NOAEL Studies
Cosmetic Ingredient
Tetraethyl Orthosilicate NOAEL Studies
INCI: TETRAETHYL ORTHOSILICATE
CAS: 78-10-4
Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.
NTP_ICE_acute_inhalation 3 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_acute_inhalation | LC50 | >16.8 | mg/L | - | Inhalation | Duration=4 hr | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=3516; Record_ID=acute_inhalation_793; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID6026450; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response_Modifier=>; Response=16.8; Response_Unit=mg/L; Reference=REACH; URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14920/7/3/3/?documentUUID=38ec8239-92d3-43ed-bc6c-46a6c3dd03e9; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6026450 |
| NTP_ICE_acute_inhalation | LC50 | 10 | mg/L | - | Inhalation | Duration=4 hr | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=3517; Record_ID=acute_inhalation_795; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID6026450; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=10; Response_Unit=mg/L; Reference=REACH; URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14920/7/3/3/?documentUUID=38ec8239-92d3-43ed-bc6c-46a6c3dd03e9; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6026450 |
| NTP_ICE_acute_inhalation | LC50 | >5.03 | mg/L | - | Inhalation | Duration=4 hr | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=3518; Record_ID=acute_inhalation_792; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID6026450; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response_Modifier=>; Response=5.03; Response_Unit=mg/L; Reference=REACH; URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14920/7/3/3/?documentUUID=e712fc15-9280-4d80-8762-ea5f0473407e; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6026450 |
NTP_ICE_acute_oral 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_acute_oral | LD50 | =6270 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_10288; row=10424; data_type=In Vivo; mixture=Chemical; chemical_name=Tetraethyl orthosilicate; preferred_name=Tetraethyl orthosilicate; dtxsid=DTXSID6026450; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6026450; source_file=acute_oral.xlsx |
| NTP_ICE_acute_oral | LD50 | >2500 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | record_id=acute_oral_10286; row=10425; data_type=In Vivo; mixture=Chemical; chemical_name=Tetraethyl orthosilicate; preferred_name=Tetraethyl orthosilicate; dtxsid=DTXSID6026450; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6026450; source_file=acute_oral.xlsx |
ToxValDB_DOE_Protective_Action_Criteria 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_DOE_Protective_Action_Criteria | LEL | =110769 | mg/m3 | Human | inhalation | - | acute | LONG_REF=U.S. Department of Energy (DOE) Protective Action Criteria (PAC). 2023. PAC Chemical Database. Updated 11 October 2023. Available: https://edms3.energy.gov/pac/ (Accessed November 16, 2023); TITLE=U.S. Department of Energy (DOE) Protective Action Criteria (PAC) Chemical Database; AUTHOR=U.S. Department of Energy; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65428efee4b045b9ff7cc432; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://edms3.energy.gov/pac/TeelDocs; YEAR=2009; ORIGINAL_YEAR=2009; STUDY_GROUP=DOE Protective Action Criteria:15520091:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_988dcb1a825e84613b98726fada57a21 |
ToxValDB_ECHA_IUCLID 9 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_ECHA_IUCLID | LEL | =20000 | mg/m3 | Mouse | inhalation | - | acute | QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059759e4b063812d6fa6de; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14920/7/3/3?documentUUID=6d40a197-04aa-42a8-be7d-d57e0c08d8bc; YEAR=2007; ORIGINAL_YEAR=2007; STUDY_GROUP=ECHA IUCLID_dup_Acute Toxicity Inhalation_15797476_15799054:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_f85f6bc2bee92cd09fed5ae41fe79229 |
