NOAEL Studies Cosmetic Ingredient

Succinic Anhydride NOAEL Studies

INCI: SUCCINIC ANHYDRIDE

CAS: 108-30-5

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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IARC Monographs 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
IARC Monographs IARC carcinogenicity classification 3 IARC group - - 1987 IARC Monographs -
NTP ICE acute oral 3 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP ICE acute oral LD50 =1510 mg/kg bw Rat oral acute Rat Acute Oral Toxicity OECD eChemPortal (undated); record_id=acute_oral_717; row=11654; data_type=In Vivo; mixture=Chemical; chemical_name=Succinic anhydride; preferred_name=Succinic anhydride; dtxsid=DTXSID7021287; url=https://www.echemportal.org/echemportal/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7021287; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID7021287; source_file=acute_oral.xlsx
NTP ICE acute oral LD50 =1794 mg/kg bw Rat oral acute Rat Acute Oral Toxicity OECD eChemPortal (undated); record_id=acute_oral_718; row=11656; data_type=In Vivo; mixture=Chemical; chemical_name=Succinic anhydride; preferred_name=Succinic anhydride; dtxsid=DTXSID7021287; url=https://www.echemportal.org/echemportal/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7021287; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID7021287; source_file=acute_oral.xlsx
NTP ICE acute oral LD50 =2157 mg/kg bw Rat oral acute Rat Acute Oral Toxicity OECD eChemPortal (undated); record_id=acute_oral_719; row=11655; data_type=In Vivo; mixture=Chemical; chemical_name=Succinic anhydride; preferred_name=Succinic anhydride; dtxsid=DTXSID7021287; url=https://www.echemportal.org/echemportal/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7021287; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID7021287; source_file=acute_oral.xlsx
NTP ICE cancer 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP ICE cancer IARC group 3 unitless - - - WOE; IARC Carcinogenicity sheet=Data; excel_row=7911; Record_ID=cancer_4521; Data_Type=WOE; Formulation_Name=Succinic anhydride; Mixture=Chemical; DTXSID=DTXSID7021287; Assay=IARC Carcinogenicity; Endpoint=IARC group; Response=3; Response_Unit=Unitless; URL=http://publications.iarc.fr/33; http://publications.iarc.fr/139; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7021287; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7021287
NTP ICE cancer Top dose 75 mg/kg bw/day Mouse Gavage - In Vivo; NTP Carcinogenicity sheet=Data; excel_row=7914; Record_ID=cancer_4518; Data_Type=In Vivo; Formulation_Name=Succinic Anhydride; Mixture=Chemical; DTXSID=DTXSID7021287; Assay=NTP Carcinogenicity; Endpoint=Top dose; Response=75; Response_Unit=mg/kg/day; Species=Mouse; Strain=B6C3F1; Sex=Male; Route=Gavage; Reference=TR-373; URL=https://ntp.niehs.nih.gov/publications/reports/tr/300s/tr373/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7021287; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7021287
NTP ICE cancer Top dose 100 mg/kg Rat Gavage - In Vivo; NTP Carcinogenicity sheet=Data; excel_row=7910; Record_ID=cancer_4520; Data_Type=In Vivo; Formulation_Name=Succinic Anhydride; Mixture=Chemical; DTXSID=DTXSID7021287; Assay=NTP Carcinogenicity; Endpoint=Top dose; Response=100; Response_Unit=mg/kg; Species=Rat; Strain=F344/N; Sex=Male; Route=Gavage; Reference=TR-373; URL=https://ntp.niehs.nih.gov/publications/reports/tr/300s/tr373/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7021287; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7021287
NTP ICE cancer Top dose 150 mg/kg bw/day Mouse Gavage - In Vivo; NTP Carcinogenicity sheet=Data; excel_row=7916; Record_ID=cancer_4519; Data_Type=In Vivo; Formulation_Name=Succinic Anhydride; Mixture=Chemical; DTXSID=DTXSID7021287; Assay=NTP Carcinogenicity; Endpoint=Top dose; Response=150; Response_Unit=mg/kg/day; Species=Mouse; Strain=B6C3F1; Sex=Female; Route=Gavage; Reference=TR-373; URL=https://ntp.niehs.nih.gov/publications/reports/tr/300s/tr373/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7021287; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7021287
