Is Synephrine HCl safe in cosmetics?
Synephrine HCl has a safety rating of "MODERATE" in our database. EU status: permitted. US status: restricted.
Moderate
Cosmetic Ingredient
Synephrine HCl
INCI: SYNEPHRINE HCL
Synephrine HCl (CAS 5985-28-4) is a cosmetic cosmetic ingredient functioning as Antioxidant, Hair Conditioning, Skin Conditioning. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety data.
View industrial chemical safety profile for CAS 5985-28-4 →
Auto-generated CPSR Part A draft with source citations
Function
Antioxidant, Hair Conditioning, Skin Conditioning
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
4-[1-hydroxy-2-(methylamino)ethyl]phenol;hydrochloride
InChIKey
COTCEGYSNTWJQV-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
restricted
US Notes
Not specifically restricted for cosmetic use; permitted under manufacturer safety substantiation
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Synephrine HCl.
Calculate MoS for your specific formulation with the MoS Calculator.
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Antioxidant
Softener and conditioner
Expert Verdict
Expert safety assessment and concern-level summary for Synephrine HCl.
Chemical Function
Antioxidant
Softener and conditioner
Frequently Asked Questions
Is Synephrine HCl allowed in the EU?
Synephrine HCl EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Synephrine HCl do in cosmetics?
Synephrine HCl functions as: Antioxidant, Hair Conditioning, Skin Conditioning. It is classified as a cosmetic ingredient in our database. CAS number: 5985-28-4.
Is Synephrine HCl used outside cosmetics?
Synephrine HCl also appears in industrial chemical safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
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Substance Compliance
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MoS Calculator
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Heavy Metal Limits
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