/F:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_173856a031b03ec26cffc11fa196edea
ToxValDB_ECHA_IUCLID NOAEL =100 mg/kg bw/day Dog oral - short-term QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eacb3e4b0a7c65d1c06ac; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/21289/7/6/2?documentUUID=4809115e-3599-48ba-82e2-200926545229; YEAR=2017; ORIGINAL_YEAR=2017; STUDY_GROUP=ECHA IUCLID:15847457:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_74ed3dff70b5329e5d9af878891ccb94
ToxValDB_ECHA_IUCLID NOAEL >240 mg/kg bw/day Rat oral - developmental QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eabace4b0a7c65d1bb373; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/21289/7/9/3?documentUUID=4809115e-3599-48ba-82e2-200926545229; YEAR=2017; ORIGINAL_YEAR=2017; STUDY_GROUP=ECHA IUCLID:15823892:M/F:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_37641980960274cfff1cd0db47c3d063
ToxValDB_ECHA_IUCLID NOAEL ~250 mg/kg bw/day Rat oral chronic; 104 weeks chronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eacb3e4b0a7c65d1c06b0; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/21289/7/6/2?documentUUID=4809115e-3599-48ba-82e2-200926545229; YEAR=2017; ORIGINAL_YEAR=2017; STUDY_GROUP=ECHA IUCLID:15850236:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_21aca4461620f4f1bd2c59f1bb5143a4
ToxValDB_ECHA_IUCLID NOAEL >370 mg/kg bw/day Mouse oral - developmental QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eabace4b0a7c65d1bb377; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/21289/7/9/3?documentUUID=4809115e-3599-48ba-82e2-200926545229; YEAR=2017; ORIGINAL_YEAR=2017; STUDY_GROUP=ECHA IUCLID:15823894:M/F:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_0d3b064af8f4b6392882556c10333f1f
ToxValDB_ECHA_IUCLID NOAEL =1000 mg/kg bw/day Rat oral short-term; 28 days short-term QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eacb3e4b0a7c65d1c06ae; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/21289/7/6/2?documentUUID=4809115e-3599-48ba-82e2-200926545229; YEAR=2017; ORIGINAL_YEAR=2017; TOXICOLOGICAL_EFFECT=body weight and weight gain; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=ECHA IUCLID:15850235:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_aa44d218138ba3181910c74427090e4c
ToxValDB_GESTIS_DNEL 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_GESTIS_DNEL DNEL systemic =5.88 mg/m3 Human inhalation - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15634838:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_1092a6ed827ee3603b6f8f067c6df7d1
openFDA substances 8 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier 532IUT7IRV UNII - - - chemical {"approval_status":null,"molecular_formula":"Na.O3P","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"532IUT7IRV"}
openFDA substances FDA UNII substance identifier 532IUT7IRV UNII - - - chemical {"approval_status":null,"molecular_formula":"Na.O3P","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"532IUT7IRV"}
openFDA substances FDA UNII substance identifier 532IUT7IRV UNII - - - chemical {"approval_status":null,"molecular_formula":"Na.O3P","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"532IUT7IRV"}
openFDA substances FDA UNII substance identifier 532IUT7IRV UNII - - - chemical {"approval_status":null,"molecular_formula":"Na.O3P","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"532IUT7IRV"}
openFDA substances FDA UNII substance identifier P1BM4ZH95L UNII - - - polymer {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"polymer","unii_code":"P1BM4ZH95L"}
openFDA substances FDA UNII substance identifier P1BM4ZH95L UNII - - - polymer {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"polymer","unii_code":"P1BM4ZH95L"}
openFDA substances FDA UNII substance identifier P1BM4ZH95L UNII - - - polymer {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"polymer","unii_code":"P1BM4ZH95L"}
openFDA substances FDA UNII substance identifier P1BM4ZH95L UNII - - - polymer {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"polymer","unii_code":"P1BM4ZH95L"}