Is TETRAHYDROPYRANYLOXY PHENOL safe in cosmetics?
TETRAHYDROPYRANYLOXY PHENOL has a safety rating of "GOOD" in our database. EU status: permitted. 10 toxicological study endpoint(s) are available in our database.
TETRAHYDROPYRANYLOXY PHENOL
TETRAHYDROPYRANYLOXY PHENOL (CAS 53936-56-4) is a cosmetic cosmetic ingredient functioning as Bleaching. Reported NOAEL =0.0218 mg/kg bw/day in rat (SCCS_vision_codex); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 53936-56-4 →
Auto-generated CPSR Part A draft with source citations
Function
Bleaching
Safety Rating
GOOD
Chemistry & Identifiers
IUPAC Name
4-(oxan-2-yloxy)phenol
InChIKey
GFBCWCDNXDKFRH-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
Not specifically regulated
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Toxicological Studies
10 study endpoints found for TETRAHYDROPYRANYLOXY PHENOL. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =0.0218 mg/kg bw/day | oral | rat | repeated dose toxicity | SCCS_vision_codex |
| NOAEL | =0.0218 mg/kg bw/day | oral | rat | repeated dose toxicity | SCCS_vision_codex |
| NOAEL | =0.0218 mg/kg bw/day | oral | rat | repeated dose toxicity | SCCS_vision_codex |
| NOAEL | =0.0218 mg/kg bw/day | oral | rat | repeated dose toxicity | SCCS_vision_codex |
| NOAEL | =0.77 mg/kg | oral | rat | repeated dose toxicity | SCCS_vision_codex |
| NOAEL | =0.77 mg/kg | oral | rat | repeated dose toxicity | SCCS_vision_codex |
| NOAEL | =0.77 mg/kg | oral | rat | repeated dose toxicity | SCCS_vision_codex |
| NOAEL | =0.77 mg/kg | oral | rat | repeated dose toxicity | SCCS_vision_codex |
| NOAEL | =15 mg/kg/day | oral | rat | reproductive toxicity | SCCS_vision_codex |
| NOAEL | =15 mg/kg/day | oral | rat | reproductive toxicity | SCCS_vision_codex |
EU CosIng Annex Listing
European Commission CosIng database Annex references per Regulation (EC) No 1223/2009.
Annex II — Prohibited
Ref: 1657
(EU) 2021/1099
Expanded Jurisdictional Detail
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
SA Saudi SFDA (II - Prohibited)
BRIN Brazil/India Cosmetics
India: Prohibited (GNRAS)
Additional Jurisdictional Restrictions (1)
| Jurisdiction | Status | Max % | Product Type |
|---|---|---|---|
| UK | banned | - | - |
Expanded Dermal Absorption Data
Cross-database dermal penetration: EPA Dryad physics-based, Roberts Mendeley permeation, and SCCS-aggregated measured values.
Aggregated DA Values (1 records across 5 sources)
| Type | DA % | Method | Skin Model | SCCS Ref |
|---|---|---|---|---|
| measured_sccs_opinion | 82.04% | - | - | SCCS/1554/15 |
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Bleaching agent
Expert Verdict
Expert safety assessment and concern-level summary for TETRAHYDROPYRANYLOXY PHENOL.
Regulatory Flags
cosing-sourced
eu-permitted
needs-enrichment
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to TETRAHYDROPYRANYLOXY PHENOL by CAS number or substance name.
Studies
44
Lowest NOAEL
0.0218
Highest NOAEL
800
Units vary across source rows: mg/kg bw/day, mg/kg, mg/kg/day
SCCS_vision_codex
Dermal Absorption
View details ->| Absorption % | Method | Vehicle |
|---|---|---|
| 82.04% | SCCS opinion extraction | - |
Chemical Function
Bleaching agent
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL4303145
Frequently Asked Questions
Is TETRAHYDROPYRANYLOXY PHENOL allowed in the EU?
TETRAHYDROPYRANYLOXY PHENOL EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does TETRAHYDROPYRANYLOXY PHENOL do in cosmetics?
TETRAHYDROPYRANYLOXY PHENOL functions as: Bleaching. It is classified as a cosmetic ingredient in our database. CAS number: 53936-56-4.
What is the NOAEL for TETRAHYDROPYRANYLOXY PHENOL?
The NOAEL (No Observed Adverse Effect Level) for TETRAHYDROPYRANYLOXY PHENOL is =0.0218 mg/kg bw/day based on a repeated dose toxicity study via oral route in rat. A total of 10 study endpoints are available. Source: SCCS_vision_codex.
Is TETRAHYDROPYRANYLOXY PHENOL used outside cosmetics?
TETRAHYDROPYRANYLOXY PHENOL also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check TETRAHYDROPYRANYLOXY PHENOL compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
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Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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