NOAEL Studies Cosmetic Ingredient

SORBITAN TRISTEARATE NOAEL Studies

CAS: 26658-19-5

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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EFSA 3 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
EFSA NOAEL =2600 mg/kg bw/day Mouse oral: feed 560 days chronic/long term toxicity EFSA ANS - 2017 - OutputID 2957 - body weight - systemic - Re-evaluation of sorbitan monostearate (E 491), sorbitan tristearate (E 492), sorbitan monolaurate (E 493), sorbitan monooleate (E 494) and sorbitan monopalmitate (E 495) when used as food additives - doi:10.2903/j.efsa.2017.4788
EFSA ADI (group) =10 mg/kg bw/day Consumers - - ADI (group) EFSA ANS - 2017 - OutputID 2957 - Consumers - Re-evaluation of sorbitan monostearate (E 491), sorbitan tristearate (E 492), sorbitan monolaurate (E 493), sorbitan monooleate (E 494) and sorbitan monopalmitate (E 495) when used as food additives - doi:10.2903/j.efsa.2017.4788
EFSA NOAEL =2600 mg/kg bw/day Mouse oral chronic; 80 weeks chronic LONG_REF=EFSA ANS (2017). Re-evaluation of sorbitan monostearate (E 491), sorbitan tristearate (E 492), sorbitan monolaurate (E 493), sorbitan monooleate (E 494) and sorbitan monopalmitate (E 495) when used as food additives. doi:10.2903/j.efsa.2017.4788.; TITLE=Re-evaluation of sorbitan monostearate (E 491), sorbitan tristearate (E 492), sorbitan monolaurate (E 493), sorbitan monooleate (E 494) and sorbitan monopalmitate (E 495) when used as food additives; AUTHOR=EFSA ANS; DOI=doi:10.2903/j.efsa.2017.4788; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65201d30e4b0f0a60ddd1165; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://zenodo.org/record/5076033#.Y9fEoXbMI2z; YEAR=2017; ORIGINAL_YEAR=2017; TOXICOLOGICAL_EFFECT=body weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=EFSA:15625115:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_ae520e5a9ba13ebce38210b23ccceb83
NTP ICE acute oral 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP ICE acute oral LD50 >2000 mg/kg bw Rat oral acute Rat Acute Oral Toxicity record_id=acute_oral_4817; row=14487; data_type=In Vivo; mixture=Chemical; chemical_name=Sorbitan tristearate; preferred_name=Sorbitan tristearate; dtxsid=DTXSID8047054; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8047054; source_file=acute_oral.xlsx
NTP ICE acute oral LD50 >15900 mg/kg bw Rat oral acute Rat Acute Oral Toxicity record_id=acute_oral_4818; row=14488; data_type=In Vivo; mixture=Chemical; chemical_name=Sorbitan tristearate; preferred_name=Sorbitan tristearate; dtxsid=DTXSID8047054; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8047054; source_file=acute_oral.xlsx
ECHA 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ECHA NOAEL >=1000 mg/kg bw/day Rat oral - reproduction developmental QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaae0e4b0a7c65d1b7d40; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/5384/7/9/2?documentUUID=a3486de8-d308-445e-9c95-be31a71016a4; YEAR=1963; ORIGINAL_YEAR=1963; STUDY_GROUP=ECHA IUCLID:15857636:M/F:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_9964c38961887617bf84bf4be7273145
ECHA NOAEL >=1600 mg/kg bw/day Rabbit oral - developmental QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eac0de4b0a7c65d1bd269; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/5384/7/9/3?documentUUID=a3486de8-d308-445e-9c95-be31a71016a4; YEAR=1963; ORIGINAL_YEAR=1963; STUDY_GROUP=ECHA IUCLID:15821145:-:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_64046afbfe99c65051a09fb68e555332
openFDA substances 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier 6LUM696811 UNII - - - chemical -