Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
2 study endpoints found for t-Butylacrylamide. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | >=450 mg/kg bw/day | oral | rat | oral | REACH |
| NOAEL | 500 mg/kg bw/day | oral | rat | oral | REACH |
Expert Verdict
Free acrylamide monomer is a neurotoxin and suspected carcinogen — strict residual monomer control mandatory; GMP must ensure <5 ppm in finished product
Frequently Asked Questions
Is t-Butylacrylamide safe in cosmetics?
Free acrylamide monomer is a neurotoxin and suspected carcinogen — strict residual monomer control mandatory; GMP must ensure <5 ppm in finished product The EU classifies t-Butylacrylamide as "permitted". Safety rating: GOOD. 2 toxicological study endpoint(s) are available in our database.
Is t-Butylacrylamide allowed in the EU?
t-Butylacrylamide EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does t-Butylacrylamide do in cosmetics?
t-Butylacrylamide functions as: Monomer; used in polymerization to produce film-forming copolymers for hair fixation and cosmetic coatings. It is classified as a cosmetic ingredient in our database. CAS number: 107-58-4.
What is the Margin of Safety for t-Butylacrylamide?
adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for t-Butylacrylamide?
The NOAEL (No Observed Adverse Effect Level) for t-Butylacrylamide is >=450 mg/kg bw/day based on a oral study via oral route in rat. A total of 2 study endpoints are available. Source: REACH.
Compliance Tools
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Related Ingredients
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