NOAEL Studies
Preservative
Sodium Salicylate NOAEL Studies
INCI: SODIUM SALICYLATE
CAS: 54-21-7
Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.
NTP_ICE_acute_oral 4 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_acute_oral | LD50 | =2000 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | record_id=acute_oral_7391; row=8641; data_type=In Vivo; mixture=Chemical; chemical_name=Sodium salicylate; preferred_name=Sodium salicylate; dtxsid=DTXSID5021708; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021708; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID5021708; source_file=acute_oral.xlsx |
| NTP_ICE_acute_oral | LD50 | =200 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | OECD eChemPortal (undated); record_id=acute_oral_7388; row=8642; data_type=In Vivo; mixture=Chemical; chemical_name=Sodium salicylate; preferred_name=Sodium salicylate; dtxsid=DTXSID5021708; url=https://www.echemportal.org/echemportal/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021708; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID5021708; source_file=acute_oral.xlsx |
| NTP_ICE_acute_oral | LD50 | =1000 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | ECHA ChemProp (undated); record_id=acute_oral_7390; row=8643; data_type=In Vivo; mixture=Chemical; chemical_name=Sodium salicylate; preferred_name=Sodium salicylate; dtxsid=DTXSID5021708; url=https://echa.europa.eu/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021708; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID5021708; source_file=acute_oral.xlsx |
| NTP_ICE_acute_oral | LD50 | =930 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | NLM ChemIDplus TEST (undated); record_id=acute_oral_7389; row=8644; data_type=In Vivo; mixture=Chemical; chemical_name=Sodium salicylate; preferred_name=Sodium salicylate; dtxsid=DTXSID5021708; url=https://chem.nlm.nih.gov/chemidplus/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021708; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID5021708; source_file=acute_oral.xlsx |
NTP_ICE_eye_irritation 5 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_eye_irritation | Draize rabbit irritation score | 83.7 | unitless | Rabbit | Ocular | - | In Vivo; Draize Eye Irritation/Corrosion Test | sheet=Data; excel_row=1511; Record_ID=eye_irritation_170; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID5021708; Assay=Draize Eye Irritation/Corrosion Test; Endpoint=Draize rabbit irritation score; Response=83.7; Response_Unit=Unitless; Species=Rabbit; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021708; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021708 |
| NTP_ICE_eye_irritation | EPA Classification | 1 | unitless | Rabbit | Ocular | - | In Vivo; Draize Eye Irritation/Corrosion Test | sheet=Data; excel_row=1506; Record_ID=eye_irritation_170; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID5021708; Assay=Draize Eye Irritation/Corrosion Test; Endpoint=EPA Classification; Response=1; Response_Unit=Unitless; Species=Rabbit; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021708; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021708 |
| NTP_ICE_eye_irritation | Intensity | 1.01 | %/sec | - | Ocular | - | In Vitro; Vitrigel | sheet=Data; excel_row=1508; Record_ID=eye_irritation_1303; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID5021708; Assay=Vitrigel; Endpoint=Intensity; Response=1.01; Response_Unit=%/sec; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021708; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021708 |
| NTP_ICE_eye_irritation | Lag time | 0 | s | - | Ocular | - | In Vitro; Vitrigel | sheet=Data; excel_row=1510; Record_ID=eye_irritation_1303; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID5021708; Assay=Vitrigel; Endpoint=Lag time; Response=0; Response_Unit=sec; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021708; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021708 |
| NTP_ICE_eye_irritation | Plateau level | 60 | % | - | Ocular | - | In Vitro; Vitrigel | sheet=Data; excel_row=1507; Record_ID=eye_irritation_1303; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID5021708; Assay=Vitrigel; Endpoint=Plateau level; Response=60; Response_Unit=%; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021708; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021708 |
