NOAEL Studies Cosmetic Ingredient

Testosterone NOAEL Studies

INCI: TESTOSTERONE

CAS: 58-22-0

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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California Proposition 65 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
California Proposition 65 California Proposition 65 listing SQEcancer listing type - - 1988-04-01 California Proposition 65 listing {"cancer_reproductive":"cancer","listed_date":"1988-04-01","listing_mechanism":"SQE","madl":null,"nsrl":null,"source_table":"prop65_listings"}
California Proposition 65 California Proposition 65 listing SQEcancer listing type - - 1988-04-01 California Proposition 65 listing {"cancer_reproductive":"cancer","listed_date":"1988-04-01","listing_mechanism":"SQE","madl":null,"nsrl":null,"source_table":"prop65_listings"}
California Proposition 65 California Proposition 65 listing SQEcancer listing type - - 1988-04-01 California Proposition 65 listing {"cancer_reproductive":"cancer","listed_date":"1988-04-01","listing_mechanism":"SQE","madl":null,"nsrl":null,"source_table":"prop65_listings"}
California Proposition 65 California Proposition 65 listing SQEcancer listing type - - 1988-04-01 California Proposition 65 listing {"cancer_reproductive":"cancer","listed_date":"1988-04-01","listing_mechanism":"SQE","madl":null,"nsrl":null,"source_table":"prop65_listings"}
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip 6 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip NOAEL 2 mg/kg bw/day rat subcutaneous - sub-chronic toxicity: other route dossier=2420928f-a98d-48fa-aba7-56039b7fad71.i6z; document=d197eec8-b948-4e92-9010-958c52594075_2420928f-a98d-48fa-aba7-56039b7fad71.i6d; document_key=d197eec8-b948-4e92-9010-958c52594075/2420928f-a98d-48fa-aba7-56039b7fad71; document_subtype=RepeatedDoseToxicityOther; literature=Name=Unnamed; ReferenceYear=1973; ReportDate=1973-11-08; basis=other:; key_result=false; entry_uuid=8b3f2a44-20fd-437d-bf49-2fb91bd77649
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip NOAEL 2 mg/kg bw/day rat subcutaneous - sub-chronic toxicity: other route dossier=2420928f-a98d-48fa-aba7-56039b7fad71.i6z; document=d197eec8-b948-4e92-9010-958c52594075_2420928f-a98d-48fa-aba7-56039b7fad71.i6d; document_key=d197eec8-b948-4e92-9010-958c52594075/2420928f-a98d-48fa-aba7-56039b7fad71; document_subtype=RepeatedDoseToxicityOther; literature=Name=Unnamed; ReferenceYear=1973; ReportDate=1973-11-08; basis=other:; key_result=false; entry_uuid=8b3f2a44-20fd-437d-bf49-2fb91bd77649
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip NOAEL 2 mg/kg bw/day rat subcutaneous - sub-chronic toxicity: other route dossier=2420928f-a98d-48fa-aba7-56039b7fad71.i6z; document=d197eec8-b948-4e92-9010-958c52594075_2420928f-a98d-48fa-aba7-56039b7fad71.i6d; document_key=d197eec8-b948-4e92-9010-958c52594075/2420928f-a98d-48fa-aba7-56039b7fad71; document_subtype=RepeatedDoseToxicityOther; literature=Name=Unnamed; ReferenceYear=1973; ReportDate=1973-11-08; basis=other:; key_result=false; entry_uuid=8b3f2a44-20fd-437d-bf49-2fb91bd77649
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip NOEL 2 mg/kg bw/day dog subcutaneous - sub-chronic toxicity: other route dossier=2420928f-a98d-48fa-aba7-56039b7fad71.i6z; document=8c26c09c-9242-41a5-90e2-6551cdd83000_2420928f-a98d-48fa-aba7-56039b7fad71.i6d; document_key=8c26c09c-9242-41a5-90e2-6551cdd83000/2420928f-a98d-48fa-aba7-56039b7fad71; document_subtype=RepeatedDoseToxicityOther; literature=Name=Unnamed; ReferenceYear=1973; ReportDate=1973-11-16; basis=other:; key_result=false; entry_uuid=a5143179-445e-4270-8234-1727b7fb736b
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip NOEL 2 mg/kg bw/day dog subcutaneous - sub-chronic toxicity: other route dossier=2420928f-a98d-48fa-aba7-56039b7fad71.i6z; document=8c26c09c-9242-41a5-90e2-6551cdd83000_2420928f-a98d-48fa-aba7-56039b7fad71.i6d; document_key=8c26c09c-9242-41a5-90e2-6551cdd83000/2420928f-a98d-48fa-aba7-56039b7fad71; document_subtype=RepeatedDoseToxicityOther; literature=Name=Unnamed; ReferenceYear=1973; ReportDate=1973-11-16; basis=other:; key_result=false; entry_uuid=a5143179-445e-4270-8234-1727b7fb736b
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip NOEL 2 mg/kg bw/day dog subcutaneous - sub-chronic toxicity: other route dossier=2420928f-a98d-48fa-aba7-56039b7fad71.i6z; document=8c26c09c-9242-41a5-90e2-6551cdd83000_2420928f-a98d-48fa-aba7-56039b7fad71.i6d; document_key=8c26c09c-9242-41a5-90e2-6551cdd83000/2420928f-a98d-48fa-aba7-56039b7fad71; document_subtype=RepeatedDoseToxicityOther; literature=Name=Unnamed; ReferenceYear=1973; ReportDate=1973-11-16; basis=other:; key_result=false; entry_uuid=a5143179-445e-4270-8234-1727b7fb736b
NTP_ICE_adme_parameters 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_adme_parameters Clint 28.83 uL/min/10^6 cells Human - - Measured; httk, Human Hepatic Intrinsic Clearance sheet=Data; excel_row=3161; Record_ID=adme_parameters_660; Data_Type=Measured; DTXSID=DTXSID8022371; Assay=httk, Human Hepatic Intrinsic Clearance; Endpoint=Clint; Response=28.83; Response_Unit=ul/min/10^6 cells; Species=Human; Reference=httk2.3.1, Brown 2007; URL=https://cran.r-project.org/web/packages/httk/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8022371
NTP_ICE_adme_parameters Fu 0.057 fraction Human - - Measured; httk, Human Plasma Fraction Unbound sheet=Data; excel_row=3162; Record_ID=adme_parameters_660; Data_Type=Measured; DTXSID=DTXSID8022371; Assay=httk, Human Plasma Fraction Unbound; Endpoint=Fu; Response=0.057; Response_Unit=Unitless Fraction; Species=Human; Reference=httk2.3.1, Lombardo 2018; URL=https://cran.r-project.org/web/packages/httk/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8022371
NTP_ICE_endocrine 171 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_endocrine AC50/EC50/IC50 363.1 nM - - - In Vitro; AR Binding sheet=Data_invitro; excel_row=52; Record_ID=endocrine_invitro_46; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8022371; Assay=AR Binding; Endpoint=AC50/EC50/IC50; Reported_Response=363.07805480000002; Reported_Response_Unit=nM; Response=363.1; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Wilson et al. 2007; 17705648; 10.1897/06-593r.1; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8022371
NTP_ICE_endocrine AC50/EC50/IC50 107.2 nM - - - In Vitro; AR Binding sheet=Data_invitro; excel_row=54; Record_ID=endocrine_invitro_48; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8022371; Assay=AR Binding; Endpoint=AC50/EC50/IC50; Reported_Response=107.15193050000001; Reported_Response_Unit=nM; Response=107.2; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Wilson et al. 2007; 17705648; 10.1897/06-593r.1; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8022371
NTP_ICE_endocrine AC50/EC50/IC50 120.2 nM - - - In Vitro; AR Binding sheet=Data_invitro; excel_row=55; Record_ID=endocrine_invitro_49; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8022371; Assay=AR Binding; Endpoint=AC50/EC50/IC50; Reported_Response=120.2264435; Reported_Response_Unit=nM; Response=120.2; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Wilson et al. 2007; 17705648; 10.1897/06-593r.1; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8022371
NTP_ICE_endocrine AC50/EC50/IC50 5.623 nM - - - In Vitro; AR Binding sheet=Data_invitro; excel_row=56; Record_ID=endocrine_invitro_50; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8022371; Assay=AR Binding; Endpoint=AC50/EC50/IC50; Reported_Response=5.6234132519999998; Reported_Response_Unit=nM; Response=5.623; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Hartig et al. 2008; 18691642; 10.1016/j.toxlet.2008.07.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8022371
NTP_ICE_endocrine AC50/EC50/IC50 4.571 nM - - - In Vitro; AR Binding sheet=Data_invitro; excel_row=64; Record_ID=endocrine_invitro_58; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8022371; Assay=AR Binding; Endpoint=AC50/EC50/IC50; Reported_Response=4.5708818960000004; Reported_Response_Unit=nM; Response=4.571; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Poutiainen et al. 2012; 22746350; 10.1021/jm300233k; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8022371
NTP_ICE_endocrine AC50/EC50/IC50 15.9 nM - - - In Vitro; AR Binding sheet=Data_invitro; excel_row=135; Record_ID=endocrine_invitro_129; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8022371; Assay=AR Binding; Endpoint=AC50/EC50/IC50; Reported_Response=15.9; Reported_Response_Unit=nM; Response=15.9; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Fang et al. 2003; 14565775; 10.1021/tx030011g; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8022371
NTP_ICE_endocrine AC50/EC50/IC50 10 nM - - - In Vitro; AR Binding sheet=Data_invitro; excel_row=138; Record_ID=endocrine_invitro_132; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8022371; Assay=AR Binding; Endpoint=AC50/EC50/IC50; Reported_Response=10; Reported_Response_Unit=nM; Response=10; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Thomas et al. 2006; 16289637; 10.1016/j.steroids.2005.09.015; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8022371
NTP_ICE_endocrine AC50/EC50/IC50 250 nM - - - In Vitro; AR Binding sheet=Data_invitro; excel_row=353; Record_ID=endocrine_invitro_347; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8022371; Assay=AR Binding; Endpoint=AC50/EC50/IC50; Reported_Response=250; Reported_Response_Unit=nM; Response=250; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Fitzpatrick et al. 1994; 7821777; 10.1006/gcen.1994.1139; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8022371
NTP_ICE_endocrine AC50/EC50/IC50 27.2 nM - - - In Vitro; AR Binding sheet=Data_invitro; excel_row=355; Record_ID=endocrine_invitro_349; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8022371; Assay=AR Binding; Endpoint=AC50/EC50/IC50; Reported_Response=27.2; Reported_Response_Unit=nM; Response=27.2; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Attardi et al. 2010; 19941958; 10.1016/j.jsbmb.2009.11.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8022371
NTP_ICE_endocrine AC50/EC50/IC50 1 nM - - - In Vitro; AR Binding sheet=Data_invitro; excel_row=356; Record_ID=endocrine_invitro_350; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8022371; Assay=AR Binding; Endpoint=AC50/EC50/IC50; Reported_Response=1; Reported_Response_Unit=nM; Response=1; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Paris et al. 2002; 12573822; 10.1016/s0303-7207(02)00375-1; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8022371
NTP_ICE_endocrine AC50/EC50/IC50 2.5 nM - - - In Vitro; AR Binding sheet=Data_invitro; excel_row=358; Record_ID=endocrine_invitro_352; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8022371; Assay=AR Binding; Endpoint=AC50/EC50/IC50; Reported_Response=2.5; Reported_Response_Unit=nM; Response=2.5; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Sperry and Thomas 1999; 10098494; 10.1210/endo.140.4.6631; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8022371
NTP_ICE_endocrine AC50/EC50/IC50 4.5 nM - - - In Vitro; AR Binding sheet=Data_invitro; excel_row=360; Record_ID=endocrine_invitro_354; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8022371; Assay=AR Binding; Endpoint=AC50/EC50/IC50; Reported_Response=4.5; Reported_Response_Unit=nM; Response=4.5; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Ozers et al. 2007; 17223690; 10.1021/bi061321b; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8022371
NTP_ICE_endocrine AC50/EC50/IC50 5.1 nM - - - In Vitro; AR Binding sheet=Data_invitro; excel_row=361; Record_ID=endocrine_invitro_355; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8022371; Assay=AR Binding; Endpoint=AC50/EC50/IC50; Reported_Response=5.0999999999999996; Reported_Response_Unit=nM; Response=5.1; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Wiita et al. 1995; 7482693; 10.1097/00007691-199508000-00011; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8022371
NTP_ICE_endocrine AC50/EC50/IC50 1.2 nM - - - In Vitro; AR Binding sheet=Data_invitro; excel_row=362; Record_ID=endocrine_invitro_356; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8022371; Assay=AR Binding; Endpoint=AC50/EC50/IC50; Reported_Response=1.2; Reported_Response_Unit=nM; Response=1.2; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Sperry and Thomas 1999; 10098494; 10.1210/endo.140.4.6631; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8022371
