NOAEL Studies Cosmetic Ingredient

TETRAHYDROPYRANYLOXY PHENOL NOAEL Studies

CAS: 53936-56-4

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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SCCS Opinion 13 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
SCCS Opinion NOAEL =0.0218 mg/kg bw/day rat oral chronic repeated dose toxicity p.41
SCCS Opinion NOAEL =0.77 mg/kg rat oral subchronic repeated dose toxicity (ref. 40), p.40
SCCS Opinion NOAEL =3 % rabbit oral subchronic repeated dose toxicity p.43
SCCS Opinion NOAEL =15 mg/kg/day rat oral 28d reproductive toxicity p.38
SCCS Opinion NOAEL =20 mg/kg/day rat oral 8 weeks reproductive toxicity p.38
SCCS Opinion NOAEL =20 mg/kg bw/day rat oral chronic repeated dose toxicity p.41
SCCS Opinion NOAEL =25 mg/kg/day rat oral 8 weeks reproductive toxicity p.38
SCCS Opinion NOAEL =40 % rabbit dermal subchronic repeated dose toxicity p.43
SCCS Opinion NOAEL =74 mg/kg/day rat oral 8 weeks reproductive toxicity p.38
SCCS Opinion NOAEL =75 mg/kg/day rat oral 28d reproductive toxicity p.38
SCCS Opinion NOAEL =150 mg/kg/day rat - - reproductive toxicity p.38
SCCS Opinion NOAEL =316 mg/kg bw rat dermal 28 day NOAEL study p.23
SCCS Opinion NOAEL =800 mg/kg bw rabbit dermal 91-day repeated dose toxicity p.26
Regulatory source 21 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
Regulatory source - =15 mg/kg/day rat - - - p.38
Regulatory source - =20 mg/kg/day rat oral 28d - p.38
Regulatory source - =74 mg/kg/day rat dermal 28d - p.38
Regulatory source - 316 mg/kg bw rat dermal 28 day - p.23
Regulatory source - 316 mg/kg bw rat oral 90-day - p.40
Regulatory source developmental toxicity =25 mg/kg/day rabbit - developmental developmental toxicity p.38
Regulatory source developmental toxicity =75 mg/kg/day rabbit - developmental developmental toxicity p.38
Regulatory source repeated dose toxicity 0.0218 mg/kg bw/day rat oral chronic repeated dose toxicity p.41
Regulatory source repeated dose toxicity =0.77 mg/kg rat oral subchronic repeated dose toxicity p.40
Regulatory source repeated dose toxicity 3 % rabbit oral subchronic repeated dose toxicity p.43
Regulatory source repeated dose toxicity 20 mg/kg bw/day rat oral chronic repeated dose toxicity p.41
Regulatory source repeated dose toxicity 40 % rabbit dermal subchronic repeated dose toxicity p.43
Regulatory source repeated dose toxicity 316 mg/kg bw rat oral subacute repeated dose toxicity p.25
Regulatory source repeated dose toxicity 316 mg/kg bw rat oral subchronic repeated dose toxicity p.40
Regulatory source repeated dose toxicity 800 mg/kg bw rabbit dermal 91-day repeated dose toxicity p.26
Regulatory source reproductive toxicity =15 mg/kg/day rat oral 28d reproductive toxicity p.38
Regulatory source reproductive toxicity =20 mg/kg/day rat oral 8 weeks reproductive toxicity p.38
Regulatory source reproductive toxicity =25 mg/kg/day rat oral 8 weeks reproductive toxicity p.38
Regulatory source reproductive toxicity =74 mg/kg/day rat oral 8 weeks reproductive toxicity p.38
Regulatory source reproductive toxicity =75 mg/kg/day rat oral 28d reproductive toxicity p.38
Regulatory source reproductive toxicity =150 mg/kg/day rat - - reproductive toxicity p.38
openFDA substances 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier RG969BY5EN UNII - - - chemical -