NOAEL Studies Cosmetic Ingredient

Tetrabromophenol Blue NOAEL Studies

INCI: TETRABROMOPHENOL BLUE

CAS: 4430-25-5

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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COSMOS DB 3 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
COSMOS DB LOAEL 3 mg/kg bw/day rat oral 92 day Subchronic SCCS; van Otterdijk, F. M.; 90-day oral toxicity study with Royal Blue/802175/Tetrabromophenolblue by daily gavage in the rat; NOTOX; 2005
COSMOS DB LOAEL 30 mg/kg bw/day rat oral 6-20 Gestation day Developmental SCCS; Gerspach, R.; Flade, D.; Tetrabromophenol Blue (WR 18042): Prenatal developmentaltoxicity study in the Han Wistar Rat; RCC; 2005
COSMOS DB NOAEL 3 mg/kg bw/day rat oral 6-20 Gestation day Developmental SCCS; Gerspach, R.; Flade, D.; Tetrabromophenol Blue (WR 18042): Prenatal developmentaltoxicity study in the Han Wistar Rat; RCC; 2005
SCCNFP Opinion 5 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
SCCNFP Opinion NOAEL =0.2 % - - sub-chronic repeated dose toxicity p.16
SCCNFP Opinion NOAEL =3 mg/kg bw/day rat oral Subchronic repeated dose toxicity Ref.: 2b 2, p.8
SCCNFP Opinion NOAEL =5 mg/kg bw/day - - - NOAEL study p.12
SCCNFP Opinion NOAEL =10 mg/kg bw/day - dermal Sub-chronic repeated dose toxicity p.9
SCCNFP Opinion NOAEL =50 mg/kg bw/day - - - NOAEL study p.12
SCCS Opinion 14 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
SCCS Opinion NOAEL =3 mg/kg bw/day rat oral Sub-chronic repeated dose toxicity Ref.: 2b, subm I 3, p.16
SCCS Opinion NOAEL =10 mg/kg bw/day - - 90-day NOAEL study p.17
SCCS Opinion NOAEL =50 mg/kg bw/day rat - - NOAEL study p.21
SCCS Opinion NOAEL =5 mg/kg bw/day rat - - NOAEL study p.21
SCCS Opinion NOAEL =30 mg/kg bw/ day rat - - NOAEL study p.23
SCCS Opinion NOAEL =0.0434 mg/kg bw/d rat oral sub-chronic repeated dose toxicity (Ref. 21), p.26
SCCS Opinion NOAEL =4 - human - - genotoxicity p.12
SCCS Opinion NOAEL =100 mg/kg bw/day - - 90-day NOAEL study Ref.: 1 (Submission I) Ref, p.31
SCCS Opinion NOAEL =0.00068 mg/kg bw rat oral 90-day dermal absorption (ref. 21), p.46
SCCS Opinion NOAEL =3 mg/kg bw/d rat oral 90-day dermal absorption (ref. 21), p.46
SCCS Opinion NOAEL =0.9 mg/kg bw/d rat oral 90-day dermal absorption (ref. 21), p.46
SCCS Opinion NOAEL =0.00039 mg/kg bw rat oral 90-day dermal absorption (ref. 21), p.46
SCCS Opinion NOAEL =3 mg/kg bw/day - - 90-day NOAEL study p.23
SCCS Opinion NOAEL =5 mg/kg bw/day rat oral - NOAEL study p.29
Regulatory source 33 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
Regulatory source - 5 mg/kg bw/day - - - - p.12
Regulatory source - 50 mg/kg bw/day - - - - p.12
Regulatory source repeated dose toxicity 0.2 % - - sub-chronic repeated dose toxicity p.16
Regulatory source repeated dose toxicity 3 mg/kg bw/day rat oral Subchronic repeated dose toxicity p.8
Regulatory source repeated dose toxicity 3 mg/kg bw/day rabbit dermal Sub-chronic repeated dose toxicity p.9
Regulatory source repeated dose toxicity 3 mg/kg bw/day - - sub-chronic repeated dose toxicity p.16
Regulatory source repeated dose toxicity 5 mg/kg bw/day - - sub-chronic repeated dose toxicity p.16
Regulatory source repeated dose toxicity 10 mg/kg bw/day - dermal Sub-chronic repeated dose toxicity p.9
Regulatory source repeated dose toxicity 50 mg/kg bw/day - - sub-chronic repeated dose toxicity p.16
Regulatory source - 10 mg/kg bw/day - - 90-day - p.17
Regulatory source - 3 mg/kg bw/day - - 90-day - p.17
Regulatory source - 50 mg/kg bw/day rat - - - p.21
Regulatory source - 5 mg/kg bw/day rat - - - p.21
Regulatory source - 30 mg/kg bw/ day rat - - - p.23
Regulatory source - 100 mg/kg bw/day - - 90-day - p.31
Regulatory source - 5 mg/kg bw/day rat oral - - p.29
Regulatory source dermal absorption =0.00068 mg/kg bw rat oral 90-day dermal absorption p.46
Regulatory source dermal absorption =3 mg/kg bw/d rat oral 90-day dermal absorption p.46
Regulatory source dermal absorption =0.9 mg/kg bw/d rat oral 90-day dermal absorption p.46
Regulatory source dermal absorption =0.00039 mg/kg bw rat oral 90-day dermal absorption p.46
Regulatory source developmental toxicity 100 mg/kg bw/day - oral 90-day developmental toxicity p.32
Regulatory source developmental toxicity 3 mg/kg bw/day - oral 90-day developmental toxicity p.32
Regulatory source developmental toxicity 3 mg/kg bw/day - - developmental developmental toxicity p.32
Regulatory source genotoxicity 4 - human - - genotoxicity p.12
Regulatory source repeated dose toxicity 3 mg/kg bw/day rat oral Sub-chronic repeated dose toxicity p.16
Regulatory source repeated dose toxicity =0.0434 mg/kg bw/d rat oral sub-chronic repeated dose toxicity p.26
Regulatory source repeated dose toxicity =3 mg/kg bw/d rat oral sub-chronic repeated dose toxicity p.26
Regulatory source repeated dose toxicity 10 mg/kg bw/day - oral 90 day repeated dose toxicity p.27
Regulatory source repeated dose toxicity 3 mg/kg bw/day - dermal 90 day repeated dose toxicity p.27
Regulatory source repeated dose toxicity 3 mg/kg bw/day - - 90 day repeated dose toxicity p.27
Regulatory source repeated dose toxicity 100 mg/kg bw/day - - subchronic repeated dose toxicity p.47
Regulatory source repeated dose toxicity 3 mg/kg bw/day - - subchronic repeated dose toxicity p.47
Regulatory source repeated dose toxicity 3 mg/kg bw/day human dermal subchronic repeated dose toxicity p.47
openFDA substances 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier S6FO6931N7 UNII - - - chemical -