ToxValDB_ECHA_IUCLID 14 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_ECHA_IUCLID | LEL | =200 | mg/kg bw/day | Rat | oral | - | acute | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6605975fe4b063812d6fa6ed; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/13593/7/3/2?documentUUID=b703ebdb-8235-470e-830d-33622f851a8f; YEAR=2006; ORIGINAL_YEAR=2006; STUDY_GROUP=ECHA IUCLID:15800891:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_0e983af1780b357b6eac4a94fe9b8cf6 |
| ToxValDB_ECHA_IUCLID | LEL | =2000 | mg/kg bw/day | Rat | oral | - | acute | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6605975fe4b063812d6fa6ed; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/13593/7/3/2?documentUUID=b703ebdb-8235-470e-830d-33622f851a8f; YEAR=2006; ORIGINAL_YEAR=2006; STUDY_GROUP=ECHA IUCLID:15800892:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_ef12124ecf5b32d6e0cb36b098b1e1fa |
| ToxValDB_ECHA_IUCLID | LOAEL | =300 | mg/kg bw/day | Rat | oral | - | developmental | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eac32e4b0a7c65d1bde14; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/13593/7/9/3?documentUUID=b703ebdb-8235-470e-830d-33622f851a8f; YEAR=2006; ORIGINAL_YEAR=2006; TOXICOLOGICAL_EFFECT=fetus: fetal/pup body weight changes|fetus: skeletal malformations; TOXICOLOGICAL_EFFECT_CATEGORY=development; STUDY_GROUP=ECHA IUCLID_dup_Developmental Toxicity Teratogenicity_15820772_15820799_15824909:-:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_8fe5cbd7cf27b107e97295fa98383648 |
| ToxValDB_ECHA_IUCLID | LOAEL | =1500 | mg/kg bw/day | Mouse | oral | - | developmental | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eac32e4b0a7c65d1bde1e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/13593/7/9/3?documentUUID=b703ebdb-8235-470e-830d-33622f851a8f; YEAR=2006; ORIGINAL_YEAR=2006; TOXICOLOGICAL_EFFECT=fetus: reduction in number of live offspring|fetus: skeletal malformations; TOXICOLOGICAL_EFFECT_CATEGORY=development; STUDY_GROUP=ECHA IUCLID_dup_Developmental Toxicity Teratogenicity_15821320_15824914:-:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_a5a4de95a0c1d2d10ddc8fd09c7a71a6 |
| ToxValDB_ECHA_IUCLID | LOAEL | =1600 | mg/kg bw/day | Mouse | oral | - | reproduction developmental | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eac32e4b0a7c65d1bde1c; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/13593/7/9/3?documentUUID=b703ebdb-8235-470e-830d-33622f851a8f; YEAR=2006; ORIGINAL_YEAR=2006; TOXICOLOGICAL_EFFECT=maternal: body weight and weight gain|maternal: mortality; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|mortality/survival; STUDY_GROUP=ECHA IUCLID:15824910:F:-maternal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_9e50b83a969eb73bd55231487dab2009 |
| ToxValDB_ECHA_IUCLID | LOAEL | <=200 | mg/kg bw/day | Rat | oral | - | reproduction developmental | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eac32e4b0a7c65d1bde20; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/13593/7/9/3?documentUUID=b703ebdb-8235-470e-830d-33622f851a8f; YEAR=2006; ORIGINAL_YEAR=2006; TOXICOLOGICAL_EFFECT=maternal: dead fetuses|maternal: total litter losses by resorption; TOXICOLOGICAL_EFFECT_CATEGORY=development|reproduction; STUDY_GROUP=ECHA IUCLID:15824912:F:-maternal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_c9e6234c8ffce8589407d7ca92904d6a |
| ToxValDB_ECHA_IUCLID | LOAEL | =800 | mg/kg bw/day | Mouse | oral | - | developmental | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eac32e4b0a7c65d1bde22; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/13593/7/9/3?documentUUID=b703ebdb-8235-470e-830d-33622f851a8f; YEAR=2006; ORIGINAL_YEAR=2006; TOXICOLOGICAL_EFFECT=fetus: reduction in number of live offspring|fetus: fetal/pup body weight changes; TOXICOLOGICAL_EFFECT_CATEGORY=development; STUDY_GROUP=ECHA IUCLID_dup_Developmental Toxicity Teratogenicity_15821320_15824914:-:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_c308ac26e42cb70eeaf1a8601e152051 |
