NOAEL Studies
Cosmetic Ingredient
Thiram NOAEL Studies
INCI: THIRAM (TETRAMETHYLTHIURAM DISULFIDE) — NO COSMETIC INCI ASSIGNMENT
CAS: 137-26-8
Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.
ECHA 46 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ECHA | LOAEL | 1000 | mg/kg bw/day | rabbit | - | - | short-term repeated dose toxicity: dermal | dossier=502ddbbe-8660-42be-8155-be5a2f6657e5.i6z; document=02e0c25b-686e-4b72-85ea-6b330c61cfe1_502ddbbe-8660-42be-8155-be5a2f6657e5.i6d; document_key=02e0c25b-686e-4b72-85ea-6b330c61cfe1/502ddbbe-8660-42be-8155-be5a2f6657e5; document_subtype=RepeatedDoseToxicityDermal; literature=Name=Unnamed; ReferenceYear=1992; ReportDate=1992-11-12; basis=body weight and weight gain; key_result=true; entry_uuid=ae19c21b-3d44-452d-8c3a-ef06d8070e24 |
| ECHA | LOAEL | 15 | mg/kg bw/day | rat | oral: gavage | - | developmental toxicity | dossier=502ddbbe-8660-42be-8155-be5a2f6657e5.i6z; document=83357a3a-e769-4c75-9f6b-910beffc2e5d_502ddbbe-8660-42be-8155-be5a2f6657e5.i6d; document_key=83357a3a-e769-4c75-9f6b-910beffc2e5d/502ddbbe-8660-42be-8155-be5a2f6657e5; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=1988; ReportDate=1988-01-28; basis=fetal/pup body weight changes; key_result=true; entry_uuid=30b8e14a-ffe2-462f-b1a8-b0d3b9abf9c8 |
| ECHA | LOAEL | 150 | mg/kg bw/day | rat | oral: gavage | - | neurotoxicity: acute oral | dossier=502ddbbe-8660-42be-8155-be5a2f6657e5.i6z; document=0b9d24b8-0126-459d-89f7-eee317e75c76_502ddbbe-8660-42be-8155-be5a2f6657e5.i6d; document_key=0b9d24b8-0126-459d-89f7-eee317e75c76/502ddbbe-8660-42be-8155-be5a2f6657e5; document_subtype=Neurotoxicity; literature=Name=Unnamed; ReferenceYear=1993; ReportDate=1993-07-26; basis=other:; key_result=false; entry_uuid=1fd88ec5-3799-40da-87c0-22ed1046bd4b |
| ECHA | LOAEL | 20 | mg/kg bw/day | rat | oral: gavage | - | developmental toxicity | dossier=502ddbbe-8660-42be-8155-be5a2f6657e5.i6z; document=3550e3a2-60e4-496f-9dd2-ae0a394500dd_502ddbbe-8660-42be-8155-be5a2f6657e5.i6d; document_key=3550e3a2-60e4-496f-9dd2-ae0a394500dd/502ddbbe-8660-42be-8155-be5a2f6657e5; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=1986; ReportDate=1986-11-27; basis=body weight and weight gain; key_result=false; entry_uuid=f1df5349-dd7d-456a-93ae-bbc762caf009 |
| ECHA | LOAEL | 300 | mg/kg bw/day | rat | oral: gavage | - | short-term repeated dose toxicity: oral | dossier=502ddbbe-8660-42be-8155-be5a2f6657e5.i6z; document=72ea5e5e-e767-46bf-98aa-4b855be624fb_502ddbbe-8660-42be-8155-be5a2f6657e5.i6d; document_key=72ea5e5e-e767-46bf-98aa-4b855be624fb/502ddbbe-8660-42be-8155-be5a2f6657e5; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=2015; ReportDate=2015-04-01; basis=body weight and weight gain; key_result=true; entry_uuid=c7853f29-7237-43ae-b4b1-12fd28e11c02 |
| ECHA | NOAEL | 300 | mg/kg bw/day | rabbit | - | - | short-term repeated dose toxicity: dermal | dossier=502ddbbe-8660-42be-8155-be5a2f6657e5.i6z; document=02e0c25b-686e-4b72-85ea-6b330c61cfe1_502ddbbe-8660-42be-8155-be5a2f6657e5.i6d; document_key=02e0c25b-686e-4b72-85ea-6b330c61cfe1/502ddbbe-8660-42be-8155-be5a2f6657e5; document_subtype=RepeatedDoseToxicityDermal; literature=Name=Unnamed; ReferenceYear=1992; ReportDate=1992-11-12; basis=other:; key_result=true; entry_uuid=fa48b909-f577-42e9-bdb1-ec61768f007e |
| ECHA | NOAEL | <=100 | mg/kg bw/day | rabbit | - | - | short-term repeated dose toxicity: dermal | dossier=502ddbbe-8660-42be-8155-be5a2f6657e5.i6z; document=02e0c25b-686e-4b72-85ea-6b330c61cfe1_502ddbbe-8660-42be-8155-be5a2f6657e5.i6d; document_key=02e0c25b-686e-4b72-85ea-6b330c61cfe1/502ddbbe-8660-42be-8155-be5a2f6657e5; document_subtype=RepeatedDoseToxicityDermal; literature=Name=Unnamed; ReferenceYear=1992; ReportDate=1992-11-12; basis=other:; key_result=true; upper_value=100; entry_uuid=31828de1-b0ca-44be-b918-c3b5b62ce4a3 |
| ECHA | NOAEL | >=10 | mg/kg bw/day | rabbit | oral: gavage | - | developmental toxicity | dossier=502ddbbe-8660-42be-8155-be5a2f6657e5.i6z; document=d4236cd5-b438-4af6-a776-9a9bf95a562d_502ddbbe-8660-42be-8155-be5a2f6657e5.i6d; document_key=d4236cd5-b438-4af6-a776-9a9bf95a562d/502ddbbe-8660-42be-8155-be5a2f6657e5; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=1992; ReportDate=1992-02-18; basis=other:; key_result=true; entry_uuid=749e69a4-2227-466a-8167-1fd6cf293cb2 |
| ECHA | NOAEL | 5 | mg/kg bw/day | rabbit | oral: gavage | - | developmental toxicity | dossier=502ddbbe-8660-42be-8155-be5a2f6657e5.i6z; document=d4236cd5-b438-4af6-a776-9a9bf95a562d_502ddbbe-8660-42be-8155-be5a2f6657e5.i6d; document_key=d4236cd5-b438-4af6-a776-9a9bf95a562d/502ddbbe-8660-42be-8155-be5a2f6657e5; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=1992; ReportDate=1992-02-18; basis=other:; key_result=true; entry_uuid=993cdc3d-78f6-47a7-96b1-0306745a2d50 |
| ECHA | NOAEL | 2.5 | mg/kg bw/day | rabbit | oral: gavage | - | developmental toxicity | dossier=502ddbbe-8660-42be-8155-be5a2f6657e5.i6z; document=9ceb7105-1ce3-4ddd-bb9d-d800552184bc_502ddbbe-8660-42be-8155-be5a2f6657e5.i6d; document_key=9ceb7105-1ce3-4ddd-bb9d-d800552184bc/502ddbbe-8660-42be-8155-be5a2f6657e5; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=1988; ReportDate=1988-03-15; basis=other:; key_result=true; entry_uuid=0d755818-564f-4f44-88f4-08655e5d1798 |
| ECHA | NOAEL | <=7.5 | mg/kg bw/day | rat | oral: gavage | - | developmental toxicity | dossier=502ddbbe-8660-42be-8155-be5a2f6657e5.i6z; document=83357a3a-e769-4c75-9f6b-910beffc2e5d_502ddbbe-8660-42be-8155-be5a2f6657e5.i6d; document_key=83357a3a-e769-4c75-9f6b-910beffc2e5d/502ddbbe-8660-42be-8155-be5a2f6657e5; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=1988; ReportDate=1988-01-28; basis=body weight and weight gain; key_result=true; upper_value=7.5; entry_uuid=dbbc9da9-dc73-4c95-ad6e-b67f797e4fe2 |
| ECHA | NOAEL | 1000 | mg/kg bw/day | rat | oral: gavage | - | short-term repeated dose toxicity: oral | dossier=502ddbbe-8660-42be-8155-be5a2f6657e5.i6z; document=72ea5e5e-e767-46bf-98aa-4b855be624fb_502ddbbe-8660-42be-8155-be5a2f6657e5.i6d; document_key=72ea5e5e-e767-46bf-98aa-4b855be624fb/502ddbbe-8660-42be-8155-be5a2f6657e5; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=2015; ReportDate=2015-04-01; basis=other:; key_result=false; entry_uuid=ce3db584-176f-428c-8445-9d0cc3605978 |
| ECHA | LOAEL | =5 | mg/kg bw/day | Dog | oral | chronic; 52 weeks | chronic | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7ca78e4b0a7c65d2220d8; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/11311/7/6/2?documentUUID=502ddbbe-8660-42be-8155-be5a2f6657e5; YEAR=1985; ORIGINAL_YEAR=1985; TOXICOLOGICAL_EFFECT=liver: clinical biochemistry|haematology|organ weights and organ / body weight ratios; TOXICOLOGICAL_EFFECT_CATEGORY=clinical chemistry|hematology|organ weight; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15841286_15841288:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_6f078eff30aed043b4024b90ee13bc34 |
| ECHA | LOAEL | =9.25 | mg/kg bw/day | Dog | oral | subchronic; 90 days | subchronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7ca78e4b0a7c65d2220c8; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/11311/7/6/2?documentUUID=502ddbbe-8660-42be-8155-be5a2f6657e5; YEAR=1985; ORIGINAL_YEAR=1985; TOXICOLOGICAL_EFFECT=body weight and weight gain|clinical biochemistry|food consumption and compound intake|haematology; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical chemistry|food and/or water consumption|hematology; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15837590_15837591_15840866_15840867:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_855b7bae3079447eaae58885373e3495 |
| ECHA | LOAEL | =11.7 | mg/kg bw/day | Rat | oral | - | chronic | GUIDELINE=OECD Guideline 453 (Combined Chronic Toxicity / Carcinogenicity Studies); QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c80fe4b0a7c65d2166c6; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/11311/7/8?documentUUID=502ddbbe-8660-42be-8155-be5a2f6657e5; YEAR=1985; ORIGINAL_YEAR=1985; TOXICOLOGICAL_EFFECT=liver: body weight and weight gain|food consumption and compound intake|gross pathology|haematology|histopathology: non-neoplastic|liver: histopathology: neoplastic; TOXICOLOGICAL_EFFECT_CATEGORY=cancer|food and/or water consumption|gross pathology|hematology|nonneoplastic histopathology|organ weight; STUDY_GROUP=ECHA IUCLID_dup_Carcinogenicity_15817560_15817561:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_62c17fe71608959eddc92ed98dad4abb |
| ECHA | LOAEL | =27.75 | mg/kg bw/day | Mouse | oral | - | chronic | GUIDELINE=OECD Guideline 451 (Carcinogenicity Studies); QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c80fe4b0a7c65d2166c8; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/11311/7/8?documentUUID=502ddbbe-8660-42be-8155-be5a2f6657e5; YEAR=1985; ORIGINAL_YEAR=1985; TOXICOLOGICAL_EFFECT=body weight and weight gain|food consumption and compound intake|haematology|histopathology: non-neoplastic; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|food and/or water consumption|hematology|nonneoplastic histopathology; STUDY_GROUP=ECHA IUCLID_dup_Carcinogenicity_15817939_15817942:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_fb812a7a377a9544e238f592f9a269b8 |
| ECHA | LOAEL | =48 | mg/kg bw/day | Rat | oral | subchronic; 13 weeks | subchronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7ca77e4b0a7c65d222053; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/11311/7/6/2?documentUUID=502ddbbe-8660-42be-8155-be5a2f6657e5; YEAR=1985; ORIGINAL_YEAR=1985; TOXICOLOGICAL_EFFECT=body weight and weight gain|clinical biochemistry|gross pathology|haematology|histopathology: non-neoplastic; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical chemistry|gross pathology|hematology|nonneoplastic histopathology; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15833271_15833272_15836628_15836629:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_71820374655bcfefffbe15e76eefa9a1 |
| ECHA | LOAEL | =60 | mg/kg bw/day | Rat | oral | - | repeat dose other | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c85ae4b0a7c65d218171; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/11311/7/10/1?documentUUID=502ddbbe-8660-42be-8155-be5a2f6657e5; YEAR=1985; ORIGINAL_YEAR=1985; TOXICOLOGICAL_EFFECT=body weight and weight gain|food consumption and compound intake; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|food and/or water consumption; STUDY_GROUP=ECHA IUCLID_dup_Neurotoxicity_15825800_15825801:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_5c98116772e335e72435b5b44a870f0e |
| ECHA | LOAEL | =60 | ppm | Rat | oral | - | reproduction developmental | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c8bde4b0a7c65d219fbc; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/11311/7/9/2?documentUUID=502ddbbe-8660-42be-8155-be5a2f6657e5; YEAR=1985; ORIGINAL_YEAR=1985; STUDY_GROUP=ECHA IUCLID_dup_Toxicity Reproduction_15855336_15856171_15856717:M/F:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_a150a952b16e525e9ba3b5ce36b0ac55 |
| ECHA | LOAEL | =88.65 | mg/kg bw/day | Mouse | oral | - | subchronic | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c851e4b0a7c65d217e7e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/11311/7/10/2?documentUUID=502ddbbe-8660-42be-8155-be5a2f6657e5; YEAR=1985; ORIGINAL_YEAR=1985; TOXICOLOGICAL_EFFECT=hepatobiliary: spleen: immunology; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ECHA IUCLID_dup_Immunotoxicity_15825513_15825514:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_2fd8ea3a51ac07daeaf9ca5a3128ca28 |
| ECHA | LOAEL | =90 | ppm | Rat | oral | - | repeat dose other | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c85ae4b0a7c65d21816b; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/11311/7/10/1?documentUUID=502ddbbe-8660-42be-8155-be5a2f6657e5; YEAR=1985; ORIGINAL_YEAR=1985; TOXICOLOGICAL_EFFECT=body weight and weight gain|clinical signs|food consumption and compound intake; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical signs|food and/or water consumption; STUDY_GROUP=ECHA IUCLID_dup_Neurotoxicity_15825586_15825587:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_c2e6aee59ec40f534a00e14c565cf1cd |
| ECHA | LOAEL | =125 | ppm | Rat | oral | - | repeat dose other | GUIDELINE=OECD Guideline 424 (Neurotoxicity Study in Rodents); QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c85ae4b0a7c65d21816f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/11311/7/10/1?documentUUID=502ddbbe-8660-42be-8155-be5a2f6657e5; YEAR=1985; ORIGINAL_YEAR=1985; TOXICOLOGICAL_EFFECT=body weight and weight gain|food consumption and compound intake; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|food and/or water consumption; STUDY_GROUP=ECHA IUCLID_dup_Neurotoxicity_15825588_15825589_15825590_15825763_15825764_15825765_15825766:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_3cdb2af307e8a89287f4ddb47260273e |
| ECHA | LOAEL | =150 | mg/kg bw/day | Rat | oral | - | repeat dose other | GUIDELINE=OECD Guideline 418 (Delayed Neurotoxicity of Organophosphorus Substances Following Acute Exposure); QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c85ae4b0a7c65d218169; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/11311/7/10/1?documentUUID=502ddbbe-8660-42be-8155-be5a2f6657e5; YEAR=1985; ORIGINAL_YEAR=1985; STUDY_GROUP=ECHA IUCLID_dup_Neurotoxicity_15825580_15825581:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_71506f0b6d992279f283dfe7e4840716 |
| ECHA | LOAEL | =300 | mg/kg bw/day | Rat | oral | - | short-term | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7ca77e4b0a7c65d222074; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/11311/7/6/2?documentUUID=502ddbbe-8660-42be-8155-be5a2f6657e5; YEAR=1985; ORIGINAL_YEAR=1985; TOXICOLOGICAL_EFFECT=body weight and weight gain|food consumption and compound intake|gross pathology; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|food and/or water consumption|gross pathology; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15837261_15837262:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_3ae84defe7c6bc6697c36519a3d66540 |
| ECHA | LOAEL | =300 | ppm | Mouse | oral | short-term; 4 weeks | short-term | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7ca78e4b0a7c65d2220d0; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/11311/7/6/2?documentUUID=502ddbbe-8660-42be-8155-be5a2f6657e5; YEAR=1985; ORIGINAL_YEAR=1985; TOXICOLOGICAL_EFFECT=body weight and weight gain|food consumption and compound intake|haematology|organ weights and organ / body weight ratios; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|food and/or water consumption|hematology|organ weight; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15838325_15838327_15839196:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_0cb7211e2c4b0e9b180010c612947276 |
| ECHA | LOAEL | =500 | ppm | Rat | oral | - | repeat dose other | GUIDELINE=OECD Guideline 424 (Neurotoxicity Study in Rodents); QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c85ae4b0a7c65d21816f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/11311/7/10/1?documentUUID=502ddbbe-8660-42be-8155-be5a2f6657e5; YEAR=1985; ORIGINAL_YEAR=1985; TOXICOLOGICAL_EFFECT=behavior: functional findings; TOXICOLOGICAL_EFFECT_CATEGORY=neurobehavior; STUDY_GROUP=ECHA IUCLID_dup_Neurotoxicity_15825588_15825589_15825590_15825763_15825764_15825765_15825766:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_99144b3df616a6c10f6df6edb26d9643 |
| ECHA | LOAEL | =600 | ppm | Mouse | oral | short-term; 4 weeks | short-term | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7ca78e4b0a7c65d2220d0; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/11311/7/6/2?documentUUID=502ddbbe-8660-42be-8155-be5a2f6657e5; YEAR=1985; ORIGINAL_YEAR=1985; TOXICOLOGICAL_EFFECT=body weight and weight gain|food consumption and compound intake|haematology|organ weights and organ / body weight ratios; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|food and/or water consumption|hematology|organ weight; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15838325_15838327_15839196:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_c05d35a88ab9d3a9b4d77fc448a37735 |
