Is Soytrimonium Chloride safe in cosmetics?
Soytrimonium Chloride has a safety rating of "MODERATE" in our database. EU status: permitted. US status: permitted. 10 toxicological study endpoint(s) are available in our database.
Soytrimonium Chloride
INCI: SOYTRIMONIUM CHLORIDE
Soytrimonium Chloride (CAS 61790-41-8) is a cosmetic cosmetic ingredient functioning as Antistatic, emulsifying, hair conditioning, surfactant, preservative. NOAEL 72.5 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: permitted, max 3.0%. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety data.
View industrial chemical safety profile for CAS 61790-41-8 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
Soytrimonium Chloride is classified GHS Danger (H302, H314, H318, H410) in the chemicals database but is allowed in EU cosmetics at max 3.0%.
Source: Cosmetics: ingredients.eu_status/eu_max; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Antistatic, emulsifying, hair conditioning, surfactant, preservative
Safety Rating
MODERATE
Chemistry & Identifiers
EC Number
263-134-0
Regulatory Status
EU EU Status
permitted
EU Max Conc.
3.0%
US US Status
permitted
US Notes
Permitted for cosmetic use; VCRP listed
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Soytrimonium Chloride.
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
10 study endpoints found for Soytrimonium Chloride. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =10 mg/kg bw/day | - | - | irritation | SCCS_vision_codex |
| NOAEL | =10 mg/kg bw/day | - | - | irritation | SCCS_vision_codex |
| NOAEL | =10 mg/kg bw/day | - | - | irritation | SCCS_vision_codex |
| NOAEL | =10 mg/kg bw/day | - | - | irritation | SCCS_vision_codex |
| NOAEL | =63 mg/kg | - | - | NOAEL study | SCCS_vision_codex |
| NOAEL | =63 mg/kg | - | - | NOAEL study | SCCS_vision_codex |
| NOAEL | =63 mg/kg | - | - | NOAEL study | SCCS_vision_codex |
| NOAEL | =63 mg/kg | - | - | NOAEL study | SCCS_vision_codex |
| NOAEL | =125 mg/kg bw/d | dermal | rat | developmental toxicity | SCCS_vision_codex |
| NOAEL | =125 mg/kg bw/d | dermal | rat | developmental toxicity | SCCS_vision_codex |
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for Soytrimonium Chloride across SCCS product categories, with measured dermal absorption where available.
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
1 - 10 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Expanded Dermal Absorption Data
Cross-database dermal penetration: EPA Dryad physics-based, Roberts Mendeley permeation, and SCCS-aggregated measured values.
Aggregated DA Values (2 records across 5 sources)
| Type | DA % | Method | Skin Model | SCCS Ref |
|---|---|---|---|---|
| default | 0.6% | - | - | SCCS/0091 |
| measured | 0.35% | - | - | SCCS/0091 |
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Anti-static agent
Emulsifier
Preservative
Softener and conditioner
Surfactant (surface active agent)
Expert Verdict
Expert safety assessment and concern-level summary for Soytrimonium Chloride.
Regulatory Flags
preservative
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to Soytrimonium Chloride by CAS number or substance name.
Studies
12
Lowest NOAEL
10
Highest NOAEL
125
Units vary across source rows: mg/kg bw/day, mg/kg, mg/kg bw/d
SCCS_vision_codex
Dermal Absorption
View details ->| Absorption % | Method | Vehicle |
|---|---|---|
| 0.6% | - | - |
| 0.35% | - | - |
Chemical Function
Surfactant (surface active agent)
Preservative
Anti-static agent
Emulsifier
Softener and conditioner
Regulatory Lists
active_ingredient; Europe; Pesticides
inert_ingredient; non_food_use; Pesticides
Australian Status
AICIS status: listed
Frequently Asked Questions
Is Soytrimonium Chloride allowed in the EU?
Soytrimonium Chloride EU regulatory status: permitted. Maximum allowed concentration: 3.0%. This is based on EU Regulation 1223/2009 and its amendments.
What does Soytrimonium Chloride do in cosmetics?
Soytrimonium Chloride functions as: Antistatic, emulsifying, hair conditioning, surfactant, preservative. It is classified as a cosmetic ingredient in our database. CAS number: 61790-41-8.
What is the NOAEL for Soytrimonium Chloride?
The NOAEL (No Observed Adverse Effect Level) for Soytrimonium Chloride is =10 mg/kg bw/day based on a irritation study via oral route in rat. A total of 10 study endpoints are available. Source: SCCS_vision_codex.
Is Soytrimonium Chloride used outside cosmetics?
Soytrimonium Chloride also appears in industrial chemical safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does Soytrimonium Chloride have different safety status in cosmetics vs industrial chemicals?
Soytrimonium Chloride is classified GHS Danger (H302, H314, H318, H410) in the chemicals database but is allowed in EU cosmetics at max 3.0%.
Compliance Tools
Check Soytrimonium Chloride compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
Related Ingredients
Dipotassium EDTA
Excellent
Same category
Chelating agent; preservative booster
Glyceryl Caprylate/Caprate
Excellent
Same category
Emulsifier; Humectant; Softener and c...
Hexanediol (1,2-Hexanediol)
Excellent
Same category
Solvent, humectant, emollient, preser...
Phenethyl Alcohol
Excellent
Same category
Fragrance ingredient; preservative (a...
Polyepsilon-Lysine
Excellent
Same category
Preservative (antimicrobial); hair co...
Sodium Lauriminodipropionate Tocopheryl Phosphate
Excellent
Same category
Antistatic, cleansing, foaming, hair ...
(20S)-Protopanaxadiol
Moderate
Similar safety
(Cnidium Officinale/Coptis Chinensis/Glycyrrhiza Uralensis) Root Extract
Moderate
Similar safety
Skin conditioning
(Cryptomeria Japonica/Chamaecyparis Obtusa) Stem Ferment Extract
Moderate
Similar safety
Antimicrobial, antioxidant, humectant
(Eclipta Prostrata/Houttuynia Cordata) Leaf Extract
Moderate
Similar safety
Skin conditioning
(Lepidium Meyenii/Sarcodon Aspratus) Root Water
Moderate
Similar safety
Skin conditioning
(Licorice/Reynoutria Japonica) Root/Stem Extract
Moderate
Similar safety
Skin conditioning, antioxidant
Hydrogenated Tallow Acid
Good
Chemical family
Emulsifying, Surfactant, Cleansing
Hydrogenated Tallow Amide
Good
Chemical family
Viscosity controlling, Opacifying
PEG-10 LANOLIN
Good
Chemical family
Skin Conditioning - Emollient, Surfac...
Is Soytrimonium Chloride in Your Products?
Scan any product label with Piro — our free ingredient scanner. Point your camera at the ingredients list and get instant safety scores for every ingredient.
Try Piro Free →Analyze Your Full Ingredient List
Paste any INCI list into the Decoder for instant safety analysis, or calculate the Margin of Safety for Soytrimonium Chloride in your formulation.