Synephrine HCl

INCI: SYNEPHRINE HCL

CAS Number
5985-28-4
Function
Antioxidant, Hair Conditioning, Skin Conditioning
Safety Rating
MODERATE

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status restricted
US Notes Not specifically restricted for cosmetic use; permitted under manufacturer safety substantiation

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
moderate
Sensitization
moderate

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Same sympathomimetic concerns as free base synephrine; skin/eye irritant; salt form may enhance percutaneous absorption โ€” requires careful safety assessment in leave-on products

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Concern Level: Moderate

Frequently Asked Questions

Is Synephrine HCl safe in cosmetics?

Same sympathomimetic concerns as free base synephrine; skin/eye irritant; salt form may enhance percutaneous absorption โ€” requires careful safety assessment in leave-on products The EU classifies Synephrine HCl as "permitted". Safety rating: MODERATE.

Is Synephrine HCl allowed in the EU?

Synephrine HCl EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Synephrine HCl do in cosmetics?

Synephrine HCl functions as: Antioxidant, Hair Conditioning, Skin Conditioning. It is classified as a cosmetic ingredient in our database. CAS number: 5985-28-4.

What is the Margin of Safety for Synephrine HCl?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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