NTP_ICE_endocrine AC50/EC50/IC50 53 nM - - - In Vitro; AR Binding sheet=Data_invitro; excel_row=363; Record_ID=endocrine_invitro_357; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8022371; Assay=AR Binding; Endpoint=AC50/EC50/IC50; Reported_Response=53; Reported_Response_Unit=nM; Response=53; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Rabe et al. 2000; 11075290; 10.3109/09513590009167685; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8022371
NTP_ICE_endocrine AC50/EC50/IC50 1850 nM - - - In Vitro; AR Binding sheet=Data_invitro; excel_row=364; Record_ID=endocrine_invitro_358; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8022371; Assay=AR Binding; Endpoint=AC50/EC50/IC50; Reported_Response=1850; Reported_Response_Unit=nM; Response=1850; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Muddana and Peterson 2003; 12964159; 10.1002/cbic.200300606; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8022371
NTP_ICE_endocrine AC50/EC50/IC50 100 nM - - - In Vitro; AR Binding sheet=Data_invitro; excel_row=365; Record_ID=endocrine_invitro_359; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8022371; Assay=AR Binding; Endpoint=AC50/EC50/IC50; Reported_Response=100; Reported_Response_Unit=nM; Response=100; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Wilson et al. 2004; 15597887; 10.1021/es049771j; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8022371
NTP_ICE_endocrine AC50/EC50/IC50 12905 nM - - - In Vitro; AR Binding sheet=Data_invitro; excel_row=367; Record_ID=endocrine_invitro_361; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8022371; Assay=AR Binding; Endpoint=AC50/EC50/IC50; Reported_Response=12905; Reported_Response_Unit=nM; Response=12905; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Charles et al. 2005; 15589981; 10.1016/j.taap.2004.06.011; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8022371
NTP_ICE_endocrine AC50/EC50/IC50 849 nM - - - In Vitro; AR Binding sheet=Data_invitro; excel_row=368; Record_ID=endocrine_invitro_362; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8022371; Assay=AR Binding; Endpoint=AC50/EC50/IC50; Reported_Response=849; Reported_Response_Unit=nM; Response=849; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Oehlmann et al. 2006; 16818258; 10.1289/ehp.8065; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8022371
NTP_ICE_endocrine AC50/EC50/IC50 0.59 nM - - - In Vitro; AR Binding sheet=Data_invitro; excel_row=369; Record_ID=endocrine_invitro_363; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8022371; Assay=AR Binding; Endpoint=AC50/EC50/IC50; Reported_Response=0.59; Reported_Response_Unit=nM; Response=0.59; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Attardi et al. 2004; 15249132; 10.1016/j.mce.2004.04.013; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8022371
NTP_ICE_endocrine AC50/EC50/IC50 5 nM - - - In Vitro; AR Binding sheet=Data_invitro; excel_row=370; Record_ID=endocrine_invitro_364; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8022371; Assay=AR Binding; Endpoint=AC50/EC50/IC50; Reported_Response=5; Reported_Response_Unit=nM; Response=5; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Olsson et al. 2005; 16107211; 10.1186/1477-7827-3-37; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8022371
NTP_ICE_endocrine AC50/EC50/IC50 97 nM - - - In Vitro; AR Binding sheet=Data_invitro; excel_row=372; Record_ID=endocrine_invitro_366; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8022371; Assay=AR Binding; Endpoint=AC50/EC50/IC50; Reported_Response=97; Reported_Response_Unit=nM; Response=97; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Ankley et al. 2003; 12785594; Not available; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8022371
NTP_ICE_endocrine AC50/EC50/IC50 11 nM - - - In Vitro; AR Binding sheet=Data_invitro; excel_row=373; Record_ID=endocrine_invitro_367; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8022371; Assay=AR Binding; Endpoint=AC50/EC50/IC50; Reported_Response=11; Reported_Response_Unit=nM; Response=11; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Freyberger and Ahr 2004; 14751668; 10.1016/j.tox.2003.09.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8022371
NTP_ICE_endocrine AC50/EC50/IC50 30 nM - - - In Vitro; AR Binding sheet=Data_invitro; excel_row=374; Record_ID=endocrine_invitro_368; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8022371; Assay=AR Binding; Endpoint=AC50/EC50/IC50; Reported_Response=30; Reported_Response_Unit=nM; Response=30; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Beck et al. 2008; 17935685; 10.1016/j.ab.2007.09.006; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8022371
NTP_ICE_endocrine AC50/EC50/IC50 15 nM - - - In Vitro; AR Binding sheet=Data_invitro; excel_row=375; Record_ID=endocrine_invitro_369; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8022371; Assay=AR Binding; Endpoint=AC50/EC50/IC50; Reported_Response=15; Reported_Response_Unit=nM; Response=15; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Roehrborn et al. 1992; 1639214; 10.1016/0303-7207(92)90065-e; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8022371
NTP_ICE_endocrine AC50/EC50/IC50 7.4 nM - - - In Vitro; AR Binding sheet=Data_invitro; excel_row=377; Record_ID=endocrine_invitro_371; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8022371; Assay=AR Binding; Endpoint=AC50/EC50/IC50; Reported_Response=7.4; Reported_Response_Unit=nM; Response=7.4; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Kumar et al. 2000; 11108869; 10.1016/s0039-128x(00)00119-7; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8022371
NTP_ICE_endocrine AC50/EC50/IC50 <40 nM - - - In Vitro; AR Binding sheet=Data_invitro; excel_row=378; Record_ID=endocrine_invitro_372; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8022371; Assay=AR Binding; Endpoint=AC50/EC50/IC50; Response_Modifier=<; Reported_Response_Modifier=<; Reported_Response=40; Reported_Response_Unit=nM; Response=40; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Zakár and Tóth 1982; 7132347; 10.1016/0022-4731(82)90202-3; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8022371
NTP_ICE_endocrine AC50/EC50/IC50 1.6 nM - - - In Vitro; AR Binding sheet=Data_invitro; excel_row=379; Record_ID=endocrine_invitro_373; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8022371; Assay=AR Binding; Endpoint=AC50/EC50/IC50; Reported_Response=1.6; Reported_Response_Unit=nM; Response=1.6; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Sperry and Thomas 2000; 10925208; 10.1016/s0960-0760(00)00069-8; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8022371
NTP_ICE_endocrine AC50/EC50/IC50 520 nM - - - In Vitro; AR Binding sheet=Data_invitro; excel_row=380; Record_ID=endocrine_invitro_374; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8022371; Assay=AR Binding; Endpoint=AC50/EC50/IC50; Reported_Response=520; Reported_Response_Unit=nM; Response=520; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Muddana and Peterson 2003; 12964159; 10.1002/cbic.200300606; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8022371
NTP_ICE_endocrine AC50/EC50/IC50 0.3 nM - - - In Vitro; AR Binding sheet=Data_invitro; excel_row=381; Record_ID=endocrine_invitro_375; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8022371; Assay=AR Binding; Endpoint=AC50/EC50/IC50; Reported_Response=0.3; Reported_Response_Unit=nM; Response=0.3; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Sperry and Thomas 1999; 10491657; 10.1095/biolreprod61.4.1152; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8022371
NTP_ICE_endocrine AC50/EC50/IC50 6.95 nM - - - In Vitro; AR Binding sheet=Data_invitro; excel_row=382; Record_ID=endocrine_invitro_376; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8022371; Assay=AR Binding; Endpoint=AC50/EC50/IC50; Reported_Response=6.95; Reported_Response_Unit=nM; Response=6.95; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Kumar et al. 1999; 10704910; 10.1016/s0960-0760(99)00143-0; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8022371
NTP_ICE_endocrine AC50/EC50/IC50 2.6 nM - - - In Vitro; AR Binding sheet=Data_invitro; excel_row=385; Record_ID=endocrine_invitro_379; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8022371; Assay=AR Binding; Endpoint=AC50/EC50/IC50; Reported_Response=2.6; Reported_Response_Unit=nM; Response=2.6; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Ozers et al. 2007; 17223690; 10.1021/bi061321b; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8022371
NTP_ICE_endocrine AC50/EC50/IC50 18 nM - - - In Vitro; AR Binding sheet=Data_invitro; excel_row=386; Record_ID=endocrine_invitro_380; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8022371; Assay=AR Binding; Endpoint=AC50/EC50/IC50; Reported_Response=18; Reported_Response_Unit=nM; Response=18; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Simon and Mueller 2006; 16413649; 10.1016/j.tox.2005.12.002; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8022371
NTP_ICE_endocrine AC50/EC50/IC50 3.9 nM - - - In Vitro; AR Binding sheet=Data_invitro; excel_row=387; Record_ID=endocrine_invitro_381; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8022371; Assay=AR Binding; Endpoint=AC50/EC50/IC50; Reported_Response=3.9; Reported_Response_Unit=nM; Response=3.9; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Jørgensen et al. 2007; 17698417; 10.1016/j.cbpc.2007.07.002; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8022371
NTP_ICE_endocrine AC50/EC50/IC50 4 nM - - - In Vitro; AR Binding sheet=Data_invitro; excel_row=388; Record_ID=endocrine_invitro_382; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8022371; Assay=AR Binding; Endpoint=AC50/EC50/IC50; Reported_Response=4; Reported_Response_Unit=nM; Response=4; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Sperry and Thomas 2000; 10925208; 10.1016/s0960-0760(00)00069-8; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8022371
NTP_ICE_endocrine AC50/EC50/IC50 2.8 nM - - - In Vitro; AR Binding sheet=Data_invitro; excel_row=459; Record_ID=endocrine_invitro_453; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8022371; Assay=AR Binding; Endpoint=AC50/EC50/IC50; Reported_Response=2.8; Reported_Response_Unit=nM; Response=2.8; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Duc et al. 1995; 7893274; Not available; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8022371
NTP_ICE_endocrine AC50/EC50/IC50 20 nM - - - In Vitro; AR Binding sheet=Data_invitro; excel_row=501; Record_ID=endocrine_invitro_495; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8022371; Assay=AR Binding; Endpoint=AC50/EC50/IC50; Reported_Response=20; Reported_Response_Unit=nM; Response=20; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Nagamine et al. 2009; 19503826; 10.1371/journal.pcbi.1000397; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8022371
NTP_ICE_endocrine AC50/EC50/IC50 6 nM - - - In Vitro; AR Binding sheet=Data_invitro; excel_row=502; Record_ID=endocrine_invitro_496; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8022371; Assay=AR Binding; Endpoint=AC50/EC50/IC50; Reported_Response=6; Reported_Response_Unit=nM; Response=6; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Lee et al. 2003; 12805653; 10.1093/toxsci/kfg150; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8022371
NTP_ICE_endocrine AC50/EC50/IC50 0.182 nM - - - In Vitro; AR Transactivation-Agonist sheet=Data_invitro; excel_row=7860; Record_ID=endocrine_invitro_2423; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8022371; Assay=AR Transactivation-Agonist; Endpoint=AC50/EC50/IC50; Reported_Response=0.181970086; Reported_Response_Unit=nM; Response=0.182; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Sedlák et al. 2011; 21375502; 10.2174/138620711795222446; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8022371
NTP_ICE_endocrine AC50/EC50/IC50 2.291 nM - - - In Vitro; AR Transactivation-Agonist sheet=Data_invitro; excel_row=7861; Record_ID=endocrine_invitro_2425; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8022371; Assay=AR Transactivation-Agonist; Endpoint=AC50/EC50/IC50; Reported_Response=2.2908676529999998; Reported_Response_Unit=nM; Response=2.291; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Sedlák et al. 2011; 21375502; 10.2174/138620711795222446; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8022371
NTP_ICE_endocrine AC50/EC50/IC50 0.631 nM - - - In Vitro; AR Transactivation-Agonist sheet=Data_invitro; excel_row=7862; Record_ID=endocrine_invitro_1739; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8022371; Assay=AR Transactivation-Agonist; Endpoint=AC50/EC50/IC50; Reported_Response=0.63095734400000003; Reported_Response_Unit=nM; Response=0.631; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Sonneveld et al. 2005; 15483189; 10.1093/toxsci/kfi005; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8022371