| ECHA | LOAEL | =1000 | mg/kg bw/day | Rabbit | dermal | short-term; 21 days | short-term | GUIDELINE=OECD Guideline 410 (Repeated Dose Dermal Toxicity: 21/28-Day Study); QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/67c61d3ae4b096bca8774fa1; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/11311/7/6/4?documentUUID=502ddbbe-8660-42be-8155-be5a2f6657e5; YEAR=1985; ORIGINAL_YEAR=1985; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Dermal_15826099_15826100_15826101:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_65b8c9c571b5b8af8e2efefa13bfa934 |
| ECHA | NOAEL | =0.6 | mg/kg bw/day | Dog | oral | chronic; 52 weeks | chronic | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7ca78e4b0a7c65d2220d8; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/11311/7/6/2?documentUUID=502ddbbe-8660-42be-8155-be5a2f6657e5; YEAR=1985; ORIGINAL_YEAR=1985; TOXICOLOGICAL_EFFECT=liver; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15841285_15841287:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_b9e35fc3510947ee0217551f9f299fe5 |
| ECHA | NOAEL | =1.8 | mg/kg bw/day | Dog | oral | chronic; 52 weeks | chronic | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7ca78e4b0a7c65d2220d8; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/11311/7/6/2?documentUUID=502ddbbe-8660-42be-8155-be5a2f6657e5; YEAR=1985; ORIGINAL_YEAR=1985; TOXICOLOGICAL_EFFECT=liver; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15841286_15841288:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_77cb92ccb35364e4e94345fc0b12d9ae |
| ECHA | NOAEL | =2.34 | mg/kg bw/day | Rat | oral | - | chronic | GUIDELINE=OECD Guideline 453 (Combined Chronic Toxicity / Carcinogenicity Studies); QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c80fe4b0a7c65d2166c6; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/11311/7/8?documentUUID=502ddbbe-8660-42be-8155-be5a2f6657e5; YEAR=1985; ORIGINAL_YEAR=1985; TOXICOLOGICAL_EFFECT=liver; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ECHA IUCLID_dup_Carcinogenicity_15817560_15817561:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_7426a733f94e671aa9196191282587f4 |
| ECHA | NOAEL | =2.775 | mg/kg bw/day | Mouse | oral | - | chronic | GUIDELINE=OECD Guideline 451 (Carcinogenicity Studies); QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c80fe4b0a7c65d2166c8; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/11311/7/8?documentUUID=502ddbbe-8660-42be-8155-be5a2f6657e5; YEAR=1985; ORIGINAL_YEAR=1985; STUDY_GROUP=ECHA IUCLID:15817941:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_791ecdb9f2c3342c33a9b053b36a09e8 |
| ECHA | NOAEL | =4.8 | mg/kg bw/day | Rat | oral | subchronic; 13 weeks | subchronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7ca77e4b0a7c65d222053; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/11311/7/6/2?documentUUID=502ddbbe-8660-42be-8155-be5a2f6657e5; YEAR=1985; ORIGINAL_YEAR=1985; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15833271_15833272_15836628_15836629:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_a7cc4d0aba969ea2fb9939248a4154ff |
| ECHA | NOAEL | >5 | mg/kg bw/day | Rabbit | oral | - | developmental | GUIDELINE=OECD Guideline 414 (Prenatal Developmental Toxicity Study); QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eac93e4b0a7c65d1bfdf4; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/11549/7/9/3?documentUUID=bffc9e90-e74d-4644-9f2b-e987470690fd; YEAR=1977; ORIGINAL_YEAR=1977; STUDY_GROUP=ECHA IUCLID_dup_Developmental Toxicity Teratogenicity_15820672_15821426:M/F:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_5b5d3065cc32ca5fa0e4b693fd14189c |
| ECHA | NOAEL | =20 | ppm | Rat | oral | - | repeat dose other | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c85ae4b0a7c65d21816b; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/11311/7/10/1?documentUUID=502ddbbe-8660-42be-8155-be5a2f6657e5; YEAR=1985; ORIGINAL_YEAR=1985; STUDY_GROUP=ECHA IUCLID_dup_Neurotoxicity_15825588_15825589_15825590_15825763_15825764_15825765_15825766:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_64cd00f94483e75b4f464f68c44d0827 |
| ECHA | NOAEL | =25 | mg/kg bw/day | Rat | oral | - | repeat dose other | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c85ae4b0a7c65d218171; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/11311/7/10/1?documentUUID=502ddbbe-8660-42be-8155-be5a2f6657e5; YEAR=1985; ORIGINAL_YEAR=1985; STUDY_GROUP=ECHA IUCLID_dup_Neurotoxicity_15825800_15825801:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_01c17850d2d8ce1533d2175de6d9251d |
| ECHA | NOAEL | =29.55 | mg/kg bw/day | Mouse | oral | - | subchronic | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c851e4b0a7c65d217e7e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/11311/7/10/2?documentUUID=502ddbbe-8660-42be-8155-be5a2f6657e5; YEAR=1985; ORIGINAL_YEAR=1985; TOXICOLOGICAL_EFFECT=hepatobiliary: spleen; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ECHA IUCLID_dup_Immunotoxicity_15825513_15825514:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_116c9323993ab82e309bc7c385a9e3e8 |
| ECHA | NOAEL | =30 | ppm | Rat | oral | - | repeat dose other | GUIDELINE=OECD Guideline 424 (Neurotoxicity Study in Rodents); QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c85ae4b0a7c65d21816f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/11311/7/10/1?documentUUID=502ddbbe-8660-42be-8155-be5a2f6657e5; YEAR=1985; ORIGINAL_YEAR=1985; STUDY_GROUP=ECHA IUCLID_dup_Neurotoxicity_15825588_15825589_15825590_15825763_15825764_15825765_15825766:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_e5b1961a511623b564ffcdd97302df16 |
| ECHA | NOAEL | =45 | ppm | Rat | oral | - | repeat dose other | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c85ae4b0a7c65d21816b; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/11311/7/10/1?documentUUID=502ddbbe-8660-42be-8155-be5a2f6657e5; YEAR=1985; ORIGINAL_YEAR=1985; STUDY_GROUP=ECHA IUCLID_dup_Neurotoxicity_15825586_15825587:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_6b01a256d02f7c6847f267cf34606955 |
| ECHA | NOAEL | =55.5 | mg/kg bw/day | Mouse | oral | - | chronic | GUIDELINE=OECD Guideline 451 (Carcinogenicity Studies); QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c80fe4b0a7c65d2166c8; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/11311/7/8?documentUUID=502ddbbe-8660-42be-8155-be5a2f6657e5; YEAR=1985; ORIGINAL_YEAR=1985; STUDY_GROUP=ECHA IUCLID_dup_Carcinogenicity_15817939_15817942:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_2ce959a42caa75611a7d0e0387b960d1 |
| ECHA | NOAEL | <100 | mg/kg bw/day | Rabbit | dermal | short-term; 21 days | short-term | GUIDELINE=OECD Guideline 410 (Repeated Dose Dermal Toxicity: 21/28-Day Study); QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/67c61d3ae4b096bca8774fa1; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/11311/7/6/4?documentUUID=502ddbbe-8660-42be-8155-be5a2f6657e5; YEAR=1985; ORIGINAL_YEAR=1985; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Dermal_15826099_15826100_15826101:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_4885b3ba2167b8208c4b52fb9d02629e |
| ECHA | NOAEL | =111 | mg/kg bw/day | Mouse | oral | - | chronic | GUIDELINE=OECD Guideline 451 (Carcinogenicity Studies); QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c80fe4b0a7c65d2166c8; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/11311/7/8?documentUUID=502ddbbe-8660-42be-8155-be5a2f6657e5; YEAR=1985; ORIGINAL_YEAR=1985; STUDY_GROUP=ECHA IUCLID_dup_Carcinogenicity_15817940_15817943:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_f705b0fb57d0ca1c745029e66c4e2848 |
| ECHA | NOAEL | =125 | ppm | Dog | oral | short-term; 4 weeks | short-term | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7ca77e4b0a7c65d222060; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/11311/7/6/2?documentUUID=502ddbbe-8660-42be-8155-be5a2f6657e5; YEAR=1985; ORIGINAL_YEAR=1985; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15834088_15834089_15836232_15836233:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_2c4885936a628f20dfdcf0b9bd534f13 |
| ECHA | NOAEL | =180 | ppm | Rat | oral | - | reproduction developmental | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c8bde4b0a7c65d219fbc; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/11311/7/9/2?documentUUID=502ddbbe-8660-42be-8155-be5a2f6657e5; YEAR=1985; ORIGINAL_YEAR=1985; STUDY_GROUP=ECHA IUCLID_dup_Toxicity Reproduction_15855336_15856171_15856717:M/F:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_7f23de17ff1dcb95bfe35f0fad8a5580 |
| ECHA | NOAEL | =300 | mg/kg bw/day | Rabbit | dermal | short-term; 21 days | short-term | GUIDELINE=OECD Guideline 410 (Repeated Dose Dermal Toxicity: 21/28-Day Study); QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/67c61d3ae4b096bca8774fa1; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/11311/7/6/4?documentUUID=502ddbbe-8660-42be-8155-be5a2f6657e5; YEAR=1985; ORIGINAL_YEAR=1985; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Dermal_15826099_15826100_15826101:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_0d88efcd686eaf467f2137440d12cd9e |
| ECHA | NOAEL | =1000 | mg/kg bw/day | Rat | oral | - | short-term | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7ca77e4b0a7c65d222074; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/11311/7/6/2?documentUUID=502ddbbe-8660-42be-8155-be5a2f6657e5; YEAR=1985; ORIGINAL_YEAR=1985; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15837261_15837262:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_9efa4253c6fd1508336a2d82c2e4819b |
EFSA 15 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| EFSA | NOAEL | =1.6 | mg/kg bw/day | Rat | - | - | chronic/long term toxicity | EFSA - 2017 - OutputID 3606 - Peer review of the pesticide risk assessment of the active substance thiram - doi:10.2903/j.efsa.2017.4700 |
| EFSA | NOAEL | =0.84 | mg/kg bw/day | Dog | - | 365 days | chronic/long term toxicity | EFSA - 2017 - OutputID 3606 - haematology - hepatotoxicity - Peer review of the pesticide risk assessment of the active substance thiram - doi:10.2903/j.efsa.2017.4700 |
| EFSA | NOAEL | =1.5 | mg/kg bw/day | Rat | - | 730 days | chronic/long term toxicity | EFSA - 2017 - OutputID 3606 - body weight - systemic - Peer review of the pesticide risk assessment of the active substance thiram - doi:10.2903/j.efsa.2017.4700 |
| EFSA | NOAEL | <7.5 | mg/kg bw/day | Rat | - | - | reproduction toxicity | EFSA - 2017 - OutputID 3606 - body weight - systemic - Peer review of the pesticide risk assessment of the active substance thiram - doi:10.2903/j.efsa.2017.4700 |
| EFSA | NOAEL | =3 | mg/kg bw/day | Rat | - | - | reproduction toxicity | EFSA - 2017 - OutputID 3606 - body weight - systemic - Peer review of the pesticide risk assessment of the active substance thiram - doi:10.2903/j.efsa.2017.4700 |
| EFSA | NOAEL | =2 | mg/kg bw/day | Dog | - | 90 days | subchronic | EFSA - 2017 - OutputID 3606 - haematology - hepatotoxicity - Peer review of the pesticide risk assessment of the active substance thiram - doi:10.2903/j.efsa.2017.4700 |
| EFSA | ADI | =0.01 | mg/kg bw/day | Consumers | - | - | ADI | EFSA - 2017 - OutputID 3606 - Consumers - Peer review of the pesticide risk assessment of the active substance thiram - doi:10.2903/j.efsa.2017.4700 |
| EFSA | ARfD | =0.025 | mg/kg bw/day | Consumers | - | - | ARfD | EFSA - 2017 - OutputID 3606 - Consumers - Peer review of the pesticide risk assessment of the active substance thiram - doi:10.2903/j.efsa.2017.4700 |
| EFSA | NOAEL | =0.84 | mg/kg bw/day | Dog | oral | chronic; 1 years | chronic | LONG_REF=EFSA (2017). Peer review of the pesticide risk assessment of the active substance thiram. doi:10.2903/j.efsa.2017.4700.; TITLE=Peer review of the pesticide risk assessment of the active substance thiram; AUTHOR=EFSA; DOI=doi:10.2903/j.efsa.2017.4700; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65201d30e4b0f0a60ddd1165; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://zenodo.org/record/5076033#.Y9fEoXbMI2z; YEAR=2017; ORIGINAL_YEAR=2017; TOXICOLOGICAL_EFFECT=hematological; TOXICOLOGICAL_EFFECT_CATEGORY=hematology; STUDY_GROUP=EFSA:15623340:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_f32149ef25c5b2291cebd1b92accbf77 |
| EFSA | NOAEL | =1.5 | mg/kg bw/day | Rat | oral | chronic; 2 years | chronic | LONG_REF=EFSA (2017). Peer review of the pesticide risk assessment of the active substance thiram. doi:10.2903/j.efsa.2017.4700.; TITLE=Peer review of the pesticide risk assessment of the active substance thiram; AUTHOR=EFSA; DOI=doi:10.2903/j.efsa.2017.4700; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65201d30e4b0f0a60ddd1165; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://zenodo.org/record/5076033#.Y9fEoXbMI2z; YEAR=2017; ORIGINAL_YEAR=2017; TOXICOLOGICAL_EFFECT=body weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=EFSA:15623339:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_bf3c3dfee4c734740417e9fa939557f9 |
| EFSA | NOAEL | =1.6 | mg/kg bw/day | Rat | oral | - | chronic | LONG_REF=EFSA (2017). Peer review of the pesticide risk assessment of the active substance thiram. doi:10.2903/j.efsa.2017.4700.; TITLE=Peer review of the pesticide risk assessment of the active substance thiram; AUTHOR=EFSA; DOI=doi:10.2903/j.efsa.2017.4700; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65201d30e4b0f0a60ddd1165; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://zenodo.org/record/5076033#.Y9fEoXbMI2z; YEAR=2017; ORIGINAL_YEAR=2017; STUDY_GROUP=EFSA:15623345:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_c4948426c199a3861759771567c38a30 |
| EFSA | NOAEL | =2 | mg/kg bw/day | Dog | oral | subchronic; 90 days | subchronic | LONG_REF=EFSA (2017). Peer review of the pesticide risk assessment of the active substance thiram. doi:10.2903/j.efsa.2017.4700.; TITLE=Peer review of the pesticide risk assessment of the active substance thiram; AUTHOR=EFSA; DOI=doi:10.2903/j.efsa.2017.4700; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65201d30e4b0f0a60ddd1165; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://zenodo.org/record/5076033#.Y9fEoXbMI2z; YEAR=2017; ORIGINAL_YEAR=2017; TOXICOLOGICAL_EFFECT=hematological; TOXICOLOGICAL_EFFECT_CATEGORY=hematology; STUDY_GROUP=EFSA:15623343:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_1351304bc95f0785803e296ecc5df7e5 |
| EFSA | NOAEL | =3 | mg/kg bw/day | Rat | oral | - | reproduction developmental | LONG_REF=EFSA (2017). Peer review of the pesticide risk assessment of the active substance thiram. doi:10.2903/j.efsa.2017.4700.; TITLE=Peer review of the pesticide risk assessment of the active substance thiram; AUTHOR=EFSA; DOI=doi:10.2903/j.efsa.2017.4700; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65201d30e4b0f0a60ddd1165; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://zenodo.org/record/5076033#.Y9fEoXbMI2z; YEAR=2017; ORIGINAL_YEAR=2017; TOXICOLOGICAL_EFFECT=body weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=EFSA_dup_-_15623341_15623344:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_64d314bfe070c03d4252a652a2742be7 |
| EFSA | NOAEL | <7.5 | mg/kg bw/day | Rat | oral | - | reproduction developmental | LONG_REF=EFSA (2017). Peer review of the pesticide risk assessment of the active substance thiram. doi:10.2903/j.efsa.2017.4700.; TITLE=Peer review of the pesticide risk assessment of the active substance thiram; AUTHOR=EFSA; DOI=doi:10.2903/j.efsa.2017.4700; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65201d30e4b0f0a60ddd1165; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://zenodo.org/record/5076033#.Y9fEoXbMI2z; YEAR=2017; ORIGINAL_YEAR=2017; TOXICOLOGICAL_EFFECT=body weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=EFSA_dup_-_15623341_15623344:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_be3468867fe35cb65c7b0402ca8ddbd4 |
| EFSA | NOEC | =37.5 | mg/kg bw/day | Northern Bobwhite Quail | inhalation | - | reproduction developmental | LONG_REF=EFSA (2017). Peer review of the pesticide risk assessment of the active substance thiram. doi:10.2903/j.efsa.2017.4700.; TITLE=Peer review of the pesticide risk assessment of the active substance thiram; AUTHOR=EFSA; DOI=doi:10.2903/j.efsa.2017.4700; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65201d30e4b0f0a60ddd1165; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://zenodo.org/record/5076033#.Y9fEoXbMI2z; YEAR=2017; ORIGINAL_YEAR=2017; STUDY_GROUP=EFSA:15623350:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_8f3a2acd27e59c676c74e3777facd629 |
