Tetrahydrofurfuryl Alcohol
INCI: TETRAHYDROFURFURYL ALCOHOL
Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
3 study endpoints found for Tetrahydrofurfuryl Alcohol. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 100 mg/kg bw/day | dermal | rat | dermal | REACH |
| NOAEL | 500 ppm | oral | rat | oral | REACH |
| NOAEL | 40 mg/kg bw/day | oral | rat | oral | REACH |
GHS Hazard Classification
Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.
Expert Verdict
Eye irritant (H319); harmful if swallowed (H302); combustible (H227); occupational TWA 0.5 ppm with skin absorption notation (WEEL); oral LD50 1,600 mg/kg in rabbit; most safety-flagged ingredient on this list
Regulatory Flags
Frequently Asked Questions
Is Tetrahydrofurfuryl Alcohol safe in cosmetics?
Eye irritant (H319); harmful if swallowed (H302); combustible (H227); occupational TWA 0.5 ppm with skin absorption notation (WEEL); oral LD50 1,600 mg/kg in rabbit; most safety-flagged ingredient on this list The EU classifies Tetrahydrofurfuryl Alcohol as "permitted". Safety rating: MODERATE. 3 toxicological study endpoint(s) are available in our database.
Is Tetrahydrofurfuryl Alcohol allowed in the EU?
Tetrahydrofurfuryl Alcohol EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Tetrahydrofurfuryl Alcohol do in cosmetics?
Tetrahydrofurfuryl Alcohol functions as: Solvent, Fragrance. It is classified as a cosmetic ingredient in our database. CAS number: 97-99-4.
What is the Margin of Safety for Tetrahydrofurfuryl Alcohol?
adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Tetrahydrofurfuryl Alcohol?
The NOAEL (No Observed Adverse Effect Level) for Tetrahydrofurfuryl Alcohol is 100 mg/kg bw/day based on a dermal study via dermal route in rat. A total of 3 study endpoints are available. Source: REACH.
Is Tetrahydrofurfuryl Alcohol classified as hazardous under GHS?
Tetrahydrofurfuryl Alcohol carries a GHS signal word of "WARNING". Hazard statements: Combustible liquid Causes serious eye irritation Suspected of damaging fertility or the unborn child. This classification is based on the ILO/WHO International Chemical Safety Card and ECHA C&L inventory data. Note: GHS classification applies to the pure substance — at cosmetic use concentrations, hazard thresholds may not be met.
Compliance Tools
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