NOAEL Studies Cosmetic Ingredient

Tetrahydrofurfuryl Alcohol NOAEL Studies

INCI: TETRAHYDROFURFURYL ALCOHOL

CAS: 97-99-4

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

Back to parent ingredient page
NTP_ICE_acute_oral 3 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_acute_oral LD50 =1600 mg/kg bw Rat oral acute Rat Acute Oral Toxicity NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_11865; row=2841; data_type=In Vivo; mixture=Chemical; chemical_name=Tetrahydrofurfuryl alcohol; preferred_name=Tetrahydrofurfuryl alcohol; dtxsid=DTXSID1029128; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1029128; source_file=acute_oral.xlsx
NTP_ICE_acute_oral LD50 >2000 mg/kg bw Rat oral acute Rat Acute Oral Toxicity record_id=acute_oral_11866; row=2840; data_type=In Vivo; mixture=Chemical; chemical_name=Tetrahydrofurfuryl alcohol; preferred_name=Tetrahydrofurfuryl alcohol; dtxsid=DTXSID1029128; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1029128; source_file=acute_oral.xlsx
NTP_ICE_acute_oral LD50 <3200 mg/kg bw Rat oral acute Rat Acute Oral Toxicity record_id=acute_oral_11867; row=2839; data_type=In Vivo; mixture=Chemical; chemical_name=Tetrahydrofurfuryl alcohol; preferred_name=Tetrahydrofurfuryl alcohol; dtxsid=DTXSID1029128; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1029128; source_file=acute_oral.xlsx
NTP_ICE_endocrine 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_endocrine Model Score 0 unitless - - - ARPathway2016; AR Pathway Model, Antagonist sheet=Integrated_approaches; excel_row=15342; RecordID=ARPathway2016_1793; DatasetName=ARPathway2016; DTXSID=DTXSID1029128; Assay=AR Pathway Model, Antagonist; Endpoint=Model Score; Response=0; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1029128
ToxValDB_ECHA_IUCLID 16 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_ECHA_IUCLID LOAEL =159 mg/kg bw/day Mouse oral - reproduction developmental QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eab95e4b0a7c65d1bae95; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/13371/7/9/2?documentUUID=0ed7f098-4122-4a81-8152-750fb05f3b6d; YEAR=2004; ORIGINAL_YEAR=2004; STUDY_GROUP=ECHA IUCLID_dup_Toxicity Reproduction_15857240_15857887_15863210:M/F:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_8e7af949c730ad5ec0130e429088811b
ToxValDB_ECHA_IUCLID LOAEL =300 mg/kg bw/day Rat dermal - reproduction developmental QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c96ee4b0a7c65d21cf69; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/13371/7/9/2?documentUUID=0ed7f098-4122-4a81-8152-750fb05f3b6d; YEAR=2004; ORIGINAL_YEAR=2004; STUDY_GROUP=ECHA IUCLID_dup_Toxicity Reproduction_15855108_15855991:M:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_c2c8e625eb4edee7158bfef7758acaa7
ToxValDB_ECHA_IUCLID NOAEC =208.862 mg/m3 Rat inhalation acute; 6 hours acute QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059786e4b063812d6fa765; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/13371/7/6/3?documentUUID=0ed7f098-4122-4a81-8152-750fb05f3b6d; YEAR=2004; ORIGINAL_YEAR=2004; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Inhalation_15827649_15827650:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_fee1382ea075074453775ad55069c91d
ToxValDB_ECHA_IUCLID NOAEL <37 mg/kg bw/day Dog oral subchronic; 90 days subchronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669ead7de4b0a7c65d1c4702; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/en/registration-dossier/-/registered-dossier/17286?documentUUID=787a1587-0296-47c9-a399-3230b7e21cd8; YEAR=1999; ORIGINAL_YEAR=1999; TOXICOLOGICAL_EFFECT=gross pathology|histopathology: non-neoplastic|organ weights and organ / body weight ratios; TOXICOLOGICAL_EFFECT_CATEGORY=gross pathology|nonneoplastic histopathology|organ weight; STUDY_GROUP=ECHA IUCLID:15848571:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_b29c1022767132417f9c0f46c33125a3
ToxValDB_ECHA_IUCLID NOAEL =39 mg/kg bw/day Rat oral chronic; 93 days chronic QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaf8ee4b0a7c65d1ce710; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/13371/7/6/2?documentUUID=0ed7f098-4122-4a81-8152-750fb05f3b6d; YEAR=2004; ORIGINAL_YEAR=2004; STUDY_GROUP=ECHA IUCLID:15847185:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_900cc5eb723d08ea218ba587e9b4d424
ToxValDB_ECHA_IUCLID NOAEL =40 mg/kg bw/day Rat oral short-term; 28 days short-term QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaf8ee4b0a7c65d1ce71b; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/13371/7/6/2?documentUUID=0ed7f098-4122-4a81-8152-750fb05f3b6d; YEAR=2004; ORIGINAL_YEAR=2004; STUDY_GROUP=ECHA IUCLID:15850052:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_c3e0d5a437c832df805591bb3b302042
ToxValDB_ECHA_IUCLID NOAEL =50 mg/kg bw/day Rat oral - developmental QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eac9ce4b0a7c65d1bff75; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/13371/7/9/3?documentUUID=0ed7f098-4122-4a81-8152-750fb05f3b6d; YEAR=2004; ORIGINAL_YEAR=2004; TOXICOLOGICAL_EFFECT=fetus: changes in postnatal survival; TOXICOLOGICAL_EFFECT_CATEGORY=development; STUDY_GROUP=ECHA IUCLID:15825338:M/F:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_7d0c98040e17a642614c65e8f2d2209b
