Moderate Cosmetic Ingredient NOAEL Data GHS Classified

Tetraethyl Orthosilicate

INCI: TETRAETHYL ORTHOSILICATE

CAS Number
78-10-4
Function
Binding agent (cosmetic film-forming/binding); cross-linking agent in silicone chemistry
Safety Rating
MODERATE

Regulatory Status

🇪🇺 EU Status restricted
🇺🇸 US Status restricted
US Notes Not specifically restricted; permitted under general cosmetic ingredient rules; TSCA listed

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
low
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

5 study endpoints found for Tetraethyl Orthosilicate. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
NOAEL >=2000 mg/kg bw/day oral rat oral REACH
NOAEL >=2000 mg/kg bw/day oral - oral REACH
NOAEL 62.5 ppm 1995 code:3544 inhalation REACH
NOAEL >=2500 mg/kg bw/day oral rat oral REACH
NOAEL 50 mg/kg bw/day oral rat oral REACH

GHS Hazard Classification

Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.

Short-term Exposure Effects
The substance is irritating to the eyes, skin and respiratory tract. Exposure could cause lowering of consciousness.
Long-term Exposure Effects
The substance defats the skin, which may cause dryness or cracking. The substance may have effects on the kidneys.
Routes of Exposure
The substance can be absorbed into the body by inhalation of its vapour and by ingestion.

Expert Verdict

Flammable; respiratory irritant — avoid inhalation exposure; serious eye irritant; hydrolysis releases ethanol; not suitable for spray/aerosol products without risk mitigation

⚠️
Concern Level: Moderate

Frequently Asked Questions

Is Tetraethyl Orthosilicate safe in cosmetics?

Flammable; respiratory irritant — avoid inhalation exposure; serious eye irritant; hydrolysis releases ethanol; not suitable for spray/aerosol products without risk mitigation The EU classifies Tetraethyl Orthosilicate as "restricted". Safety rating: MODERATE. 5 toxicological study endpoint(s) are available in our database.

Is Tetraethyl Orthosilicate allowed in the EU?

Tetraethyl Orthosilicate EU regulatory status: restricted. This is based on EU Regulation 1223/2009 and its amendments.

What does Tetraethyl Orthosilicate do in cosmetics?

Tetraethyl Orthosilicate functions as: Binding agent (cosmetic film-forming/binding); cross-linking agent in silicone chemistry. It is classified as a cosmetic ingredient in our database. CAS number: 78-10-4.

What is the Margin of Safety for Tetraethyl Orthosilicate?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

What is the NOAEL for Tetraethyl Orthosilicate?

The NOAEL (No Observed Adverse Effect Level) for Tetraethyl Orthosilicate is >=2000 mg/kg bw/day based on a oral study via oral route in rat. A total of 5 study endpoints are available. Source: REACH.

Compliance Tools

Check Tetraethyl Orthosilicate compliance across multiple jurisdictions:

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Ingredient Decoder
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82 Allergen Checker
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Substance Compliance
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MoS Calculator
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Heavy Metal Limits
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