NTP_ICE_endocrine AC50/EC50/IC50 0.7943 nM - - - In Vitro; AR Transactivation-Agonist sheet=Data_invitro; excel_row=7863; Record_ID=endocrine_invitro_2795; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8022371; Assay=AR Transactivation-Agonist; Endpoint=AC50/EC50/IC50; Reported_Response=0.79432823500000005; Reported_Response_Unit=nM; Response=0.7943; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Bartonkova et al. 2015; 25811655; 10.1371/journal.pone.0121316; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8022371
NTP_ICE_endocrine AC50/EC50/IC50 0.1 nM - - - In Vitro; AR Transactivation-Agonist sheet=Data_invitro; excel_row=7864; Record_ID=endocrine_invitro_2422; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8022371; Assay=AR Transactivation-Agonist; Endpoint=AC50/EC50/IC50; Reported_Response=0.1; Reported_Response_Unit=nM; Response=0.1; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Sedlák et al. 2011; 21375502; 10.2174/138620711795222446; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8022371
NTP_ICE_endocrine AC50/EC50/IC50 1.202 nM - - - In Vitro; AR Transactivation-Agonist sheet=Data_invitro; excel_row=7865; Record_ID=endocrine_invitro_2787; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8022371; Assay=AR Transactivation-Agonist; Endpoint=AC50/EC50/IC50; Reported_Response=1.202264435; Reported_Response_Unit=nM; Response=1.202; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Bartonkova et al. 2015; 25811655; 10.1371/journal.pone.0121316; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8022371
NTP_ICE_endocrine AC50/EC50/IC50 100000000000000000 nM - - - In Vitro; AR Transactivation-Agonist sheet=Data_invitro; excel_row=7880; Record_ID=endocrine_invitro_2586; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8022371; Assay=AR Transactivation-Agonist; Endpoint=AC50/EC50/IC50; Reported_Response=1E+17; Reported_Response_Unit=nM; Response=1E+17; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8022371
NTP_ICE_endocrine AC50/EC50/IC50 29.7 nM - - - In Vitro; AR Transactivation-Agonist sheet=Data_invitro; excel_row=7993; Record_ID=endocrine_invitro_3228; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8022371; Assay=AR Transactivation-Agonist; Endpoint=AC50/EC50/IC50; Reported_Response=29.7; Reported_Response_Unit=nM; Response=29.7; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8022371
NTP_ICE_endocrine AC50/EC50/IC50 0.979 nM - - - In Vitro; AR Transactivation-Agonist sheet=Data_invitro; excel_row=7995; Record_ID=endocrine_invitro_2111; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8022371; Assay=AR Transactivation-Agonist; Endpoint=AC50/EC50/IC50; Reported_Response=0.97899999999999998; Reported_Response_Unit=nM; Response=0.979; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Houtman et al. 2009; 19286037; 10.1016/j.aca.2008.09.037; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8022371
NTP_ICE_endocrine AC50/EC50/IC50 0.04 nM - - - In Vitro; AR Transactivation-Agonist sheet=Data_invitro; excel_row=7997; Record_ID=endocrine_invitro_1385; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8022371; Assay=AR Transactivation-Agonist; Endpoint=AC50/EC50/IC50; Reported_Response=0.04; Reported_Response_Unit=nM; Response=0.04; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Paris et al. 2002; 12573822; 10.1016/s0303-7207(02)00375-1; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8022371
NTP_ICE_endocrine AC50/EC50/IC50 2.1 nM - - - In Vitro; AR Transactivation-Agonist sheet=Data_invitro; excel_row=7999; Record_ID=endocrine_invitro_3242; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8022371; Assay=AR Transactivation-Agonist; Endpoint=AC50/EC50/IC50; Reported_Response=2.1; Reported_Response_Unit=nM; Response=2.1; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8022371
NTP_ICE_endocrine AC50/EC50/IC50 4.6 nM - - - In Vitro; AR Transactivation-Agonist sheet=Data_invitro; excel_row=8001; Record_ID=endocrine_invitro_2875; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8022371; Assay=AR Transactivation-Agonist; Endpoint=AC50/EC50/IC50; Reported_Response=4.5999999999999996; Reported_Response_Unit=nM; Response=4.6; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Eldridge et al. 2007; 17675419; 10.1128/aem.00589-07; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8022371
NTP_ICE_endocrine AC50/EC50/IC50 13.6 nM - - - In Vitro; AR Transactivation-Agonist sheet=Data_invitro; excel_row=8003; Record_ID=endocrine_invitro_2915; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8022371; Assay=AR Transactivation-Agonist; Endpoint=AC50/EC50/IC50; Reported_Response=13.6; Reported_Response_Unit=nM; Response=13.6; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8022371
NTP_ICE_endocrine AC50/EC50/IC50 8.31 nM - - - In Vitro; AR Transactivation-Agonist sheet=Data_invitro; excel_row=8005; Record_ID=endocrine_invitro_2867; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8022371; Assay=AR Transactivation-Agonist; Endpoint=AC50/EC50/IC50; Reported_Response=8.31; Reported_Response_Unit=nM; Response=8.31; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Sanseverino et al. 2009; 18996888; 10.1093/toxsci/kfn229; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8022371
NTP_ICE_endocrine AC50/EC50/IC50 0.8 nM - - - In Vitro; AR Transactivation-Agonist sheet=Data_invitro; excel_row=8007; Record_ID=endocrine_invitro_1479; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8022371; Assay=AR Transactivation-Agonist; Endpoint=AC50/EC50/IC50; Reported_Response=0.8; Reported_Response_Unit=nM; Response=0.8; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Willemsen et al. 2004; 14513195; 10.1007/s00216-003-2217-2; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8022371
NTP_ICE_endocrine AC50/EC50/IC50 0.4 nM - - - In Vitro; AR Transactivation-Agonist sheet=Data_invitro; excel_row=8009; Record_ID=endocrine_invitro_2846; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8022371; Assay=AR Transactivation-Agonist; Endpoint=AC50/EC50/IC50; Reported_Response=0.4; Reported_Response_Unit=nM; Response=0.4; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8022371
NTP_ICE_endocrine AC50/EC50/IC50 0.862 nM - - - In Vitro; AR Transactivation-Agonist sheet=Data_invitro; excel_row=8011; Record_ID=endocrine_invitro_2107; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8022371; Assay=AR Transactivation-Agonist; Endpoint=AC50/EC50/IC50; Reported_Response=0.86199999999999999; Reported_Response_Unit=nM; Response=0.862; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Houtman et al. 2009; 19286037; 10.1016/j.aca.2008.09.037; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8022371
NTP_ICE_endocrine AC50/EC50/IC50 110 nM - - - In Vitro; AR Transactivation-Agonist sheet=Data_invitro; excel_row=8021; Record_ID=endocrine_invitro_3234; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8022371; Assay=AR Transactivation-Agonist; Endpoint=AC50/EC50/IC50; Reported_Response=110; Reported_Response_Unit=nM; Response=110; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8022371
NTP_ICE_endocrine AC50/EC50/IC50 14 nM - - - In Vitro; AR Transactivation-Agonist sheet=Data_invitro; excel_row=8022; Record_ID=endocrine_invitro_2259; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8022371; Assay=AR Transactivation-Agonist; Endpoint=AC50/EC50/IC50; Reported_Response=14; Reported_Response_Unit=nM; Response=14; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Attardi et al. 2010; 20599585; 10.1016/j.mce.2010.06.010; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8022371
NTP_ICE_endocrine AC50/EC50/IC50 9.9 nM - - - In Vitro; AR Transactivation-Agonist sheet=Data_invitro; excel_row=8023; Record_ID=endocrine_invitro_3039; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8022371; Assay=AR Transactivation-Agonist; Endpoint=AC50/EC50/IC50; Reported_Response=9.9; Reported_Response_Unit=nM; Response=9.9; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|O'Connor et al. 1999; 10496676; 10.1093/toxsci/51.1.44; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8022371
NTP_ICE_endocrine AC50/EC50/IC50 1.3 nM - - - In Vitro; AR Transactivation-Agonist sheet=Data_invitro; excel_row=8026; Record_ID=endocrine_invitro_2825; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8022371; Assay=AR Transactivation-Agonist; Endpoint=AC50/EC50/IC50; Reported_Response=1.3; Reported_Response_Unit=nM; Response=1.3; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8022371
NTP_ICE_endocrine AC50/EC50/IC50 2.722 nM - - - In Vitro; AR Transactivation-Agonist sheet=Data_invitro; excel_row=8072; Record_ID=endocrine_invitro_3070; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8022371; Assay=AR Transactivation-Agonist; Endpoint=AC50/EC50/IC50; Reported_Response=785; Reported_Response_Unit=ng/L; Conversion_Factor=Molecular Weight; Conversion_Factor_Value=288.43099999999998; Conversion_Factor_Source=EPA Dashboard; Converted_Response=2.7216214623254782; Converted_Response_Unit=nM; Response=2.722; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8022371
NTP_ICE_endocrine AC50/EC50/IC50 0.9812 nM - - - In Vitro; AR Transactivation-Agonist sheet=Data_invitro; excel_row=8099; Record_ID=endocrine_invitro_2714; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8022371; Assay=AR Transactivation-Agonist; Endpoint=AC50/EC50/IC50; Reported_Response=283; Reported_Response_Unit=ng/L; Conversion_Factor=Molecular Weight; Conversion_Factor_Value=288.43099999999998; Conversion_Factor_Source=EPA Dashboard; Converted_Response=0.98117053992115966; Converted_Response_Unit=nM; Response=0.9812; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8022371
NTP_ICE_endocrine AC50/EC50/IC50 0.62 nM - - - In Vitro; AR Transactivation-Agonist sheet=Data_invitro; excel_row=8200; Record_ID=endocrine_invitro_1802; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8022371; Assay=AR Transactivation-Agonist; Endpoint=AC50/EC50/IC50; Reported_Response=0.62; Reported_Response_Unit=nM; Response=0.62; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Simon and Mueller 2006; 16413649; 10.1016/j.tox.2005.12.002; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8022371
NTP_ICE_endocrine AC50/EC50/IC50 16 nM - - - In Vitro; AR Transactivation-Agonist sheet=Data_invitro; excel_row=8204; Record_ID=endocrine_invitro_2499; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8022371; Assay=AR Transactivation-Agonist; Endpoint=AC50/EC50/IC50; Reported_Response=16; Reported_Response_Unit=nM; Response=16; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Chatterjee et al. 2007; 21783798; 10.1016/j.etap.2007.04.006; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8022371
NTP_ICE_endocrine AC50/EC50/IC50 235 nM - - - In Vitro; AR Transactivation-Agonist sheet=Data_invitro; excel_row=8206; Record_ID=endocrine_invitro_1780; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8022371; Assay=AR Transactivation-Agonist; Endpoint=AC50/EC50/IC50; Reported_Response=235; Reported_Response_Unit=nM; Response=235; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Simon and Mueller 2006; 16413649; 10.1016/j.tox.2005.12.002; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8022371
NTP_ICE_endocrine AC50/EC50/IC50 27 nM - - - In Vitro; AR Transactivation-Agonist sheet=Data_invitro; excel_row=8211; Record_ID=endocrine_invitro_1944; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8022371; Assay=AR Transactivation-Agonist; Endpoint=AC50/EC50/IC50; Reported_Response=27; Reported_Response_Unit=nM; Response=27; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Beck et al. 2008; 17935685; 10.1016/j.ab.2007.09.006; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8022371
NTP_ICE_endocrine AC50/EC50/IC50 2 nM - - - In Vitro; AR Transactivation-Agonist sheet=Data_invitro; excel_row=8213; Record_ID=endocrine_invitro_2744; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8022371; Assay=AR Transactivation-Agonist; Endpoint=AC50/EC50/IC50; Reported_Response=2; Reported_Response_Unit=nM; Response=2; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Melo et al. 2015; 25435279; 10.1016/j.ygcen.2014.11.015; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8022371
NTP_ICE_endocrine AC50/EC50/IC50 3.96 nM - - - In Vitro; AR Transactivation-Agonist sheet=Data_invitro; excel_row=8215; Record_ID=endocrine_invitro_2768; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8022371; Assay=AR Transactivation-Agonist; Endpoint=AC50/EC50/IC50; Reported_Response=3.96; Reported_Response_Unit=nM; Response=3.96; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Bain et al. 2015; 25644213; 10.1016/j.ygcen.2015.01.024; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8022371