Regulatory source 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| Regulatory source | NOEL | =5 | mg/kg/day | - | oral | chronic | IRIS chronic oral RfD system PoD | row_hash=840487bde155d1b7; file=iris_rfd_systems.csv; kind=point_of_departure; raw_column=point_of_departure; raw_value=NOEL : 5 mg/kg-day; system=Nervous; basis=Neurotoxicity; point_of_departure=NOEL : 5 mg/kg-day; composite_uf=1000; confidence=Low; dtxsid=DTXSID5021332; detail_url=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=267; rfd_pdf_url=https://iris.epa.gov/static/pdfs/0267_summary.pdf |
| Regulatory source | RfD | =0.005 | mg/kg/day | - | oral | chronic | IRIS chronic oral RfD system | row_hash=f665b7bdf24592c5; file=iris_rfd_systems.csv; kind=reference_value; raw_column=rfd_mg_per_kg_day; raw_value=5e-3; system=Nervous; basis=Neurotoxicity; point_of_departure=NOEL : 5 mg/kg-day; composite_uf=1000; confidence=Low; dtxsid=DTXSID5021332; detail_url=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=267; rfd_pdf_url=https://iris.epa.gov/static/pdfs/0267_summary.pdf |
IARC Monographs 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| IARC Monographs | IARC carcinogenicity classification | 3 | IARC group | - | - | 1990 | IARC Monographs | - |
WHO/JECFA 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| WHO/JECFA | ADI | range:0-0.0250.025 | mg/kg bw/day | - | - | - | Health guidance value | document_id=jmpr_jmpmono_v065pr41; title=041. Thiram (FAO Meeting Report PL/1965/10/1); path=mirror/documents/jmpr/jmpmono/v065pr41.htm; row_hash=a626e3fa292ff37b; raw_unit=mg/kg; context=An effect was found in the chick at 6.8 mg/kg body-weight.) Estimate of acceptable daily intake for man 0-0.025 mg/kg body-weight. |
NTP ICE acute dermal 5 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE acute dermal | EPA classification | 3 | unitless | Rat | Dermal | - | In Vivo; Rat Acute Dermal Toxicity | sheet=Data; excel_row=1283; Record_ID=acute_dermal_234; Data_Type=In Vivo; Formulation_ID=MIX227; Formulation_Name=Foundation Lite; Percent_Active_Ingredient=6.8; Mixture=Mixture; DTXSID=DTXSID5021332; Assay=Rat Acute Dermal Toxicity; Endpoint=EPA classification; Response=3.0; Response_Unit=Unitless; Species=Rat; Route=Dermal; Reference=FIFRA data; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP ICE acute dermal | EPA classification | 4 | unitless | Rat | Dermal | - | In Vivo; Rat Acute Dermal Toxicity | sheet=Data; excel_row=1287; Record_ID=acute_dermal_436; Data_Type=In Vivo; Formulation_ID=MIX430; Formulation_Name=Sativa IMX Max; Percent_Active_Ingredient=10.78; Mixture=Mixture; DTXSID=DTXSID5021332; Assay=Rat Acute Dermal Toxicity; Endpoint=EPA classification; Response=4.0; Response_Unit=Unitless; Species=Rat; Route=Dermal; Reference=FIFRA data; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP ICE acute dermal | GHS classification | 5 | unitless | Rat | Dermal | - | In Vivo; Rat Acute Dermal Toxicity | sheet=Data; excel_row=1284; Record_ID=acute_dermal_148; Data_Type=In Vivo; Formulation_ID=MIX144; Formulation_Name=DeerPro Winter Animal Repellant; Percent_Active_Ingredient=25.8; Mixture=Mixture; DTXSID=DTXSID5021332; Assay=Rat Acute Dermal Toxicity; Endpoint=GHS classification; Response=5; Response_Unit=Unitless; Species=Rat; Route=Dermal; Reference=FIFRA data; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP ICE acute dermal | LD50 | >5000 | mg/kg | Rat | Dermal | - | In Vivo; Rat Acute Dermal Toxicity | sheet=Data; excel_row=1281; Record_ID=acute_dermal_148; Data_Type=In Vivo; Formulation_ID=MIX144; Formulation_Name=DeerPro Winter Animal Repellant; Percent_Active_Ingredient=25.8; Mixture=Mixture; DTXSID=DTXSID5021332; Assay=Rat Acute Dermal Toxicity; Endpoint=LD50; Response_Modifier=>; Response=5000; Response_Unit=mg/kg; Species=Rat; Route=Dermal; Reference=FIFRA data; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP ICE acute dermal | LD50 | >2000 | mg/kg | Rat | Dermal | - | In Vivo; Rat Acute Dermal Toxicity | sheet=Data; excel_row=1282; Record_ID=acute_dermal_234; Data_Type=In Vivo; Formulation_ID=MIX227; Formulation_Name=Foundation Lite; Percent_Active_Ingredient=6.8; Mixture=Mixture; DTXSID=DTXSID5021332; Assay=Rat Acute Dermal Toxicity; Endpoint=LD50; Response_Modifier=>; Response=2000.0; Response_Unit=mg/kg; Species=Rat; Route=Dermal; Reference=FIFRA data; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
NTP ICE acute inhalation 9 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE acute inhalation | EPA Classification | 3 | unitless | - | Inhalation | - | In Vivo; AcuteInhal6pack; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=2814; Record_ID=acute_inhalation_160; Data_Type=In Vivo; Internal_Data_Source=AcuteInhal6pack; Formulation_ID=MIX227; Formulation_Name=Foundation Lite; Percent_Active_Ingredient=6.8; Mixture=Mixture; DTXSID=DTXSID5021332; Assay=Rat Acute Inhalation Toxicity; Endpoint=EPA Classification; Response=3; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP ICE acute inhalation | GHS Classification | 4 | unitless | - | Inhalation | - | In Vivo; AcuteInhal6pack; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=2804; Record_ID=acute_inhalation_160; Data_Type=In Vivo; Internal_Data_Source=AcuteInhal6pack; Formulation_ID=MIX227; Formulation_Name=Foundation Lite; Percent_Active_Ingredient=6.8; Mixture=Mixture; DTXSID=DTXSID5021332; Assay=Rat Acute Inhalation Toxicity; Endpoint=GHS Classification; Response=4; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP ICE acute inhalation | GHS Classification | 5 | unitless | - | Inhalation | - | In Vivo; AcuteInhal6pack; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=2808; Record_ID=acute_inhalation_343; Data_Type=In Vivo; Internal_Data_Source=AcuteInhal6pack; Formulation_ID=MIX430; Formulation_Name=Sativa IMX Max; Percent_Active_Ingredient=10.78; Mixture=Mixture; DTXSID=DTXSID5021332; Assay=Rat Acute Inhalation Toxicity; Endpoint=GHS Classification; Response=5; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP ICE acute inhalation | LC50 | 4.42 | mg/L | - | Inhalation | Duration=4 hr | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=2802; Record_ID=acute_inhalation_1665; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID5021332; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=4.42; Response_Unit=mg/L; Reference=NIOSH; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP ICE acute inhalation | LC50 | >5.13 | mg/L | - | Inhalation | - | In Vivo; AcuteInhal6pack; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=2803; Record_ID=acute_inhalation_343; Data_Type=In Vivo; Internal_Data_Source=AcuteInhal6pack; Formulation_ID=MIX430; Formulation_Name=Sativa IMX Max; Percent_Active_Ingredient=10.78; Mixture=Mixture; DTXSID=DTXSID5021332; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response_Modifier=>; Response=5.13; Response_Unit=mg/L; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP ICE acute inhalation | LC50 | 0.5 | mg/L | - | Inhalation | Duration=4 hr | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=2805; Record_ID=acute_inhalation_1185; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID5021332; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=0.5; Response_Unit=mg/L; Reference=ChemIDplus; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP ICE acute inhalation | LC50 | >2.54 | mg/L | - | Inhalation | - | In Vivo; AcuteInhal6pack; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=2806; Record_ID=acute_inhalation_400; Data_Type=In Vivo; Internal_Data_Source=AcuteInhal6pack; Formulation_ID=MIX494; Formulation_Name=Tital FL; Percent_Active_Ingredient=9.49; Mixture=Mixture; DTXSID=DTXSID5021332; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response_Modifier=>; Response=2.54; Response_Unit=mg/L; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP ICE acute inhalation | LC50 | 1.4 | mg/L | - | Inhalation | - | In Vivo; AcuteInhal6pack; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=2810; Record_ID=acute_inhalation_160; Data_Type=In Vivo; Internal_Data_Source=AcuteInhal6pack; Formulation_ID=MIX227; Formulation_Name=Foundation Lite; Percent_Active_Ingredient=6.8; Mixture=Mixture; DTXSID=DTXSID5021332; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=1.4; Response_Unit=mg/L; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP ICE acute inhalation | LC50 | 2.06 | mg/L | - | Inhalation | - | In Vivo; AcuteInhal6pack; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=2811; Record_ID=acute_inhalation_90; Data_Type=In Vivo; Internal_Data_Source=AcuteInhal6pack; Formulation_ID=MIX144; Formulation_Name=DeerPro Winter Animal Repellant; Percent_Active_Ingredient=25.8; Mixture=Mixture; DTXSID=DTXSID5021332; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=2.06; Response_Unit=mg/L; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
NTP ICE acute oral 12 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE acute oral | EPA classification | =3 | Unitless | Rat (Female) | oral | acute | Rat Acute Oral Toxicity | Studies submitted to EPA in support of pesticide registration applications (undated); record_id=acute_oral_12960; row=8591; data_type=In Vivo; mixture=Mixture; formulation_id=MIX430; formulation_name=Sativa IMX Max; chemical_name=Thiram; preferred_name=Bis(dimethylaminothiocarbonyl) disulfide; percent_active_ingredient=10.78; dtxsid=DTXSID5021332; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID5021332; source_file=acute_oral.xlsx |
| NTP ICE acute oral | EPA classification | =4 | Unitless | Rat (Male/Female) | oral | acute | Rat Acute Oral Toxicity | Studies submitted to EPA in support of pesticide registration applications (undated); record_id=acute_oral_12601; row=8587; data_type=In Vivo; mixture=Mixture; formulation_id=MIX227; formulation_name=Foundation Lite; chemical_name=Thiram; preferred_name=Bis(dimethylaminothiocarbonyl) disulfide; percent_active_ingredient=6.8; dtxsid=DTXSID5021332; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID5021332; source_file=acute_oral.xlsx |
| NTP ICE acute oral | EPA classification | =4 | Unitless | Rat (Female) | oral | acute | Rat Acute Oral Toxicity | Studies submitted to EPA in support of pesticide registration applications (undated); record_id=acute_oral_12457; row=8596; data_type=In Vivo; mixture=Mixture; formulation_id=MIX144; formulation_name=DeerPro Winter Animal Repellant; chemical_name=Thiram; preferred_name=Bis(dimethylaminothiocarbonyl) disulfide; percent_active_ingredient=25.8; dtxsid=DTXSID5021332; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID5021332; source_file=acute_oral.xlsx |
| NTP ICE acute oral | GHS classification | =5 | Unitless | Rat (Female) | oral | acute | Rat Acute Oral Toxicity | Studies submitted to EPA in support of pesticide registration applications (undated); record_id=acute_oral_12457; row=8604; data_type=In Vivo; mixture=Mixture; formulation_id=MIX144; formulation_name=DeerPro Winter Animal Repellant; chemical_name=Thiram; preferred_name=Bis(dimethylaminothiocarbonyl) disulfide; percent_active_ingredient=25.8; dtxsid=DTXSID5021332; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID5021332; source_file=acute_oral.xlsx |
| NTP ICE acute oral | GHS classification | =5 | Unitless | Rat (Male) | oral | acute | Rat Acute Oral Toxicity | Studies submitted to EPA in support of pesticide registration applications (undated); record_id=acute_oral_13030; row=8605; data_type=In Vivo; mixture=Mixture; formulation_id=MIX494; formulation_name=Tital FL; chemical_name=Thiram; preferred_name=Bis(dimethylaminothiocarbonyl) disulfide; percent_active_ingredient=9.49; dtxsid=DTXSID5021332; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID5021332; source_file=acute_oral.xlsx |
| NTP ICE acute oral | GHS classification | =5 | Unitless | Rat (Male/Female) | oral | acute | Rat Acute Oral Toxicity | Studies submitted to EPA in support of pesticide registration applications (undated); record_id=acute_oral_12601; row=8606; data_type=In Vivo; mixture=Mixture; formulation_id=MIX227; formulation_name=Foundation Lite; chemical_name=Thiram; preferred_name=Bis(dimethylaminothiocarbonyl) disulfide; percent_active_ingredient=6.8; dtxsid=DTXSID5021332; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID5021332; source_file=acute_oral.xlsx |
| NTP ICE acute oral | LD50 | =560 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_2410; row=8597; data_type=In Vivo; mixture=Chemical; chemical_name=Thiram; preferred_name=Bis(dimethylaminothiocarbonyl) disulfide; dtxsid=DTXSID5021332; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID5021332; source_file=acute_oral.xlsx |
| NTP ICE acute oral | LD50 | >1800 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | record_id=acute_oral_2412; row=8598; data_type=In Vivo; mixture=Chemical; chemical_name=Thiram; preferred_name=Bis(dimethylaminothiocarbonyl) disulfide; dtxsid=DTXSID5021332; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID5021332; source_file=acute_oral.xlsx |
| NTP ICE acute oral | LD50 | <2700 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | record_id=acute_oral_2414; row=8599; data_type=In Vivo; mixture=Chemical; chemical_name=Thiram; preferred_name=Bis(dimethylaminothiocarbonyl) disulfide; dtxsid=DTXSID5021332; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID5021332; source_file=acute_oral.xlsx |
| NTP ICE acute oral | LD50 | =3129 | mg/kg bw | Rat (Female) | oral | acute | Rat Acute Oral Toxicity | Studies submitted to EPA in support of pesticide registration applications (undated); record_id=acute_oral_12960; row=8585; data_type=In Vivo; mixture=Mixture; formulation_id=MIX430; formulation_name=Sativa IMX Max; chemical_name=Thiram; preferred_name=Bis(dimethylaminothiocarbonyl) disulfide; percent_active_ingredient=10.78; dtxsid=DTXSID5021332; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID5021332; source_file=acute_oral.xlsx |
| NTP ICE acute oral | LD50 | >5000 | mg/kg bw | Rat (Female) | oral | acute | Rat Acute Oral Toxicity | Studies submitted to EPA in support of pesticide registration applications (undated); record_id=acute_oral_12457; row=8586; data_type=In Vivo; mixture=Mixture; formulation_id=MIX144; formulation_name=DeerPro Winter Animal Repellant; chemical_name=Thiram; preferred_name=Bis(dimethylaminothiocarbonyl) disulfide; percent_active_ingredient=25.8; dtxsid=DTXSID5021332; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID5021332; source_file=acute_oral.xlsx |
| NTP ICE acute oral | LD50 | >5000 | mg/kg bw | Rat (Male) | oral | acute | Rat Acute Oral Toxicity | Studies submitted to EPA in support of pesticide registration applications (undated); record_id=acute_oral_12605; row=8590; data_type=In Vivo; mixture=Mixture; formulation_id=MIX227; formulation_name=Foundation Lite; chemical_name=Thiram; preferred_name=Bis(dimethylaminothiocarbonyl) disulfide; percent_active_ingredient=6.8; dtxsid=DTXSID5021332; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID5021332; source_file=acute_oral.xlsx |
NTP ICE adme parameters 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE adme parameters | Clint | 816 | uL/min/10^6 cells | Human | - | - | Measured; httk, Human Hepatic Intrinsic Clearance | sheet=Data; excel_row=1969; Record_ID=adme_parameters_1093; Data_Type=Measured; DTXSID=DTXSID5021332; Assay=httk, Human Hepatic Intrinsic Clearance; Endpoint=Clint; Response=816.0; Response_Unit=ul/min/10^6 cells; Species=Human; Reference=httk2.3.1, Wambaugh 2019; URL=https://cran.r-project.org/web/packages/httk/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP ICE adme parameters | Fu | 3.86e-8 | fraction | Human | - | - | Measured; httk, Human Plasma Fraction Unbound | sheet=Data; excel_row=1968; Record_ID=adme_parameters_1093; Data_Type=Measured; DTXSID=DTXSID5021332; Assay=httk, Human Plasma Fraction Unbound; Endpoint=Fu; Response=3.86e-08; Response_Unit=Unitless Fraction; Species=Human; Reference=httk2.3.1, Wambaugh 2019; URL=https://cran.r-project.org/web/packages/httk/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
NTP ICE cancer 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE cancer | IARC group | 3 | unitless | - | - | - | WOE; IARC Carcinogenicity | sheet=Data; excel_row=5698; Record_ID=cancer_6778; Data_Type=WOE; Formulation_Name=Thiram; Mixture=Chemical; DTXSID=DTXSID5021332; Assay=IARC Carcinogenicity; Endpoint=IARC group; Response=3; Response_Unit=Unitless; URL=http://publications.iarc.fr/139; http://publications.iarc.fr/71; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
