NOAEL Studies Cosmetic Ingredient

Sodium Oxymethylene Sulfoxylate NOAEL Studies

INCI: SODIUM OXYMETHYLENE SULFOXYLATE

CAS: 149-44-0

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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NTP_ICE_acute_oral 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_acute_oral LD50 >2000 mg/kg bw Rat oral acute Rat Acute Oral Toxicity record_id=acute_oral_2888; row=12030; data_type=In Vivo; mixture=Chemical; chemical_name=Sodium hydroxymethanesulfinate; preferred_name=Sodium hydroxymethanesulfinate; dtxsid=DTXSID7027120; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7027120; source_file=acute_oral.xlsx
NTP_ICE_acute_oral LD50 >5000 mg/kg bw Rat oral acute Rat Acute Oral Toxicity record_id=acute_oral_2890; row=12031; data_type=In Vivo; mixture=Chemical; chemical_name=Sodium hydroxymethanesulfinate; preferred_name=Sodium hydroxymethanesulfinate; dtxsid=DTXSID7027120; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7027120; source_file=acute_oral.xlsx
ToxValDB_ECHA_IUCLID 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_ECHA_IUCLID NOAEL =300 mg/kg bw/day Rat oral - reproduction developmental QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eabe9e4b0a7c65d1bc6b6; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14124/7/9/3?documentUUID=86cd0d07-5647-4921-ae6e-480fed05a177; YEAR=2008; ORIGINAL_YEAR=2008; STUDY_GROUP=ECHA IUCLID:15822795:F:-maternal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_887ab9010b64e5885e448c44be591448
ToxValDB_ECHA_IUCLID NOAEL =1000 mg/kg bw/day Rat oral subchronic; 53 days subchronic QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669ead7de4b0a7c65d1c46e0; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14124/7/6/2?documentUUID=86cd0d07-5647-4921-ae6e-480fed05a177; YEAR=2008; ORIGINAL_YEAR=2008; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15831359_15831360:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_cb1ff6063c6dac3d5a8d794a4a47a87a
ToxValDB_ECHA_IUCLID NOAEL =600 mg/kg bw/day Rat oral subchronic; 13 weeks subchronic QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669ead7de4b0a7c65d1c46e3; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14124/7/6/2?documentUUID=86cd0d07-5647-4921-ae6e-480fed05a177; YEAR=2008; ORIGINAL_YEAR=2008; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15832176_15832177:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_2d9d5bf1c37291c8be00a512ffe7384c
ToxValDB_ECHA_IUCLID NOEL =100 mg/kg bw/day Rat oral subchronic; 13 weeks subchronic QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669ead7de4b0a7c65d1c46e3; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14124/7/6/2?documentUUID=86cd0d07-5647-4921-ae6e-480fed05a177; YEAR=2008; ORIGINAL_YEAR=2008; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15832176_15832177:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_366205eff7bf2b0bb0895c6d01e27bb9
ToxValDB_GESTIS_DNEL 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_GESTIS_DNEL DNEL systemic =21 mg/m3 Human inhalation - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL_dup_-_15632714_15632715:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_60c36bfdce4093f72a5a87eaa98e6745
ToxValDB_GESTIS_DNEL DNEL systemic =4.94 mg/m3 Human inhalation - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL_dup_-_15632714_15632715:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_1907bf9cd48bc5b0b85796dae4ace11d
openFDA substances 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier X4ZGP7K714 UNII - - - chemical {"approval_status":null,"molecular_formula":"CH3O3S.Na","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"X4ZGP7K714"}
openFDA substances FDA UNII substance identifier X4ZGP7K714 UNII - - - chemical {"approval_status":null,"molecular_formula":"CH3O3S.Na","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"X4ZGP7K714"}
openFDA substances FDA UNII substance identifier X4ZGP7K714 UNII - - - chemical {"approval_status":null,"molecular_formula":"CH3O3S.Na","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"X4ZGP7K714"}
openFDA substances FDA UNII substance identifier X4ZGP7K714 UNII - - - chemical {"approval_status":null,"molecular_formula":"CH3O3S.Na","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"X4ZGP7K714"}