NTP_ICE_endocrine AC50/EC50/IC50 4.2 nM - - - In Vitro; AR Transactivation-Agonist sheet=Data_invitro; excel_row=8218; Record_ID=endocrine_invitro_1394; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8022371; Assay=AR Transactivation-Agonist; Endpoint=AC50/EC50/IC50; Reported_Response=4.2; Reported_Response_Unit=nM; Response=4.2; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Lutz et al. 2003; 12637588; 10.1210/me.2003-0032; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8022371
NTP_ICE_endocrine AC50/EC50/IC50 0.5 nM - - - In Vitro; AR Transactivation-Agonist sheet=Data_invitro; excel_row=8220; Record_ID=endocrine_invitro_2392; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8022371; Assay=AR Transactivation-Agonist; Endpoint=AC50/EC50/IC50; Reported_Response=0.5; Reported_Response_Unit=nM; Response=0.5; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Akram et al. 2011; 21329390; 10.1021/ac102845y; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8022371
NTP_ICE_endocrine AC50/EC50/IC50 5.8 nM - - - In Vitro; AR Transactivation-Agonist sheet=Data_invitro; excel_row=8221; Record_ID=endocrine_invitro_1814; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8022371; Assay=AR Transactivation-Agonist; Endpoint=AC50/EC50/IC50; Reported_Response=5.8; Reported_Response_Unit=nM; Response=5.8; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Simon and Mueller 2006; 16413649; 10.1016/j.tox.2005.12.002; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8022371
NTP_ICE_endocrine AC50/EC50/IC50 0.51 nM - - - In Vitro; AR Transactivation-Agonist sheet=Data_invitro; excel_row=8223; Record_ID=endocrine_invitro_1810; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8022371; Assay=AR Transactivation-Agonist; Endpoint=AC50/EC50/IC50; Reported_Response=0.51; Reported_Response_Unit=nM; Response=0.51; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Simon and Mueller 2006; 16413649; 10.1016/j.tox.2005.12.002; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8022371
NTP_ICE_endocrine AC50/EC50/IC50 0.9 nM - - - In Vitro; AR Transactivation-Agonist sheet=Data_invitro; excel_row=8224; Record_ID=endocrine_invitro_2774; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8022371; Assay=AR Transactivation-Agonist; Endpoint=AC50/EC50/IC50; Reported_Response=0.9; Reported_Response_Unit=nM; Response=0.9; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Fan et al. 2015; 25752796; 10.1093/toxsci/kfv052; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8022371
NTP_ICE_endocrine AC50/EC50/IC50 158 nM - - - In Vitro; AR Transactivation-Agonist sheet=Data_invitro; excel_row=8226; Record_ID=endocrine_invitro_1767; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8022371; Assay=AR Transactivation-Agonist; Endpoint=AC50/EC50/IC50; Reported_Response=158; Reported_Response_Unit=nM; Response=158; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Simon and Mueller 2006; 16413649; 10.1016/j.tox.2005.12.002; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8022371
NTP_ICE_endocrine AC50/EC50/IC50 23 nM - - - In Vitro; AR Transactivation-Agonist sheet=Data_invitro; excel_row=8228; Record_ID=endocrine_invitro_1948; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8022371; Assay=AR Transactivation-Agonist; Endpoint=AC50/EC50/IC50; Reported_Response=23; Reported_Response_Unit=nM; Response=23; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Beck et al. 2008; 17935685; 10.1016/j.ab.2007.09.006; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8022371
NTP_ICE_endocrine AC50/EC50/IC50 4.4 nM - - - In Vitro; AR Transactivation-Agonist sheet=Data_invitro; excel_row=8229; Record_ID=endocrine_invitro_3261; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8022371; Assay=AR Transactivation-Agonist; Endpoint=AC50/EC50/IC50; Reported_Response=4.4000000000000004; Reported_Response_Unit=nM; Response=4.4; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|McRobb et al. 2008; 18395441; 10.1016/j.jsbmb.2007.10.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8022371
NTP_ICE_endocrine AC50/EC50/IC50 106 nM - - - In Vitro; AR Transactivation-Agonist sheet=Data_invitro; excel_row=8230; Record_ID=endocrine_invitro_1759; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8022371; Assay=AR Transactivation-Agonist; Endpoint=AC50/EC50/IC50; Reported_Response=106; Reported_Response_Unit=nM; Response=106; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Simon and Mueller 2006; 16413649; 10.1016/j.tox.2005.12.002; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8022371
NTP_ICE_endocrine AC50/EC50/IC50 12 nM - - - In Vitro; AR Transactivation-Agonist sheet=Data_invitro; excel_row=8231; Record_ID=endocrine_invitro_2754; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8022371; Assay=AR Transactivation-Agonist; Endpoint=AC50/EC50/IC50; Reported_Response=12; Reported_Response_Unit=nM; Response=12; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Bain et al. 2015; 25644213; 10.1016/j.ygcen.2015.01.024; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8022371
NTP_ICE_endocrine AC50/EC50/IC50 50 nM - - - In Vitro; AR Transactivation-Agonist sheet=Data_invitro; excel_row=8232; Record_ID=endocrine_invitro_1973; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8022371; Assay=AR Transactivation-Agonist; Endpoint=AC50/EC50/IC50; Reported_Response=50; Reported_Response_Unit=nM; Response=50; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Bovee et al. 2008; 17945480; 10.1016/j.jsbmb.2007.05.035; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8022371
NTP_ICE_endocrine AC50/EC50/IC50 0.505 nM - - - In Vitro; AR Transactivation-Agonist sheet=Data_invitro; excel_row=8234; Record_ID=endocrine_invitro_2338; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8022371; Assay=AR Transactivation-Agonist; Endpoint=AC50/EC50/IC50; Reported_Response=0.505; Reported_Response_Unit=nM; Response=0.505; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Blake et al. 2010; 20821581; 10.1002/etc.166; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8022371
NTP_ICE_endocrine AC50/EC50/IC50 32 nM - - - In Vitro; AR Transactivation-Agonist sheet=Data_invitro; excel_row=8235; Record_ID=endocrine_invitro_1388; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8022371; Assay=AR Transactivation-Agonist; Endpoint=AC50/EC50/IC50; Reported_Response=32; Reported_Response_Unit=nM; Response=32; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Lutz et al. 2003; 12637588; 10.1210/me.2003-0032; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8022371
NTP_ICE_endocrine AC50/EC50/IC50 6.9 nM - - - In Vitro; AR Transactivation-Agonist sheet=Data_invitro; excel_row=8236; Record_ID=endocrine_invitro_1400; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8022371; Assay=AR Transactivation-Agonist; Endpoint=AC50/EC50/IC50; Reported_Response=6.9; Reported_Response_Unit=nM; Response=6.9; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Lutz et al. 2003; 12637588; 10.1210/me.2003-0032; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8022371
NTP_ICE_endocrine AC50/EC50/IC50 0.07 nM - - - In Vitro; AR Transactivation-Agonist sheet=Data_invitro; excel_row=8237; Record_ID=endocrine_invitro_2387; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8022371; Assay=AR Transactivation-Agonist; Endpoint=AC50/EC50/IC50; Reported_Response=7.0000000000000007E-2; Reported_Response_Unit=nM; Response=0.07; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Akram et al. 2011; 21329390; 10.1021/ac102845y; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8022371
NTP_ICE_endocrine AC50/EC50/IC50 487 nM - - - In Vitro; AR Transactivation-Agonist sheet=Data_invitro; excel_row=8242; Record_ID=endocrine_invitro_1774; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8022371; Assay=AR Transactivation-Agonist; Endpoint=AC50/EC50/IC50; Reported_Response=487; Reported_Response_Unit=nM; Response=487; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Simon and Mueller 2006; 16413649; 10.1016/j.tox.2005.12.002; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8022371
NTP_ICE_endocrine AC50/EC50/IC50 88 nM - - - In Vitro; AR Transactivation-Agonist sheet=Data_invitro; excel_row=8248; Record_ID=endocrine_invitro_2999; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8022371; Assay=AR Transactivation-Agonist; Endpoint=AC50/EC50/IC50; Reported_Response=88; Reported_Response_Unit=nM; Response=88; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Rijk et al. 2011; 21742131; 10.1016/j.aca.2010.11.016; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8022371
NTP_ICE_endocrine AC50/EC50/IC50 0.42 nM - - - In Vitro; AR Transactivation-Agonist sheet=Data_invitro; excel_row=8250; Record_ID=endocrine_invitro_2066; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8022371; Assay=AR Transactivation-Agonist; Endpoint=AC50/EC50/IC50; Reported_Response=0.42; Reported_Response_Unit=nM; Response=0.42; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|de Waal et al. 2008; 18469035; 10.1530/rep-08-0055; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8022371
NTP_ICE_endocrine AC50/EC50/IC50 0.35 nM - - - In Vitro; AR Transactivation-Agonist sheet=Data_invitro; excel_row=8255; Record_ID=endocrine_invitro_2691; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8022371; Assay=AR Transactivation-Agonist; Endpoint=AC50/EC50/IC50; Reported_Response=0.35; Reported_Response_Unit=nM; Response=0.35; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8022371
NTP_ICE_endocrine AC50/EC50/IC50 0.0042 nM - - - In Vitro; AR Transactivation-Agonist sheet=Data_invitro; excel_row=8257; Record_ID=endocrine_invitro_2080; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8022371; Assay=AR Transactivation-Agonist; Endpoint=AC50/EC50/IC50; Reported_Response=4.1999999999999997E-3; Reported_Response_Unit=nM; Response=0.0042; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Wilkinson et al. 2008; 18753690; 10.1177/1087057108322155; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8022371
NTP_ICE_endocrine EC50 1.5 nM - - - In Vitro; AR Binding sheet=Data_invitro; excel_row=199; Record_ID=endocrine_invitro_193; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8022371; Assay=AR Binding; Endpoint=EC50; Reported_Response=1.5; Reported_Response_Unit=EC50 (nM); Response=1.5; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Sperry and Thomas 1999; 10491657; 10.1095/biolreprod61.4.1152; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8022371
NTP_ICE_endocrine EC50 17500 nM - - - In Vitro; ER Transactivation-Agonist (VM7Luc Assay) sheet=Data_invitro; excel_row=16614; Record_ID=endocrine_invitro_4451; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8022371; Assay=ER Transactivation-Agonist (VM7Luc Assay); Endpoint=EC50; Reported_Response=1.7499999999999998E-5; Reported_Response_Unit=M; Conversion_Factor=1000000000; Conversion_Factor_Value=1000000000; Converted_Response=17499.999999999902; Converted_Response_Unit=nM; Response=17500; Response_Unit=nM; Reference=|OECD TG 455; https://www.oecd.org/env/test-no-455-performance-based-test-guideline-for-stably-transfected-transactivation-in-vitro-assays-to-detect-estrogen-receptor-9789264265295-en.htm; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8022371
NTP_ICE_endocrine Kd 1.59 nM - - - In Vitro; AR Binding sheet=Data_invitro; excel_row=1751; Record_ID=endocrine_invitro_947; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8022371; Assay=AR Binding; Endpoint=Kd; Reported_Response=1.59; Reported_Response_Unit=nM; Response=1.59; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8022371
NTP_ICE_endocrine Kd 6.2 nM - - - In Vitro; AR Binding sheet=Data_invitro; excel_row=1752; Record_ID=endocrine_invitro_11; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8022371; Assay=AR Binding; Endpoint=Kd; Reported_Response=6.2; Reported_Response_Unit=nM; Response=6.2; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Sperry and Thomas 1999; 10098494; 10.1210/endo.140.4.6631; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8022371
NTP_ICE_endocrine Kd 1.03 nM - - - In Vitro; AR Binding sheet=Data_invitro; excel_row=1754; Record_ID=endocrine_invitro_939; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8022371; Assay=AR Binding; Endpoint=Kd; Reported_Response=1.03; Reported_Response_Unit=nM; Response=1.03; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Lutz et al. 2003; 12637588; 10.1210/me.2003-0032; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8022371