NTP ICE dart 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE dart | LOEL | 7.5 | mg/kg bw/day | Rat | Oral | - | In Vivo; DART, In life observation | sheet=Data; excel_row=78621; Record_ID=dart_17126; Data_Type=In Vivo; DTXSID=DTXSID5021332; Assay=DART, In life observation; Endpoint=LOEL; Response=7.5; Response_Unit=mg/kg/day; Species=Rat; Strain=Sprague Dawley (CD); Sex=Female; Life_Stage=Adult; Route=Oral; Critical_Effect=Yes; Unified_Medical_Language_System=UMLS;C0005910;CUI;Body Weight|UMLS;C3540840;CUI;Sign or Symptom|UMLS;C0043094;CUI;Weight Gain; Reference=ToxRefDB v2 , ID = 3546; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP ICE dart | LOEL | 15 | mg/kg bw/day | Rat | Oral | - | In Vivo; DART, Developmental malformation | sheet=Data; excel_row=78625; Record_ID=dart_17207; Data_Type=In Vivo; DTXSID=DTXSID5021332; Assay=DART, Developmental malformation; Endpoint=LOEL; Response=15; Response_Unit=mg/kg/day; Species=Rat; Strain=Sprague Dawley (CD); Sex=Male/Female; Life_Stage=Fetal; Route=Oral; Critical_Effect=Yes; Unified_Medical_Language_System=UMLS;C0000768;CUI;Congenital Abnormality|UMLS;C0265509;CUI;Congenital anomaly of skeletal bone|UMLS;C1282719;CUI;Incomplete ossification; Reference=ToxRefDB v2 , ID = 3546; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
NTP ICE endocrine 7 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE endocrine | AC50 | 15.8495315173844 | uM | - | - | - | ERPathway2016; ER Pathway Model, Antagonist | sheet=Integrated_approaches; excel_row=5634; RecordID=ERPathway2016_442; DatasetName=ERPathway2016; DTXSID=DTXSID5021332; Assay=ER Pathway Model, Antagonist; Endpoint=AC50; Response=15.8495315173844; Response_Unit=uM; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP ICE endocrine | AC50 | 25.92490805 | uM | - | - | - | ARPathway2016; AR Pathway Model, Agonist | sheet=Integrated_approaches; excel_row=5628; RecordID=ARPathway2016_70; DatasetName=ARPathway2016; DTXSID=DTXSID5021332; Assay=AR Pathway Model, Agonist; Endpoint=AC50; Response=25.92490805; Response_Unit=uM; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP ICE endocrine | ACC | 1.69650633256529 | uM | - | - | - | ARPathway2016; AR Pathway Model, Agonist | sheet=Integrated_approaches; excel_row=5629; RecordID=ARPathway2016_70; DatasetName=ARPathway2016; DTXSID=DTXSID5021332; Assay=AR Pathway Model, Agonist; Endpoint=ACC; Response=1.69650633256529; Response_Unit=uM; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP ICE endocrine | ACC | 13.9488404367794 | uM | - | - | - | ERPathway2016; ER Pathway Model, Antagonist | sheet=Integrated_approaches; excel_row=5635; RecordID=ERPathway2016_442; DatasetName=ERPathway2016; DTXSID=DTXSID5021332; Assay=ER Pathway Model, Antagonist; Endpoint=ACC; Response=13.9488404367794; Response_Unit=uM; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP ICE endocrine | Model Score | 0 | unitless | - | - | - | ARPathway2016; AR Pathway Model, Agonist | sheet=Integrated_approaches; excel_row=5631; RecordID=ARPathway2016_70; DatasetName=ARPathway2016; DTXSID=DTXSID5021332; Assay=AR Pathway Model, Agonist; Endpoint=Model Score; Response=0; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP ICE endocrine | Model Score | 0.00506 | unitless | - | - | - | ERPathway2016; ER Pathway Model, Agonist | sheet=Integrated_approaches; excel_row=5636; RecordID=ERPathway2016_442; DatasetName=ERPathway2016; DTXSID=DTXSID5021332; Assay=ER Pathway Model, Agonist; Endpoint=Model Score; Response=0.00506; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP ICE endocrine | Model Score | 0.0731 | unitless | - | - | - | ARPathway2016; AR Pathway Model, Antagonist | sheet=Integrated_approaches; excel_row=5630; RecordID=ARPathway2016_70; DatasetName=ARPathway2016; DTXSID=DTXSID5021332; Assay=AR Pathway Model, Antagonist; Endpoint=Model Score; Response=0.0731; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
NTP ICE eye irritation 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE eye irritation | EPA Classification | 3 | unitless | Rabbit | Ocular | - | In Vivo; Draize Eye Irritation/Corrosion Test | sheet=Data; excel_row=1493; Record_ID=eye_irritation_626; Data_Type=In Vivo; Formulation_ID=EyeIrritation6pack_PID475; Formulation_Name=Foundation Lite; Percent_Active_Ingredient=6.8; Mixture=Mixture; DTXSID=DTXSID5021332; Assay=Draize Eye Irritation/Corrosion Test; Endpoint=EPA Classification; Response=3; Response_Unit=Unitless; Species=Rabbit; Reference=FIFRA data; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP ICE eye irritation | EPA Classification | 4 | unitless | Rabbit | Ocular | - | In Vivo; Draize Eye Irritation/Corrosion Test | sheet=Data; excel_row=1490; Record_ID=eye_irritation_481; Data_Type=In Vivo; Formulation_ID=EyeIrritation6pack_PID303; Formulation_Name=DeerPro Winter Animal Repellant; Percent_Active_Ingredient=25.8; Mixture=Mixture; DTXSID=DTXSID5021332; Assay=Draize Eye Irritation/Corrosion Test; Endpoint=EPA Classification; Response=4; Response_Unit=Unitless; Species=Rabbit; Reference=FIFRA data; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
NTP ICE skin irritation 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE skin irritation | EPA classification | 4 | unitless | Rabbit | Dermal | - | In Vivo; Draize Skin Irritation/Corrosion Test | sheet=Data_invivo; excel_row=1011; Record_ID=skin_irritation_invivo_1316; Data_Type=In Vivo; Formulation_ID=MIX227; Formulation_Name=Foundation Lite; Percent_Active_Ingredient=6.8; Mixture=Mixture; DTXSID=DTXSID5021332; Assay=Draize Skin Irritation/Corrosion Test; Endpoint=EPA classification; Response=4; Response_Unit=Unitless; Species=Rabbit; Reported_Strain=New Zealand white; Strain=New Zealand White; Reference=FIFRA (undated); URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP ICE skin irritation | EPA classification | 3 | unitless | Rabbit | Dermal | - | In Vivo; Draize Skin Irritation/Corrosion Test | sheet=Data_invivo; excel_row=1013; Record_ID=skin_irritation_invivo_435; Data_Type=In Vivo; Formulation_ID=MIX430; Formulation_Name=Sativa IMX Max; Percent_Active_Ingredient=10.78; Mixture=Mixture; DTXSID=DTXSID5021332; Assay=Draize Skin Irritation/Corrosion Test; Endpoint=EPA classification; Response=3; Response_Unit=Unitless; Species=Rabbit; Reference=FIFRA (undated); URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
NTP ICE skin sensitization 120 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE skin sensitization | CD54, EC200 | 0.1 | ug/mL | - | Dermal | - | In Vitro; hCLAT2015; h-CLAT | sheet=Data_invitro; excel_row=3344; Record_ID=skin_sensitization_invitro_775; Data_Type=In Vitro; Internal_Data_Source=hCLAT2015; Mixture=Chemical; DTXSID=DTXSID5021332; Assay=h-CLAT; Endpoint=CD54, EC200; Reported_Response=0.1; Reported_Response_Unit=ug/mL; Response=0.1; Response_Unit=ug/mL; Reference=Sakaguchi et al. 2010; 20510347; 10.1016/j.tiv.2010.05.012|h-CLAT RingTrial EC values for NICEATM (undated); URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP ICE skin sensitization | CD54, EC200 | 2.46 | ug/mL | - | Dermal | - | In Vitro; hCLAT2015; h-CLAT | sheet=Data_invitro; excel_row=3313; Record_ID=skin_sensitization_invitro_769; Data_Type=In Vitro; Internal_Data_Source=hCLAT2015; Mixture=Chemical; DTXSID=DTXSID5021332; Assay=h-CLAT; Endpoint=CD54, EC200; Reported_Response=2.46; Reported_Response_Unit=ug/mL; Response=2.46; Response_Unit=ug/mL; Reference=Ashikaga et al. 2010; 20822320; 10.1177/026119291003800403|Nukada et al. 2011; 21767275; 10.1111/j.1600-0536.2011.01952.x|Nukada et al. 2012; 22796097; 10.1016/j.tiv.2012.07.001|Nukada personal communication (undated)|Nukada et al. 2013; 23149339; 10.1016/j.tiv.2012.11.006; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP ICE skin sensitization | CD54, EC200 | 2.7 | ug/mL | - | Dermal | - | In Vitro; CE_hCLAT2018; h-CLAT | sheet=Data_invitro; excel_row=2174; Record_ID=skin_sensitization_invitro_537; Data_Type=In Vitro; Internal_Data_Source=CE_hCLAT2018; Mixture=Chemical; DTXSID=DTXSID5021332; Assay=h-CLAT; Endpoint=CD54, EC200; Reported_Response=2.7; Reported_Response_Unit=ug/mL; Response=2.7; Response_Unit=ug/mL; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP ICE skin sensitization | CD54, EC200 | 3 | ug/mL | - | Dermal | - | In Vitro; hCLAT2015; h-CLAT | sheet=Data_invitro; excel_row=3354; Record_ID=skin_sensitization_invitro_777; Data_Type=In Vitro; Internal_Data_Source=hCLAT2015; Mixture=Chemical; DTXSID=DTXSID5021332; Assay=h-CLAT; Endpoint=CD54, EC200; Reported_Response=3; Reported_Response_Unit=ug/mL; Response=3; Response_Unit=ug/mL; Reference=Sakaguchi et al. 2010; 20510347; 10.1016/j.tiv.2010.05.012|h-CLAT RingTrial EC values for NICEATM (undated); URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP ICE skin sensitization | CD54, EC200 | 3.9 | ug/mL | - | Dermal | - | In Vitro; hCLAT2015; h-CLAT | sheet=Data_invitro; excel_row=3324; Record_ID=skin_sensitization_invitro_771; Data_Type=In Vitro; Internal_Data_Source=hCLAT2015; Mixture=Chemical; DTXSID=DTXSID5021332; Assay=h-CLAT; Endpoint=CD54, EC200; Reported_Response=3.9; Reported_Response_Unit=ug/mL; Response=3.9; Response_Unit=ug/mL; Reference=Sakaguchi et al. 2010; 20510347; 10.1016/j.tiv.2010.05.012|h-CLAT RingTrial EC values for NICEATM (undated); URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP ICE skin sensitization | CD54, EC200 | 5.2 | ug/mL | - | Dermal | - | In Vitro; hCLAT2015; h-CLAT | sheet=Data_invitro; excel_row=3334; Record_ID=skin_sensitization_invitro_773; Data_Type=In Vitro; Internal_Data_Source=hCLAT2015; Mixture=Chemical; DTXSID=DTXSID5021332; Assay=h-CLAT; Endpoint=CD54, EC200; Reported_Response=5.2; Reported_Response_Unit=ug/mL; Response=5.2; Response_Unit=ug/mL; Reference=Sakaguchi et al. 2010; 20510347; 10.1016/j.tiv.2010.05.012|h-CLAT RingTrial EC values for NICEATM (undated); URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP ICE skin sensitization | CD86, EC150 | 0.06 | ug/mL | - | Dermal | - | In Vitro; Urbisch_SkinSensitization2020; U-SENS | sheet=Data_invitro; excel_row=8245; Record_ID=skin_sensitization_invitro_2268; Data_Type=In Vitro; Internal_Data_Source=Urbisch_SkinSensitization2020; Mixture=Chemical; DTXSID=DTXSID5021332; Assay=U-SENS; Endpoint=CD86, EC150; Reported_Response=0.249543543; Reported_Response_Unit=uM; Conversion_Factor_Value=240.42; Conversion_Factor_Source=EPA Dashboard; Converted_Response=0.06; Converted_Response_Unit=ug/mL; Response=0.06; Response_Unit=ug/mL; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP ICE skin sensitization | CD86, EC150 | <0.1 | ug/mL | - | Dermal | - | In Vitro; CE_USENSE2018; U-SENS | sheet=Data_invitro; excel_row=8480; Record_ID=skin_sensitization_invitro_2336; Data_Type=In Vitro; Internal_Data_Source=CE_USENSE2018; Mixture=Chemical; DTXSID=DTXSID5021332; Assay=U-SENS; Endpoint=CD86, EC150; Response_Modifier=<; Reported_Response_Modifier=<; Reported_Response=0.1; Reported_Response_Unit=ug/mL; Response=0.1; Response_Unit=ug/mL; Reference=Piroird et al. 2015; 25820135; 10.1016/j.tiv.2015.03.009; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP ICE skin sensitization | CD86, EC150 | 3.8 | ug/mL | - | Dermal | - | In Vitro; hCLAT2015; h-CLAT | sheet=Data_invitro; excel_row=3355; Record_ID=skin_sensitization_invitro_777; Data_Type=In Vitro; Internal_Data_Source=hCLAT2015; Mixture=Chemical; DTXSID=DTXSID5021332; Assay=h-CLAT; Endpoint=CD86, EC150; Reported_Response=3.8; Reported_Response_Unit=ug/mL; Response=3.8; Response_Unit=ug/mL; Reference=Sakaguchi et al. 2010; 20510347; 10.1016/j.tiv.2010.05.012|h-CLAT RingTrial EC values for NICEATM (undated); URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP ICE skin sensitization | CD86, EC150 | 8.1 | ug/mL | - | Dermal | - | In Vitro; hCLAT2015; h-CLAT | sheet=Data_invitro; excel_row=3326; Record_ID=skin_sensitization_invitro_771; Data_Type=In Vitro; Internal_Data_Source=hCLAT2015; Mixture=Chemical; DTXSID=DTXSID5021332; Assay=h-CLAT; Endpoint=CD86, EC150; Reported_Response=8.1; Reported_Response_Unit=ug/mL; Response=8.1; Response_Unit=ug/mL; Reference=Sakaguchi et al. 2010; 20510347; 10.1016/j.tiv.2010.05.012|h-CLAT RingTrial EC values for NICEATM (undated); URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP ICE skin sensitization | CD86, EC150 | <8.9 | ug/mL | - | Dermal | - | In Vitro; hCLAT2015; h-CLAT | sheet=Data_invitro; excel_row=3346; Record_ID=skin_sensitization_invitro_775; Data_Type=In Vitro; Internal_Data_Source=hCLAT2015; Mixture=Chemical; DTXSID=DTXSID5021332; Assay=h-CLAT; Endpoint=CD86, EC150; Response_Modifier=<; Reported_Response_Modifier=<; Reported_Response=8.9; Reported_Response_Unit=ug/mL; Response=8.9; Response_Unit=ug/mL; Reference=Sakaguchi et al. 2010; 20510347; 10.1016/j.tiv.2010.05.012|h-CLAT RingTrial EC values for NICEATM (undated); URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP ICE skin sensitization | CD86, EC150 | 9.11 | ug/mL | - | Dermal | - | In Vitro; CE_hCLAT2018; h-CLAT | sheet=Data_invitro; excel_row=2176; Record_ID=skin_sensitization_invitro_537; Data_Type=In Vitro; Internal_Data_Source=CE_hCLAT2018; Mixture=Chemical; DTXSID=DTXSID5021332; Assay=h-CLAT; Endpoint=CD86, EC150; Reported_Response=9.11; Reported_Response_Unit=ug/mL; Response=9.11; Response_Unit=ug/mL; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP ICE skin sensitization | CD86, EC150 | 14.6 | ug/mL | - | Dermal | - | In Vitro; hCLAT2015; h-CLAT | sheet=Data_invitro; excel_row=3335; Record_ID=skin_sensitization_invitro_773; Data_Type=In Vitro; Internal_Data_Source=hCLAT2015; Mixture=Chemical; DTXSID=DTXSID5021332; Assay=h-CLAT; Endpoint=CD86, EC150; Reported_Response=14.6; Reported_Response_Unit=ug/mL; Response=14.6; Response_Unit=ug/mL; Reference=Sakaguchi et al. 2010; 20510347; 10.1016/j.tiv.2010.05.012|h-CLAT RingTrial EC values for NICEATM (undated); URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP ICE skin sensitization | CV70 | 3.06 | ug/mL | - | Dermal | - | In Vitro; CE_USENSE2018; U-SENS | sheet=Data_invitro; excel_row=8481; Record_ID=skin_sensitization_invitro_2336; Data_Type=In Vitro; Internal_Data_Source=CE_USENSE2018; Mixture=Chemical; DTXSID=DTXSID5021332; Assay=U-SENS; Endpoint=CV70; Reported_Response=3.06; Reported_Response_Unit=ug/mL; Response=3.06; Response_Unit=ug/mL; Reference=Piroird et al. 2015; 25820135; 10.1016/j.tiv.2015.03.009; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP ICE skin sensitization | CV75 | 8.2 | ug/mL | - | Dermal | - | In Vitro; hCLAT2015; h-CLAT | sheet=Data_invitro; excel_row=3328; Record_ID=skin_sensitization_invitro_771; Data_Type=In Vitro; Internal_Data_Source=hCLAT2015; Mixture=Chemical; DTXSID=DTXSID5021332; Assay=h-CLAT; Endpoint=CV75; Reported_Response=8.1999999999999904; Reported_Response_Unit=ug/mL; Response=8.2; Response_Unit=ug/mL; Reference=Sakaguchi et al. 2010; 20510347; 10.1016/j.tiv.2010.05.012|h-CLAT RingTrial EC values for NICEATM (undated); URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP ICE skin sensitization | CV75 | 10 | ug/mL | - | Dermal | - | In Vitro; CE_hCLAT2018; h-CLAT | sheet=Data_invitro; excel_row=2178; Record_ID=skin_sensitization_invitro_537; Data_Type=In Vitro; Internal_Data_Source=CE_hCLAT2018; Mixture=Chemical; DTXSID=DTXSID5021332; Assay=h-CLAT; Endpoint=CV75; Reported_Response=10; Reported_Response_Unit=ug/mL; Response=10; Response_Unit=ug/mL; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP ICE skin sensitization | CV75 | 11.5 | ug/mL | - | Dermal | - | In Vitro; hCLAT2015; h-CLAT | sheet=Data_invitro; excel_row=3356; Record_ID=skin_sensitization_invitro_777; Data_Type=In Vitro; Internal_Data_Source=hCLAT2015; Mixture=Chemical; DTXSID=DTXSID5021332; Assay=h-CLAT; Endpoint=CV75; Reported_Response=11.5; Reported_Response_Unit=ug/mL; Response=11.5; Response_Unit=ug/mL; Reference=Sakaguchi et al. 2010; 20510347; 10.1016/j.tiv.2010.05.012|h-CLAT RingTrial EC values for NICEATM (undated); URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP ICE skin sensitization | CV75 | 14.7 | ug/mL | - | Dermal | - | In Vitro; hCLAT2015; h-CLAT | sheet=Data_invitro; excel_row=3337; Record_ID=skin_sensitization_invitro_773; Data_Type=In Vitro; Internal_Data_Source=hCLAT2015; Mixture=Chemical; DTXSID=DTXSID5021332; Assay=h-CLAT; Endpoint=CV75; Reported_Response=14.7; Reported_Response_Unit=ug/mL; Response=14.7; Response_Unit=ug/mL; Reference=Sakaguchi et al. 2010; 20510347; 10.1016/j.tiv.2010.05.012|h-CLAT RingTrial EC values for NICEATM (undated); URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP ICE skin sensitization | CV75 | 26.7 | ug/mL | - | Dermal | - | In Vitro; hCLAT2015; h-CLAT | sheet=Data_invitro; excel_row=3345; Record_ID=skin_sensitization_invitro_775; Data_Type=In Vitro; Internal_Data_Source=hCLAT2015; Mixture=Chemical; DTXSID=DTXSID5021332; Assay=h-CLAT; Endpoint=CV75; Reported_Response=26.7; Reported_Response_Unit=ug/mL; Response=26.7; Response_Unit=ug/mL; Reference=Sakaguchi et al. 2010; 20510347; 10.1016/j.tiv.2010.05.012|h-CLAT RingTrial EC values for NICEATM (undated); URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP ICE skin sensitization | Concentration, 5% incidence of positive responses | 1.5 | % | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Maximization Test | sheet=Data_invivo; excel_row=4908; Record_ID=skin_sensitization_invivo_1172; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=10.