Is Tetrapeptide-5 safe in cosmetics?
Tetrapeptide-5 has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted.
Good
Cosmetic Ingredient
Tetrapeptide-5
INCI: ACETYL TETRAPEPTIDE-5
Tetrapeptide-5 (CAS 883220-97-1 (Tetrapeptide-5); 820959-17-9 (Acetyl Tetrapeptide-5)) is a cosmetic cosmetic ingredient functioning as Humectant, moisturizing, soothing, smoothing, refreshing; anti-puffiness agent;. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database.
Auto-generated CPSR Part A draft with source citations
CAS Number
883220-97-1 (Tetrapeptide-5); 820959-17-9 (Acetyl Tetrapeptide-5)
View industrial chemical safety profile →
Function
Humectant, moisturizing, soothing, smoothing, refreshing; anti-puffiness agent; inhibits glycosylation; increases SOD activity
Safety Rating
GOOD
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Permitted — no specific CIR review; marketed widely in OTC eye creams and serums
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Tetrapeptide-5.
Calculate MoS for your specific formulation with the MoS Calculator.
Additional Ingredient Properties
9 property records from structured ingredient metadata.
acne
{"cas_number": "820959-17-9", "anti_acne_mechanism": "anti_inflammatory", "comedogenicity_rating_0_to_5": "0", "acne_type_efficacy": "inflammatory", "sebum_reduction_pct_clinical": "0-5", "prescription_required_usa": "No", "otc_drug_monograph_category": "No", "max_otc_concentration_pct": "No limit", "japan_quasi_drug_anti_acne": "No", "korea_functional_cosmetic_acne": "No", "eu_cosmetic_restrictio…
anti_aging
{"anti_aging_claim": "firming, anti-puffiness", "mechanism_of_action": "Signal peptide for fibroblast activation", "target_skin_layer": "dermis", "collagen_stimulation": "Moderate", "elastin_protection": "Moderate", "wrinkle_reduction_pct": "10-18", "clinical_study_duration_weeks": "8", "sample_size": "25", "double_blind": "Yes", "placebo_controlled": "Yes", "published_journal": "JOCD, Int J Pept …
anti_pollution
{"cas_number": "820959-17-9", "ingredient_class": "other", "primary_mechanism": "barrier_reinforcement", "pollution_types_targeted": "PM2_5", "IR_A_protection": "no", "visible_light_protection": "no", "digital_screen_protection_claim": "no", "PAH_neutralization": "no", "ozone_protection": "no", "mitochondrial_protection": "no", "Nrf2_activation": "no", "AhR_pathway_modulation": "no", "NF_kB_inhibi…
concentration
{"min_concentration_pct": "0.01", "max_concentration_pct": "0.5", "typical_concentration_pct": "0.1", "product_type": "Eye Cream", "function_at_concentration": "Anti-puffiness, drainage", "source": "Supplier TDS (Eyeseryl)"}
peptide
{"cas_number": "820959-17-9", "trade_name": "Eyeseryl", "peptide_sequence_amino_acids": "Ac-Gly-Gln-Pro-Arg", "peptide_length_residues": "4", "molecular_weight_daltons": "539.6", "peptide_class": "signal", "mechanism_of_action": "Anti-edema, improves lymphatic drainage, reduces periorbital puffiness", "target_protein_or_receptor": "Aquaporin modulation", "collagen_boost_pct_in_vitro": "18", "elast…
ph_stability
{"optimal_ph_min": "5.5", "optimal_ph_max": "6.5", "stable_ph_min": "5.0", "stable_ph_max": "7.0", "degrades_above_ph": "7.5", "degrades_below_ph": "4.5", "ph_dependent_function": "Anti-puffiness peptide", "formulation_note": "Standard peptide stability", "source": "Formulation literature"}
skin_suitability
{"oily_skin": "acceptable", "dry_skin": "recommended", "sensitive_skin": "recommended", "combination_skin": "acceptable", "normal_skin": "recommended", "acne_prone": "acceptable", "rosacea": "recommended", "eczema": "acceptable", "hyperpigmentation": "acceptable", "aging_mature": "recommended", "dehydrated": "recommended", "skin_benefit_primary": "anti-puffiness", "skin_benefit_secondary": "draina…
synergy
{"inci_name_2": "Caffeine", "synergy_type": "efficacy-boost", "synergy_description": "De-puffing peptide with vasoconstrictor for eye area", "combined_benefit": "Superior under-eye bag reduction, enhanced microcirculation, reduced puffiness", "efficacy_multiplier": "2.1x", "mechanism_of_action": "Tetrapeptide-5 reduces edema; caffeine constricts blood vessels and mobilizes fat", "optimal_ratio": "…
Expert Verdict
Expert safety assessment and concern-level summary for Tetrapeptide-5.
Frequently Asked Questions
Is Tetrapeptide-5 allowed in the EU?
Tetrapeptide-5 EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Tetrapeptide-5 do in cosmetics?
Tetrapeptide-5 functions as: Humectant, moisturizing, soothing, smoothing, refreshing; anti-puffiness agent; inhibits glycosylation; increases SOD activity. It is classified as a cosmetic ingredient in our database. CAS number: 883220-97-1 (Tetrapeptide-5); 820959-17-9 (Acetyl Tetrapeptide-5).
Compliance Tools
Check Tetrapeptide-5 compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
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Substance Compliance
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MoS Calculator
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Heavy Metal Limits
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