NTP_ICE_endocrine Kd 1.53 nM - - - In Vitro; AR Binding sheet=Data_invitro; excel_row=1755; Record_ID=endocrine_invitro_966; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8022371; Assay=AR Binding; Endpoint=Kd; Reported_Response=1.53; Reported_Response_Unit=nM; Response=1.53; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8022371
NTP_ICE_endocrine Kd 0.6 nM - - - In Vitro; AR Binding sheet=Data_invitro; excel_row=1757; Record_ID=endocrine_invitro_965; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8022371; Assay=AR Binding; Endpoint=Kd; Reported_Response=0.6; Reported_Response_Unit=nM; Response=0.6; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Feldkoren and Andersson 2005; 15876413; 10.1016/j.jsbmb.2004.12.036; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8022371
NTP_ICE_endocrine Kd 8.2 nM - - - In Vitro; AR Binding sheet=Data_invitro; excel_row=1758; Record_ID=endocrine_invitro_964; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8022371; Assay=AR Binding; Endpoint=Kd; Reported_Response=8.1999999999999993; Reported_Response_Unit=nM; Response=8.2; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Feldkoren and Andersson 2005; 15876413; 10.1016/j.jsbmb.2004.12.036; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8022371
NTP_ICE_endocrine Kd 0.82 nM - - - In Vitro; AR Binding sheet=Data_invitro; excel_row=1761; Record_ID=endocrine_invitro_974; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8022371; Assay=AR Binding; Endpoint=Kd; Reported_Response=0.82; Reported_Response_Unit=nM; Response=0.82; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Lutz et al. 2003; 12637588; 10.1210/me.2003-0032; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8022371
NTP_ICE_endocrine Kd 1.7 nM - - - In Vitro; AR Binding sheet=Data_invitro; excel_row=1783; Record_ID=endocrine_invitro_950; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8022371; Assay=AR Binding; Endpoint=Kd; Reported_Response=1.7; Reported_Response_Unit=nM; Response=1.7; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Feldkoren and Andersson 2005; 15876413; 10.1016/j.jsbmb.2004.12.036; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8022371
NTP_ICE_endocrine Kd 0.92 nM - - - In Vitro; AR Binding sheet=Data_invitro; excel_row=1785; Record_ID=endocrine_invitro_943; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8022371; Assay=AR Binding; Endpoint=Kd; Reported_Response=0.92; Reported_Response_Unit=nM; Response=0.92; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8022371
NTP_ICE_endocrine Kd 0.95 nM - - - In Vitro; AR Binding sheet=Data_invitro; excel_row=1788; Record_ID=endocrine_invitro_12; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8022371; Assay=AR Binding; Endpoint=Kd; Reported_Response=0.95; Reported_Response_Unit=nM; Response=0.95; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Sperry and Thomas 1999; 10098494; 10.1210/endo.140.4.6631; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8022371
NTP_ICE_endocrine Kd 5.7 nM - - - In Vitro; AR Binding sheet=Data_invitro; excel_row=1792; Record_ID=endocrine_invitro_9; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8022371; Assay=AR Binding; Endpoint=Kd; Reported_Response=5.7; Reported_Response_Unit=nM; Response=5.7; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Sperry and Thomas 1999; 10098494; 10.1210/endo.140.4.6631; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8022371
NTP_ICE_endocrine Kd 1.43 nM - - - In Vitro; AR Binding sheet=Data_invitro; excel_row=1795; Record_ID=endocrine_invitro_935; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8022371; Assay=AR Binding; Endpoint=Kd; Reported_Response=1.43; Reported_Response_Unit=nM; Response=1.43; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8022371
NTP_ICE_endocrine Kd 1.1 nM - - - In Vitro; AR Binding sheet=Data_invitro; excel_row=1799; Record_ID=endocrine_invitro_10; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8022371; Assay=AR Binding; Endpoint=Kd; Reported_Response=1.1000000000000001; Reported_Response_Unit=nM; Response=1.1; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Sperry and Thomas 1999; 10098494; 10.1210/endo.140.4.6631; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8022371
NTP_ICE_endocrine Ki 12.1 nM - - - In Vitro; AR Binding sheet=Data_invitro; excel_row=11; Record_ID=endocrine_invitro_6; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8022371; Assay=AR Binding; Endpoint=Ki; Reported_Response=12.1; Reported_Response_Unit=nM; Response=12.1; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Lemus et al. 1997; 9182866; 10.1016/s0960-0760(96)00172-0; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8022371
NTP_ICE_endocrine Ki 32.9 nM - - - In Vitro; AR Binding sheet=Data_invitro; excel_row=1859; Record_ID=endocrine_invitro_955; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8022371; Assay=AR Binding; Endpoint=Ki; Reported_Response=32.9; Reported_Response_Unit=nM; Response=32.9; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Lutz et al. 2003; 12637588; 10.1210/me.2003-0032; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8022371
NTP_ICE_endocrine Ki 1.01 nM - - - In Vitro; AR Binding sheet=Data_invitro; excel_row=1863; Record_ID=endocrine_invitro_946; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8022371; Assay=AR Binding; Endpoint=Ki; Reported_Response=1.01; Reported_Response_Unit=nM; Response=1.01; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Eil and Edelson 1984; 6725525; 10.1210/jcem-59-1-51; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8022371
NTP_ICE_endocrine Ki 0.8 nM - - - In Vitro; AR Binding sheet=Data_invitro; excel_row=1866; Record_ID=endocrine_invitro_949; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8022371; Assay=AR Binding; Endpoint=Ki; Reported_Response=0.8; Reported_Response_Unit=nM; Response=0.8; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Feldkoren and Andersson 2005; 15876413; 10.1016/j.jsbmb.2004.12.036; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8022371
NTP_ICE_endocrine LEL 100 nM - - - In Vitro; AR Transactivation-Agonist sheet=Data_invitro; excel_row=10335; Record_ID=endocrine_invitro_1673; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8022371; Assay=AR Transactivation-Agonist; Endpoint=LEL; Reported_Response=100; Reported_Response_Unit=nM; Response=100; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Michelini et al. 2005; 15797324; 10.1016/j.bios.2004.10.018; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8022371
NTP_ICE_endocrine LEL 0.1585 nM - - - In Vitro; AR Transactivation-Agonist sheet=Data_invitro; excel_row=10336; Record_ID=endocrine_invitro_2099; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8022371; Assay=AR Transactivation-Agonist; Endpoint=LEL; Reported_Response=0.15848931899999999; Reported_Response_Unit=nM; Response=0.1585; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Van der Linden et al. 2008; 18754514; 10.1021/es702897y; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8022371
NTP_ICE_endocrine LEL 0.0631 nM - - - In Vitro; AR Transactivation-Agonist sheet=Data_invitro; excel_row=10471; Record_ID=endocrine_invitro_1316; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8022371; Assay=AR Transactivation-Agonist; Endpoint=LEL; Reported_Response=6.3095700000000005E-2; Reported_Response_Unit=nM; Response=0.0631; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Avancès et al. 2001; 11694337; 10.1016/s0303-7207(01)00669-4; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8022371
NTP_ICE_endocrine LEL 0.0316228 nM - - - In Vitro; AR Transactivation-Agonist sheet=Data_invitro; excel_row=10474; Record_ID=endocrine_invitro_1326; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8022371; Assay=AR Transactivation-Agonist; Endpoint=LEL; Reported_Response=3.16228E-2; Reported_Response_Unit=nM; Response=3.16228E-2; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Avancès et al. 2001; 11694337; 10.1016/s0303-7207(01)00669-4; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8022371
NTP_ICE_endocrine LEL 0.01 nM - - - In Vitro; AR Transactivation-Agonist sheet=Data_invitro; excel_row=10476; Record_ID=endocrine_invitro_3171; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8022371; Assay=AR Transactivation-Agonist; Endpoint=LEL; Reported_Response=0.01; Reported_Response_Unit=nM; Response=0.01; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Sneddon et al. 2005; 16166216; 10.1210/en.2005-0914; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8022371
NTP_ICE_endocrine LEL 0.3162 nM - - - In Vitro; AR Transactivation-Agonist sheet=Data_invitro; excel_row=10478; Record_ID=endocrine_invitro_1265; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8022371; Assay=AR Transactivation-Agonist; Endpoint=LEL; Reported_Response=0.31622800000000001; Reported_Response_Unit=nM; Response=0.3162; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Sohoni and Sumpter 1998; 9846162; 10.1677/joe.0.1580327; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8022371
NTP_ICE_endocrine LEL 1 nM - - - In Vitro; AR Transactivation-Agonist sheet=Data_invitro; excel_row=10479; Record_ID=endocrine_invitro_2744; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8022371; Assay=AR Transactivation-Agonist; Endpoint=LEL; Reported_Response=1; Reported_Response_Unit=nM; Response=1; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Melo et al. 2015; 25435279; 10.1016/j.ygcen.2014.11.015; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8022371
NTP_ICE_endocrine LEL 1000 nM - - - In Vitro; AR Transactivation-Agonist sheet=Data_invitro; excel_row=10480; Record_ID=endocrine_invitro_2749; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8022371; Assay=AR Transactivation-Agonist; Endpoint=LEL; Reported_Response=1000; Reported_Response_Unit=nM; Response=1000; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Melo et al. 2015; 25435279; 10.1016/j.ygcen.2014.11.015; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8022371
NTP_ICE_endocrine LEL 0.03467 nM - - - In Vitro; AR Transactivation-Agonist sheet=Data_invitro; excel_row=10485; Record_ID=endocrine_invitro_2580; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8022371; Assay=AR Transactivation-Agonist; Endpoint=LEL; Reported_Response=10; Reported_Response_Unit=ng/L; Conversion_Factor=Molecular Weight; Conversion_Factor_Value=288.43099999999998; Conversion_Factor_Source=EPA Dashboard; Converted_Response=3.4670337099687622E-2; Converted_Response_Unit=nM; Response=0.03467; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8022371
NTP_ICE_endocrine LEL 0.001 nM - - - In Vitro; AR Transactivation-Agonist sheet=Data_invitro; excel_row=10504; Record_ID=endocrine_invitro_3105; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8022371; Assay=AR Transactivation-Agonist; Endpoint=LEL; Reported_Response=1E-3; Reported_Response_Unit=nM; Response=1E-3; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Holterhus et al. 2002; 12589933; 10.1016/s0960-0760(02)00220-0; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8022371
NTP_ICE_endocrine LEL 0.0125 nM - - - In Vitro; AR Transactivation-Agonist sheet=Data_invitro; excel_row=10657; Record_ID=endocrine_invitro_2392; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8022371; Assay=AR Transactivation-Agonist; Endpoint=LEL; Reported_Response=1.2500000000000001E-2; Reported_Response_Unit=nM; Response=0.0125; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Akram et al. 2011; 21329390; 10.1021/ac102845y; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8022371
NTP_ICE_endocrine LEL 0.00125 nM - - - In Vitro; AR Transactivation-Agonist sheet=Data_invitro; excel_row=10660; Record_ID=endocrine_invitro_2387; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8022371; Assay=AR Transactivation-Agonist; Endpoint=LEL; Reported_Response=1.25E-3; Reported_Response_Unit=nM; Response=1.25E-3; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Akram et al. 2011; 21329390; 10.1021/ac102845y; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8022371
NTP_ICE_endocrine LEL 55 nM - - - In Vitro; AR Transactivation-Agonist sheet=Data_invitro; excel_row=10663; Record_ID=endocrine_invitro_2191; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8022371; Assay=AR Transactivation-Agonist; Endpoint=LEL; Reported_Response=55; Reported_Response_Unit=nM; Response=55; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Bovee et al. 2010; 19883760; 10.1016/j.jsbmb.2009.10.007; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8022371
