Regulatory Status
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Safety Data
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Toxicological Studies
9 study endpoints found for Soytrimonium Chloride. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOEL | ca.100 mg/kg bw/day | oral | rat | oral | REACH |
| NOAEL | 10 mg/kg bw/day | dermal | code:3484 | dermal | REACH |
| NOAEL | ca.113 mg/kg bw/day | oral | rat | oral | REACH |
| NOAEL | 10 mg/kg bw/day | dermal | code:3484 | dermal | REACH |
| NOAEL | ca.113 mg/kg bw/day | oral | rat | oral | REACH |
| NOAEL | 45 mg/kg bw/day | oral | rat | oral | REACH |
| NOEL | ca.100 mg/kg bw/day | oral | rat | oral | REACH |
| NOAEL | 45 mg/kg bw/day | oral | rat | oral | REACH |
| NOAEL | 25 mg/kg bw/day | oral | - | - | SCCS_Perplexity |
Expert Verdict
Irritation potential — especially in leave-on and combination quat formulas; concentration limits: rinse-off hair ≤2.5%, leave-on hair ≤1.0%, leave-on facial ≤0.5% (for C16/C18 quats); SCCS requested safety opinion for use in hair dyes at ≤3.0%
Regulatory Flags
Frequently Asked Questions
Is Soytrimonium Chloride safe in cosmetics?
Irritation potential — especially in leave-on and combination quat formulas; concentration limits: rinse-off hair ≤2.5%, leave-on hair ≤1.0%, leave-on facial ≤0.5% (for C16/C18 quats); SCCS requested safety opinion for use in hair dyes at ≤3.0% The EU classifies Soytrimonium Chloride as "permitted". Safety rating: MODERATE. 9 toxicological study endpoint(s) are available in our database.
Is Soytrimonium Chloride allowed in the EU?
Soytrimonium Chloride EU regulatory status: permitted. Maximum allowed concentration: 3.0%. This is based on EU Regulation 1223/2009 and its amendments.
What does Soytrimonium Chloride do in cosmetics?
Soytrimonium Chloride functions as: Antistatic, emulsifying, hair conditioning, surfactant, preservative. It is classified as a cosmetic ingredient in our database. CAS number: 61790-41-8.
What is the Margin of Safety for Soytrimonium Chloride?
adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Soytrimonium Chloride?
The NOAEL (No Observed Adverse Effect Level) for Soytrimonium Chloride is ca.100 mg/kg bw/day based on a oral study via oral route in rat. A total of 9 study endpoints are available. Source: REACH.
Compliance Tools
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Related Ingredients
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