Is Sodium Toluenesulfonate safe in cosmetics?
Sodium Toluenesulfonate has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted. 2 toxicological study endpoint(s) are available in our database.
Sodium Toluenesulfonate
Also known as: Sodium p-tolylsulfonate, EINECS 211-522-5, Naxonate hydrotrope, NSC 203318, para-Toluenesulfonic acid, sodium salt (+5 more)
INCI: SODIUM TOLUENESULFONATE
Sodium Toluenesulfonate (CAS 657-84-1) is a cosmetic cosmetic ingredient functioning as Hydrotrope, solubilizer, viscosity controlling agent (keeps surfactant systems. Reported NOAEL =300 mg/kg bw/day in Rat (ToxValDB_ECHA_IUCLID); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 657-84-1 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
Sodium Toluenesulfonate is classified GHS Danger (H301, H312, H317, H319, H332, H341, H351, H400) in the chemicals database but is allowed in EU cosmetics.
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Hydrotrope, solubilizer, viscosity controlling agent (keeps surfactant systems clear and stable)
Safety Rating
GOOD
Chemistry & Identifiers
InChIKey
CUYTYLVEYFUAAX-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Permitted for cosmetic use; CIR (Cosmetic Ingredient Review) assessed as safe in current practices of use
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Sodium Toluenesulfonate.
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
2 study endpoints found for Sodium Toluenesulfonate. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =300 mg/kg bw/day | oral | Rat | reproduction developmental | ToxValDB_ECHA_IUCLID |
| NOAEL | =1000 mg/kg bw/day | oral | Rat | short-term | ToxValDB_ECHA_IUCLID |
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
100 - 1,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Expert Verdict
Expert safety assessment and concern-level summary for Sodium Toluenesulfonate.
Regulatory Flags
epa_safer_alternative
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to Sodium Toluenesulfonate by CAS number or substance name.
Studies
2
Lowest NOAEL
300 mg/kg bw/day
Highest NOAEL
1000 mg/kg bw/day
ToxValDB_ECHA_IUCLID
Known Synonyms
Sodium p-tolylsulfonate
EINECS 211-522-5
Naxonate hydrotrope
NSC 203318
para-Toluenesulfonic acid, sodium salt
Sodium paratoluene sulphonate
Sodium toluene-p-sulphonate
p-Toluenesulfonic acid sodium salt
Tosylate, sodium
UNII-2V179P6Q43
Regulatory Lists
inert_ingredient; non_food_use; Pesticides
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL3186382
Frequently Asked Questions
Is Sodium Toluenesulfonate allowed in the EU?
Sodium Toluenesulfonate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Sodium Toluenesulfonate do in cosmetics?
Sodium Toluenesulfonate functions as: Hydrotrope, solubilizer, viscosity controlling agent (keeps surfactant systems clear and stable). It is classified as a cosmetic ingredient in our database. CAS number: 657-84-1.
What is the NOAEL for Sodium Toluenesulfonate?
The NOAEL (No Observed Adverse Effect Level) for Sodium Toluenesulfonate is =300 mg/kg bw/day based on a reproduction developmental study via oral route in Rat. A total of 2 study endpoints are available. Source: ToxValDB_ECHA_IUCLID.
Is Sodium Toluenesulfonate used outside cosmetics?
Sodium Toluenesulfonate also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does Sodium Toluenesulfonate have different safety status in cosmetics vs industrial chemicals?
Sodium Toluenesulfonate is classified GHS Danger (H301, H312, H317, H319, H332, H341, H351, H400) in the chemicals database but is allowed in EU cosmetics.
Compliance Tools
Check Sodium Toluenesulfonate compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
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Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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