NOAEL Studies Cosmetic Ingredient

Tetraaminopyrimidine Sulfate NOAEL Studies

INCI: TETRAAMINOPYRIMIDINE SULFATE

CAS: 5392-28-9

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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NTP ICE eye irritation 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP ICE eye irritation EPA Classification 3 unitless Rabbit Ocular - In Vivo; Draize Eye Irritation/Corrosion Test sheet=Data; excel_row=388; Record_ID=eye_irritation_96; Data_Type=In Vivo; Concentration=100.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID0037023; Assay=Draize Eye Irritation/Corrosion Test; Endpoint=EPA Classification; Response=3; Response_Unit=Unitless; Species=Rabbit; Reference=ICCVAM 2006; URL=https://ntp.niehs.nih.gov/sites/default/files/iccvam/docs/ocutox_docs/oteval/otevalrpt.pdf; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0037023
SCCS Opinion 6 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
SCCS Opinion NOAEL =28 - - - 28 days NOAEL study p.14
SCCS Opinion NOAEL =150 mg/kg bw/d rat oral 90-day repeated dose toxicity p.15
SCCS Opinion NOAEL =375 mg/kg/d rat dermal - developmental toxicity p.20
SCCS Opinion NOAEL =375 mg/kg bw/day rat oral subchronic repeated dose toxicity p.24
SCCS Opinion NOAEL =500 mg/kg bw human oral sub-chronic repeated dose toxicity p.5
SCCS Opinion NOAEL =600 mg/kg bw human oral sub-chronic repeated dose toxicity p.5
Regulatory source 6 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
Regulatory source - 28 - - - 28 days - p.14
Regulatory source developmental toxicity 375 mg/kg/d rat dermal - developmental toxicity p.20
Regulatory source repeated dose toxicity 150 mg/kg bw/d rat oral 90-day repeated dose toxicity p.15
Regulatory source repeated dose toxicity 375 mg/kg bw/day rat oral subchronic repeated dose toxicity p.24
Regulatory source repeated dose toxicity 500 mg/kg bw human oral sub-chronic repeated dose toxicity p.5
Regulatory source repeated dose toxicity 600 mg/kg bw human oral sub-chronic repeated dose toxicity p.5
openFDA substances 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier 53QQY0I99M UNII - - - chemical -