NOAEL Studies
Cosmetic Ingredient
Thioglycolic Acid NOAEL Studies
INCI: THIOGLYCOLIC ACID
CAS: 68-11-1
Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.
NTP ICE acute inhalation 4 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE acute inhalation | LC50 | 0.21 | mg/L | - | Inhalation | Duration=4 hr | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=4625; Record_ID=acute_inhalation_977; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID8026141; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=0.21; Response_Unit=mg/L; Reference=ChemIDplus; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8026141; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8026141 |
| NTP ICE acute inhalation | LC50 | 1.094 | mg/L | - | Inhalation | Duration=4 hr | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=4624; Record_ID=acute_inhalation_1070; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID8026141; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=1.094; Response_Unit=mg/L; Reference=REACH; URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/2175/7/3/3/?documentUUID=29f6fa98-8d79-4e5f-90c4-abd63dedb2a1; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8026141; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8026141 |
| NTP ICE acute inhalation | LC50 | 1.388 | mg/L | - | Inhalation | Duration=4 hr | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=4622; Record_ID=acute_inhalation_1075; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID8026141; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=1.388; Response_Unit=mg/L; Reference=REACH; URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/2175/7/3/3/?documentUUID=29f6fa98-8d79-4e5f-90c4-abd63dedb2a1; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8026141; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8026141 |
| NTP ICE acute inhalation | LC50 | 1.981 | mg/L | - | Inhalation | Duration=4 hr | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=4623; Record_ID=acute_inhalation_1072; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID8026141; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=1.981; Response_Unit=mg/L; Reference=REACH; URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/2175/7/3/3/?documentUUID=29f6fa98-8d79-4e5f-90c4-abd63dedb2a1; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8026141; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8026141 |
NTP ICE endocrine 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE endocrine | Model Score | 0 | unitless | - | - | - | ARPathway2016; AR Pathway Model, Antagonist | sheet=Integrated_approaches; excel_row=15474; RecordID=ARPathway2016_1477; DatasetName=ARPathway2016; DTXSID=DTXSID8026141; Assay=AR Pathway Model, Antagonist; Endpoint=Model Score; Response=0; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8026141; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8026141 |
NTP ICE skin irritation 5 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE skin irritation | Breakthrough Time | 11.62 | min | - | Dermal | - | In Vitro; Corrositex | sheet=Data_invitro; excel_row=5178; Record_ID=skin_irritation_invitro_116; Data_Type=In Vitro; Concentration=97; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID8026141; Assay=Corrositex; Endpoint=Breakthrough Time; Response=11.62; Response_Unit=min; Reference=Gordon et al. 1994; Not available; Not available; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8026141; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8026141 |
| NTP ICE skin irritation | Breakthrough Time | 35.6 | min | - | Dermal | - | In Vitro; Corrositex | sheet=Data_invitro; excel_row=5171; Record_ID=skin_irritation_invitro_119; Data_Type=In Vitro; Concentration=15.1; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID8026141; Assay=Corrositex; Endpoint=Breakthrough Time; Response=35.6; Response_Unit=min; Reference=Botham et al. 1995; Not available; 10.1177/026119299502300207; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8026141; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8026141 |