ToxValDB_ECHA_IUCLID NOAEL =60 mg/kg bw/day Mouse oral - developmental QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eab95e4b0a7c65d1baea4; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/13371/7/9/2?documentUUID=0ed7f098-4122-4a81-8152-750fb05f3b6d; YEAR=2004; ORIGINAL_YEAR=2004; STUDY_GROUP=ECHA IUCLID:15862062:M/F:F2-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_fc4c0927e793f91819a82b2baeb7f504
ToxValDB_ECHA_IUCLID NOAEL =78 mg/kg bw/day Rat oral chronic; 93 days chronic QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaf8ee4b0a7c65d1ce710; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/13371/7/6/2?documentUUID=0ed7f098-4122-4a81-8152-750fb05f3b6d; YEAR=2004; ORIGINAL_YEAR=2004; STUDY_GROUP=ECHA IUCLID:15848137:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_9ffb46636dd61e39cbbd9975468ece76
ToxValDB_ECHA_IUCLID NOAEL ~96 mg/kg bw/day Rat oral subchronic; 90 days subchronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669ead7de4b0a7c65d1c4704; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/en/registration-dossier/-/registered-dossier/17286?documentUUID=787a1587-0296-47c9-a399-3230b7e21cd8; YEAR=1999; ORIGINAL_YEAR=1999; TOXICOLOGICAL_EFFECT=body weight and weight gain|histopathology: non-neoplastic|organ weights and organ / body weight ratios; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|nonneoplastic histopathology|organ weight; STUDY_GROUP=ECHA IUCLID:15848525:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_385bc4a13a11102712316be4777c3779
ToxValDB_ECHA_IUCLID NOAEL =100 mg/kg bw/day Rat dermal acute; 6 hours acute QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/67c61e3be4b096bca8778d0e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/13371/7/6/4?documentUUID=0ed7f098-4122-4a81-8152-750fb05f3b6d; YEAR=2004; ORIGINAL_YEAR=2004; STUDY_GROUP=ECHA IUCLID:15826437:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_f4a546831045114dab59bc66cae95c19
ToxValDB_ECHA_IUCLID NOAEL =150 mg/kg bw/day Rat oral - reproduction developmental QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eab95e4b0a7c65d1bae9b; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/13371/7/9/2?documentUUID=0ed7f098-4122-4a81-8152-750fb05f3b6d; YEAR=2004; ORIGINAL_YEAR=2004; TOXICOLOGICAL_EFFECT=P0: reproductive function (sperm measures); TOXICOLOGICAL_EFFECT_CATEGORY=reproduction; STUDY_GROUP=ECHA IUCLID_dup_Toxicity Reproduction_15857962_15860644:M:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_46700e603c252523434da98bcf6cb037
ToxValDB_ECHA_IUCLID NOAEL =300 mg/kg bw/day Rat dermal acute; 6 hours acute QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/67c61e3be4b096bca8778d0e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/13371/7/6/4?documentUUID=0ed7f098-4122-4a81-8152-750fb05f3b6d; YEAR=2004; ORIGINAL_YEAR=2004; STUDY_GROUP=ECHA IUCLID:15826438:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_26dd5f54a992ded51e05e8264739fd3a
ToxValDB_ECHA_IUCLID NOAEL =500 ppm Rat oral - reproduction developmental QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c96ee4b0a7c65d21cf75; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/13371/7/9/2?documentUUID=0ed7f098-4122-4a81-8152-750fb05f3b6d; YEAR=2004; ORIGINAL_YEAR=2004; STUDY_GROUP=ECHA IUCLID_dup_Toxicity Reproduction_15855795_15856550:M:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_49ddcf735ecf56554d73cf4092008e43
ToxValDB_ECHA_IUCLID NOAEL =760 mg/kg bw/day Mouse oral - reproduction developmental QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eab95e4b0a7c65d1baeae; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/13371/7/9/2?documentUUID=0ed7f098-4122-4a81-8152-750fb05f3b6d; YEAR=2004; ORIGINAL_YEAR=2004; STUDY_GROUP=ECHA IUCLID_dup_Toxicity Reproduction_15857240_15857887_15863210:M/F:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_33046b26fd7298c1fd71c31e30bd903a
ToxValDB_ECHA_IUCLID NOAEL =1000 ppm Rat oral - reproduction developmental QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c96ee4b0a7c65d21cf75; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/13371/7/9/2?documentUUID=0ed7f098-4122-4a81-8152-750fb05f3b6d; YEAR=2004; ORIGINAL_YEAR=2004; STUDY_GROUP=ECHA IUCLID_dup_Toxicity Reproduction_15855795_15856550:M:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_fe82dd0bd64116ccd058379ce6f4d640
ToxValDB_GESTIS_DNEL 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_GESTIS_DNEL DNEL systemic =1.4 mg/m3 Human inhalation - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15635117:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_20c3aeb03a925215fbb3ad14d38c4a43
openFDA substances 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier XD95821VF9 UNII - - - chemical {"approval_status":null,"molecular_formula":"C5H10O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"XD95821VF9"}
openFDA substances FDA UNII substance identifier XD95821VF9 UNII - - - chemical {"approval_status":null,"molecular_formula":"C5H10O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"XD95821VF9"}
openFDA substances FDA UNII substance identifier XD95821VF9 UNII - - - chemical {"approval_status":null,"molecular_formula":"C5H10O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"XD95821VF9"}
openFDA substances FDA UNII substance identifier XD95821VF9 UNII - - - chemical {"approval_status":null,"molecular_formula":"C5H10O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"XD95821VF9"}