Good Cosmetic Ingredient NOAEL Data GHS Classified

Sodium Nitrate

INCI: SODIUM NITRATE

CAS Number
7631-99-4
Function
Anticorrosive (packaging protection); also oral care agent in some contexts
Safety Rating
GOOD

Regulatory Status

🇪🇺 EU Status permitted
🇺🇸 US Status permitted
US Notes Generally permitted in cosmetics; widely used in food (GRAS); no specific CIR restriction

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
low
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

10 study endpoints found for Sodium Nitrate. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
NOAEL 10000 mg/kg bw/day oral rat Short Term Toxicity COSMOS_DB
NOAEL 5000 mg/kg bw/day oral rat Short Term Toxicity COSMOS_DB
NOAEL 10000 mg/kg bw/day oral rat Chronic COSMOS_DB
NOAEL 1845 mg/kg bw/day oral mouse Subchronic COSMOS_DB
NOAEL 500 mg/kg bw/day oral dog Subchronic COSMOS_DB
NOAEL 5000 mg/kg bw/day oral rat Carcinogenicity COSMOS_DB
NOAEL 7500 mg/kg bw/day oral mouse Carcinogenicity COSMOS_DB
NOAEL 40 mg/kg bw/day oral rat Subchronic COSMOS_DB
NOAEL 81 mg/kg bw/day oral rabbit Reproductive COSMOS_DB
NOAEL 20 mg/kg bw/day oral rat Special Toxicology Study COSMOS_DB

GHS Hazard Classification

Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.

Short-term Exposure Effects
The substance is irritating to the eyes, skin and respiratory tract. Ingestion could cause effects on the blood. This may result in the formation of methaemoglobin. The effects may be delayed. Medical observation is indicated.
Routes of Exposure
The substance can be absorbed into the body by inhalation of its aerosol and by ingestion.

Expert Verdict

Must not be used alongside secondary/tertiary amines or amine-forming agents due to nitrosamine formation risk (conversion to nitrite → nitrosamines); EU restricts nitrosamine content to <50 ppb in finished products

⚠️
Concern Level: Low

Regulatory Flags

endocrine_disruptor epa_safer_alternative fda_food_additive

Frequently Asked Questions

Is Sodium Nitrate safe in cosmetics?

Must not be used alongside secondary/tertiary amines or amine-forming agents due to nitrosamine formation risk (conversion to nitrite → nitrosamines); EU restricts nitrosamine content to <50 ppb in finished products The EU classifies Sodium Nitrate as "permitted". Safety rating: GOOD. 10 toxicological study endpoint(s) are available in our database.

Is Sodium Nitrate allowed in the EU?

Sodium Nitrate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Sodium Nitrate do in cosmetics?

Sodium Nitrate functions as: Anticorrosive (packaging protection); also oral care agent in some contexts. It is classified as a cosmetic ingredient in our database. CAS number: 7631-99-4.

What is the Margin of Safety for Sodium Nitrate?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

What is the NOAEL for Sodium Nitrate?

The NOAEL (No Observed Adverse Effect Level) for Sodium Nitrate is 10000 mg/kg bw/day based on a Short Term Toxicity study via oral route in rat. A total of 10 study endpoints are available. Source: COSMOS_DB.

Compliance Tools

Check Sodium Nitrate compliance across multiple jurisdictions:

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Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
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Substance Compliance
Check compliance across 55 jurisdictions
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
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Heavy Metal Limits
Compare limits across jurisdictions

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