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID5021332; Assay=Human Maximization Test; Endpoint=Concentration, 5% incidence of positive responses; Response=1.5; Response_Unit=%; Species=Human; Route=Dermal; Reference=Kligman 1966; 5924293; 10.1038/jid.1966.159; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP ICE skin sensitization | Concentration, 5% incidence of positive responses | 5.5 | % | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Maximization Test | sheet=Data_invivo; excel_row=4895; Record_ID=skin_sensitization_invivo_1171; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=10.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID5021332; Assay=Human Maximization Test; Endpoint=Concentration, 5% incidence of positive responses; Response=5.5; Response_Unit=%; Species=Human; Route=Dermal; Reference=Kligman 1966; 5924293; 10.1038/jid.1966.159|Akkan et al. 2003; Not available; Not available|Schneider and Akkan 2004; 15135206; 10.1016/j.yrtph.2004.02.002; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP ICE skin sensitization | Concentration, 5% incidence of positive responses | 6.875 | % | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Maximization Test | sheet=Data_invivo; excel_row=4937; Record_ID=skin_sensitization_invivo_1177; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=25.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID5021332; Assay=Human Maximization Test; Endpoint=Concentration, 5% incidence of positive responses; Response=6.875; Response_Unit=%; Species=Human; Route=Dermal; Reference=Kligman 1966; 5924294; 10.1038/jid.1966.160; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP ICE skin sensitization | Concentration, 5% incidence of positive responses | 7.8125 | % | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Maximization Test | sheet=Data_invivo; excel_row=4923; Record_ID=skin_sensitization_invivo_1175; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=25.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID5021332; Assay=Human Maximization Test; Endpoint=Concentration, 5% incidence of positive responses; Response=7.8125; Response_Unit=%; Species=Human; Route=Dermal; Reference=Kligman 1966; 5924294; 10.1038/jid.1966.160|Marzulli and Maibach 1976; 801606; 10.1111/j.1600-0536.1976.tb02972.x|Basketter et al. 1996; 9012774; 10.1016/s0278-6915(96)00059-2|Gerberick et al. 2000; 10684384; 10.1053/ajcd.2000.0003|Akkan et al. 2003; Not available; Not available|Griem et al. 2003; 14623479; 10.1016/j.yrtph.2003.07.001|Schneider and Akkan 2004; 15135206; 10.1016/j.yrtph.2004.02.002; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP ICE skin sensitization | Concentration, 5% incidence of positive responses | 28.75 | % | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Maximization Test | sheet=Data_invivo; excel_row=4954; Record_ID=skin_sensitization_invivo_1176; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=25.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID5021332; Assay=Human Maximization Test; Endpoint=Concentration, 5% incidence of positive responses; Response=28.75; Response_Unit=%; Species=Human; Route=Dermal; Reference=Kligman 1966; 5924294; 10.1038/jid.1966.160; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP ICE skin sensitization | Concentration, 5% incidence of positive responses | 31.25 | % | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Maximization Test | sheet=Data_invivo; excel_row=4940; Record_ID=skin_sensitization_invivo_1178; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=25.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID5021332; Assay=Human Maximization Test; Endpoint=Concentration, 5% incidence of positive responses; Response=31.25; Response_Unit=%; Species=Human; Route=Dermal; Reference=Kligman 1966; 5924294; 10.1038/jid.1966.160; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP ICE skin sensitization | Concentration, one positive response | 1.667 | % | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Maximization Test | sheet=Data_invivo; excel_row=4904; Record_ID=skin_sensitization_invivo_1172; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=10.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID5021332; Assay=Human Maximization Test; Endpoint=Concentration, one positive response; Response=1.667; Response_Unit=%; Species=Human; Route=Dermal; Reference=Kligman 1966; 5924293; 10.1038/jid.1966.159; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP ICE skin sensitization | Concentration, one positive response | 5 | % | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Maximization Test | sheet=Data_invivo; excel_row=4893; Record_ID=skin_sensitization_invivo_1171; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=10.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID5021332; Assay=Human Maximization Test; Endpoint=Concentration, one positive response; Response=5; Response_Unit=%; Species=Human; Route=Dermal; Reference=Kligman 1966; 5924293; 10.1038/jid.1966.159|Akkan et al. 2003; Not available; Not available|Schneider and Akkan 2004; 15135206; 10.1016/j.yrtph.2004.02.002; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP ICE skin sensitization | Concentration, one positive response | 6.25 | % | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Maximization Test | sheet=Data_invivo; excel_row=4920; Record_ID=skin_sensitization_invivo_1175; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=25.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID5021332; Assay=Human Maximization Test; Endpoint=Concentration, one positive response; Response=6.25; Response_Unit=%; Species=Human; Route=Dermal; Reference=Kligman 1966; 5924294; 10.1038/jid.1966.160|Marzulli and Maibach 1976; 801606; 10.1111/j.1600-0536.1976.tb02972.x|Basketter et al. 1996; 9012774; 10.1016/s0278-6915(96)00059-2|Gerberick et al. 2000; 10684384; 10.1053/ajcd.2000.0003|Akkan et al. 2003; Not available; Not available|Griem et al. 2003; 14623479; 10.1016/j.yrtph.2003.07.001|Schneider and Akkan 2004; 15135206; 10.1016/j.yrtph.2004.02.002; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP ICE skin sensitization | Concentration, one positive response | 25 | % | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Maximization Test | sheet=Data_invivo; excel_row=4936; Record_ID=skin_sensitization_invivo_1178; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=25.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID5021332; Assay=Human Maximization Test; Endpoint=Concentration, one positive response; Response=25; Response_Unit=%; Species=Human; Route=Dermal; Reference=Kligman 1966; 5924294; 10.1038/jid.1966.160; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP ICE skin sensitization | Depletion Cys | 99.5 | % | - | Dermal | - | In Vitro; DPRA2015; DPRA | sheet=Data_invitro; excel_row=1164; Record_ID=skin_sensitization_invitro_315; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID5021332; Assay=DPRA; Endpoint=Depletion Cys; Reported_Response=99.5; Reported_Response_Unit=%; Response=99.5; Response_Unit=%; Reference=Jaworska 2011; 23670904; 10.1002/jat.2869|Natsch et al. 2013; 23576290; 10.1002/jat.2868; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP ICE skin sensitization | Depletion Cys | 100 | % | - | Dermal | - | In Vitro; DPRA2015; DPRA | sheet=Data_invitro; excel_row=1174; Record_ID=skin_sensitization_invitro_317; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID5021332; Assay=DPRA; Endpoint=Depletion Cys; Reported_Response=100; Reported_Response_Unit=%; Response=100; Response_Unit=%; Reference=Nukada et al. 2013; 23149339; 10.1016/j.tiv.2012.11.006|Nukada personal communication (undated); URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP ICE skin sensitization | Depletion Lys | 1.6 | % | - | Dermal | - | In Vitro; DPRA2015; DPRA | sheet=Data_invitro; excel_row=1172; Record_ID=skin_sensitization_invitro_317; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID5021332; Assay=DPRA; Endpoint=Depletion Lys; Reported_Response=1.6; Reported_Response_Unit=%; Response=1.6; Response_Unit=%; Reference=Nukada et al. 2013; 23149339; 10.1016/j.tiv.2012.11.006|Nukada personal communication (undated); URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP ICE skin sensitization | Depletion Lys | 6.9 | % | - | Dermal | - | In Vitro; DPRA2015; DPRA | sheet=Data_invitro; excel_row=1163; Record_ID=skin_sensitization_invitro_315; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID5021332; Assay=DPRA; Endpoint=Depletion Lys; Reported_Response=6.9; Reported_Response_Unit=%; Response=6.9; Response_Unit=%; Reference=Jaworska 2011; 23670904; 10.1002/jat.2869|Natsch et al. 2013; 23576290; 10.1002/jat.2868; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP ICE skin sensitization | Depletion Lys + Cys | 51 | % | - | Dermal | - | In Vitro; DPRA2015; DPRA | sheet=Data_invitro; excel_row=1176; Record_ID=skin_sensitization_invitro_317; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID5021332; Assay=DPRA; Endpoint=Depletion Lys + Cys; Reported_Response=51; Reported_Response_Unit=%; Response=51; Response_Unit=%; Reference=Nukada et al. 2013; 23149339; 10.1016/j.tiv.2012.11.006|Nukada personal communication (undated); URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP ICE skin sensitization | Depletion Lys + Cys | 53.2 | % | - | Dermal | - | In Vitro; DPRA2015; DPRA | sheet=Data_invitro; excel_row=1168; Record_ID=skin_sensitization_invitro_315; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID5021332; Assay=DPRA; Endpoint=Depletion Lys + Cys; Reported_Response=53.2; Reported_Response_Unit=%; Response=53.2; Response_Unit=%; Reference=Jaworska 2011; 23670904; 10.1002/jat.2869|Natsch et al. 2013; 23576290; 10.1002/jat.2868; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP ICE skin sensitization | EC1.5 | 0.8 | uM | - | Dermal | - | In Vitro; KeratinoSens2015; KeratinoSens | sheet=Data_invitro; excel_row=5117; Record_ID=skin_sensitization_invitro_1187; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID5021332; Assay=KeratinoSens; Endpoint=EC1.5; Reported_Response=0.8; Reported_Response_Unit=uM; Response=0.8; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP ICE skin sensitization | EC1.5 | 0.827 | uM | - | Dermal | - | In Vitro; CE_KeratinoSense2018; KeratinoSens | sheet=Data_invitro; excel_row=5030; Record_ID=skin_sensitization_invitro_1163; Data_Type=In Vitro; Internal_Data_Source=CE_KeratinoSense2018; Mixture=Chemical; DTXSID=DTXSID5021332; Assay=KeratinoSens; Endpoint=EC1.5; Reported_Response=0.82699999999999996; Reported_Response_Unit=uM; Response=0.827; Response_Unit=uM; Reference=Emter et al. 2010; 20307559; 10.1016/j.taap.2010.03.009|Natsch et al. 2013; 23576290; 10.1002/jat.2868; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP ICE skin sensitization | EC1.5 | 0.89 | uM | - | Dermal | - | In Vitro; KeratinoSens2015; KeratinoSens | sheet=Data_invitro; excel_row=5031; Record_ID=skin_sensitization_invitro_1164; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID5021332; Assay=KeratinoSens; Endpoint=EC1.5; Reported_Response=0.89; Reported_Response_Unit=uM; Response=0.89; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP ICE skin sensitization | EC1.5 | 0.9 | uM | - | Dermal | - | In Vitro; KeratinoSens2015; KeratinoSens | sheet=Data_invitro; excel_row=5032; Record_ID=skin_sensitization_invitro_1165; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID5021332; Assay=KeratinoSens; Endpoint=EC1.5; Reported_Response=0.9; Reported_Response_Unit=uM; Response=0.9; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP ICE skin sensitization | EC1.5 | <0.97 | uM | - | Dermal | - | In Vitro; KeratinoSens2015; KeratinoSens | sheet=Data_invitro; excel_row=5033; Record_ID=skin_sensitization_invitro_1166; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID5021332; Assay=KeratinoSens; Endpoint=EC1.5; Response_Modifier=<; Reported_Response_Modifier=<; Reported_Response=0.97; Reported_Response_Unit=uM; Response=0.97; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP ICE skin sensitization | EC1.5 | <0.98 | uM | - | Dermal | - | In Vitro; KeratinoSens2015; KeratinoSens | sheet=Data_invitro; excel_row=5036; Record_ID=skin_sensitization_invitro_1169; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID5021332; Assay=KeratinoSens; Endpoint=EC1.5; Response_Modifier=<; Reported_Response_Modifier=<; Reported_Response=0.98; Reported_Response_Unit=uM; Response=0.98; Response_Unit=uM; Reference=Natsch et al. 2011; 22023385; 10.1021/tx2003678; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP ICE skin sensitization | EC1.5 | 1.6 | uM | - | Dermal | - | In Vitro; KeratinoSens2015; KeratinoSens | sheet=Data_invitro; excel_row=5043; Record_ID=skin_sensitization_invitro_1176; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID5021332; Assay=KeratinoSens; Endpoint=EC1.5; Reported_Response=1.6; Reported_Response_Unit=uM; Response=1.6; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP ICE skin sensitization | EC1.5 | 1.9 | uM | - | Dermal | - | In Vitro; KeratinoSens2015; KeratinoSens | sheet=Data_invitro; excel_row=5044; Record_ID=skin_sensitization_invitro_1177; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID5021332; Assay=KeratinoSens; Endpoint=EC1.5; Reported_Response=1.9; Reported_Response_Unit=uM; Response=1.9; Response_Unit=uM; Reference=Natsch et al. 2011; 22023385; 10.1021/tx2003678; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP ICE skin sensitization | EC1.5 | 2.33 | uM | - | Dermal | - | In Vitro; KeratinoSens2015; KeratinoSens | sheet=Data_invitro; excel_row=5045; Record_ID=skin_sensitization_invitro_1178; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID5021332; Assay=KeratinoSens; Endpoint=EC1.5; Reported_Response=2.33; Reported_Response_Unit=uM; Response=2.33; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP ICE skin sensitization | EC1.5 | 3.11 | uM | - | Dermal | - | In Vitro; KeratinoSens2015; KeratinoSens | sheet=Data_invitro; excel_row=5046; Record_ID=skin_sensitization_invitro_1179; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID5021332; Assay=KeratinoSens; Endpoint=EC1.5; Reported_Response=3.11; Reported_Response_Unit=uM; Response=3.11; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP ICE skin sensitization | EC1.5 | 3.32 | uM | - | Dermal | - | In Vitro; KeratinoSens2015; KeratinoSens | sheet=Data_invitro; excel_row=5047; Record_ID=skin_sensitization_invitro_1180; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID5021332; Assay=KeratinoSens; Endpoint=EC1.5; Reported_Response=3.32; Reported_Response_Unit=uM; Response=3.32; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP ICE skin sensitization | EC1.5 | 4.1 | uM | - | Dermal | - | In Vitro; KeratinoSens2015; KeratinoSens | sheet=Data_invitro; excel_row=5049; Record_ID=skin_sensitization_invitro_1181; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID5021332; Assay=KeratinoSens; Endpoint=EC1.5; Reported_Response=4.0999999999999996; Reported_Response_Unit=uM; Response=4.1; Response_Unit=uM; Reference=Natsch et al. 2011; 22023385; 10.1021/tx2003678; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP ICE skin sensitization | EC1.5 | 4.39 | uM | - | Dermal | - | In Vitro; KeratinoSens2015; KeratinoSens | sheet=Data_invitro; excel_row=5050; Record_ID=skin_sensitization_invitro_1182; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID5021332; Assay=KeratinoSens; Endpoint=EC1.5; Reported_Response=4.3899999999999997; Reported_Response_Unit=uM; Response=4.39; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP ICE skin sensitization | EC1.5 | 5.12 | uM | - | Dermal | - | In Vitro; KeratinoSens2015; KeratinoSens | sheet=Data_invitro; excel_row=5052; Record_ID=skin_sensitization_invitro_1183; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID5021332; Assay=KeratinoSens; Endpoint=EC1.5; Reported_Response=5.12; Reported_Response_Unit=uM; Response=5.12; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP ICE skin sensitization | EC1.5 | 9.8 | uM | - | Dermal | - | In Vitro; KeratinoSens2015; KeratinoSens | sheet=Data_invitro; excel_row=5054; Record_ID=skin_sensitization_invitro_1184; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID5021332; Assay=KeratinoSens; Endpoint=EC1.5; Reported_Response=9.8000000000000007; Reported_Response_Unit=uM; Response=9.8; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP ICE skin sensitization | EC1.5 | <20.82 | uM | - | Dermal | - | In Vitro; Urbisch_SkinSensitization2020; LuSens | sheet=Data_invitro; excel_row=7598; Record_ID=skin_sensitization_invitro_1837; Data_Type=In Vitro; Internal_Data_Source=Urbisch_SkinSensitization2020; Mixture=Chemical; DTXSID=DTXSID5021332; Assay=LuSens; Endpoint=EC1.5; Response_Modifier=<; Reported_Response_Modifier=<; Reported_Response=20.82; Reported_Response_Unit=uM; Response=20.82; Response_Unit=uM; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP ICE skin sensitization | EC3 | 0.13 | % | Mouse | Dermal | - | In Vivo; LLNAdb2013; LLNA | sheet=Data_invivo; excel_row=12908; Record_ID=skin_sensitization_invivo_2841; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID5021332; Assay=LLNA; Endpoint=EC3; Response=0.13; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=De Jong et al. 2002; 12062936; 10.1016/s0300-483x(02)00131-2; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP ICE skin sensitization | EC3 | 5.2 | % | Mouse | Dermal | - | In Vivo; LLNAdb2013; LLNA | sheet=Data_invivo; excel_row=12905; Record_ID=skin_sensitization_invivo_2840; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID5021332; Assay=LLNA; Endpoint=EC3; Response=5.2; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Gerberick et al. 2005; 16536334; Not available; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP ICE skin sensitization | EC3 | 10.676 | uM | - | Dermal | - | In Vitro; CE_KeratinoSense2018; KeratinoSens | sheet=Data_invitro; excel_row=5056; Record_ID=skin_sensitization_invitro_1163; Data_Type=In Vitro; Internal_Data_Source=CE_KeratinoSense2018; Mixture=Chemical; DTXSID=DTXSID5021332; Assay=KeratinoSens; Endpoint=EC3; Reported_Response=10.676; Reported_Response_Unit=uM; Response=10.676; Response_Unit=uM; Reference=Emter et al. 2010; 20307559; 10.1016/j.taap.2010.03.009|Natsch et al. 2013; 23576290; 10.1002/jat.2868; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP ICE skin sensitization | GHS Classification | 1 | unitless | Mouse | Dermal | - | In Vivo; SkinSensitization6pack; LLNA | sheet=Data_invivo; excel_row=13884; Record_ID=skin_sensitization_invivo_3949; Data_Type=In Vivo; Internal_Data_Source=SkinSensitization6pack; Formulation_ID=MIX430; Formulation_Name=Sativa IMX Max; Percent_Active_Ingredient=10.78; Mixture=Mixture; DTXSID=DTXSID5021332; Assay=LLNA; Endpoint=GHS Classification; Response=1; Response_Unit=Unitless; Species=Mouse; Route=Dermal; Reference=FIFRA (undated); URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP ICE skin sensitization | IC50 | 9.78 | uM | - | Dermal | - | In Vitro; KeratinoSens2015; KeratinoSens | sheet=Data_invitro; excel_row=5100; Record_ID=skin_sensitization_invitro_1174; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID5021332; Assay=KeratinoSens; Endpoint=IC50; Reported_Response=9.7799999999999994; Reported_Response_Unit=uM; Response=9.78; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP ICE skin sensitization | IC50 | 11.8 | uM | - | Dermal | - | In Vitro; KeratinoSens2015; KeratinoSens | sheet=Data_invitro; excel_row=5058; Record_ID=skin_sensitization_invitro_1171; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID5021332; Assay=KeratinoSens; Endpoint=IC50; Reported_Response=11.8; Reported_Response_Unit=uM; Response=11.8; Response_Unit=uM; Reference=Natsch et al. 2011; 22023385; 10.1021/tx2003678; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP ICE skin sensitization | IC50 | 12.35 | uM | - | Dermal | - | In Vitro; KeratinoSens2015; KeratinoSens | sheet=Data_invitro; excel_row=5060; Record_ID=skin_sensitization_invitro_1176; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID5021332; Assay=KeratinoSens; Endpoint=IC50; Reported_Response=12.35; Reported_Response_Unit=uM; Response=12.35; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP ICE skin sensitization | IC50 | 13.74 | uM | - | Dermal | - | In Vitro; KeratinoSens2015; KeratinoSens | sheet=Data_invitro; excel_row=5062; Record_ID=skin_sensitization_invitro_1175; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID5021332; Assay=KeratinoSens; Endpoint=IC50; Reported_Response=13.74; Reported_Response_Unit=uM; Response=13.74; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP ICE skin sensitization | IC50 | 17.39 | uM | - | Dermal | - | In Vitro; KeratinoSens2015; KeratinoSens | sheet=Data_invitro; excel_row=5064; Record_ID=skin_sensitization_invitro_1184; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID5021332; Assay=KeratinoSens; Endpoint=IC50; Reported_Response=17.39; Reported_Response_Unit=uM; Response=17.39; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP ICE skin sensitization | IC50 | 22.94 | uM | - | Dermal | - | In Vitro; KeratinoSens2015; KeratinoSens | sheet=Data_invitro; excel_row=5066; Record_ID=skin_sensitization_invitro_1166; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID5021332; Assay=KeratinoSens; Endpoint=IC50; Reported_Response=22.94; Reported_Response_Unit=uM; Response=22.94; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP ICE skin sensitization | IC50 | 22.98 | uM | - | Dermal | - | In Vitro; KeratinoSens2015; KeratinoSens | sheet=Data_invitro; excel_row=5068; Record_ID=skin_sensitization_invitro_1167; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID5021332; Assay=KeratinoSens; Endpoint=IC50; Reported_Response=22.98; Reported_Response_Unit=uM; Response=22.98; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP ICE skin sensitization | IC50 | 23.59 | uM | - | Dermal | - | In Vitro; KeratinoSens2015; KeratinoSens | sheet=Data_invitro; excel_row=5070; Record_ID=skin_sensitization_invitro_1173; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID5021332; Assay=KeratinoSens; Endpoint=IC50; Reported_Response=23.59; Reported_Response_Unit=uM; Response=23.59; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP ICE skin sensitization | IC50 | 23.8 | uM | - | Dermal | - | In Vitro; KeratinoSens2015; KeratinoSens | sheet=Data_invitro; excel_row=5072; Record_ID=skin_sensitization_invitro_1169; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID5021332; Assay=KeratinoSens; Endpoint=IC50; Reported_Response=23.8; Reported_Response_Unit=uM; Response=23.8; Response_Unit=uM; Reference=Natsch et al. 2011; 22023385; 10.1021/tx2003678; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP ICE skin sensitization | IC50 | 25.68 | uM | - | Dermal | - | In Vitro; KeratinoSens2015; KeratinoSens | sheet=Data_invitro; excel_row=5076; Record_ID=skin_sensitization_invitro_1168; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID5021332; Assay=KeratinoSens; Endpoint=IC50; Reported_Response=25.68; Reported_Response_Unit=uM; Response=25.68; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP ICE skin sensitization | IC50 | 26.8 | uM | - | Dermal | - | In Vitro; KeratinoSens2015; KeratinoSens | sheet=Data_invitro; excel_row=5078; Record_ID=skin_sensitization_invitro_1170; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID5021332; Assay=KeratinoSens; Endpoint=IC50; Reported_Response=26.8; Reported_Response_Unit=uM; Response=26.8; Response_Unit=uM; Reference=Natsch et al. 2011; 22023385; 10.1021/tx2003678; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP ICE skin sensitization | IC50 | 27.03 | uM | - | Dermal | - | In Vitro; KeratinoSens2015; KeratinoSens | sheet=Data_invitro; excel_row=5080; Record_ID=skin_sensitization_invitro_1164; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID5021332; Assay=KeratinoSens; Endpoint=IC50; Reported_Response=27.03; Reported_Response_Unit=uM; Response=27.03; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP ICE skin sensitization | IC50 | 36.6 | uM | - | Dermal | - | In Vitro; KeratinoSens2015; KeratinoSens | sheet=Data_invitro; excel_row=5082; Record_ID=skin_sensitization_invitro_1177; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID5021332; Assay=KeratinoSens; Endpoint=IC50; Reported_Response=36.6; Reported_Response_Unit=uM; Response=36.6; Response_Unit=uM; Reference=Natsch et al. 2011; 22023385; 10.1021/tx2003678; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP ICE skin sensitization | IC50 | 38.65 | uM | - | Dermal | - | In Vitro; KeratinoSens2015; KeratinoSens | sheet=Data_invitro; excel_row=5084; Record_ID=skin_sensitization_invitro_1178; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID5021332; Assay=KeratinoSens; Endpoint=IC50; Reported_Response=38.65; Reported_Response_Unit=uM; Response=38.65; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP ICE skin sensitization | IC50 | 39.1 | uM | - | Dermal | - | In Vitro; CE_KeratinoSense2018; KeratinoSens | sheet=Data_invitro; excel_row=5086; Record_ID=skin_sensitization_invitro_1163; Data_Type=In Vitro; Internal_Data_Source=CE_KeratinoSense2018; Mixture=Chemical; DTXSID=DTXSID5021332; Assay=KeratinoSens; Endpoint=IC50; Reported_Response=39.1; Reported_Response_Unit=uM; Response=39.1; Response_Unit=uM; Reference=Emter et al. 2010; 20307559; 10.1016/j.taap.2010.03.009|Natsch et al. 2013; 23576290; 10.1002/jat.2868; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP ICE skin sensitization | IC50 | 46.8 | uM | - | Dermal | - | In Vitro; KeratinoSens2015; KeratinoSens | sheet=Data_invitro; excel_row=5088; Record_ID=skin_sensitization_invitro_1172; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID5021332; Assay=KeratinoSens; Endpoint=IC50; Reported_Response=46.8; Reported_Response_Unit=uM; Response=46.8; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP ICE skin sensitization | IC50 | 47.01 | uM | - | Dermal | - | In Vitro; KeratinoSens2015; KeratinoSens | sheet=Data_invitro; excel_row=5090; Record_ID=skin_sensitization_invitro_1180; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID5021332; Assay=KeratinoSens; Endpoint=IC50; Reported_Response=47.01; Reported_Response_Unit=uM; Response=47.01; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP ICE skin sensitization | IC50 | 49.5 | uM | - | Dermal | - | In Vitro; Urbisch_SkinSensitization2020; LuSens | sheet=Data_invitro; excel_row=7668; Record_ID=skin_sensitization_invitro_1837; Data_Type=In Vitro; Internal_Data_Source=Urbisch_SkinSensitization2020; Mixture=Chemical; DTXSID=DTXSID5021332; Assay=LuSens; Endpoint=IC50; Reported_Response=49.49606853; Reported_Response_Unit=uM; Response=49.5; Response_Unit=uM; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP ICE skin sensitization | IC50 | 52.85 | uM | - | Dermal | - | In Vitro; KeratinoSens2015; KeratinoSens | sheet=Data_invitro; excel_row=5092; Record_ID=skin_sensitization_invitro_1179; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID5021332; Assay=KeratinoSens; Endpoint=IC50; Reported_Response=52.85; Reported_Response_Unit=uM; Response=52.85; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP ICE skin sensitization | IC50 | 53.65 | uM | - | Dermal | - | In Vitro; KeratinoSens2015; KeratinoSens | sheet=Data_invitro; excel_row=5094; Record_ID=skin_sensitization_invitro_1182; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID5021332; Assay=KeratinoSens; Endpoint=IC50; Reported_Response=53.65; Reported_Response_Unit=uM; Response=53.65; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP ICE skin sensitization | IC50 | 53.7 | uM | - | Dermal | - | In Vitro; KeratinoSens2015; KeratinoSens | sheet=Data_invitro; excel_row=5096; Record_ID=skin_sensitization_invitro_1181; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID5021332; Assay=KeratinoSens; Endpoint=IC50; Reported_Response=53.7; Reported_Response_Unit=uM; Response=53.7; Response_Unit=uM; Reference=Natsch et al. 2011; 22023385; 10.1021/tx2003678; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP ICE skin sensitization | IC50 | 54.57 | uM | - | Dermal | - | In Vitro; KeratinoSens2015; KeratinoSens | sheet=Data_invitro; excel_row=5098; Record_ID=skin_sensitization_invitro_1183; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID5021332; Assay=KeratinoSens; Endpoint=IC50; Reported_Response=54.57; Reported_Response_Unit=uM; Response=54.57; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP ICE skin sensitization | Imax | 1.978 | ratio | - | Dermal | - | In Vitro; KeratinoSens2015; KeratinoSens | sheet=Data_invitro; excel_row=5102; Record_ID=skin_sensitization_invitro_1184; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID5021332; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=1.978; Reported_Response_Unit=Unitless; Response=1.978; Response_Unit=Ratio; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP ICE skin sensitization | Imax | 3.021 | ratio | - | Dermal | - | In Vitro; KeratinoSens2015; KeratinoSens | sheet=Data_invitro; excel_row=5119; Record_ID=skin_sensitization_invitro_1173; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID5021332; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=3.0209999999999999; Reported_Response_Unit=Unitless; Response=3.021; Response_Unit=Ratio; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP ICE skin sensitization | Imax | 5.287 | ratio | - | Dermal | - | In Vitro; Urbisch_SkinSensitization2020; LuSens | sheet=Data_invitro; excel_row=7571; Record_ID=skin_sensitization_invitro_1837; Data_Type=In Vitro; Internal_Data_Source=Urbisch_SkinSensitization2020; Mixture=Chemical; DTXSID=DTXSID5021332; Assay=LuSens; Endpoint=Imax; Reported_Response=5.287027612; Reported_Response_Unit=Unitless; Response=5.287; Response_Unit=Ratio; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP ICE skin sensitization | Imax | 6.18 | ratio | - | Dermal | - | In Vitro; KeratinoSens2015; KeratinoSens | sheet=Data_invitro; excel_row=5124; Record_ID=skin_sensitization_invitro_1187; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID5021332; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=6.18; Reported_Response_Unit=Unitless; Response=6.18; Response_Unit=Ratio; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP ICE skin sensitization | Imax | 6.75 | ratio | - | Dermal | - | In Vitro; CE_KeratinoSense2018; KeratinoSens | sheet=Data_invitro; excel_row=5126; Record_ID=skin_sensitization_invitro_1163; Data_Type=In Vitro; Internal_Data_Source=CE_KeratinoSense2018; Mixture=Chemical; DTXSID=DTXSID5021332; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=6.75; Reported_Response_Unit=Unitless; Response=6.75; Response_Unit=Ratio; Reference=Emter et al. 2010; 20307559; 10.1016/j.taap.2010.03.009|Natsch et al. 2013; 23576290; 10.1002/jat.2868; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP ICE skin sensitization | Imax | 7.321 | ratio | - | Dermal | - | In Vitro; KeratinoSens2015; KeratinoSens | sheet=Data_invitro; excel_row=5130; Record_ID=skin_sensitization_invitro_1165; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID5021332; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=7.3209999999999997; Reported_Response_Unit=Unitless; Response=7.321; Response_Unit=Ratio; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP ICE skin sensitization | Imax | 8.1 | ratio | - | Dermal | - | In Vitro; KeratinoSens2015; KeratinoSens | sheet=Data_invitro; excel_row=5132; Record_ID=skin_sensitization_invitro_1170; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID5021332; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=8.1; Reported_Response_Unit=Unitless; Response=8.1; Response_Unit=Ratio; Reference=Natsch