NTP_ICE_endocrine LEL 1.25 nM - - - In Vitro; AR Transactivation-Agonist sheet=Data_invitro; excel_row=10671; Record_ID=endocrine_invitro_2397; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8022371; Assay=AR Transactivation-Agonist; Endpoint=LEL; Reported_Response=1.25; Reported_Response_Unit=nM; Response=1.25; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Akram et al. 2011; 21329390; 10.1021/ac102845y; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8022371
NTP_ICE_endocrine LEL 0.05 nM - - - In Vitro; AR Transactivation-Agonist sheet=Data_invitro; excel_row=10673; Record_ID=endocrine_invitro_1675; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8022371; Assay=AR Transactivation-Agonist; Endpoint=LEL; Reported_Response=0.05; Reported_Response_Unit=nM; Response=0.05; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Michelini et al. 2005; 15797324; 10.1016/j.bios.2004.10.018; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8022371
NTP_ICE_endocrine LEL 1e-7 nM - - - In Vitro; AR Transactivation-Agonist sheet=Data_invitro; excel_row=10695; Record_ID=endocrine_invitro_3080; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8022371; Assay=AR Transactivation-Agonist; Endpoint=LEL; Reported_Response=9.9999999999999995E-8; Reported_Response_Unit=nM; Response=1e-07; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Thomas et al. 2002; 12109746; Not available; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8022371
NTP_ICE_endocrine LEL 0.03 nM - - - In Vitro; AR Transactivation-Agonist sheet=Data_invitro; excel_row=10766; Record_ID=endocrine_invitro_1902; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8022371; Assay=AR Transactivation-Agonist; Endpoint=LEL; Reported_Response=0.03; Reported_Response_Unit=nM; Response=0.03; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Roy et al. 2006; 16893644; 10.1016/j.jsbmb.2006.06.014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8022371
NTP_ICE_endocrine LOEL 0.2 mg/day Rat Subcutaneous Treatment_Duration=3 days; Age_at_First_Dose=PND 20 to 23; Time_Elapsed_Between_Last_Dose_and_Necropsy=24 hours; Number_of_Doses_Tested=3 In Vivo; Uterotrophic-Agonist sheet=Data_invivo; excel_row=972; Record_ID=endocrine_invivo_281; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID8022371; Assay=Uterotrophic-Agonist; Endpoint=LOEL; Response=0.2; Response_Unit=mg/day; Species=Rat; Reported_Strain=Holtzman; Strain=Holtzman; Sex=Female; Route=Subcutaneous; Maximum_Dose=0.5; Maximum_Dose_Units=mg/day; Reference_Hormone=Estradiol; Reference=Schmidt et al. 1976; 177269; 10.1210/endo-98-3-702|Kleinstreuer et al. 2016; 26431337; 10.1289/ehp.1510183; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8022371
NTP_ICE_endocrine LOEL 0.05 mg/kg bw/day Rat subcutaneous Treatment_Duration=7 days; Age_at_First_Dose=PND 28; Age_Ovariectomized_or_Castrated=PND 21; Time_Elapsed_Between_Surgery_and_Treatment=7 days; Time_Elapsed_Between_Last_Dose_and_Necropsy=18 to 36 hours; Number_of_Doses_Tested=10 In Vivo; Hershberger-Agonist sheet=Data_invivo; excel_row=1273; Record_ID=endocrine_invivo_554; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID8022371; Assay=Hershberger-Agonist; Endpoint=LOEL; Response=0.05; Response_Unit=mg/kg/day; Species=Rat; Reported_Strain=Sprague-Dawley; Strain=Sprague-Dawley; Sex=Male (castrated); Route=subcutaneous; Reference_Hormone=Testosterone; Reference_Hormone_Dose=0.05; Reference_Hormone_Dose_Units=mg/kg/day; Reference_Hormone_Route=Subcutaneous; Additional_Information=Browne et al. 2018 unique record identifier 277; Reference=Kim et al. 2002; 12243870; 10.1016/s0378-4274(02)00130-3|Browne et al. 2018; 30205136; 10.1016/j.reprotox.2018.08.016; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8022371
NTP_ICE_endocrine LOEL 0.2 mg/kg bw/day Rat subcutaneous Treatment_Duration=7 days; Age_at_First_Dose=PND 49; Age_Ovariectomized_or_Castrated=PND 42; Time_Elapsed_Between_Surgery_and_Treatment=7 days; Time_Elapsed_Between_Last_Dose_and_Necropsy=18 to 36 hours; Number_of_Doses_Tested=10 In Vivo; Hershberger-Agonist sheet=Data_invivo; excel_row=1275; Record_ID=endocrine_invivo_556; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID8022371; Assay=Hershberger-Agonist; Endpoint=LOEL; Response=0.2; Response_Unit=mg/kg/day; Species=Rat; Reported_Strain=Sprague-Dawley; Strain=Sprague-Dawley; Sex=Male (castrated); Route=subcutaneous; Reference_Hormone=Testosterone; Reference_Hormone_Route=Subcutaneous; Additional_Information=Browne et al. 2018 unique record identifier 280; Reference=Kim et al. 2002; 12243870; 10.1016/s0378-4274(02)00130-3|Browne et al. 2018; 30205136; 10.1016/j.reprotox.2018.08.016; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8022371
NTP_ICE_endocrine NOEL 0.1 mg/kg bw/day Rat subcutaneous Treatment_Duration=7 days; Age_at_First_Dose=PND 49; Age_Ovariectomized_or_Castrated=PND 42; Time_Elapsed_Between_Surgery_and_Treatment=7 days; Time_Elapsed_Between_Last_Dose_and_Necropsy=18 to 36 hours; Number_of_Doses_Tested=10 In Vivo; Hershberger-Agonist sheet=Data_invivo; excel_row=1276; Record_ID=endocrine_invivo_556; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID8022371; Assay=Hershberger-Agonist; Endpoint=NOEL; Response=0.1; Response_Unit=mg/kg/day; Species=Rat; Reported_Strain=Sprague-Dawley; Strain=Sprague-Dawley; Sex=Male (castrated); Route=subcutaneous; Reference_Hormone=Testosterone; Reference_Hormone_Route=Subcutaneous; Additional_Information=Browne et al. 2018 unique record identifier 280; Reference=Kim et al. 2002; 12243870; 10.1016/s0378-4274(02)00130-3|Browne et al. 2018; 30205136; 10.1016/j.reprotox.2018.08.016; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8022371
NTP_ICE_endocrine PC10 1.4 nM - - - In Vitro; AR Transactivation-Agonist sheet=Data_invitro; excel_row=8414; Record_ID=endocrine_invitro_1446; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8022371; Assay=AR Transactivation-Agonist; Endpoint=PC10; Reported_Response=1.4; Reported_Response_Unit=PC10 (nM); Response=1.4; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Takeyoshi et al. 2003; 12734641; 10.1007/s00204-003-0437-z; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8022371
NTP_ICE_endocrine PC50 9780 nM - - - In Vitro; ER Transactivation-Agonist (STTA Assay) sheet=Data_invitro; excel_row=16521; Record_ID=endocrine_invitro_4451; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8022371; Assay=ER Transactivation-Agonist (STTA Assay); Endpoint=PC50; Reported_Response=9.7799999999999995E-6; Reported_Response_Unit=M; Conversion_Factor=1000000000; Conversion_Factor_Value=1000000000; Converted_Response=9779.9999999999891; Converted_Response_Unit=nM; Response=9780; Response_Unit=nM; Reference=|OECD TG 455; https://www.oecd.org/env/test-no-455-performance-based-test-guideline-for-stably-transfected-transactivation-in-vitro-assays-to-detect-estrogen-receptor-9789264265295-en.htm; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8022371
NTP_ICE_endocrine RBA 19.05 unitless - - - In Vitro; AR Binding sheet=Data_invitro; excel_row=1934; Record_ID=endocrine_invitro_129; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8022371; Assay=AR Binding; Endpoint=RBA; Reported_Response=1.28; Reported_Response_Unit=Unitless; Conversion_Factor=Anti-log; Converted_Response=19.054607179632477; Converted_Response_Unit=Unitless; Response=19.05; Response_Unit=Unitless; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Fang et al. 2003; 14565775; 10.1021/tx030011g; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8022371
NTP_ICE_endocrine RBA 3.02 unitless - - - In Vitro; AR Binding sheet=Data_invitro; excel_row=1938; Record_ID=endocrine_invitro_940; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8022371; Assay=AR Binding; Endpoint=RBA; Reported_Response=0.48; Reported_Response_Unit=Unitless; Conversion_Factor=Anti-log; Converted_Response=3.0199517204020165; Converted_Response_Unit=Unitless; Response=3.02; Response_Unit=Unitless; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Bohl et al. 2004; 15239655; 10.1021/jm0499007; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8022371
NTP_ICE_endocrine RBA 36.4 unitless - - - In Vitro; AR Binding sheet=Data_invitro; excel_row=2296; Record_ID=endocrine_invitro_961; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8022371; Assay=AR Binding; Endpoint=RBA; Reported_Response=36.4; Reported_Response_Unit=Unitless; Response=36.4; Response_Unit=Unitless; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|de Gooyer et al. 2003; 12475720; 10.1016/s0039-128x(02)00112-5; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8022371
NTP_ICE_endocrine RBA 17.6 unitless - - - In Vitro; AR Binding sheet=Data_invitro; excel_row=2300; Record_ID=endocrine_invitro_933; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8022371; Assay=AR Binding; Endpoint=RBA; Reported_Response=17.600000000000001; Reported_Response_Unit=Unitless; Response=17.6; Response_Unit=Unitless; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|de Gooyer et al. 2003; 12475720; 10.1016/s0039-128x(02)00112-5; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8022371
NTP_ICE_endocrine RBA 33 unitless - - - In Vitro; AR Binding sheet=Data_invitro; excel_row=2303; Record_ID=endocrine_invitro_370; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8022371; Assay=AR Binding; Endpoint=RBA; Reported_Response=33; Reported_Response_Unit=Unitless; Response=33; Response_Unit=Unitless; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Attardi et al. 2010; 20599585; 10.1016/j.mce.2010.06.010; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8022371
NTP_ICE_endocrine RBA 2 unitless - - - In Vitro; AR Binding sheet=Data_invitro; excel_row=2308; Record_ID=endocrine_invitro_193; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8022371; Assay=AR Binding; Endpoint=RBA; Reported_Response=2; Reported_Response_Unit=Unitless; Response=2; Response_Unit=Unitless; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Sperry and Thomas 1999; 10491657; 10.1095/biolreprod61.4.1152; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8022371
NTP_ICE_endocrine RBA 125 unitless - - - In Vitro; AR Binding sheet=Data_invitro; excel_row=2311; Record_ID=endocrine_invitro_6; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8022371; Assay=AR Binding; Endpoint=RBA; Reported_Response=125; Reported_Response_Unit=Unitless; Response=125; Response_Unit=Unitless; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Lemus et al. 1997; 9182866; 10.1016/s0960-0760(96)00172-0; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8022371
NTP_ICE_endocrine RBA 58 unitless - - - In Vitro; AR Binding sheet=Data_invitro; excel_row=2312; Record_ID=endocrine_invitro_975; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8022371; Assay=AR Binding; Endpoint=RBA; Reported_Response=58; Reported_Response_Unit=Unitless; Response=58; Response_Unit=Unitless; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Freyberger and Scholz 2004; 15057405; Not available; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8022371
NTP_ICE_endocrine RBA 121 unitless - - - In Vitro; AR Binding sheet=Data_invitro; excel_row=2316; Record_ID=endocrine_invitro_48; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8022371; Assay=AR Binding; Endpoint=RBA; Reported_Response=121; Reported_Response_Unit=Unitless; Response=121; Response_Unit=Unitless; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Wilson et al. 2007; 17705648; 10.1897/06-593r.1; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8022371
NTP_ICE_endocrine RBA 22 unitless - - - In Vitro; AR Binding sheet=Data_invitro; excel_row=2317; Record_ID=endocrine_invitro_349; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8022371; Assay=AR Binding; Endpoint=RBA; Reported_Response=22; Reported_Response_Unit=Unitless; Response=22; Response_Unit=Unitless; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Attardi et al. 2010; 19941958; 10.1016/j.jsbmb.2009.11.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8022371
NTP_ICE_endocrine RBA 7 unitless - - - In Vitro; AR Binding sheet=Data_invitro; excel_row=2319; Record_ID=endocrine_invitro_944; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8022371; Assay=AR Binding; Endpoint=RBA; Reported_Response=7; Reported_Response_Unit=Unitless; Response=7; Response_Unit=Unitless; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Saartok et al. 1984; 6539197; 10.1210/endo-114-6-2100; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8022371
