Is SORBITAN TRISTEARATE safe in cosmetics?
SORBITAN TRISTEARATE has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted.
Good
Cosmetic Ingredient
SORBITAN TRISTEARATE
Also known as: (Sorbitan tristearate), Span(R) 65, EINECS 247-891-4, Sorbitani tristearas, UNII-6LUM696811
SORBITAN TRISTEARATE (CAS 26658-19-5) is a cosmetic cosmetic ingredient functioning as Surfactant - Emulsifying. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and food safety data.
View industrial chemical safety profile for CAS 26658-19-5 →
Auto-generated CPSR Part A draft with source citations
Function
Surfactant - Emulsifying
Safety Rating
GOOD
Chemistry & Identifiers
IUPAC Name
[(2R)-2-[(2R,3R,4S)-4-hydroxy-3-octadecanoyloxyoxolan-2-yl]-2-octadecanoyloxyethyl] octadecanoate
InChIKey
IJCWFDPJFXGQBN-RYNSOKOISA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
CIR: S - IJT 38(S2):60-80,2019
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
EPA ToxValDB — Toxicity Values
7 toxicity values from EPA ToxValDB (aggregated from CCTE, HPV, ToxRefDB, IRIS, and other regulatory dossiers).
| Endpoint | Value | Species | Route | Duration | Source |
|---|---|---|---|---|---|
| NOAEL | =2600 mg/kg-day | Mouse | oral | chronic | EFSA |
| LD50 | >15900 mg/kg | Rat | oral | - | ECHA IUCLID |
| LD50 | >2000 mg/kg | Rat | oral | - | ECHA IUCLID |
| NOAEL | >=1600 mg/kg-day | Rabbit | oral | - | ECHA IUCLID |
| NOAEL | >=1600 mg/kg-day | Rabbit | oral | - | ECHA IUCLID |
| NOAEL | >=1000 mg/kg-day | Rat | oral | - | ECHA IUCLID |
| NOAEL | >=1000 mg/kg-day | Rat | oral | - | ECHA IUCLID |
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
100 - 1,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Additional Ingredient Properties
2 property records from structured ingredient metadata.
emulsifier
{"cas_number": "26658-19-5", "ingredient_class": "W/O_emulsifier,co_emulsifier", "chemical_type": "sorbitan_ester", "HLB_value": "2.1", "HLB_required_for_oil_phase": "2-3", "emulsion_type_primary": "W/O", "droplet_size_typical_um": "5-15", "surface_tension_reduction_mN_m": "18-22", "interfacial_tension_reduction": "20-24", "foam_formation": "low", "liquid_crystal_formation": "low", "lamellar_phase…
solubility_hlb
{"water_soluble": "no", "oil_soluble": "yes", "hlb_value": "2.1", "soluble_in": "oils, lipids", "insoluble_in": "water", "log_p": "6.8", "melting_point_c": "54-55", "appearance": "beige waxy solid", "source": "Croda"}
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Dispersing agent
Emulsifier
Surfactant (surface active agent)
Regulatory List Membership (1)
FDA Indirect Food Contact Additives
Expert Verdict
Expert safety assessment and concern-level summary for SORBITAN TRISTEARATE.
Regulatory Flags
cosing-sourced
eu-permitted
surfactant
needs-enrichment
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to SORBITAN TRISTEARATE by CAS number or substance name.
Studies
3
Lowest NOAEL
2600 mg/kg bw/day
Highest NOAEL
2600 mg/kg bw/day
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip
Known Synonyms
(Sorbitan tristearate)
Span(R) 65
EINECS 247-891-4
Sorbitani tristearas
UNII-6LUM696811
Chemical Function
Emulsifier
Surfactant (surface active agent)
Dispersing agent
Regulatory Lists
inert_ingredient; non_food_use; Pesticides
pharmaceutical
Indirect additives food contact (10/2018)
Europe; plastic_additive
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in food safety data.
SOURCE
EFSA / FDA GRAS
food_additives
Food Safety Data
Same-CAS food additive or FDA GRAS records from the core public database.
Food Name
Sorbitan tristearate
E Number
E492
ADI
25 mg/kg bw
Food Category
emulsifier
Frequently Asked Questions
Is SORBITAN TRISTEARATE allowed in the EU?
SORBITAN TRISTEARATE EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does SORBITAN TRISTEARATE do in cosmetics?
SORBITAN TRISTEARATE functions as: Surfactant - Emulsifying. It is classified as a cosmetic ingredient in our database. CAS number: 26658-19-5.
Is SORBITAN TRISTEARATE used outside cosmetics?
SORBITAN TRISTEARATE also appears in industrial chemical safety and food safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check SORBITAN TRISTEARATE compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
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Substance Compliance
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MoS Calculator
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Heavy Metal Limits
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