| ToxValDB_ECHA_IUCLID | LEL | =1704.13 | mg/m3 | Mouse | inhalation | short-term; 2 weeks | short-term | QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059786e4b063812d6fa765; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14920/7/6/3?documentUUID=6d40a197-04aa-42a8-be7d-d57e0c08d8bc; YEAR=2007; ORIGINAL_YEAR=2007; STUDY_GROUP=ECHA IUCLID:15827312:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_070c7e35766e0ab96b3492615b704769 |
| ToxValDB_ECHA_IUCLID | LEL | =3200 | mg/m3 | Rat | inhalation | short-term; 2 days | short-term | QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059786e4b063812d6fa765; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14920/7/6/3?documentUUID=6d40a197-04aa-42a8-be7d-d57e0c08d8bc; YEAR=2007; ORIGINAL_YEAR=2007; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Inhalation_15827711_15827712:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_aad777f60235c16acb718b79db8535f0 |
| ToxValDB_ECHA_IUCLID | LEL | =0.2 | mg/m3 | Rat | inhalation | short-term; 2 days | short-term | QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059786e4b063812d6fa765; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14920/7/6/3?documentUUID=6d40a197-04aa-42a8-be7d-d57e0c08d8bc; YEAR=2007; ORIGINAL_YEAR=2007; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Inhalation_15827711_15827712:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_f62645f8ff529a5dba51d9d0ddb05a6d |
| ToxValDB_ECHA_IUCLID | LEL | =1500 | mg/m3 | Rat | inhalation | short-term; 1.5 days | short-term | QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059786e4b063812d6fa765; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14920/7/6/3?documentUUID=6d40a197-04aa-42a8-be7d-d57e0c08d8bc; YEAR=2007; ORIGINAL_YEAR=2007; STUDY_GROUP=ECHA IUCLID:15828507:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_d1e813ef955ce8d1de1cd4df37068f7b |
| ToxValDB_ECHA_IUCLID | NOAEC | <426.033 | mg/m3 | Mouse | inhalation | short-term; 2 weeks | short-term | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059786e4b063812d6fa765; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14920/7/6/3?documentUUID=6d40a197-04aa-42a8-be7d-d57e0c08d8bc; YEAR=2007; ORIGINAL_YEAR=2007; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Inhalation_15828772_15829307:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_f52dafc8f21b8e1c6402e31abfcd2481 |
| ToxValDB_ECHA_IUCLID | NOAEL | =50 | mg/kg bw/day | Rat | oral | - | reproduction developmental | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eac6ee4b0a7c65d1bf158; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14920/7/9/3?documentUUID=6d40a197-04aa-42a8-be7d-d57e0c08d8bc; YEAR=2007; ORIGINAL_YEAR=2007; STUDY_GROUP=ECHA IUCLID:15825193:F:-maternal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_fd44c57335f9987e7cffb069539cb234 |
| ToxValDB_ECHA_IUCLID | NOAEL | >=100 | mg/kg bw/day | Rat | oral | - | developmental | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eac6ee4b0a7c65d1bf158; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14920/7/9/3?documentUUID=6d40a197-04aa-42a8-be7d-d57e0c08d8bc; YEAR=2007; ORIGINAL_YEAR=2007; STUDY_GROUP=ECHA IUCLID:15825194:M/F:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_60ee9d836a8b884094ae106bfbd20927 |
| ToxValDB_ECHA_IUCLID | NOAEL | =10 | mg/kg bw/day | Rat | oral | subchronic; 53 days | subchronic | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaf07e4b0a7c65d1cc169; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14920/7/6/2?documentUUID=6d40a197-04aa-42a8-be7d-d57e0c08d8bc; YEAR=2007; ORIGINAL_YEAR=2007; STUDY_GROUP=ECHA IUCLID:15847364:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_8cf65b427e986bcdcf548889fa2a552c |
ToxValDB_ECOTOX 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_ECOTOX | LOEL | =51.84 | mg/kg bw/day | Rat | oral | subchronic; 8 weeks | subchronic | LONG_REF=- | J. Anim. Sci.71:955-962 Evenson,D.P., R.J. Emerick, L.K. Jost, H. Kayongo-Male, and S.R. Stewart Zinc-Silicon Interactions Influencing Sperm Chromatin Integrity and Testicular Cell Development in the Rat as Measured by Flow Cytometry 1993; TITLE=Zinc-Silicon Interactions Influencing Sperm Chromatin Integrity and Testicular Cell Development in the Rat as Measured by Flow Cytometry; AUTHOR=Evenson,D.P., R.J. Emerick, L.K. Jost, H. Kayongo-Male, and S.R. Stewart; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=68023; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1993; ORIGINAL_YEAR=1993; TOXICOLOGICAL_EFFECT=Growth: Body weight|Reproduction: testicular germ cell count; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|reproduction; STUDY_GROUP=ECOTOX:15613163:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; Source overall passed QC, and this record was expert reviewed and revised from ECOTOX source; QC_STATUS=pass; SOURCE_HASH=99572e06328b7771d877d0bce054b02f |
