NOAEL Studies
Cosmetic Ingredient
Tetrahydro-2-isobutyl-4-methyl-2H-pyran NOAEL Studies
INCI: TETRAHYDRO-2-ISOBUTYL-4-METHYL-2H-PYRAN (FRAGRANCE INGREDIENT)
CAS: 13477-62-8
Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip 6 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | NOAEL | 500 | mg/kg bw/day | rat | oral: gavage | - | repeated dose toxicity: oral, other | dossier=c403c781-5cf7-4783-b9b7-9458324520ea.i6z; document=a12c7ac2-e41c-4c5a-9677-07cb46075033_c403c781-5cf7-4783-b9b7-9458324520ea.i6d; document_key=a12c7ac2-e41c-4c5a-9677-07cb46075033/c403c781-5cf7-4783-b9b7-9458324520ea; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=2018; ReportDate=2018-12-03; basis=other:; key_result=false; entry_uuid=067cef7c-b604-415e-af30-8a7de06199c7 |
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | NOAEL | 1000 | mg/kg bw/day | rat | oral: gavage | - | short-term repeated dose toxicity: oral | dossier=c403c781-5cf7-4783-b9b7-9458324520ea.i6z; document=2636d652-312e-48ec-92d1-28238895b491_c403c781-5cf7-4783-b9b7-9458324520ea.i6d; document_key=2636d652-312e-48ec-92d1-28238895b491/c403c781-5cf7-4783-b9b7-9458324520ea; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; basis=other:; key_result=false; entry_uuid=9b8c0ee1-1c32-4b2d-810e-4d6999d79bd8 |
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | NOAEL | 500 | mg/kg bw/day | rat | oral: gavage | - | repeated dose toxicity: oral, other | dossier=c403c781-5cf7-4783-b9b7-9458324520ea.i6z; document=a12c7ac2-e41c-4c5a-9677-07cb46075033_c403c781-5cf7-4783-b9b7-9458324520ea.i6d; document_key=a12c7ac2-e41c-4c5a-9677-07cb46075033/c403c781-5cf7-4783-b9b7-9458324520ea; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=2018; ReportDate=2018-12-03; basis=other:; key_result=false; entry_uuid=067cef7c-b604-415e-af30-8a7de06199c7 |
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | NOAEL | 1000 | mg/kg bw/day | rat | oral: gavage | - | short-term repeated dose toxicity: oral | dossier=c403c781-5cf7-4783-b9b7-9458324520ea.i6z; document=2636d652-312e-48ec-92d1-28238895b491_c403c781-5cf7-4783-b9b7-9458324520ea.i6d; document_key=2636d652-312e-48ec-92d1-28238895b491/c403c781-5cf7-4783-b9b7-9458324520ea; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; basis=other:; key_result=false; entry_uuid=9b8c0ee1-1c32-4b2d-810e-4d6999d79bd8 |
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | NOAEL | 500 | mg/kg bw/day | rat | oral: gavage | - | repeated dose toxicity: oral, other | dossier=c403c781-5cf7-4783-b9b7-9458324520ea.i6z; document=a12c7ac2-e41c-4c5a-9677-07cb46075033_c403c781-5cf7-4783-b9b7-9458324520ea.i6d; document_key=a12c7ac2-e41c-4c5a-9677-07cb46075033/c403c781-5cf7-4783-b9b7-9458324520ea; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=2018; ReportDate=2018-12-03; basis=other:; key_result=false; entry_uuid=067cef7c-b604-415e-af30-8a7de06199c7 |
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | NOAEL | 1000 | mg/kg bw/day | rat | oral: gavage | - | short-term repeated dose toxicity: oral | dossier=c403c781-5cf7-4783-b9b7-9458324520ea.i6z; document=2636d652-312e-48ec-92d1-28238895b491_c403c781-5cf7-4783-b9b7-9458324520ea.i6d; document_key=2636d652-312e-48ec-92d1-28238895b491/c403c781-5cf7-4783-b9b7-9458324520ea; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; basis=other:; key_result=false; entry_uuid=9b8c0ee1-1c32-4b2d-810e-4d6999d79bd8 |
ToxValDB_ECHA_IUCLID 3 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_ECHA_IUCLID | LEL | =23100 | mg/m3 | Rat | inhalation | - | acute | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059759e4b063812d6fa6de; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/29863/7/3/3?documentUUID=c403c781-5cf7-4783-b9b7-9458324520ea; YEAR=2011; ORIGINAL_YEAR=2011; STUDY_GROUP=ECHA IUCLID:15797867:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_8542a27c28b909cf47e028233f07091c |
| ToxValDB_ECHA_IUCLID | NOAEL | =1000 | mg/kg bw/day | Rat | oral | short-term; 14 days | short-term | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7ca76e4b0a7c65d221e41; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/29863/7/6/2?documentUUID=c403c781-5cf7-4783-b9b7-9458324520ea; YEAR=2011; ORIGINAL_YEAR=2011; STUDY_GROUP=ECHA IUCLID:15832308:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_11f92fae0917c48233aad920e0a19cfa |
| ToxValDB_ECHA_IUCLID | NOAEL | =500 | mg/kg bw/day | Rat | oral | subchronic; 55 days | subchronic | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669ead3fe4b0a7c65d1c350b; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/29863/7/6/2?documentUUID=c403c781-5cf7-4783-b9b7-9458324520ea; YEAR=2011; ORIGINAL_YEAR=2011; STUDY_GROUP=ECHA IUCLID:15840370:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_281241b69a4b462f546c186e2daf43b0 |
ToxValDB_GESTIS_DNEL 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_GESTIS_DNEL | DNEL systemic | =14.69 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15635120:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_ccbe4b92ea456d069834acb2a8a17994 |