ECHA 7 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ECHA LEL ~25 mg/kg bw/day Mouse injection - developmental QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7d189e4b0a7c65d22ef24; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/30019/7/9/3?documentUUID=0dede443-ca9f-46ce-8b04-7674d28e3291; YEAR=2004; ORIGINAL_YEAR=2004; STUDY_GROUP=ECHA IUCLID_dup_Developmental Toxicity Teratogenicity_15820940_15821810:-:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_ad111366ba647c37ddcf9a4fbb3f4ab5
ECHA LEL =50 mg/kg bw/day Mouse injection - developmental QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7d189e4b0a7c65d22ef20; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/30019/7/9/3?documentUUID=0dede443-ca9f-46ce-8b04-7674d28e3291; YEAR=2004; ORIGINAL_YEAR=2004; STUDY_GROUP=ECHA IUCLID_dup_Developmental Toxicity Teratogenicity_15820940_15821810:-:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_28ad682484272b45efd6244a6e6c5c78
ECHA LOAEL =200 mg/kg bw/day Rat oral subchronic; 13 weeks subchronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaccce4b0a7c65d1c0e3d; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/30019/7/6/2?documentUUID=0dede443-ca9f-46ce-8b04-7674d28e3291; YEAR=2004; ORIGINAL_YEAR=2004; TOXICOLOGICAL_EFFECT=body weight and weight gain|mortality; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|mortality/survival; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15835363_15850322:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_2eaa96aff7cbb730566dee2861e1ff54
ECHA LOAEL =300 mg/kg bw/day Mouse oral subchronic; 13 weeks subchronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaccce4b0a7c65d1c0e3b; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/30019/7/6/2?documentUUID=0dede443-ca9f-46ce-8b04-7674d28e3291; YEAR=2004; ORIGINAL_YEAR=2004; TOXICOLOGICAL_EFFECT=mortality; TOXICOLOGICAL_EFFECT_CATEGORY=mortality/survival; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15847405_15848095:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_1f28467caecd522503b9075ddeaa2dab
ECHA NOAEL =75 mg/kg bw/day Mouse oral - chronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669ea9cde4b0a7c65d1b2cde; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/30019/7/8?documentUUID=0dede443-ca9f-46ce-8b04-7674d28e3291; YEAR=2004; ORIGINAL_YEAR=2004; TOXICOLOGICAL_EFFECT=body weight and weight gain; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=ECHA IUCLID_dup_Carcinogenicity_15820286_15820287:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_1957a202a56397db8529098ad6e9abe8
ECHA NOAEL >100 mg/kg bw/day Rat oral - chronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669ea9cee4b0a7c65d1b2ce0; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/30019/7/8?documentUUID=0dede443-ca9f-46ce-8b04-7674d28e3291; YEAR=2004; ORIGINAL_YEAR=2004; TOXICOLOGICAL_EFFECT=histopathology: neoplastic; TOXICOLOGICAL_EFFECT_CATEGORY=cancer; STUDY_GROUP=ECHA IUCLID:15820289:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_c2964a33e384428835c44f7422521a27
ECHA NOAEL >150 mg/kg bw/day Mouse oral - chronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669ea9cde4b0a7c65d1b2cde; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/30019/7/8?documentUUID=0dede443-ca9f-46ce-8b04-7674d28e3291; YEAR=2004; ORIGINAL_YEAR=2004; TOXICOLOGICAL_EFFECT=histopathology: neoplastic; TOXICOLOGICAL_EFFECT_CATEGORY=cancer; STUDY_GROUP=ECHA IUCLID_dup_Carcinogenicity_15816743_15820288:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_e5a1b8f8a61dec8a310751c5ceb83b30
ToxValDB HESS 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB HESS NOEL =50 mg/kg bw/day Rat oral subchronic; 13 weeks subchronic STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/60da0e04e4b0a676289defec; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.nite.go.jp/en/chem/qsar/hess_update-e.html; TOXICOLOGICAL_EFFECT=Body Weight Changes: decrease; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=HESS:15638700:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_03fe90e496ef0452b6143877e8eaf4da
openFDA substances 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier 6RF4O17Z8J UNII - - - chemical -