et al. 2011; 22023385; 10.1021/tx2003678; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP ICE skin sensitization | Imax | 8.739 | ratio | - | Dermal | - | In Vitro; KeratinoSens2015; KeratinoSens | sheet=Data_invitro; excel_row=5134; Record_ID=skin_sensitization_invitro_1176; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID5021332; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=8.7390000000000008; Reported_Response_Unit=Unitless; Response=8.739; Response_Unit=Ratio; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP ICE skin sensitization | Imax | 9.3 | ratio | - | Dermal | - | In Vitro; KeratinoSens2015; KeratinoSens | sheet=Data_invitro; excel_row=5135; Record_ID=skin_sensitization_invitro_1171; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID5021332; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=9.3000000000000007; Reported_Response_Unit=Unitless; Response=9.3; Response_Unit=Ratio; Reference=Natsch et al. 2011; 22023385; 10.1021/tx2003678; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP ICE skin sensitization | Imax | 9.513 | ratio | - | Dermal | - | In Vitro; KeratinoSens2015; KeratinoSens | sheet=Data_invitro; excel_row=5137; Record_ID=skin_sensitization_invitro_1175; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID5021332; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=9.5129999999999999; Reported_Response_Unit=Unitless; Response=9.513; Response_Unit=Ratio; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP ICE skin sensitization | Imax | 9.6 | ratio | - | Dermal | - | In Vitro; KeratinoSens2015; KeratinoSens | sheet=Data_invitro; excel_row=5139; Record_ID=skin_sensitization_invitro_1174; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID5021332; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=9.6; Reported_Response_Unit=Unitless; Response=9.6; Response_Unit=Ratio; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP ICE skin sensitization | Imax | 13.119 | ratio | - | Dermal | - | In Vitro; KeratinoSens2015; KeratinoSens | sheet=Data_invitro; excel_row=5104; Record_ID=skin_sensitization_invitro_1167; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID5021332; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=13.119; Reported_Response_Unit=Unitless; Response=13.119; Response_Unit=Ratio; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP ICE skin sensitization | Imax | 13.24 | ratio | - | Dermal | - | In Vitro; KeratinoSens2015; KeratinoSens | sheet=Data_invitro; excel_row=5106; Record_ID=skin_sensitization_invitro_1172; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID5021332; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=13.244999999999999; Reported_Response_Unit=Unitless; Response=13.24; Response_Unit=Ratio; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP ICE skin sensitization | Imax | 15.413 | ratio | - | Dermal | - | In Vitro; KeratinoSens2015; KeratinoSens | sheet=Data_invitro; excel_row=5108; Record_ID=skin_sensitization_invitro_1179; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID5021332; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=15.413; Reported_Response_Unit=Unitless; Response=15.413; Response_Unit=Ratio; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP ICE skin sensitization | Imax | 16.36 | ratio | - | Dermal | - | In Vitro; KeratinoSens2015; KeratinoSens | sheet=Data_invitro; excel_row=5110; Record_ID=skin_sensitization_invitro_1168; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID5021332; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=16.364000000000001; Reported_Response_Unit=Unitless; Response=16.36; Response_Unit=Ratio; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP ICE skin sensitization | Imax | 17.7 | ratio | - | Dermal | - | In Vitro; KeratinoSens2015; KeratinoSens | sheet=Data_invitro; excel_row=5111; Record_ID=skin_sensitization_invitro_1181; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID5021332; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=17.7; Reported_Response_Unit=Unitless; Response=17.7; Response_Unit=Ratio; Reference=Natsch et al. 2011; 22023385; 10.1021/tx2003678; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP ICE skin sensitization | Imax | 18.52 | ratio | - | Dermal | - | In Vitro; KeratinoSens2015; KeratinoSens | sheet=Data_invitro; excel_row=5114; Record_ID=skin_sensitization_invitro_1182; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID5021332; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=18.515999999999998; Reported_Response_Unit=Unitless; Response=18.52; Response_Unit=Ratio; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP ICE skin sensitization | Imax | 19.16 | ratio | - | Dermal | - | In Vitro; KeratinoSens2015; KeratinoSens | sheet=Data_invitro; excel_row=5116; Record_ID=skin_sensitization_invitro_1183; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID5021332; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=19.155999999999999; Reported_Response_Unit=Unitless; Response=19.16; Response_Unit=Ratio; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP ICE skin sensitization | Imax | 22.3 | ratio | - | Dermal | - | In Vitro; KeratinoSens2015; KeratinoSens | sheet=Data_invitro; excel_row=5118; Record_ID=skin_sensitization_invitro_1169; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID5021332; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=22.3; Reported_Response_Unit=Unitless; Response=22.3; Response_Unit=Ratio; Reference=Natsch et al. 2011; 22023385; 10.1021/tx2003678; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP ICE skin sensitization | Imax | 37.32 | ratio | - | Dermal | - | In Vitro; KeratinoSens2015; KeratinoSens | sheet=Data_invitro; excel_row=5120; Record_ID=skin_sensitization_invitro_1166; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID5021332; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=37.316000000000003; Reported_Response_Unit=Unitless; Response=37.32; Response_Unit=Ratio; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP ICE skin sensitization | Imax | 48.11 | ratio | - | Dermal | - | In Vitro; KeratinoSens2015; KeratinoSens | sheet=Data_invitro; excel_row=5121; Record_ID=skin_sensitization_invitro_1164; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID5021332; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=48.110999999999997; Reported_Response_Unit=Unitless; Response=48.11; Response_Unit=Ratio; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP ICE skin sensitization | Imax | 58.427 | ratio | - | Dermal | - | In Vitro; KeratinoSens2015; KeratinoSens | sheet=Data_invitro; excel_row=5122; Record_ID=skin_sensitization_invitro_1178; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID5021332; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=58.427; Reported_Response_Unit=Unitless; Response=58.427; Response_Unit=Ratio; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP ICE skin sensitization | Imax | 67.9 | ratio | - | Dermal | - | In Vitro; KeratinoSens2015; KeratinoSens | sheet=Data_invitro; excel_row=5128; Record_ID=skin_sensitization_invitro_1177; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID5021332; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=67.900000000000006; Reported_Response_Unit=Unitless; Response=67.9; Response_Unit=Ratio; Reference=Natsch et al. 2011; 22023385; 10.1021/tx2003678; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP ICE skin sensitization | Imax | 97.17 | ratio | - | Dermal | - | In Vitro; KeratinoSens2015; KeratinoSens | sheet=Data_invitro; excel_row=5141; Record_ID=skin_sensitization_invitro_1180; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID5021332; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=97.17; Reported_Response_Unit=Unitless; Response=97.17; Response_Unit=Ratio; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP ICE skin sensitization | Incidence of positive responses | 0 | % | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Maximization Test | sheet=Data_invivo; excel_row=4905; Record_ID=skin_sensitization_invivo_1173; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=10.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID5021332; Assay=Human Maximization Test; Endpoint=Incidence of positive responses; Response=0; Response_Unit=%; Species=Human; Route=Dermal; Reference=Kligman 1966; 5924293; 10.1038/jid.1966.159|Akkan et al. 2003; Not available; Not available|Schneider and Akkan 2004; 15135206; 10.1016/j.yrtph.2004.02.002; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP ICE skin sensitization | Incidence of positive responses | 4 | % | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Maximization Test | sheet=Data_invivo; excel_row=4932; Record_ID=skin_sensitization_invivo_1178; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=25.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID5021332; Assay=Human Maximization Test; Endpoint=Incidence of positive responses; Response=4; Response_Unit=%; Species=Human; Route=Dermal; Reference=Kligman 1966; 5924294; 10.1038/jid.1966.160; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP ICE skin sensitization | Incidence of positive responses | 4.348 | % | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Maximization Test | sheet=Data_invivo; excel_row=4946; Record_ID=skin_sensitization_invivo_1176; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=25.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID5021332; Assay=Human Maximization Test; Endpoint=Incidence of positive responses; Response=4.348; Response_Unit=%; Species=Human; Route=Dermal; Reference=Kligman 1966; 5924294; 10.1038/jid.1966.160; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP ICE skin sensitization | Incidence of positive responses | 9.091 | % | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Maximization Test | sheet=Data_invivo; excel_row=4921; Record_ID=skin_sensitization_invivo_1171; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=10.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID5021332; Assay=Human Maximization Test; Endpoint=Incidence of positive responses; Response=9.091; Response_Unit=%; Species=Human; Route=Dermal; Reference=Kligman 1966; 5924293; 10.1038/jid.1966.159|Akkan et al. 2003; Not available; Not available|Schneider and Akkan 2004; 15135206; 10.1016/j.yrtph.2004.02.002; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP ICE skin sensitization | Incidence of positive responses | 16 | % | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Maximization Test | sheet=Data_invivo; excel_row=4916; Record_ID=skin_sensitization_invivo_1175; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=25.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID5021332; Assay=Human Maximization Test; Endpoint=Incidence of positive responses; Response=16; Response_Unit=%; Species=Human; Route=Dermal; Reference=Kligman 1966; 5924294; 10.1038/jid.1966.160|Marzulli and Maibach 1976; 801606; 10.1111/j.1600-0536.1976.tb02972.x|Basketter et al. 1996; 9012774; 10.1016/s0278-6915(96)00059-2|Gerberick et al. 2000; 10684384; 10.1053/ajcd.2000.0003|Akkan et al. 2003; Not available; Not available|Griem et al. 2003; 14623479; 10.1016/j.yrtph.2003.07.001|Schneider and Akkan 2004; 15135206; 10.1016/j.yrtph.2004.02.002; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP ICE skin sensitization | Incidence of positive responses | 18.18 | % | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Maximization Test | sheet=Data_invivo; excel_row=4929; Record_ID=skin_sensitization_invivo_1177; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=25.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID5021332; Assay=Human Maximization Test; Endpoint=Incidence of positive responses; Response=18.18; Response_Unit=%; Species=Human; Route=Dermal; Reference=Kligman 1966; 5924294; 10.1038/jid.1966.160; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP ICE skin sensitization | Incidence of positive responses | 33.33 | % | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Maximization Test | sheet=Data_invivo; excel_row=4900; Record_ID=skin_sensitization_invivo_1172; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=10.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID5021332; Assay=Human Maximization Test; Endpoint=Incidence of positive responses; Response=33.33; Response_Unit=%; Species=Human; Route=Dermal; Reference=Kligman 1966; 5924293; 10.1038/jid.1966.159; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP ICE skin sensitization | Induction dose per skin area | 6207 | ug/cm2 | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Maximization Test | sheet=Data_invivo; excel_row=4898; Record_ID=skin_sensitization_invivo_1172; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=10.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID5021332; Assay=Human Maximization Test; Endpoint=Induction dose per skin area; Response=6207; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Kligman 1966; 5924293; 10.1038/jid.1966.159; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP ICE skin sensitization | Induction dose per skin area | 15520 | ug/cm2 | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Maximization Test | sheet=Data_invivo; excel_row=4913; Record_ID=skin_sensitization_invivo_1175; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=25.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID5021332; Assay=Human Maximization Test; Endpoint=Induction dose per skin area; Response=15520; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Kligman 1966; 5924294; 10.1038/jid.1966.160|Marzulli and Maibach 1976; 801606; 10.1111/j.1600-0536.1976.tb02972.x|Basketter et al. 1996; 9012774; 10.1016/s0278-6915(96)00059-2|Gerberick et al. 2000; 10684384; 10.1053/ajcd.2000.0003|Akkan et al. 2003; Not available; Not available|Griem et al. 2003; 14623479; 10.1016/j.yrtph.2003.07.001|Schneider and Akkan 2004; 15135206; 10.1016/j.yrtph.2004.02.002; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP ICE skin sensitization | Induction dose per skin area, 5% incidence of positive responses | 931 | ug/cm2 | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Maximization Test | sheet=Data_invivo; excel_row=4910; Record_ID=skin_sensitization_invivo_1172; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=10.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID5021332; Assay=Human Maximization Test; Endpoint=Induction dose per skin area, 5% incidence of positive responses; Response=931; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Kligman 1966; 5924293; 10.1038/jid.1966.159; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP ICE skin sensitization | Induction dose per skin area, 5% incidence of positive responses | 3414 | ug/cm2 | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Maximization Test | sheet=Data_invivo; excel_row=4896; Record_ID=skin_sensitization_invivo_1171; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=10.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID5021332; Assay=Human Maximization Test; Endpoint=Induction dose per skin area, 5% incidence of positive responses; Response=3414; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Kligman 1966; 5924293; 10.1038/jid.1966.159|Akkan et al. 2003; Not available; Not available|Schneider and Akkan 2004; 15135206; 10.1016/j.yrtph.2004.02.002; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP ICE skin sensitization | Induction dose per skin area, 5% incidence of positive responses | 4267 | ug/cm2 | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Maximization Test | sheet=Data_invivo; excel_row=4939; Record_ID=skin_sensitization_invivo_1177; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=25.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID5021332; Assay=Human Maximization Test; Endpoint=Induction dose per skin area, 5% incidence of positive responses; Response=4267; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Kligman 1966; 5924294; 10.1038/jid.1966.160; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP ICE skin sensitization | Induction dose per skin area, 5% incidence of positive responses | 4849 | ug/cm2 | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Maximization Test | sheet=Data_invivo; excel_row=4924; Record_ID=skin_sensitization_invivo_1175; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=25.