NOAEL Studies
Cosmetic Ingredient
Succinic Anhydride NOAEL Studies
INCI: SUCCINIC ANHYDRIDE
CAS: 108-30-5
Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.
IARC Monographs 3 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| IARC Monographs | IARC carcinogenicity classification | 3 | IARC group | - | - | 1987 | IARC Monographs | {"additional_info":"volume_publication_year=1987","evaluation_year":1987,"source_table":"iarc_classifications","volume":"15, Sup 7"} |
| IARC Monographs | IARC carcinogenicity classification | 3 | IARC group | - | - | 1987 | IARC Monographs | {"additional_info":"volume_publication_year=1987","evaluation_year":1987,"source_table":"iarc_classifications","volume":"15, Sup 7"} |
| IARC Monographs | IARC carcinogenicity classification | 3 | IARC group | - | - | 1987 | IARC Monographs | {"additional_info":"volume_publication_year=1987","evaluation_year":1987,"source_table":"iarc_classifications","volume":"15, Sup 7"} |
NTP_ICE_acute_oral 3 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_acute_oral | LD50 | =1510 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | OECD eChemPortal (undated); record_id=acute_oral_717; row=11654; data_type=In Vivo; mixture=Chemical; chemical_name=Succinic anhydride; preferred_name=Succinic anhydride; dtxsid=DTXSID7021287; url=https://www.echemportal.org/echemportal/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7021287; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID7021287; source_file=acute_oral.xlsx |
| NTP_ICE_acute_oral | LD50 | =2157 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | OECD eChemPortal (undated); record_id=acute_oral_719; row=11655; data_type=In Vivo; mixture=Chemical; chemical_name=Succinic anhydride; preferred_name=Succinic anhydride; dtxsid=DTXSID7021287; url=https://www.echemportal.org/echemportal/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7021287; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID7021287; source_file=acute_oral.xlsx |
| NTP_ICE_acute_oral | LD50 | =1794 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | OECD eChemPortal (undated); record_id=acute_oral_718; row=11656; data_type=In Vivo; mixture=Chemical; chemical_name=Succinic anhydride; preferred_name=Succinic anhydride; dtxsid=DTXSID7021287; url=https://www.echemportal.org/echemportal/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7021287; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID7021287; source_file=acute_oral.xlsx |
NTP_ICE_cancer 4 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_cancer | IARC group | 3 | unitless | - | - | - | WOE; IARC Carcinogenicity | sheet=Data; excel_row=7911; Record_ID=cancer_4521; Data_Type=WOE; Formulation_Name=Succinic anhydride; Mixture=Chemical; DTXSID=DTXSID7021287; Assay=IARC Carcinogenicity; Endpoint=IARC group; Response=3; Response_Unit=Unitless; URL=http://publications.iarc.fr/33; http://publications.iarc.fr/139; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7021287; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7021287 |
| NTP_ICE_cancer | Top dose | 100 | mg/kg | Rat | Gavage | - | In Vivo; NTP Carcinogenicity | sheet=Data; excel_row=7910; Record_ID=cancer_4520; Data_Type=In Vivo; Formulation_Name=Succinic Anhydride; Mixture=Chemical; DTXSID=DTXSID7021287; Assay=NTP Carcinogenicity; Endpoint=Top dose; Response=100; Response_Unit=mg/kg; Species=Rat; Strain=F344/N; Sex=Male; Route=Gavage; Reference=TR-373; URL=https://ntp.niehs.nih.gov/publications/reports/tr/300s/tr373/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7021287; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7021287 |
| NTP_ICE_cancer | Top dose | 75 | mg/kg bw/day | Mouse | Gavage | - | In Vivo; NTP Carcinogenicity | sheet=Data; excel_row=7914; Record_ID=cancer_4518; Data_Type=In Vivo; Formulation_Name=Succinic Anhydride; Mixture=Chemical; DTXSID=DTXSID7021287; Assay=NTP Carcinogenicity; Endpoint=Top dose; Response=75; Response_Unit=mg/kg/day; Species=Mouse; Strain=B6C3F1; Sex=Male; Route=Gavage; Reference=TR-373; URL=https://ntp.niehs.nih.gov/publications/reports/tr/300s/tr373/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7021287; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7021287 |
| NTP_ICE_cancer | Top dose | 150 | mg/kg bw/day | Mouse | Gavage | - | In Vivo; NTP Carcinogenicity | sheet=Data; excel_row=7916; Record_ID=cancer_4519; Data_Type=In Vivo; Formulation_Name=Succinic Anhydride; Mixture=Chemical; DTXSID=DTXSID7021287; Assay=NTP Carcinogenicity; Endpoint=Top dose; Response=150; Response_Unit=mg/kg/day; Species=Mouse; Strain=B6C3F1; Sex=Female; Route=Gavage; Reference=TR-373; URL=https://ntp.niehs.nih.gov/publications/reports/tr/300s/tr373/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7021287; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7021287 |
