Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
7 study endpoints found for Thioglycolic Acid. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | >=180 mg/kg bw/day | dermal | rat | dermal | REACH |
| LOAEL | 60 mg/kg bw/day | oral | rat | oral | REACH |
| LOAEL | 0.45 2104 | 1991 | rat | inhalation | REACH |
| NOAEL | >=360 mg/kg bw/day | dermal | code:3543 | dermal | REACH |
| NOEL | 20 mg/kg bw/day | oral | rat | oral | REACH |
| NOEL | 20 mg/kg bw/day | oral | rat | oral | REACH |
| LOAEL | 99 mg/kg bw/day | oral | rat | oral | REACH |
GHS Hazard Classification
Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.
Expert Verdict
Strong skin/eye irritant; corrosive at high concentrations; occupational sensitizer; mandatory label warnings per Annex III; post-marketing surveillance data reviewed by SCCS
Regulatory Flags
Frequently Asked Questions
Is Thioglycolic Acid safe in cosmetics?
Strong skin/eye irritant; corrosive at high concentrations; occupational sensitizer; mandatory label warnings per Annex III; post-marketing surveillance data reviewed by SCCS The EU classifies Thioglycolic Acid as "prohibited". Safety rating: MODERATE. 7 toxicological study endpoint(s) are available in our database.
Is Thioglycolic Acid allowed in the EU?
Thioglycolic Acid EU regulatory status: prohibited. Maximum allowed concentration: 5.0%. This is based on EU Regulation 1223/2009 and its amendments.
What does Thioglycolic Acid do in cosmetics?
Thioglycolic Acid functions as: Depilatory, Hair Waving/Straightening, Keratolytic, Reducing Agent. It is classified as a cosmetic ingredient in our database. CAS number: 68-11-1.
What is the Margin of Safety for Thioglycolic Acid?
adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Thioglycolic Acid?
The NOAEL (No Observed Adverse Effect Level) for Thioglycolic Acid is >=180 mg/kg bw/day based on a dermal study via dermal route in rat. A total of 7 study endpoints are available. Source: REACH.
Compliance Tools
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Related Ingredients
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