| ToxValDB_ECHA_IUCLID | LOAEL | <=218 | mg/kg bw/day | Rat | oral | chronic; 15 weeks | chronic | QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eae65e4b0a7c65d1c8f58; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/13593/7/6/2?documentUUID=b703ebdb-8235-470e-830d-33622f851a8f; YEAR=2006; ORIGINAL_YEAR=2006; TOXICOLOGICAL_EFFECT=behaviour (functional findings)|body weight and weight gain; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|neurobehavior; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15831992_15849530:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_a4c15c4823a85b1844177e263a949bc0 |
| ToxValDB_ECHA_IUCLID | NOAEL | =30 | mg/kg bw/day | Rat | oral | - | developmental | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7d207e4b0a7c65d2314c2; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/23278/7/9/3?documentUUID=da8d09a8-236b-4588-8c8b-906fd051ede5; YEAR=1980; ORIGINAL_YEAR=1980; STUDY_GROUP=ECHA IUCLID_dup_Developmental Toxicity Teratogenicity_15820772_15820799_15824909:-:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_47fc51378448250a1d7cdd84b4ba049a |
| ToxValDB_ECHA_IUCLID | NOAEL | >=200 | mg/kg bw/day | Rat | oral | - | developmental | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eac32e4b0a7c65d1bde18; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/13593/7/9/3?documentUUID=b703ebdb-8235-470e-830d-33622f851a8f; YEAR=2006; ORIGINAL_YEAR=2006; TOXICOLOGICAL_EFFECT=fetus: reduction in number of live offspring|fetus: changes in sex ratio|fetus: fetal/pup body weight changes|fetus: changes in litter size and weights|fetus: external malformations; TOXICOLOGICAL_EFFECT_CATEGORY=development; STUDY_GROUP=ECHA IUCLID_dup_Developmental Toxicity Teratogenicity_15820772_15820799_15824909:-:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_35c3e1c96c416a549b393060ece22ac0 |
| ToxValDB_ECHA_IUCLID | NOAEL | =800 | mg/kg bw/day | Mouse | oral | - | reproduction developmental | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eac32e4b0a7c65d1bde22; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/13593/7/9/3?documentUUID=b703ebdb-8235-470e-830d-33622f851a8f; YEAR=2006; ORIGINAL_YEAR=2006; TOXICOLOGICAL_EFFECT=maternal: body weight and weight gain|maternal: changes in number of pregnant|maternal: clinical signs|maternal: mortality; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical signs|mortality/survival|reproduction; STUDY_GROUP=ECHA IUCLID_dup_Developmental Toxicity Teratogenicity_15822636_15824915:F:-maternal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_a972a0ca3efe80f2f5971081b48cd7e0 |
| ToxValDB_ECHA_IUCLID | NOAEL | =90 | mg/kg bw/day | Rat | oral | - | reproduction developmental | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7d207e4b0a7c65d2314c2; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/23278/7/9/3?documentUUID=da8d09a8-236b-4588-8c8b-906fd051ede5; YEAR=1980; ORIGINAL_YEAR=1980; STUDY_GROUP=ECHA IUCLID_dup_Developmental Toxicity Teratogenicity_15822108_15825114:F:-maternal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_7adda32f636082765c311b14eb44b3bc |
| ToxValDB_ECHA_IUCLID | NOAEL | >=138 | mg/kg bw/day | Rat | oral | chronic; 15 weeks | chronic | QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eae65e4b0a7c65d1c8f58; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/13593/7/6/2?documentUUID=b703ebdb-8235-470e-830d-33622f851a8f; YEAR=2006; ORIGINAL_YEAR=2006; TOXICOLOGICAL_EFFECT=behaviour (functional findings)|body weight and weight gain|mortality; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|mortality/survival|neurobehavior; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15831992_15849530:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_d2f9a84c377778d83cc6ef42bc365b05 |