NTP_ICE_endocrine RBA 23 unitless - - - In Vitro; AR Binding sheet=Data_invitro; excel_row=2320; Record_ID=endocrine_invitro_945; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8022371; Assay=AR Binding; Endpoint=RBA; Reported_Response=23; Reported_Response_Unit=Unitless; Response=23; Response_Unit=Unitless; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Saartok et al. 1984; 6539197; 10.1210/endo-114-6-2100; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8022371
NTP_ICE_endocrine RBA 14.2 unitless - - - In Vitro; AR Binding sheet=Data_invitro; excel_row=2324; Record_ID=endocrine_invitro_972; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8022371; Assay=AR Binding; Endpoint=RBA; Reported_Response=14.2; Reported_Response_Unit=Unitless; Response=14.2; Response_Unit=Unitless; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Culig et al. 1993; 8145761; 10.1210/mend.7.12.8145761; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8022371
NTP_ICE_endocrine RBA 67 unitless - - - In Vitro; AR Binding sheet=Data_invitro; excel_row=2326; Record_ID=endocrine_invitro_356; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8022371; Assay=AR Binding; Endpoint=RBA; Reported_Response=67; Reported_Response_Unit=Unitless; Response=67; Response_Unit=Unitless; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Sperry and Thomas 1999; 10098494; 10.1210/endo.140.4.6631; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8022371
NTP_ICE_endocrine RBA 61 unitless - - - In Vitro; AR Binding sheet=Data_invitro; excel_row=2328; Record_ID=endocrine_invitro_377; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8022371; Assay=AR Binding; Endpoint=RBA; Reported_Response=61; Reported_Response_Unit=Unitless; Response=61; Response_Unit=Unitless; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Freyberger and Ahr 2004; 14751668; 10.1016/j.tox.2003.09.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8022371
NTP_ICE_endocrine RBA 25 unitless - - - In Vitro; AR Binding sheet=Data_invitro; excel_row=2332; Record_ID=endocrine_invitro_969; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8022371; Assay=AR Binding; Endpoint=RBA; Reported_Response=25; Reported_Response_Unit=Unitless; Response=25; Response_Unit=Unitless; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8022371
NTP_ICE_endocrine RBA 19.26 unitless - - - In Vitro; AR Binding sheet=Data_invitro; excel_row=2337; Record_ID=endocrine_invitro_129; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8022371; Assay=AR Binding; Endpoint=RBA; Reported_Response=19.257100000000001; Reported_Response_Unit=Unitless; Response=19.26; Response_Unit=Unitless; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Fang et al. 2003; 14565775; 10.1021/tx030011g; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8022371
NTP_ICE_endocrine RBA 32 unitless - - - In Vitro; AR Binding sheet=Data_invitro; excel_row=2340; Record_ID=endocrine_invitro_380; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8022371; Assay=AR Binding; Endpoint=RBA; Reported_Response=32; Reported_Response_Unit=Unitless; Response=32; Response_Unit=Unitless; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Simon and Mueller 2006; 16413649; 10.1016/j.tox.2005.12.002; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8022371
NTP_ICE_endocrine RBA 38 unitless - - - In Vitro; AR Binding sheet=Data_invitro; excel_row=2344; Record_ID=endocrine_invitro_954; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8022371; Assay=AR Binding; Endpoint=RBA; Reported_Response=38; Reported_Response_Unit=Unitless; Response=38; Response_Unit=Unitless; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Bergink et al. 1983; 6645495; 10.1016/0022-4731(83)90371-0; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8022371
NTP_ICE_endocrine RBA 270 unitless - - - In Vitro; AR Binding sheet=Data_invitro; excel_row=2347; Record_ID=endocrine_invitro_977; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8022371; Assay=AR Binding; Endpoint=RBA; Reported_Response=270; Reported_Response_Unit=Unitless; Response=270; Response_Unit=Unitless; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Lovely et al. 2000; 11162929; 10.1016/s0960-0760(00)00127-8; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8022371
NTP_ICE_endocrine RBA 55 unitless - - - In Vitro; AR Binding sheet=Data_invitro; excel_row=2351; Record_ID=endocrine_invitro_367; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8022371; Assay=AR Binding; Endpoint=RBA; Reported_Response=55; Reported_Response_Unit=Unitless; Response=55; Response_Unit=Unitless; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Freyberger and Ahr 2004; 14751668; 10.1016/j.tox.2003.09.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8022371
NTP_ICE_endocrine RBA 16 unitless - - - In Vitro; AR Binding sheet=Data_invitro; excel_row=2353; Record_ID=endocrine_invitro_50; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8022371; Assay=AR Binding; Endpoint=RBA; Reported_Response=16; Reported_Response_Unit=Unitless; Response=16; Response_Unit=Unitless; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Hartig et al. 2008; 18691642; 10.1016/j.toxlet.2008.07.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8022371
NTP_ICE_endocrine RBA 17.1 unitless - - - In Vitro; AR Binding sheet=Data_invitro; excel_row=2356; Record_ID=endocrine_invitro_973; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8022371; Assay=AR Binding; Endpoint=RBA; Reported_Response=17.100000000000001; Reported_Response_Unit=Unitless; Response=17.1; Response_Unit=Unitless; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Sonneveld et al. 2006; 16221957; 10.1093/toxsci/kfj009; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8022371
NTP_ICE_endocrine RBA 0.11 unitless - - - In Vitro; AR Binding sheet=Data_invitro; excel_row=2360; Record_ID=endocrine_invitro_46; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8022371; Assay=AR Binding; Endpoint=RBA; Reported_Response=0.11; Reported_Response_Unit=Unitless; Response=0.11; Response_Unit=Unitless; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Wilson et al. 2007; 17705648; 10.1897/06-593r.1; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8022371
NTP_ICE_endocrine RBA 50 unitless - - - In Vitro; AR Binding sheet=Data_invitro; excel_row=2361; Record_ID=endocrine_invitro_373; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8022371; Assay=AR Binding; Endpoint=RBA; Reported_Response=50; Reported_Response_Unit=Unitless; Response=50; Response_Unit=Unitless; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Sperry and Thomas 2000; 10925208; 10.1016/s0960-0760(00)00069-8; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8022371
NTP_ICE_endocrine Relative potency 0.08 % - - - In Vitro; AR Transactivation-Agonist sheet=Data_invitro; excel_row=10962; Record_ID=endocrine_invitro_1780; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8022371; Assay=AR Transactivation-Agonist; Endpoint=Relative potency; Reported_Response=0.08; Reported_Response_Unit=%; Response=0.08; Response_Unit=%; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Simon and Mueller 2006; 16413649; 10.1016/j.tox.2005.12.002; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8022371
NTP_ICE_endocrine Relative potency 13 % - - - In Vitro; AR Transactivation-Agonist sheet=Data_invitro; excel_row=10965; Record_ID=endocrine_invitro_1806; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8022371; Assay=AR Transactivation-Agonist; Endpoint=Relative potency; Reported_Response=13; Reported_Response_Unit=%; Response=13; Response_Unit=%; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Simon and Mueller 2006; 16413649; 10.1016/j.tox.2005.12.002; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8022371
NTP_ICE_endocrine Relative potency 169 % - - - In Vitro; AR Transactivation-Agonist sheet=Data_invitro; excel_row=10970; Record_ID=endocrine_invitro_1810; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8022371; Assay=AR Transactivation-Agonist; Endpoint=Relative potency; Reported_Response=169; Reported_Response_Unit=%; Response=169; Response_Unit=%; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Simon and Mueller 2006; 16413649; 10.1016/j.tox.2005.12.002; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8022371
NTP_ICE_endocrine Relative potency 97.9 % - - - In Vitro; AR Transactivation-Agonist sheet=Data_invitro; excel_row=10976; Record_ID=endocrine_invitro_2714; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8022371; Assay=AR Transactivation-Agonist; Endpoint=Relative potency; Reported_Response=97.9; Reported_Response_Unit=%; Response=97.9; Response_Unit=%; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8022371
NTP_ICE_endocrine Relative potency 94 % - - - In Vitro; AR Transactivation-Agonist sheet=Data_invitro; excel_row=10979; Record_ID=endocrine_invitro_1618; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8022371; Assay=AR Transactivation-Agonist; Endpoint=Relative potency; Reported_Response=94; Reported_Response_Unit=%; Response=94; Response_Unit=%; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Sonneveld et al. 2005; 15483189; 10.1093/toxsci/kfi005; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8022371
NTP_ICE_endocrine Relative potency 2.8 % - - - In Vitro; AR Transactivation-Agonist sheet=Data_invitro; excel_row=10980; Record_ID=endocrine_invitro_2259; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8022371; Assay=AR Transactivation-Agonist; Endpoint=Relative potency; Reported_Response=2.8; Reported_Response_Unit=%; Response=2.8; Response_Unit=%; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Attardi et al. 2010; 20599585; 10.1016/j.mce.2010.06.010; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8022371
NTP_ICE_endocrine Relative potency 16.5 % - - - In Vitro; AR Transactivation-Agonist sheet=Data_invitro; excel_row=10981; Record_ID=endocrine_invitro_3294; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8022371; Assay=AR Transactivation-Agonist; Endpoint=Relative potency; Reported_Response=16.5; Reported_Response_Unit=%; Response=16.5; Response_Unit=%; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Paris et al. 2002; 12573822; 10.1016/s0303-7207(02)00375-1; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8022371
NTP_ICE_endocrine Relative potency 11 % - - - In Vitro; AR Transactivation-Agonist sheet=Data_invitro; excel_row=10988; Record_ID=endocrine_invitro_1802; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8022371; Assay=AR Transactivation-Agonist; Endpoint=Relative potency; Reported_Response=11; Reported_Response_Unit=%; Response=11; Response_Unit=%; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Simon and Mueller 2006; 16413649; 10.1016/j.tox.2005.12.002; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8022371
NTP_ICE_endocrine Relative potency 62 % - - - In Vitro; AR Transactivation-Agonist sheet=Data_invitro; excel_row=10994; Record_ID=endocrine_invitro_2495; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8022371; Assay=AR Transactivation-Agonist; Endpoint=Relative potency; Reported_Response=62; Reported_Response_Unit=%; Response=62; Response_Unit=%; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Plotan et al. 2011; 21742114; 10.1016/j.aca.2010.12.014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8022371
NTP_ICE_endocrine Relative potency 0.11 % - - - In Vitro; AR Transactivation-Agonist sheet=Data_invitro; excel_row=10999; Record_ID=endocrine_invitro_1767; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8022371; Assay=AR Transactivation-Agonist; Endpoint=Relative potency; Reported_Response=0.11; Reported_Response_Unit=%; Response=0.11; Response_Unit=%; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Simon and Mueller 2006; 16413649; 10.1016/j.tox.2005.12.002; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8022371
NTP_ICE_endocrine Relative potency 16.8 % - - - In Vitro; AR Transactivation-Agonist sheet=Data_invitro; excel_row=11005; Record_ID=endocrine_invitro_1740; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8022371; Assay=AR Transactivation-Agonist; Endpoint=Relative potency; Reported_Response=16.8; Reported_Response_Unit=%; Response=16.8; Response_Unit=%; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Paris et al. 2002; 12573822; 10.1016/s0303-7207(02)00375-1; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8022371
NTP_ICE_endocrine Relative potency 14.6 % - - - In Vitro; AR Transactivation-Agonist sheet=Data_invitro; excel_row=11007; Record_ID=endocrine_invitro_1739; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8022371; Assay=AR Transactivation-Agonist; Endpoint=Relative potency; Reported_Response=14.6; Reported_Response_Unit=%; Response=14.6; Response_Unit=%; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Sonneveld et al. 2005; 15483189; 10.1093/toxsci/kfi005; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8022371
