Limonenyldihydroxybenzyl Ethoxycarbonyl Azetidine

INCI: LIMONENYLDIHYDROXYBENZYL ETHOXYCARBONYL AZETIDINE

CAS Number
1801243-39-9 (KLS-13019 — a pharmaceutical/drug candidate compound)
Function
Investigational cannabinoid receptor modulator (CB1/CB2 pharmacology)
Safety Rating
POOR

Regulatory Status

🇪🇺 EU Status prohibited
🇺🇸 US Status prohibited
US Notes Investigational drug compound subject to FDA drug regulation (21 CFR Part 210/211). Use in cosmetic products would reclassify the product as a drug/medicinal product. Not eligible for cosmetic regulation under MoCRA.

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
low
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

CRITICAL RED FLAG: This is a pharmaceutical active compound (KLS-13019) developed as a cannabinoid receptor modulator, not a conventional cosmetic ingredient. Use in a cosmetic product would trigger drug reclassification under both EU and US regulations. No cosmetic toxicological dossier exists. A Responsible Person/Safety Assessor would reject this ingredient without full pharmaceutical-grade safety data and regulatory reclassification review.

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Concern Level: High

Frequently Asked Questions

Is Limonenyldihydroxybenzyl Ethoxycarbonyl Azetidine safe in cosmetics?

CRITICAL RED FLAG: This is a pharmaceutical active compound (KLS-13019) developed as a cannabinoid receptor modulator, not a conventional cosmetic ingredient. Use in a cosmetic product would trigger drug reclassification under both EU and US regulations. No cosmetic toxicological dossier exists. A Responsible Person/Safety Assessor would reject this ingredient without full pharmaceutical-grade safety data and regulatory reclassification review. The EU classifies Limonenyldihydroxybenzyl Ethoxycarbonyl Azetidine as "prohibited". Safety rating: POOR.

Is Limonenyldihydroxybenzyl Ethoxycarbonyl Azetidine allowed in the EU?

Limonenyldihydroxybenzyl Ethoxycarbonyl Azetidine EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.

What does Limonenyldihydroxybenzyl Ethoxycarbonyl Azetidine do in cosmetics?

Limonenyldihydroxybenzyl Ethoxycarbonyl Azetidine functions as: Investigational cannabinoid receptor modulator (CB1/CB2 pharmacology). It is classified as a cosmetic ingredient in our database. CAS number: 1801243-39-9 (KLS-13019 — a pharmaceutical/drug candidate compound).

What is the Margin of Safety for Limonenyldihydroxybenzyl Ethoxycarbonyl Azetidine?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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