| ToxValDB_ECHA_IUCLID | NOAEL | >=80 | mg/kg bw/day | Rat | oral | - | reproduction developmental | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eab0ce4b0a7c65d1b8969; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/13593/7/9/2?documentUUID=b703ebdb-8235-470e-830d-33622f851a8f; YEAR=2006; ORIGINAL_YEAR=2006; TOXICOLOGICAL_EFFECT=P0: clinical signs|P0: mortality|P0: body weight and weight gain|P0: reproductive performance; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical signs|mortality/survival|reproduction; STUDY_GROUP=ECHA IUCLID_dup_Toxicity Reproduction_15856308_15862853:F:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_744aaf2839caccf3eb509d7312f9d9ca |
ToxValDB_ECOTOX 6 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_ECOTOX | LOEL | =700 | mg/kg bw/day | Rat | oral | acute; 1 days | acute | LONG_REF=Histochem. J.23(2): 75-82 Gunther,T., R. Gossrau, J. Vormann, and M. Ruhnke Protection Against Salicylate-Induced Hepatic Injury by Zinc. A Histochemical and Biochemical Study 1991; TITLE=Protection Against Salicylate-Induced Hepatic Injury by Zinc. A Histochemical and Biochemical Study; AUTHOR=Gunther,T., R. Gossrau, J. Vormann, and M. Ruhnke; DOI=10.1007/BF01047111; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=86069; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1991; ORIGINAL_YEAR=1991; TOXICOLOGICAL_EFFECT=Biochemistry: Calcium content|Biochemistry: Glycogen|Biochemistry: Iron content|Biochemistry: Magnesium (Mg) content|Biochemistry: Metallothionein|Biochemistry: Transferrin; TOXICOLOGICAL_EFFECT_CATEGORY=clinical chemistry|hematology|other; STUDY_GROUP=ECOTOX_dup_EPA ORD_15596477_15597607:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=a89b9f127c9df0ac94c3c7c9bd532835 |
| ToxValDB_ECOTOX | NOEC | =200 | mg/L | Rat | environmental | short-term; 2 days | developmental | LONG_REF=Alt. Lab. Anim. (ATLA)32(3): 275-307 Piersma,A.H., E. Genschow, A. Verhoef, M.Q.I. Spanjersberg, N.A. Brown, M. Brady, A. Burns, N. Clemann, A. Seiler, and Validation of the Postimplantation Rat Whole-Embryo Culture Test in the International ECVAM Validation Study on Three In Vitro Embryotoxicity Tests 2004; TITLE=Validation of the Postimplantation Rat Whole-Embryo Culture Test in the International ECVAM Validation Study on Three In Vitro Embryotoxicity Tests; AUTHOR=Piersma,A.H., E. Genschow, A. Verhoef, M.Q.I. Spanjersberg, N.A. Brown, M. Brady, A. Burns, N. Clemann, A. Seiler, and; DOI=10.1177/026119290403200307; QUALITY=Control type: Multiple entries; EXTERNAL_SOURCE_ID=157474; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2004; ORIGINAL_YEAR=2004; TOXICOLOGICAL_EFFECT=Development: Deformation; TOXICOLOGICAL_EFFECT_CATEGORY=development; STUDY_GROUP=ECOTOX_dup_EPA ORD_15594200_15599413_15599414_15604241_15607699:unknown:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=aa4a9b8826343cdaf0c44a095bf18b73 |
| ToxValDB_ECOTOX | NOEC | =1000 | mg/L | Rat | environmental | short-term; 2 days | developmental | LONG_REF=Alt. Lab. Anim. (ATLA)32(3): 275-307 Piersma,A.H., E. Genschow, A. Verhoef, M.Q.I. Spanjersberg, N.A. Brown, M. Brady, A. Burns, N. Clemann, A. Seiler, and Validation of the Postimplantation Rat Whole-Embryo Culture Test in the International ECVAM Validation Study on Three In Vitro Embryotoxicity Tests 2004; TITLE=Validation of the Postimplantation Rat Whole-Embryo Culture Test in the International ECVAM Validation Study on Three In Vitro Embryotoxicity Tests; AUTHOR=Piersma,A.H., E. Genschow, A. Verhoef, M.Q.I. Spanjersberg, N.A. Brown, M. Brady, A. Burns, N. Clemann, A. Seiler, and; DOI=10.1177/026119290403200307; QUALITY=Control type: Multiple entries; EXTERNAL_SOURCE_ID=157474; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2004; ORIGINAL_YEAR=2004; TOXICOLOGICAL_EFFECT=Development: Deformation; TOXICOLOGICAL_EFFECT_CATEGORY=development; STUDY_GROUP=ECOTOX_dup_EPA ORD_15594200_15599413_15599414_15604241_15607699:unknown:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=b6e94d49d936e60e3063bf6488e99f09 |
