NOAEL Studies Emulsifier

Stearic Acid NOAEL Studies

INCI: STEARIC ACID

CAS: 57-11-4

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

Back to parent ingredient page
COSMOS_DB 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
COSMOS_DB NOAEL 10000 mg/kg bw/day rat oral 182 day Chronic US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS_DB NOAEL 3200 mg/kg bw/day rat oral 21 day Short Term Toxicity US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS_DB NOAEL 3000 mg/kg bw/day rat oral 30 day Short Term Toxicity US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS_DB NOAEL 300 mg/kg bw/day rat oral 209 day Subchronic US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx NOAEL =450 mg/kg bw/day Rat oral: gavage 91 days subchronic EFSA NDA - 2013 - OutputID 2415 - clinical chemistry - systemic - Scientific Opinion on the safety of 'coriander seed oil' as a Novel Food ingredient. - doi:10.2903/j.efsa.2013.3422
EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx NOAEL =450 mg/kg bw/day Rat oral: gavage 91 days subchronic EFSA NDA - 2013 - OutputID 2415 - clinical chemistry - systemic - Scientific Opinion on the safety of 'coriander seed oil' as a Novel Food ingredient. - doi:10.2903/j.efsa.2013.3422
NTP_ICE_acute_oral 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_acute_oral LD50 =4600 mg/kg bw Rat oral acute Rat Acute Oral Toxicity NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_7808; row=13326; data_type=In Vivo; mixture=Chemical; chemical_name=Octadecanoic acid; preferred_name=Octadecanoic acid; dtxsid=DTXSID8021642; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8021642; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID8021642; source_file=acute_oral.xlsx
NTP_ICE_endocrine 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_endocrine AC50 7.24600862010455 uM - - - ERPathway2016; ER Pathway Model, Antagonist sheet=Integrated_approaches; excel_row=12522; RecordID=ERPathway2016_192; DatasetName=ERPathway2016; DTXSID=DTXSID8021642; Assay=ER Pathway Model, Antagonist; Endpoint=AC50; Response=7.24600862010455; Response_Unit=uM; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8021642; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8021642
NTP_ICE_endocrine ACC 2.50574742502705 uM - - - ERPathway2016; ER Pathway Model, Antagonist sheet=Integrated_approaches; excel_row=12523; RecordID=ERPathway2016_192; DatasetName=ERPathway2016; DTXSID=DTXSID8021642; Assay=ER Pathway Model, Antagonist; Endpoint=ACC; Response=2.50574742502705; Response_Unit=uM; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8021642; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8021642
NTP_ICE_endocrine Model Score 0 unitless - - - ARPathway2016; AR Pathway Model, Antagonist sheet=Integrated_approaches; excel_row=12518; RecordID=ARPathway2016_1339; DatasetName=ARPathway2016; DTXSID=DTXSID8021642; Assay=AR Pathway Model, Antagonist; Endpoint=Model Score; Response=0; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8021642; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8021642
NTP_ICE_endocrine Model Score 0.248 unitless - - - ERPathway2016; ER Pathway Model, Agonist sheet=Integrated_approaches; excel_row=12524; RecordID=ERPathway2016_192; DatasetName=ERPathway2016; DTXSID=DTXSID8021642; Assay=ER Pathway Model, Agonist; Endpoint=Model Score; Response=0.248; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8021642; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8021642
NTP_ICE_skin_sensitization 3 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_skin_sensitization Incidence of positive responses 0 % Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=8260; Record_ID=skin_sensitization_invivo_1868; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=7.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID8021642; Assay=Human Maximization Test; Endpoint=Incidence of positive responses; Response=0; Response_Unit=%; Species=Human; Route=Dermal; Reference=Epstein 1976: report to RIFM|RIFM 1976; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Opdyke 1979; Not available; 10.1016/0015-6264(79)90330-4; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8021642; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8021642
NTP_ICE_skin_sensitization Induction dose per skin area 4725 ug/cm2 Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=8258; Record_ID=skin_sensitization_invivo_1868; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=7.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID8021642; Assay=Human Maximization Test; Endpoint=Induction dose per skin area; Response=4725; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Epstein 1976: report to RIFM|RIFM 1976; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Opdyke 1979; Not available; 10.1016/0015-6264(79)90330-4; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8021642; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8021642
NTP_ICE_skin_sensitization Relative reliability score 3 unitless Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=8264; Record_ID=skin_sensitization_invivo_1868; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=7.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID8021642; Assay=Human Maximization Test; Endpoint=Relative reliability score; Response=3; Response_Unit=Unitless; Species=Human; Route=Dermal; Reference=Epstein 1976: report to RIFM|RIFM 1976; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Opdyke 1979; Not available; 10.1016/0015-6264(79)90330-4; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8021642; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8021642
ToxValDB_ECOTOX 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_ECOTOX LOEL =0.9 mM European Rabbit environmental short-term; 2 days developmental LONG_REF=Biol. Reprod.20(2): 323-332 Kane,M.T. Fatty Acids as Energy Sources for Culture of One-Cell Rabbit Ova to Viable Morulae 1979; TITLE=Fatty Acids as Energy Sources for Culture of One-Cell Rabbit Ova to Viable Morulae; AUTHOR=Kane,M.T.; DOI=10.1095/biolreprod20.2.323; QUALITY=Control type: Multiple control types; EXTERNAL_SOURCE_ID=101665; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1979; ORIGINAL_YEAR=1979; TOXICOLOGICAL_EFFECT=Development: Morula stage; TOXICOLOGICAL_EFFECT_CATEGORY=development; STUDY_GROUP=ECOTOX:15596182:unknown:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=d175c34fb037159a889c56d7736b8cf4
ToxValDB_ECOTOX LOEL =0.09 mM European Rabbit environmental short-term; 5 days developmental LONG_REF=Biol. Reprod.20(2): 323-332 Kane,M.T. Fatty Acids as Energy Sources for Culture of One-Cell Rabbit Ova to Viable Morulae 1979; TITLE=Fatty Acids as Energy Sources for Culture of One-Cell Rabbit Ova to Viable Morulae; AUTHOR=Kane,M.T.; DOI=10.1095/biolreprod20.2.323; QUALITY=Control type: Multiple control types; EXTERNAL_SOURCE_ID=101665; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1979; ORIGINAL_YEAR=1979; TOXICOLOGICAL_EFFECT=Development: Blastocyst stage; TOXICOLOGICAL_EFFECT_CATEGORY=development; STUDY_GROUP=ECOTOX:15610597:unknown:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=5a92d2ac251458728ceeca82144227e1
ToxValDB_GESTIS_DNEL 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_GESTIS_DNEL DNEL systemic =17.632 mg/m3 Human inhalation - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15634944:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_fd94eb9967c18adbabd2503f6c2e8125
openFDA substances 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier 4ELV7Z65AP UNII - - - chemical {"approval_status":null,"molecular_formula":"C18H36O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"4ELV7Z65AP"}
openFDA substances FDA UNII substance identifier 4ELV7Z65AP UNII - - - chemical {"approval_status":null,"molecular_formula":"C18H36O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"4ELV7Z65AP"}
openFDA substances FDA UNII substance identifier 4ELV7Z65AP UNII - - - chemical {"approval_status":null,"molecular_formula":"C18H36O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"4ELV7Z65AP"}
openFDA substances FDA UNII substance identifier 4ELV7Z65AP UNII - - - chemical {"approval_status":null,"molecular_formula":"C18H36O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"4ELV7Z65AP"}