| NTP ICE skin irritation | Breakthrough Time | 37.7 | min | - | Dermal | - | In Vitro; Corrositex | sheet=Data_invitro; excel_row=5173; Record_ID=skin_irritation_invitro_118; Data_Type=In Vitro; Concentration=15.1; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID8026141; Assay=Corrositex; Endpoint=Breakthrough Time; Response=37.7; Response_Unit=min; Reference=Botham et al. 1995; Not available; 10.1177/026119299502300207; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8026141; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8026141 |
| NTP ICE skin irritation | TER | 1.2 | kiloohms | - | Dermal | - | In Vitro; TER Corrosion | sheet=Data_invitro; excel_row=5176; Record_ID=skin_irritation_invitro_2565; Data_Type=In Vitro; Concentration=15.1; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID8026141; Assay=TER Corrosion; Endpoint=TER; Response=1.2; Response_Unit=kiloohms; Reference=Botham et al. 1995; Not available; 10.1177/026119299502300207; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8026141; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8026141 |
| NTP ICE skin irritation | TER | 1.6 | kiloohms | - | Dermal | - | In Vitro; TER Corrosion | sheet=Data_invitro; excel_row=5179; Record_ID=skin_irritation_invitro_2566; Data_Type=In Vitro; Concentration=15.1; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID8026141; Assay=TER Corrosion; Endpoint=TER; Response=1.6; Response_Unit=kiloohms; Reference=Botham et al. 1995; Not available; 10.1177/026119299502300207; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8026141; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8026141 |
NTP ICE skin sensitization 3 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE skin sensitization | Incidence of positive responses | 0 | % | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test | sheet=Data_invivo; excel_row=9508; Record_ID=skin_sensitization_invivo_2108; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=1.25; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID8026141; Assay=Human Repeat Insult Patch Test; Endpoint=Incidence of positive responses; Response=0; Response_Unit=%; Species=Human; Route=Dermal; Reference=Voss 1958; 13598934; 10.1038/jid.1958.120; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8026141; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8026141 |
| NTP ICE skin sensitization | Induction dose per skin area | 1476 | ug/cm2 | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test | sheet=Data_invivo; excel_row=9506; Record_ID=skin_sensitization_invivo_2108; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=1.25; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID8026141; Assay=Human Repeat Insult Patch Test; Endpoint=Induction dose per skin area; Response=1476; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Voss 1958; 13598934; 10.1038/jid.1958.120; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8026141; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8026141 |
| NTP ICE skin sensitization | Relative reliability score | 4 | unitless | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test | sheet=Data_invivo; excel_row=9512; Record_ID=skin_sensitization_invivo_2108; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=1.25; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID8026141; Assay=Human Repeat Insult Patch Test; Endpoint=Relative reliability score; Response=4; Response_Unit=Unitless; Species=Human; Route=Dermal; Reference=Voss 1958; 13598934; 10.1038/jid.1958.120; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8026141; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8026141 |
SCCS Opinion 14 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| SCCS Opinion | NOAEL | =0.044 | mg/kg bw | rat | dermal | 13 weeks | dermal absorption | p.32 |
| SCCS Opinion | NOAEL | =1.66 | mg/kg bw | rat | dermal | 5 year | NOAEL study | p.32 |
| SCCS Opinion | NOAEL | =7 | mg/kg bw/d | rat | oral | 7 days | repeated dose toxicity | p.23 |
| SCCS Opinion | NOAEL | =11 | % | rat | dermal | 13 weeks | NOAEL study | p.32 |
| SCCS Opinion | NOAEL | =11.25 | mg/kg bw/d | rat | dermal | 90 days | repeated dose toxicity | p.23 |
