Is Stearoxypropyltrimonium Chloride safe in cosmetics?
Stearoxypropyltrimonium Chloride has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted. 1 toxicological study endpoint(s) are available in our database.
Stearoxypropyltrimonium Chloride
Also known as: UNII-LC1M3R2X4H, 1-Propanaminium, N,N,N-trimethyl-3-(octadecyloxy)-, chloride, 1-Propanaminium, N,N,N-trimethyl-3-(octadecyloxy)-, chloride (1:1), 3-Octadecyloxypropyltrimethylammonium chloride, Ammonium, trimethyl(3-(octadecyloxy)propyl)-, chloride (+1 more)
INCI: STEAROXYPROPYLTRIMONIUM CHLORIDE
Stearoxypropyltrimonium Chloride (CAS 23328-71-4) is a cosmetic cosmetic ingredient functioning as Antistatic agent, hair conditioning agent. Reported NOAEL =5 mg/kg bw/day in Rat (ToxValDB_ECHA_IUCLID); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety data.
View industrial chemical safety profile for CAS 23328-71-4 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
Stearoxypropyltrimonium Chloride is classified GHS Danger (H302, H318, H400, H410) in the chemicals database but is allowed in EU cosmetics.
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Antistatic agent, hair conditioning agent
Safety Rating
GOOD
Chemistry & Identifiers
IUPAC Name
trimethyl(3-octadecoxypropyl)azanium chloride
InChIKey
QMGAJHYFGBHHRR-UHFFFAOYSA-M
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
CIR-reviewed under trimoniums safety assessment — safe as used in cosmetics
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Stearoxypropyltrimonium Chloride.
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
1 study endpoint found for Stearoxypropyltrimonium Chloride. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =5 mg/kg bw/day | oral | Rat | short-term | ToxValDB_ECHA_IUCLID |
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
1 - 10 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Cleaning agent
Softener and conditioner
Surfactant (surface active agent)
Expert Verdict
Expert safety assessment and concern-level summary for Stearoxypropyltrimonium Chloride.
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to Stearoxypropyltrimonium Chloride by CAS number or substance name.
Studies
1
Lowest NOAEL
5 mg/kg bw/day
Highest NOAEL
5 mg/kg bw/day
ToxValDB_ECHA_IUCLID
Known Synonyms
UNII-LC1M3R2X4H
1-Propanaminium, N,N,N-trimethyl-3-(octadecyloxy)-, chloride
1-Propanaminium, N,N,N-trimethyl-3-(octadecyloxy)-, chloride (1:1)
3-Octadecyloxypropyltrimethylammonium chloride
Ammonium, trimethyl(3-(octadecyloxy)propyl)-, chloride
Quartamin E-80k
Chemical Function
Surfactant (surface active agent)
Cleaning agent
Softener and conditioner
Australian Status
AICIS status: listed_with_terms
Specific information requirements: Obligations to provide information apply. These obligations are: 1. A person introducing this chemical must tell us in writing within 28 calendar days if any of the following circumstances have occurred in relation to their introduction (importation or manufacture): a. the concentration of the chemical in hair conditioner...
Frequently Asked Questions
Is Stearoxypropyltrimonium Chloride allowed in the EU?
Stearoxypropyltrimonium Chloride EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Stearoxypropyltrimonium Chloride do in cosmetics?
Stearoxypropyltrimonium Chloride functions as: Antistatic agent, hair conditioning agent. It is classified as a cosmetic ingredient in our database. CAS number: 23328-71-4.
What is the NOAEL for Stearoxypropyltrimonium Chloride?
The NOAEL (No Observed Adverse Effect Level) for Stearoxypropyltrimonium Chloride is =5 mg/kg bw/day based on a short-term study via oral route in Rat. Source: ToxValDB_ECHA_IUCLID.
Is Stearoxypropyltrimonium Chloride used outside cosmetics?
Stearoxypropyltrimonium Chloride also appears in industrial chemical safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does Stearoxypropyltrimonium Chloride have different safety status in cosmetics vs industrial chemicals?
Stearoxypropyltrimonium Chloride is classified GHS Danger (H302, H318, H400, H410) in the chemicals database but is allowed in EU cosmetics.
Compliance Tools
Check Stearoxypropyltrimonium Chloride compliance across multiple jurisdictions:
Ingredient Decoder
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Substance Compliance
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MoS Calculator
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Heavy Metal Limits
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