| ToxValDB_ECOTOX | NOEC | =400 | mg/L | Rat | environmental | short-term; 2 days | developmental | LONG_REF=Alt. Lab. Anim. (ATLA)32(3): 275-307 Piersma,A.H., E. Genschow, A. Verhoef, M.Q.I. Spanjersberg, N.A. Brown, M. Brady, A. Burns, N. Clemann, A. Seiler, and Validation of the Postimplantation Rat Whole-Embryo Culture Test in the International ECVAM Validation Study on Three In Vitro Embryotoxicity Tests 2004; TITLE=Validation of the Postimplantation Rat Whole-Embryo Culture Test in the International ECVAM Validation Study on Three In Vitro Embryotoxicity Tests; AUTHOR=Piersma,A.H., E. Genschow, A. Verhoef, M.Q.I. Spanjersberg, N.A. Brown, M. Brady, A. Burns, N. Clemann, A. Seiler, and; DOI=10.1177/026119290403200307; QUALITY=Control type: Multiple entries; EXTERNAL_SOURCE_ID=157474; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2004; ORIGINAL_YEAR=2004; TOXICOLOGICAL_EFFECT=Development: Deformation; TOXICOLOGICAL_EFFECT_CATEGORY=development; STUDY_GROUP=ECOTOX_dup_EPA ORD_15594200_15599413_15599414_15604241_15607699:unknown:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=56b91e8bf5ac3492861b022eec0aeff8 |
| ToxValDB_ECOTOX | NOEC | =100 | mg/L | Rat | environmental | short-term; 2 days | developmental | LONG_REF=Alt. Lab. Anim. (ATLA)32(3): 275-307 Piersma,A.H., E. Genschow, A. Verhoef, M.Q.I. Spanjersberg, N.A. Brown, M. Brady, A. Burns, N. Clemann, A. Seiler, and Validation of the Postimplantation Rat Whole-Embryo Culture Test in the International ECVAM Validation Study on Three In Vitro Embryotoxicity Tests 2004; TITLE=Validation of the Postimplantation Rat Whole-Embryo Culture Test in the International ECVAM Validation Study on Three In Vitro Embryotoxicity Tests; AUTHOR=Piersma,A.H., E. Genschow, A. Verhoef, M.Q.I. Spanjersberg, N.A. Brown, M. Brady, A. Burns, N. Clemann, A. Seiler, and; DOI=10.1177/026119290403200307; QUALITY=Control type: Multiple entries; EXTERNAL_SOURCE_ID=157474; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2004; ORIGINAL_YEAR=2004; TOXICOLOGICAL_EFFECT=Development: Deformation; TOXICOLOGICAL_EFFECT_CATEGORY=development; STUDY_GROUP=ECOTOX_dup_EPA ORD_15594200_15599413_15599414_15604241_15607699:unknown:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=e11bc2cd3206487e2bf6cc76551de0ad |
| ToxValDB_ECOTOX | NOEC | =300 | mg/L | Rat | environmental | short-term; 2 days | developmental | LONG_REF=Alt. Lab. Anim. (ATLA)32(3): 275-307 Piersma,A.H., E. Genschow, A. Verhoef, M.Q.I. Spanjersberg, N.A. Brown, M. Brady, A. Burns, N. Clemann, A. Seiler, and Validation of the Postimplantation Rat Whole-Embryo Culture Test in the International ECVAM Validation Study on Three In Vitro Embryotoxicity Tests 2004; TITLE=Validation of the Postimplantation Rat Whole-Embryo Culture Test in the International ECVAM Validation Study on Three In Vitro Embryotoxicity Tests; AUTHOR=Piersma,A.H., E. Genschow, A. Verhoef, M.Q.I. Spanjersberg, N.A. Brown, M. Brady, A. Burns, N. Clemann, A. Seiler, and; DOI=10.1177/026119290403200307; QUALITY=Control type: Multiple entries; EXTERNAL_SOURCE_ID=157474; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2004; ORIGINAL_YEAR=2004; TOXICOLOGICAL_EFFECT=Development: Deformation; TOXICOLOGICAL_EFFECT_CATEGORY=development; STUDY_GROUP=ECOTOX_dup_EPA ORD_15594200_15599413_15599414_15604241_15607699:unknown:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=a09cacf429a5a7c1e5e1401cb58f0394 |
ToxValDB_GESTIS_DNEL 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_GESTIS_DNEL | DNEL systemic | =1.32 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15634873:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_2c2659a84f8d8c6ac7ba5a947dd563f7 |
openFDA substances 4 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| openFDA substances | FDA UNII substance identifier | WIQ1H85SYP | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C7H5O3.Na","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"WIQ1H85SYP"} |
| openFDA substances | FDA UNII substance identifier | WIQ1H85SYP | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C7H5O3.Na","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"WIQ1H85SYP"} |
| openFDA substances | FDA UNII substance identifier | WIQ1H85SYP | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C7H5O3.Na","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"WIQ1H85SYP"} |
| openFDA substances | FDA UNII substance identifier | WIQ1H85SYP | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C7H5O3.Na","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"WIQ1H85SYP"} |