NTP_ICE_endocrine Relative potency 3.2 % - - - In Vitro; AR Transactivation-Agonist sheet=Data_invitro; excel_row=11012; Record_ID=endocrine_invitro_3234; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8022371; Assay=AR Transactivation-Agonist; Endpoint=Relative potency; Reported_Response=3.2; Reported_Response_Unit=%; Response=3.2; Response_Unit=%; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8022371
NTP_ICE_endocrine Relative potency 38 % - - - In Vitro; AR Transactivation-Agonist sheet=Data_invitro; excel_row=11013; Record_ID=endocrine_invitro_2749; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8022371; Assay=AR Transactivation-Agonist; Endpoint=Relative potency; Reported_Response=38; Reported_Response_Unit=%; Response=38; Response_Unit=%; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Melo et al. 2015; 25435279; 10.1016/j.ygcen.2014.11.015; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8022371
NTP_ICE_endocrine Relative potency 26 % - - - In Vitro; AR Transactivation-Agonist sheet=Data_invitro; excel_row=11014; Record_ID=endocrine_invitro_2768; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8022371; Assay=AR Transactivation-Agonist; Endpoint=Relative potency; Reported_Response=26; Reported_Response_Unit=%; Response=26; Response_Unit=%; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Bain et al. 2015; 25644213; 10.1016/j.ygcen.2015.01.024; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8022371
NTP_ICE_endocrine Relative potency 98 % - - - In Vitro; AR Transactivation-Agonist sheet=Data_invitro; excel_row=11015; Record_ID=endocrine_invitro_2744; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8022371; Assay=AR Transactivation-Agonist; Endpoint=Relative potency; Reported_Response=98; Reported_Response_Unit=%; Response=98; Response_Unit=%; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Melo et al. 2015; 25435279; 10.1016/j.ygcen.2014.11.015; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8022371
NTP_ICE_endocrine Uterine weight increase vs control 180 % Rat Subcutaneous Treatment_Duration=3 days; Age_at_First_Dose=PND 20 to 23; Time_Elapsed_Between_Last_Dose_and_Necropsy=24 hours; Number_of_Doses_Tested=3 In Vivo; Uterotrophic-Agonist sheet=Data_invivo; excel_row=644; Record_ID=endocrine_invivo_281; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID8022371; Assay=Uterotrophic-Agonist; Endpoint=Uterine weight increase vs control; Response=180; Response_Unit=%; Species=Rat; Reported_Strain=Holtzman; Strain=Holtzman; Sex=Female; Route=Subcutaneous; Maximum_Dose=0.5; Maximum_Dose_Units=mg/day; Reference_Hormone=Estradiol; Reference=Schmidt et al. 1976; 177269; 10.1210/endo-98-3-702|Kleinstreuer et al. 2016; 26431337; 10.1289/ehp.1510183; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8022371
NTP_ICE_skin_sensitization 3 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_skin_sensitization Incidence of positive responses 0 % Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=8432; Record_ID=skin_sensitization_invivo_1896; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=25.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID8022371; Assay=Human Maximization Test; Endpoint=Incidence of positive responses; Response=0; Response_Unit=%; Species=Human; Route=Dermal; Reference=Kligman 1966; 5924294; 10.1038/jid.1966.160; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8022371
NTP_ICE_skin_sensitization Induction dose per skin area 15520 ug/cm2 Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=8430; Record_ID=skin_sensitization_invivo_1896; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=25.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID8022371; Assay=Human Maximization Test; Endpoint=Induction dose per skin area; Response=15520; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Kligman 1966; 5924294; 10.1038/jid.1966.160; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8022371
NTP_ICE_skin_sensitization Relative reliability score 1 unitless Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=8436; Record_ID=skin_sensitization_invivo_1896; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=25.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID8022371; Assay=Human Maximization Test; Endpoint=Relative reliability score; Response=1; Response_Unit=Unitless; Species=Human; Route=Dermal; Reference=Kligman 1966; 5924294; 10.1038/jid.1966.160; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8022371
ToxValDB_ECOTOX 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_ECOTOX LOEL =0.25 mg/org Rat injection short-term; 7 days short-term LONG_REF=Neuroendocrinology78(5): 280-286 Rulli,S.B., K. Zitta, R.S. Calandra, and S. Campo Effect of Dihydrotestosterone on Pituitary Follicle-Stimulating Hormone Isoforms in Adult Male Rats Treated with a Gonadotropin-Releasing Hormone Antagonist 2003; TITLE=Effect of Dihydrotestosterone on Pituitary Follicle-Stimulating Hormone Isoforms in Adult Male Rats Treated with a Gonadotropin-Releasing Hormone Antagonist; AUTHOR=Rulli,S.B., K. Zitta, R.S. Calandra, and S. Campo; DOI=10.1159/000074449; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=109130; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2003; ORIGINAL_YEAR=2003; TOXICOLOGICAL_EFFECT=Hormone(s): Dihydrotestosterone|Hormone(s): Follicle stimulating hormone; TOXICOLOGICAL_EFFECT_CATEGORY=clinical chemistry; STUDY_GROUP=ECOTOX_dup_EPA ORD_15594470_15600170:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=7b7856e8d2e99634e839f2390d94705c
ToxValDB_ECOTOX LOEL =0.2 mg Rat injection short-term; 16 days reproduction developmental LONG_REF=J. Endocrinol.184(1): 107-117 Atanassova,N.N., M. Walker, C. McKinnell, J.S. Fisher, and R.M. Sharpe Evidence that Androgens and Oestrogens, as well as Follicle-Stimulating Hormone, can Alter Sertoli Cell Number in the Neonatal Rat 2005; TITLE=Evidence that Androgens and Oestrogens, as well as Follicle-Stimulating Hormone, can Alter Sertoli Cell Number in the Neonatal Rat; AUTHOR=Atanassova,N.N., M. Walker, C. McKinnell, J.S. Fisher, and R.M. Sharpe; DOI=10.1677/joe.1.05884; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=108766; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2005; ORIGINAL_YEAR=2005; TOXICOLOGICAL_EFFECT=Cell(s): Volume|Hormone(s): Follicle stimulating hormone|Hormone(s): Inhibin|Hormone(s): Testosterone|Morphology: Organ weight in relationship to body weight; TOXICOLOGICAL_EFFECT_CATEGORY=clinical chemistry|organ weight|other; STUDY_GROUP=ECOTOX_dup_EPA ORD_15594522_15598396:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=8dbd77a0e11dc38abfcc7d5d70c9c7cf
ToxValDB_Uterotrophic_Hershberger_DB 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_Uterotrophic_Hershberger_DB LEL =0.2 mg/day Rat injection short-term; 3 days uterotrophic LONG_REF=Kleinstreuer et al., A Curated Database of Rodent Uterotrophic Bioactivity, EHP Vol 124 2106, https://doi.org/10.1289/ehp.1510183; TITLE=A Curated Database of Rodent Uterotrophic Bioactivity; AUTHOR=Kleinstreuer et al., A Curated Database of Rodent Uterotrophic Bioactivity, EHP Vol 124; DOI=10.1289/ehp.1510183; GUIDELINE=1; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759abc7e4b0a7c65d37b40c; RECORD_SOURCE_LEVEL=Extraction document; TOXICOLOGICAL_EFFECT=Active; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=Uterotrophic Hershberger DB:15713336:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_0eb229e1ccc857a779956f28a2621e2d
ToxValDB_Uterotrophic_Hershberger_DB LOEL =0.05 mg/kg bw/day Rat injection short-term; 7 days Hershberger LONG_REF=Kim, H. S. Han, S. Y. Kim, T. S. Kwack, S. J. Lee, R. D. Kim, I. Y. Seok, J. H. Lee, B. M. Yoo, S. D. Park, K. L. (2002). "No androgenic/anti-androgenic effects of bisphenol-A in Hershberger assay using immature castrated rats", Toxicol Lett, 135(1-2) 111-23 doi: S0378427402001303 [pii]; TITLE=No androgenic/anti-androgenic effects of bisphenol-A in Hershberger assay using immature castrated rats; AUTHOR=Kim, H. S. Han, S. Y. Kim, T. S. Kwack, S. J. Lee, R. D. Kim, I. Y. Seok, J. H. Lee, B. M. Yoo, S. D. Park, K. L; DOI=S0378427402001303; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759abc7e4b0a7c65d37b40a; RECORD_SOURCE_LEVEL=Extraction document; TOXICOLOGICAL_EFFECT=active|Androgenic|androgenic; STUDY_GROUP=Uterotrophic Hershberger DB_dup_-_15714549_15714550_15714551:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_1e247f64e5aab2254b5d6e3d0a5a48e0
ToxValDB_Uterotrophic_Hershberger_DB LOEL =0.2 mg/kg bw/day Rat injection short-term; 7 days Hershberger LONG_REF=Kim, H. S. Han, S. Y. Kim, T. S. Kwack, S. J. Lee, R. D. Kim, I. Y. Seok, J. H. Lee, B. M. Yoo, S. D. Park, K. L. (2002). "No androgenic/anti-androgenic effects of bisphenol-A in Hershberger assay using immature castrated rats", Toxicol Lett, 135(1-2) 111-23 doi: S0378427402001303 [pii]; TITLE=No androgenic/anti-androgenic effects of bisphenol-A in Hershberger assay using immature castrated rats; AUTHOR=Kim, H. S. Han, S. Y. Kim, T. S. Kwack, S. J. Lee, R. D. Kim, I. Y. Seok, J. H. Lee, B. M. Yoo, S. D. Park, K. L; DOI=S0378427402001303; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759abc7e4b0a7c65d37b40a; RECORD_SOURCE_LEVEL=Extraction document; TOXICOLOGICAL_EFFECT=active|Androgenic|androgenic; STUDY_GROUP=Uterotrophic Hershberger DB_dup_-_15714549_15714550_15714551:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_843275cd5b08451993191a0b7e99b32c
ToxValDB_Uterotrophic_Hershberger_DB NOEL =0.1 mg/kg bw/day Rat injection short-term; 7 days Hershberger LONG_REF=Kim, H. S. Han, S. Y. Kim, T. S. Kwack, S. J. Lee, R. D. Kim, I. Y. Seok, J. H. Lee, B. M. Yoo, S. D. Park, K. L. (2002). "No androgenic/anti-androgenic effects of bisphenol-A in Hershberger assay using immature castrated rats", Toxicol Lett, 135(1-2) 111-23 doi: S0378427402001303 [pii]; TITLE=No androgenic/anti-androgenic effects of bisphenol-A in Hershberger assay using immature castrated rats; AUTHOR=Kim, H. S. Han, S. Y. Kim, T. S. Kwack, S. J. Lee, R. D. Kim, I. Y. Seok, J. H. Lee, B. M. Yoo, S. D. Park, K. L; DOI=S0378427402001303; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759abc7e4b0a7c65d37b40a; RECORD_SOURCE_LEVEL=Extraction document; TOXICOLOGICAL_EFFECT=active|Androgenic|androgenic; STUDY_GROUP=Uterotrophic Hershberger DB_dup_-_15714549_15714550_15714551:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_88885068990979f15595fad6673e19de
ToxValDB_WHO_JECFA_ADI 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_WHO_JECFA_ADI ADI <=0.002 mg/kg Human oral - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/650b0467e4b0d99f5a889b34; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://apps.who.int/food-additives-contaminants-jecfa-database/; SUBSOURCE_URL=https://apps.who.int/food-additives-contaminants-jecfa-database/Home/Chemical/2452; YEAR=2000; ORIGINAL_YEAR=2000; STUDY_GROUP=WHO JECFA ADI:15715848:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_6433270ad26d8ac5faae629711dc7499
ToxValDB_WHO_JECFA_Tox_Studies 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_WHO_JECFA_Tox_Studies NOEL =1.7 mg/kg bw/day Human oral - clinical STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/650b0467e4b0d99f5a889b34; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://apps.who.int/food-additives-contaminants-jecfa-database/; SUBSOURCE_URL=https://apps.who.int/food-additives-contaminants-jecfa-database/Home/Chemical/2452; YEAR=2000; ORIGINAL_YEAR=2000; TOXICOLOGICAL_EFFECT=Restoration normal sexual desire, erection, ejaculation, and general well-being; TOXICOLOGICAL_EFFECT_CATEGORY=reproduction; STUDY_GROUP=WHO JECFA Tox Studies:15716152:M:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_43a571234a8c796c09044ede101634e3
openFDA substances 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier 3XMK78S47O UNII - - - chemical {"approval_status":null,"molecular_formula":"C19H28O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"3XMK78S47O"}
openFDA substances FDA UNII substance identifier 3XMK78S47O UNII - - - chemical {"approval_status":null,"molecular_formula":"C19H28O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"3XMK78S47O"}
openFDA substances FDA UNII substance identifier 3XMK78S47O UNII - - - chemical {"approval_status":null,"molecular_formula":"C19H28O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"3XMK78S47O"}
openFDA substances FDA UNII substance identifier 3XMK78S47O UNII - - - chemical {"approval_status":null,"molecular_formula":"C19H28O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"3XMK78S47O"}