NOAEL Studies Cosmetic Ingredient

Soytrimonium Chloride NOAEL Studies

INCI: SOYTRIMONIUM CHLORIDE

CAS: 61790-41-8

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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SCCS Opinion 6 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
SCCS Opinion NOAEL =0.1 - rabbit dermal - reproductive toxicity Ref.: 1, 40 (subm 2004) 3, p.32
SCCS Opinion NOAEL =9.9 % rat dermal - developmental toxicity p.33
SCCS Opinion NOAEL =10 mg/kg bw/day - - - irritation p.30
SCCS Opinion NOAEL =24 % rabbit dermal 28-day irritation Ref.: 33 B, p.29
SCCS Opinion NOAEL =63 mg/kg - - chronic NOAEL study p.31
SCCS Opinion NOAEL =125 mg/kg bw/d rat dermal Developmental developmental toxicity (Ref. 4, 31), p.39
ECHA 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ECHA NOEL ~100 mg/kg bw/day Rat oral short-term; 28 days short-term QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eae8be4b0a7c65d1c9b1e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/25410/7/6/2?documentUUID=e9a8e7c3-8174-4522-9381-f1760ba6c1e4; YEAR=1987; ORIGINAL_YEAR=1987; STUDY_GROUP=ECHA IUCLID:15843236:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_c30fbbeadab086440d72d3430c26a5af
Regulatory source 10 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
Regulatory source - 63 mg/kg - - chronic - p.31
Regulatory source developmental toxicity 9.9 % rat dermal - developmental toxicity p.33
Regulatory source developmental toxicity 10 mg/kg bw/day rat oral 12 months developmental toxicity p.39
Regulatory source developmental toxicity 125 mg/kg bw/d rat dermal Developmental developmental toxicity p.39
Regulatory source genotoxicity 10 mg/kg bw/day - - chronic genotoxicity p.31
Regulatory source irritation 10 mg/kg bw/day - - - irritation p.30
Regulatory source irritation 24 % rabbit dermal 28-day irritation p.29
Regulatory source repeated dose toxicity 10 mg/kg bw/day - oral 28-day repeated dose toxicity p.30
Regulatory source repeated dose toxicity 10 mg/kg bw/day rat oral chronic repeated dose toxicity p.39
Regulatory source reproductive toxicity 0.1 - rabbit dermal - reproductive toxicity p.32