ToxValDB_ECHA_IUCLID 7 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_ECHA_IUCLID | LEL | =50 | mg/kg bw/day | Mouse | injection | - | developmental | QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7d189e4b0a7c65d22ef20; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/30019/7/9/3?documentUUID=0dede443-ca9f-46ce-8b04-7674d28e3291; YEAR=2004; ORIGINAL_YEAR=2004; STUDY_GROUP=ECHA IUCLID_dup_Developmental Toxicity Teratogenicity_15820940_15821810:-:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_28ad682484272b45efd6244a6e6c5c78 |
| ToxValDB_ECHA_IUCLID | LEL | ~25 | mg/kg bw/day | Mouse | injection | - | developmental | QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7d189e4b0a7c65d22ef24; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/30019/7/9/3?documentUUID=0dede443-ca9f-46ce-8b04-7674d28e3291; YEAR=2004; ORIGINAL_YEAR=2004; STUDY_GROUP=ECHA IUCLID_dup_Developmental Toxicity Teratogenicity_15820940_15821810:-:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_ad111366ba647c37ddcf9a4fbb3f4ab5 |
| ToxValDB_ECHA_IUCLID | LOAEL | =200 | mg/kg bw/day | Rat | oral | subchronic; 13 weeks | subchronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaccce4b0a7c65d1c0e3d; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/30019/7/6/2?documentUUID=0dede443-ca9f-46ce-8b04-7674d28e3291; YEAR=2004; ORIGINAL_YEAR=2004; TOXICOLOGICAL_EFFECT=body weight and weight gain|mortality; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|mortality/survival; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15835363_15850322:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_2eaa96aff7cbb730566dee2861e1ff54 |
| ToxValDB_ECHA_IUCLID | LOAEL | =300 | mg/kg bw/day | Mouse | oral | subchronic; 13 weeks | subchronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaccce4b0a7c65d1c0e3b; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/30019/7/6/2?documentUUID=0dede443-ca9f-46ce-8b04-7674d28e3291; YEAR=2004; ORIGINAL_YEAR=2004; TOXICOLOGICAL_EFFECT=mortality; TOXICOLOGICAL_EFFECT_CATEGORY=mortality/survival; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15847405_15848095:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_1f28467caecd522503b9075ddeaa2dab |
| ToxValDB_ECHA_IUCLID | NOAEL | >150 | mg/kg bw/day | Mouse | oral | - | chronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669ea9cde4b0a7c65d1b2cde; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/30019/7/8?documentUUID=0dede443-ca9f-46ce-8b04-7674d28e3291; YEAR=2004; ORIGINAL_YEAR=2004; TOXICOLOGICAL_EFFECT=histopathology: neoplastic; TOXICOLOGICAL_EFFECT_CATEGORY=cancer; STUDY_GROUP=ECHA IUCLID_dup_Carcinogenicity_15816743_15820288:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_e5a1b8f8a61dec8a310751c5ceb83b30 |
| ToxValDB_ECHA_IUCLID | NOAEL | =75 | mg/kg bw/day | Mouse | oral | - | chronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669ea9cde4b0a7c65d1b2cde; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/30019/7/8?documentUUID=0dede443-ca9f-46ce-8b04-7674d28e3291; YEAR=2004; ORIGINAL_YEAR=2004; TOXICOLOGICAL_EFFECT=body weight and weight gain; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=ECHA IUCLID_dup_Carcinogenicity_15820286_15820287:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_1957a202a56397db8529098ad6e9abe8 |
| ToxValDB_ECHA_IUCLID | NOAEL | >100 | mg/kg bw/day | Rat | oral | - | chronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669ea9cee4b0a7c65d1b2ce0; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/30019/7/8?documentUUID=0dede443-ca9f-46ce-8b04-7674d28e3291; YEAR=2004; ORIGINAL_YEAR=2004; TOXICOLOGICAL_EFFECT=histopathology: neoplastic; TOXICOLOGICAL_EFFECT_CATEGORY=cancer; STUDY_GROUP=ECHA IUCLID:15820289:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_c2964a33e384428835c44f7422521a27 |
ToxValDB_HESS 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_HESS | NOEL | =50 | mg/kg bw/day | Rat | oral | subchronic; 13 weeks | subchronic | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/60da0e04e4b0a676289defec; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.nite.go.jp/en/chem/qsar/hess_update-e.html; TOXICOLOGICAL_EFFECT=Body Weight Changes: decrease; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=HESS:15638700:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_03fe90e496ef0452b6143877e8eaf4da |
openFDA substances 4 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| openFDA substances | FDA UNII substance identifier | 6RF4O17Z8J | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C4H4O3","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"6RF4O17Z8J"} |
| openFDA substances | FDA UNII substance identifier | 6RF4O17Z8J | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C4H4O3","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"6RF4O17Z8J"} |
| openFDA substances | FDA UNII substance identifier | 6RF4O17Z8J | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C4H4O3","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"6RF4O17Z8J"} |
| openFDA substances | FDA UNII substance identifier | 6RF4O17Z8J | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C4H4O3","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"6RF4O17Z8J"} |