Good Colorant NOAEL Data

Acid Red 92 (Phloxine B)

INCI: CI 45410

CAS Number

18472-87-2

Function

Colorant (red/fluorescent pink), Hair dyeing

Safety Rating

GOOD

Regulatory Status

🇪🇺 EU Status restricted

EU Max Conc. 2.0% oxidative hair dye; 0.4% non-oxidative hair dye (Annex III)

🇺🇸 US Status permitted

US Notes Permanently listed as D&C Red No. 27 (free acid) and D&C Red No. 28 (Na salt). Certification required.

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)

adequate

Dermal Absorption

negligible

Sensitization

none

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

1 study endpoint found for Acid Red 92 (Phloxine B). NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint	Value	Route	Species	Study Type	Source
LOAEL	10 mg/kg bw/day	oral	rat	Subchronic	COSMOS_DB

Expert Verdict

Well-characterized xanthene colorant with SCCS opinion confirming adequate margin of safety for hair dye use.

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Concern Level: Low

Regulatory Flags

eu_children_restricted eu_cosing_listed

Frequently Asked Questions

Is Acid Red 92 (Phloxine B) safe in cosmetics?

Well-characterized xanthene colorant with SCCS opinion confirming adequate margin of safety for hair dye use. The EU classifies Acid Red 92 (Phloxine B) as "restricted". Safety rating: GOOD. 1 toxicological study endpoint(s) are available in our database.

Is Acid Red 92 (Phloxine B) allowed in the EU?

Acid Red 92 (Phloxine B) EU regulatory status: restricted. Maximum allowed concentration: 2.0% oxidative hair dye; 0.4% non-oxidative hair dye (Annex III). This is based on EU Regulation 1223/2009 and its amendments.

What does Acid Red 92 (Phloxine B) do in cosmetics?

Acid Red 92 (Phloxine B) functions as: Colorant (red/fluorescent pink), Hair dyeing. It is classified as a Colorant in our database. CAS number: 18472-87-2.

What is the Margin of Safety for Acid Red 92 (Phloxine B)?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

What is the NOAEL for Acid Red 92 (Phloxine B)?

The NOAEL (No Observed Adverse Effect Level) for Acid Red 92 (Phloxine B) is 10 mg/kg bw/day based on a Subchronic study via oral route in rat. Source: COSMOS_DB.

Compliance Tools

Check Acid Red 92 (Phloxine B) compliance across multiple jurisdictions:

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82 Allergen Checker

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Substance Compliance

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MoS Calculator

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Heavy Metal Limits

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