NOAEL Studies
Cosmetic Ingredient
Terpinolene NOAEL Studies
INCI: TERPINOLENE
CAS: 586-62-9
Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.
NTP_ICE_acute_oral 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_acute_oral | LD50 | =4390 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_8029; row=849; data_type=In Vivo; mixture=Chemical; chemical_name=Terpinolene; preferred_name=Terpinolene; dtxsid=DTXSID0027222; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0027222; source_file=acute_oral.xlsx |
NTP_ICE_endocrine 4 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_endocrine | AC50 | 69.4775145314972 | uM | - | - | - | ERPathway2016; ER Pathway Model, Antagonist | sheet=Integrated_approaches; excel_row=15180; RecordID=ERPathway2016_411; DatasetName=ERPathway2016; DTXSID=DTXSID0027222; Assay=ER Pathway Model, Antagonist; Endpoint=AC50; Response=69.4775145314972; Response_Unit=uM; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0027222 |
| NTP_ICE_endocrine | ACC | 65.3108670446833 | uM | - | - | - | ERPathway2016; ER Pathway Model, Antagonist | sheet=Integrated_approaches; excel_row=15181; RecordID=ERPathway2016_411; DatasetName=ERPathway2016; DTXSID=DTXSID0027222; Assay=ER Pathway Model, Antagonist; Endpoint=ACC; Response=65.3108670446833; Response_Unit=uM; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0027222 |
| NTP_ICE_endocrine | Model Score | 0 | unitless | - | - | - | ARPathway2016; AR Pathway Model, Antagonist | sheet=Integrated_approaches; excel_row=15176; RecordID=ARPathway2016_1363; DatasetName=ARPathway2016; DTXSID=DTXSID0027222; Assay=AR Pathway Model, Antagonist; Endpoint=Model Score; Response=0; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0027222 |
| NTP_ICE_endocrine | Model Score | 0.00827 | unitless | - | - | - | ERPathway2016; ER Pathway Model, Agonist | sheet=Integrated_approaches; excel_row=15182; RecordID=ERPathway2016_411; DatasetName=ERPathway2016; DTXSID=DTXSID0027222; Assay=ER Pathway Model, Agonist; Endpoint=Model Score; Response=0.00827; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0027222 |
NTP_ICE_skin_sensitization 3 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_skin_sensitization | Incidence of positive responses | 0 | % | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Maximization Test | sheet=Data_invivo; excel_row=8462; Record_ID=skin_sensitization_invivo_1902; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=20.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID0027222; Assay=Human Maximization Test; Endpoint=Incidence of positive responses; Response=0; Response_Unit=%; Species=Human; Route=Dermal; Reference=Epstein 1975: report to RIFM|Opdyke 1976; Not available; 10.1016/S0015-6264(76)80163-0; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0027222 |
| NTP_ICE_skin_sensitization | Induction dose per skin area | 13500 | ug/cm2 | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Maximization Test | sheet=Data_invivo; excel_row=8460; Record_ID=skin_sensitization_invivo_1902; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=20.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID0027222; Assay=Human Maximization Test; Endpoint=Induction dose per skin area; Response=13500; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Epstein 1975: report to RIFM|Opdyke 1976; Not available; 10.1016/S0015-6264(76)80163-0; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0027222 |
| NTP_ICE_skin_sensitization | Relative reliability score | 3 | unitless | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Maximization Test | sheet=Data_invivo; excel_row=8466; Record_ID=skin_sensitization_invivo_1902; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=20.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID0027222; Assay=Human Maximization Test; Endpoint=Relative reliability score; Response=3; Response_Unit=Unitless; Species=Human; Route=Dermal; Reference=Epstein 1975: report to RIFM|Opdyke 1976; Not available; 10.1016/S0015-6264(76)80163-0; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0027222 |
ToxValDB_ECHA_IUCLID 3 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_ECHA_IUCLID | NOAEL | =371 | mg/kg bw/day | Rat | oral | - | developmental | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7d1ece4b0a7c65d230cc0; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/en/registration-dossier/-/registered-dossier/29908?documentUUID=935a300e-3c6f-4090-9a07-98de4895d0a3; YEAR=2013; ORIGINAL_YEAR=2013; STUDY_GROUP=ECHA IUCLID:15821674:M/F:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_e61e8964a44680f3e2eb8e3b19105c4f |
| ToxValDB_ECHA_IUCLID | NOAEL | =294.6 | mg/kg bw/day | Rat | oral | subchronic; 56 days | subchronic | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7ca91e4b0a7c65d222868; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/en/registration-dossier/-/registered-dossier/29908?documentUUID=935a300e-3c6f-4090-9a07-98de4895d0a3; YEAR=2013; ORIGINAL_YEAR=2013; STUDY_GROUP=ECHA IUCLID:15834641:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_c95a26fcb6d0f17b405da0829c4dc19c |
| ToxValDB_ECHA_IUCLID | NOAEL | =312.5 | mg/kg bw/day | Rat | oral | subchronic; 56 days | subchronic | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7ca91e4b0a7c65d222868; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/en/registration-dossier/-/registered-dossier/29908?documentUUID=935a300e-3c6f-4090-9a07-98de4895d0a3; YEAR=2013; ORIGINAL_YEAR=2013; STUDY_GROUP=ECHA IUCLID:15834642:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_a5d9578ebe43b0f53707c3f840ac30f1 |
ToxValDB_GESTIS_DNEL 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_GESTIS_DNEL | DNEL systemic | =3.6 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL_dup_-_15633212_15633213:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_d832a8680ea0c0016ee8dd28f0064a2e |
| ToxValDB_GESTIS_DNEL | DNEL systemic | =5.88 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL_dup_-_15633212_15633213:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_0318f788d1f926f1c5c6d1b894552d0b |
openFDA substances 4 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| openFDA substances | FDA UNII substance identifier | N9830X5KSL | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C10H16","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"N9830X5KSL"} |
| openFDA substances | FDA UNII substance identifier | N9830X5KSL | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C10H16","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"N9830X5KSL"} |
| openFDA substances | FDA UNII substance identifier | N9830X5KSL | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C10H16","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"N9830X5KSL"} |
| openFDA substances | FDA UNII substance identifier | N9830X5KSL | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C10H16","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"N9830X5KSL"} |