| SCCS Opinion | NOAEL | =20 | mg/kg bw/d | rat | oral | 7 days | repeated dose toxicity | p.23 |
| SCCS Opinion | NOAEL | =45 | mg/kg bw/d | rat | oral | 5 days | repeated dose toxicity | p.23 |
| SCCS Opinion | NOAEL | =65 | mg/kg bw/day | rat | oral | developmental | reproductive toxicity | p.30 |
| SCCS Opinion | NOAEL | =80 | mg/kg bw/d | rat | dermal | developmental | repeated dose toxicity | p.29 |
| SCCS Opinion | NOAEL | =100 | mg/kg bw/day | rat | oral | developmental | reproductive toxicity | p.30 |
| SCCS Opinion | NOAEL | =129 | mg/kg bw/d | rat | dermal | 13 weeks | NOAEL study | p.32 |
| SCCS Opinion | NOAEL | =180 | mg/kg bw/d | rat | dermal | 90 days | repeated dose toxicity | p.23 |
| SCCS Opinion | NOAEL | =300 | mg/kg bw/day | - | oral | 28 days | repeated dose toxicity | p.24 |
| SCCS Opinion | NOAEL | =1000 | mg/kg bw/day | rat | - | subacute | repeated dose toxicity | p.23 |
ToxValDB GESTIS DNEL 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB GESTIS DNEL | DNEL systemic | =1.58 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15635236:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_e8e55d559c8f9e21814982bc8446d96f |
Regulatory source 25 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| Regulatory source | - | =1.66 | mg/kg bw | rat | dermal | 5 year | - | p.32 |
| Regulatory source | - | 11 | % | rat | dermal | 13 weeks | - | p.32 |
| Regulatory source | - | =129 | mg/kg bw/d | rat | dermal | 13 weeks | - | p.32 |
| Regulatory source | - | =180 | mg/kg bw/d | rat | dermal | 5 year | - | p.32 |
| Regulatory source | - | 1000 | mg/kg bw/day | rat | - | 28 days | - | p.23 |
| Regulatory source | - | 1000 | mg/kg bw/day | rat | - | 28-day | - | p.24 |
| Regulatory source | dermal absorption | =0.044 | mg/kg bw | rat | dermal | 13 weeks | dermal absorption | p.32 |
| Regulatory source | dermal absorption | =129 | mg/kg bw/d | rat | dermal | 5 days | dermal absorption | p.32 |
| Regulatory source | dermal absorption | =129 | mg/kg bw/d | rat | dermal | 13 weeks | dermal absorption | p.32 |
| Regulatory source | dermal absorption | =180 | mg/kg bw/d | rat | dermal | 13 weeks | dermal absorption | p.32 |
| Regulatory source | repeated dose toxicity | 7 | mg/kg bw/d | rat | oral | 7 days | repeated dose toxicity | p.23 |
| Regulatory source | repeated dose toxicity | 11.25 | mg/kg bw/d | rat | dermal | 90 days | repeated dose toxicity | p.23 |
| Regulatory source | repeated dose toxicity | 11.25 | mg/kg bw/d | rat | oral | 5 days | repeated dose toxicity | p.33 |
| Regulatory source | repeated dose toxicity | 20 | mg/kg bw/d | rat | oral | 7 days | repeated dose toxicity | p.23 |
| Regulatory source | repeated dose toxicity | 20 | mg/kg bw/d | rat | dermal | developmental | repeated dose toxicity | p.29 |
| Regulatory source | repeated dose toxicity | 45 | mg/kg bw/d | rat | oral | 5 days | repeated dose toxicity | p.23 |
| Regulatory source | repeated dose toxicity | 80 | mg/kg bw/d | rat | dermal | developmental | repeated dose toxicity | p.29 |
| Regulatory source | repeated dose toxicity | 180 | mg/kg bw/d | rat | dermal | 90 days | repeated dose toxicity | p.23 |
| Regulatory source | repeated dose toxicity | 180 | mg/kg bw/d | rat | oral | 5 days | repeated dose toxicity | p.33 |
| Regulatory source | repeated dose toxicity | 300 | mg/kg bw/day | - | oral | 28 days | repeated dose toxicity | p.24 |
| Regulatory source | repeated dose toxicity | 300 | mg/kg bw/day | rat | oral | 28-day | repeated dose toxicity | p.43 |
| Regulatory source | repeated dose toxicity | 1000 | mg/kg bw/day | rat | - | subacute | repeated dose toxicity | p.23 |
| Regulatory source | reproductive toxicity | 20 | mg/kg bw/d | - | - | developmental | reproductive toxicity | p.29 |
| Regulatory source | reproductive toxicity | 65 | mg/kg bw/day | rat | oral | developmental | reproductive toxicity | p.30 |
| Regulatory source | reproductive toxicity | 100 | mg/kg bw/day | rat | oral | developmental | reproductive toxicity | p.30 |
openFDA substances 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| openFDA substances | FDA UNII substance identifier | 7857H94KHM | UNII | - | - | - | chemical | - |