Is Terpinolene safe in cosmetics?
Terpinolene has a safety rating of "GOOD" in our database. EU status: restricted. US status: permitted. 3 toxicological study endpoint(s) are available in our database.
Terpinolene
Also known as: Cyclohexene, 1-methyl-4-(1-methylethylidene)-, EINECS 209-578-0, FEMA No. 3046, FEMA Number 3046, p-Menth-1,4(8)-diene (+14 more)
INCI: TERPINOLENE
Terpinolene (CAS 586-62-9) is a cosmetic cosmetic ingredient functioning as Fragrance. Reported NOAEL =294.6 mg/kg bw/day in Rat (ToxValDB_ECHA_IUCLID); EU Regulation 1223/2009 status: restricted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety, pharmaceutical, and food safety data.
View industrial chemical safety profile for CAS 586-62-9 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
Terpinolene is classified GHS Danger (H226, H304, H315, H317, H400, H410, H411, H227) in the chemicals database but is restricted in EU cosmetics.
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Chemistry & Identifiers
IUPAC Name
1-methyl-4-propan-2-ylidenecyclohexene
InChIKey
MOYAFQVGZZPNRA-UHFFFAOYSA-N
Regulatory Status
EU EU Status
restricted
US US Status
permitted
US Notes
Permitted; California requires reporting per Cosmetic Fragrance and Flavor Ingredient Right to Know Act of 2020 when above thresholds
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Terpinolene.
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
3 study endpoints found for Terpinolene. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =294.6 mg/kg bw/day | oral | Rat | subchronic | ToxValDB_ECHA_IUCLID |
| NOAEL | =312.5 mg/kg bw/day | oral | Rat | subchronic | ToxValDB_ECHA_IUCLID |
| NOAEL | =371 mg/kg bw/day | oral | Rat | developmental | ToxValDB_ECHA_IUCLID |
HRIPT Human Patch Test Studies
1 human repeat insult patch test aggregated from dermatological literature.
| Test Type | N | Sensitized | Dose µg/cm² | NESIL µg/cm² | Potency |
|---|---|---|---|---|---|
| HMT | - | 0 | 13500 | - | - |
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
100 - 1,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Expanded Jurisdictional Detail
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
SA Saudi SFDA (III - Restricted)
BRIN Brazil/India Cosmetics
India: Restricted
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (2)
Carcinogen Classification
No indication of carcinogenicity to humans (not listed by IARC).
Source: Toxin and Toxin Target Database (T3DB)
Endocrine Disruptors
Potential endocrine disrupting compound
Source: NORMAN Suspect List Exchange
Regulatory (4)
JECFA Number
1331
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
ISOTERPINENE | 2004 | No safety concern at current levels of intake when used as a flavouring agent | TRS 928-JECFA 63/64 | FAS 54-JECFA 63/235
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
TERPINOLENE | 2004 | No safety concern at current levels of intake when used as a flavouring agent | TRS 928-JECFA 63/64 | FAS 54-JECFA 63/235
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
p-MENTHA-1,4(8)-DIENE | 2004 | No safety concern at current levels of intake when used as a flavouring agent | TRS 928-JECFA 63/64 | FAS 54-JECFA 63/235
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Flavouring and nutrient
Fragrance
No specific technical function
Solubility enhancer
Regulatory List Membership (5)
IFRA Fragrance Transparency List
EPA Safer Chemical Ingredients List (SCIL)
FDA Substances Added to Food (EAFUS)
Consumer Product Chemical
EU CosIng Cosmetics Ingredient Database
Expert Verdict
Expert safety assessment and concern-level summary for Terpinolene.
Regulatory Flags
potential-allergen
fragrance-component
epa_safer_alternative
ifra_fragrance
fda_food_additive
eu_cosing_listed
jecfa_safe
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to Terpinolene by CAS number or substance name.
Studies
3
Lowest NOAEL
294.6 mg/kg bw/day
Highest NOAEL
371 mg/kg bw/day
ToxValDB_ECHA_IUCLID
Known Synonyms
Cyclohexene, 1-methyl-4-(1-methylethylidene)-
EINECS 209-578-0
FEMA No. 3046
FEMA Number 3046
p-Menth-1,4(8)-diene
1-Methyl-4-isopropylidene-1-cyclohexene
Tereben
1,4(8)-Terpadiene
UNII-N9830X5KSL
1,4(8)-p-menthadiene
1-Methyl-4-(1-methylethylidene)-Cyclohexene
1-Methyl-4-(1-methylethylidene)cyclohexene, 9CI
1-Methyl-4-(propan-2-ylidene)cyclohexene
1-methyl-4-(1-methylethylidene)-1-cyclohexene
1-methyl-4-(propan-2-ylidene)cyclohex-1-ene
1-methyl-4-propan-2-ylidene-cyclohexene
1-methyl-4-propan-2-ylidenecyclohexene
4-isopropylidene-1-methyl-cyclohexene
Cyclohexene, 3-methyl-6-(1-methylethylidene)- (9CI)
Chemical Function
Fragrance
Regulatory Lists
active_ingredient; Europe; Pesticides
air; Cleaning products and household care - laundry and fabric treatment; detected; emissions
air; detected; emissions; Personal care
air; Cleaning products and household care; detected; emissions
inert_ingredient; non_food_use; Pesticides
active_ingredient; Europe; Pesticides
Australia; Food and drug - smoking-related products
IFRA Transparency
Europe
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
SCIL (9/2019)
consumer_product
Europe; Personal care; restricted
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical and food safety data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
TERPINOLENE
ChEMBL ID
CHEMBL454697
SOURCE
EFSA / FDA GRAS
food_additives
Food Safety Data
Same-CAS food additive or FDA GRAS records from the core public database.
Food Name
TERPINOLENE
ADI
No safety concern at current levels of intake when used as a flavouring agent mg/kg bw
Food Category
flavoring
Frequently Asked Questions
Is Terpinolene allowed in the EU?
Terpinolene EU regulatory status: restricted. This is based on EU Regulation 1223/2009 and its amendments.
What does Terpinolene do in cosmetics?
Terpinolene functions as: Fragrance. It is classified as a cosmetic ingredient in our database. CAS number: 586-62-9.
What is the NOAEL for Terpinolene?
The NOAEL (No Observed Adverse Effect Level) for Terpinolene is =294.6 mg/kg bw/day based on a subchronic study via oral route in Rat. A total of 3 study endpoints are available. Source: ToxValDB_ECHA_IUCLID.
Is Terpinolene used outside cosmetics?
Terpinolene also appears in industrial chemical safety, pharmaceutical, and food safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does Terpinolene have different safety status in cosmetics vs industrial chemicals?
Terpinolene is classified GHS Danger (H226, H304, H315, H317, H400, H410, H411, H227) in the chemicals database but is restricted in EU cosmetics.
Compliance Tools
Check Terpinolene compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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