ToxValDB_EU_SCOEL 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_EU_SCOEL | NOAEL | =426.033 | mg/m3 | Mouse | inhalation | subchronic; 90 days | subchronic | LONG_REF=Omae, K., Nakashima, H., Takebayashi, T., Uemura, T., Ishizuka, C., Yamazaki, K., Sakurai, H. (1995). No-effect level of subacute tetraethoxysilane inhalation on the mouse kidney. Sangyo Eiseigaku Zasshi (J Occup Health). 37, 1-4. Pozzani, U. C. and Carpenter, C. P. (1951). Response of rodents to repeated inhalation of vapors of tetraethyl orthosilicate. Arch. Ind. Hyg. Occup. Med. 4, 465-468.; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/68c985c4e4b02565fc7d3919; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu; SUBSOURCE_URL=https://echa.europa.eu/documents/10162/35144386/055_tetraethyl_orthosilicate_oel_en.pdf; YEAR=2008; ORIGINAL_YEAR=2008; TOXICOLOGICAL_EFFECT=kidney effects; TOXICOLOGICAL_EFFECT_CATEGORY=nonneoplastic histopathology; STUDY_GROUP=EU SCOEL:15952551:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_72c7b30998a61818173567a3a94f9ab3 |
ToxValDB_GESTIS_DNEL 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_GESTIS_DNEL | DNEL local | =44 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL_dup_-_15635106_15635107:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_184c4143fa845ea53f1d2dc08c332425 |
ToxValDB_NIOSH_IDLH 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_NIOSH_IDLH | LEL | =10224.8 | mg/m3 | Human | inhalation | acute | occupational | LONG_REF=Smyth HF Jr, Seaton J [1940]. Acute response of guinea pigs and rats to inhalation of the vapors of tetraethyl orthosilicate (ethyl silicate). J Ind Hyg Toxicol 22(7):288-296.; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/68c9b369e4b02565fc7d6a64; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.cdc.gov/niosh/idlh/; SUBSOURCE_URL=https://www.cdc.gov/niosh/idlh/78104.html; YEAR=1994; ORIGINAL_YEAR=1994; TOXICOLOGICAL_EFFECT=lacrimation; STUDY_GROUP=NIOSH IDLH_dup_-_15953309_15953310:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_2174d96b86190e368e50ef419177a452 |
| ToxValDB_NIOSH_IDLH | LEL | =2130.16 | mg/m3 | Human | inhalation | acute | occupational | LONG_REF=Smyth HF Jr, Seaton J [1940]. Acute response of guinea pigs and rats to inhalation of the vapors of tetraethyl orthosilicate (ethyl silicate). J Ind Hyg Toxicol 22(7):288-296.; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/68c9b369e4b02565fc7d6a64; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.cdc.gov/niosh/idlh/; SUBSOURCE_URL=https://www.cdc.gov/niosh/idlh/78104.html; YEAR=1994; ORIGINAL_YEAR=1994; TOXICOLOGICAL_EFFECT=irritation of the eyes and nose; STUDY_GROUP=NIOSH IDLH_dup_-_15953309_15953310:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_7d35e7aa664877254199b32b01c52329 |
openFDA substances 4 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| openFDA substances | FDA UNII substance identifier | 42064KRE49 | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C8H20O4Si","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"42064KRE49"} |
| openFDA substances | FDA UNII substance identifier | 42064KRE49 | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C8H20O4Si","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"42064KRE49"} |
| openFDA substances | FDA UNII substance identifier | 42064KRE49 | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C8H20O4Si","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"42064KRE49"} |
| openFDA substances | FDA UNII substance identifier | 42064KRE49 | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C8H20O4Si","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"42064KRE49"} |