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID5021332; Assay=Human Maximization Test; Endpoint=Induction dose per skin area, 5% incidence of positive responses; Response=4849; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Kligman 1966; 5924294; 10.1038/jid.1966.160|Marzulli and Maibach 1976; 801606; 10.1111/j.1600-0536.1976.tb02972.x|Basketter et al. 1996; 9012774; 10.1016/s0278-6915(96)00059-2|Gerberick et al. 2000; 10684384; 10.1053/ajcd.2000.0003|Akkan et al. 2003; Not available; Not available|Griem et al. 2003; 14623479; 10.1016/j.yrtph.2003.07.001|Schneider and Akkan 2004; 15135206; 10.1016/j.yrtph.2004.02.002; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP ICE skin sensitization | Induction dose per skin area, 5% incidence of positive responses | 17840 | ug/cm2 | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Maximization Test | sheet=Data_invivo; excel_row=4925; Record_ID=skin_sensitization_invivo_1176; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=25.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID5021332; Assay=Human Maximization Test; Endpoint=Induction dose per skin area, 5% incidence of positive responses; Response=17840; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Kligman 1966; 5924294; 10.1038/jid.1966.160; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP ICE skin sensitization | Induction dose per skin area, 5% incidence of positive responses | 19400 | ug/cm2 | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Maximization Test | sheet=Data_invivo; excel_row=4942; Record_ID=skin_sensitization_invivo_1178; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=25.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID5021332; Assay=Human Maximization Test; Endpoint=Induction dose per skin area, 5% incidence of positive responses; Response=19400; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Kligman 1966; 5924294; 10.1038/jid.1966.160; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP ICE skin sensitization | Induction dose per skin area, one positive response | 1034 | ug/cm2 | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Maximization Test | sheet=Data_invivo; excel_row=4906; Record_ID=skin_sensitization_invivo_1172; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=10.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID5021332; Assay=Human Maximization Test; Endpoint=Induction dose per skin area, one positive response; Response=1034; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Kligman 1966; 5924293; 10.1038/jid.1966.159; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP ICE skin sensitization | Induction dose per skin area, one positive response | 3103 | ug/cm2 | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Maximization Test | sheet=Data_invivo; excel_row=4894; Record_ID=skin_sensitization_invivo_1171; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=10.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID5021332; Assay=Human Maximization Test; Endpoint=Induction dose per skin area, one positive response; Response=3103; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Kligman 1966; 5924293; 10.1038/jid.1966.159|Akkan et al. 2003; Not available; Not available|Schneider and Akkan 2004; 15135206; 10.1016/j.yrtph.2004.02.002; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP ICE skin sensitization | Induction dose per skin area, one positive response | 3879 | ug/cm2 | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Maximization Test | sheet=Data_invivo; excel_row=4922; Record_ID=skin_sensitization_invivo_1175; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=25.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID5021332; Assay=Human Maximization Test; Endpoint=Induction dose per skin area, one positive response; Response=3879; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Kligman 1966; 5924294; 10.1038/jid.1966.160|Marzulli and Maibach 1976; 801606; 10.1111/j.1600-0536.1976.tb02972.x|Basketter et al. 1996; 9012774; 10.1016/s0278-6915(96)00059-2|Gerberick et al. 2000; 10684384; 10.1053/ajcd.2000.0003|Akkan et al. 2003; Not available; Not available|Griem et al. 2003; 14623479; 10.1016/j.yrtph.2003.07.001|Schneider and Akkan 2004; 15135206; 10.1016/j.yrtph.2004.02.002; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP ICE skin sensitization | Relative reliability score | 1 | unitless | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Maximization Test | sheet=Data_invivo; excel_row=4897; Record_ID=skin_sensitization_invivo_1171; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=10.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID5021332; Assay=Human Maximization Test; Endpoint=Relative reliability score; Response=1; Response_Unit=Unitless; Species=Human; Route=Dermal; Reference=Kligman 1966; 5924293; 10.1038/jid.1966.159|Akkan et al. 2003; Not available; Not available|Schneider and Akkan 2004; 15135206; 10.1016/j.yrtph.2004.02.002; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
EPA ToxRefDB v3 29 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| EPA ToxRefDB v3 | LEL | =2.35 | mg/kg bw/day | dog (beagle; beagle) | oral | 0 day to 90 day | SUB | study_id=3542; toxval_study_source_id=studyid3542_Adult_F0_F_systemic; toxval_effect_list=hematology-erythrocyte (rbc) count differential-erythrocyte (rbc)|clinical chemistry-cholesterol-cholesterol|hematology-hemoglobin (hgb)-hemoglobin (hgb)|hematology-mean corpuscular (cell) volume (mcv)-mean corpuscular (cell) volume (mcv)|clinical chemistry-albumin-albumin|hematology-hematocrit (hct)-hematocrit (hct)|hematology-mean corpuscular hemoglobin (mch)-mean corpuscular hemoglobin (mch)|clinical chemistry-protein-protein|in life observation-clinical signs-emesis|clinical chemistry-calcium-calcium|in life observation-food consumption-food consumption|in life observation-body weight-body weight|hematology-platelet-platelet|hematology-mean corpuscular hemoglobin concentration (mchc)-mean corpuscular hemoglobin concentration (mchc); dose_level=1; study_year=1990; study_citation=Kehoe, D. (1990) 13-Week Toxicity Study with Thiram in Dogs: Lab Project Number: HLA 6111-121: 90-017. Unpublished study prepar- ed Hazleton Laboratories America, Inc. 237 p.; dsstox_substance_id=DTXSID5021332; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | LEL | =2.26 | mg/kg bw/day | dog (beagle; beagle) | oral | 0 day to 90 day | SUB | study_id=3542; toxval_study_source_id=studyid3542_Adult_F0_M_systemic; toxval_effect_list=hematology-hematocrit (hct)-hematocrit (hct)|hematology-mean corpuscular (cell) volume (mcv)-mean corpuscular (cell) volume (mcv)|hematology-erythrocyte (rbc) count differential-erythrocyte (rbc)|clinical chemistry-cholesterol-cholesterol|in life observation-body weight-body weight|clinical chemistry-calcium-calcium|hematology-platelet-platelet|in life observation-clinical signs-emesis|in life observation-food consumption-food consumption|hematology-mean corpuscular hemoglobin (mch)-mean corpuscular hemoglobin (mch)|clinical chemistry-protein-protein|clinical chemistry-albumin-albumin|hematology-hemoglobin (hgb)-hemoglobin (hgb)|hematology-mean corpuscular hemoglobin concentration (mchc)-mean corpuscular hemoglobin concentration (mchc); dose_level=1; study_year=1990; study_citation=Kehoe, D. (1990) 13-Week Toxicity Study with Thiram in Dogs: Lab Project Number: HLA 6111-121: 90-017. Unpublished study prepar- ed Hazleton Laboratories America, Inc. 237 p.; dsstox_substance_id=DTXSID5021332; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | LEL | =7.5 | mg/kg bw/day | rat (sprague dawley; Sprague Dawley (CD)) | oral | 6 GD to 15 GD | DEV | study_id=3546; toxval_study_source_id=studyid3546_Adult_F0_F_systemic; toxval_effect_list=in life observation-clinical signs-skin discoloration|in life observation-clinical signs-scabbing|in life observation-clinical signs-alopecia|in life observation-body weight-body weight gain|in life observation-clinical signs-[other]|in life observation-clinical signs-salivation|organ weight-placenta-nos; dose_level=1; study_year=1988; study_citation=Tesh, J.; McAnulty, P.; Willoughby, C.; et al. (1988) Thiram: Teratology Study in the Rat: 87/TRK002/179. Unpublished study prepared by Life Science Research. 91 p.; dsstox_substance_id=DTXSID5021332; admin_method=Gavage/Intubation; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | LEL | =4.7 | mg/kg bw/day | rat (sprague dawley; Sprague Dawley (CD)) | oral | 90 days (premating) to 2 generation | MGR | study_id=3549; toxval_study_source_id=studyid3549_Adult_F0_F_systemic; toxval_effect_list=in life observation-body weight-body weight gain|in life observation-food consumption-food consumption|in life observation-body weight-body weight|pathology microscopic-pituitary gland-angiectasis; dose_level=2; study_year=1997; study_citation=Turck, P. (1997) Two Generation Reproduction/Fertility Study in Rats with Thiram: Lab Project Number: 399-180. Unpublished study prepared by MPI Research. 1579 p.; dsstox_substance_id=DTXSID5021332; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | LEL | =12.2 | mg/kg bw/day | rat (sprague dawley; Sprague Dawley (CD)) | oral | 90 days (premating) to 2 generation | MGR | study_id=3549; toxval_study_source_id=studyid3549_Adult_F0_M_systemic; toxval_effect_list=pathology microscopic-prostate-inflammation|in life observation-food consumption-food consumption; dose_level=3; study_year=1997; study_citation=Turck, P. (1997) Two Generation Reproduction/Fertility Study in Rats with Thiram: Lab Project Number: 399-180. Unpublished study prepared by MPI Research. 1579 p.; dsstox_substance_id=DTXSID5021332; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | LEL | =5.4 | mg/kg bw/day | rat (sprague dawley; Sprague Dawley (CD)) | oral | 90 days (premating) to 2 generation | MGR | study_id=3549; toxval_study_source_id=studyid3549_Adult_F1_F_systemic; toxval_effect_list=in life observation-body weight-body weight gain; dose_level=2; study_year=1997; study_citation=Turck, P. (1997) Two Generation Reproduction/Fertility Study in Rats with Thiram: Lab Project Number: 399-180. Unpublished study prepared by MPI Research. 1579 p.; dsstox_substance_id=DTXSID5021332; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | LEL | =4.9 | mg/kg bw/day | rat (sprague dawley; Sprague Dawley (CD)) | oral | 90 days (premating) to 2 generation | MGR | study_id=3549; toxval_study_source_id=studyid3549_Juvenile_F1_M_systemic; toxval_effect_list=in life observation-body weight-offspring (pup) weight gain|in life observation-body weight-offspring (pup) weight; dose_level=2; study_year=1997; study_citation=Turck, P. (1997) Two Generation Reproduction/Fertility Study in Rats with Thiram: Lab Project Number: 399-180. Unpublished study prepared by MPI Research. 1579 p.; dsstox_substance_id=DTXSID5021332; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | LEL | =0.9 | mg/kg bw/day | dog (beagle; beagle) | oral | 0 week to 52 week | CHR | study_id=3550; toxval_study_source_id=studyid3550_Adult_F0_F_systemic; toxval_effect_list=hematology-mean corpuscular (cell) volume (mcv)-mean corpuscular (cell) volume (mcv)|hematology-mean corpuscular hemoglobin (mch)-mean corpuscular hemoglobin (mch)|clinical chemistry-cholesterol-cholesterol|clinical chemistry-albumin-albumin|organ weight-liver-relative to body weight|clinical chemistry-protein-protein; dose_level=1; study_year=1991; study_citation=Kehoe, D. (1991) 52-Week Dietary Chronic Toxicity Study with Thiram in Dogs: Final Report: Lab Project Number: HLA 6111-112. Unpublished study prepared by Hazleton Laboratories America, Inc. 545 p.; dsstox_substance_id=DTXSID5021332; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | LEL | =0.84 | mg/kg bw/day | dog (beagle; beagle) | oral | 0 week to 52 week | CHR | study_id=3550; toxval_study_source_id=studyid3550_Adult_F0_M_systemic; toxval_effect_list=clinical chemistry-cholesterol-cholesterol|clinical chemistry-protein-protein|hematology-mean corpuscular (cell) volume (mcv)-mean corpuscular (cell) volume (mcv)|organ weight-liver-relative to body weight|hematology-mean corpuscular hemoglobin (mch)-mean corpuscular hemoglobin (mch)|clinical chemistry-albumin-albumin|hematology-erythrocyte (rbc) count differential-erythrocyte (rbc)|in life observation-body weight-body weight; dose_level=1; study_year=1991; study_citation=Kehoe, D. (1991) 52-Week Dietary Chronic Toxicity Study with Thiram in Dogs: Final Report: Lab Project Number: HLA 6111-112. Unpublished study prepared by Hazleton Laboratories America, Inc. 545 p.; dsstox_substance_id=DTXSID5021332; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | LEL | =57 | mg/kg bw/day | mouse (cd1; Crl:CD-1(ICR)BR) | oral | 0 day to 97 week | CHR | study_id=3551; toxval_study_source_id=studyid3551_Adult_F0_F_systemic; toxval_effect_list=pathology microscopic-spleen-pigmentation|hematology-erythrocyte (rbc) count differential-erythrocyte (rbc)|pathology microscopic-urinary bladder-[other]|in life observation-body weight-body weight gain|hematology-platelet-platelet|pathology microscopic-eye-atrophy|pathology microscopic-stomach-hyperkeratosis|pathology microscopic-skin-inflammation|in life observation-body weight-body weight|hematology-hemoglobin (hgb)-hemoglobin (hgb)|hematology-hematocrit (hct)-hematocrit (hct)|pathology microscopic-skin-necrosis; dose_level=2; study_year=1992; study_citation=Trutter, J. (1992) Oncogenicity Study in Mice with Thiram: Lab Project Number: 798-223. Unpublished study prepared by Hazleton Washington, Inc. 2965 p.; dsstox_substance_id=DTXSID5021332; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | LEL | =24 | mg/kg bw/day | mouse (cd1; Crl:CD-1(ICR)BR) | oral | 0 day to 97 week | CHR | study_id=3551; toxval_study_source_id=studyid3551_Adult_F0_M_systemic; toxval_effect_list=pathology microscopic-skin-necrosis|in life observation-body weight-body weight|pathology microscopic-eye-atrophy|in life observation-body weight-body weight gain|pathology microscopic-skin-inflammation|hematology-mean corpuscular hemoglobin concentration (mchc)-mean corpuscular hemoglobin concentration (mchc)|pathology microscopic-urinary bladder-[other]|pathology microscopic-stomach-hyperkeratosis; dose_level=2; study_year=1992; study_citation=Trutter, J. (1992) Oncogenicity Study in Mice with Thiram: Lab Project Number: 798-223. Unpublished study prepared by Hazleton Washington, Inc. 2965 p.; dsstox_substance_id=DTXSID5021332; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | LEL | =1.8 | mg/kg bw/day | rat (sprague dawley; CD(SD)BR) | oral | 0 day to 104 week | CHR | study_id=3552; toxval_study_source_id=studyid3552_Adult_F0_F_systemic; toxval_effect_list=pathology microscopic-spleen-hematopoietic cell proliferation|hematology-mean corpuscular hemoglobin concentration (mchc)-mean corpuscular hemoglobin concentration (mchc)|hematology-erythrocyte (rbc) count differential-erythrocyte (rbc)|hematology-mean corpuscular (cell) volume (mcv)-mean corpuscular (cell) volume (mcv)|hematology-hemoglobin (hgb)-hemoglobin (hgb)|hematology-hematocrit (hct)-hematocrit (hct)|pathology gross-adrenal gland-cyst|pathology microscopic-liver-hyperplasia|pathology microscopic-pancreas-steatosis|pathology microscopic-thyroid gland-hyperplasia|in life observation-body weight-body weight gain|clinical chemistry-urea nitrogen-urea nitrogen|pathology microscopic-pancreas-infiltration cellular|clinical chemistry-glucose-glucose|pathology microscopic-liver-hematopoietic cell proliferation|organ weight-ovary-relative to brain weight|organ weight-ovary-absolute; dose_level=1; study_year=1991; study_citation=Kehoe, D. (1991) 104-Week Combined Chronic Toxicity and Carcino- genicity Study with Thiram in Rats: Lab Project Number: HLA 6111 113. Unpublished study prepared by Hazleton Labs America, Inc. 2513 p.; dsstox_substance_id=DTXSID5021332; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | LEL | =7.3 | mg/kg bw/day | rat (sprague dawley; CD(SD)BR) | oral | 0 day to 104 week | CHR | study_id=3552; toxval_study_source_id=studyid3552_Adult_F0_M_systemic; toxval_effect_list=pathology microscopic-pancreas-infiltration cellular|pathology microscopic-pancreas-steatosis|in life observation-body weight-body weight gain|pathology microscopic-pancreas-atrophy|pathology gross-kidney-discolored|hematology-mean corpuscular (cell) volume (mcv)-mean corpuscular (cell) volume (mcv)|clinical chemistry-glucose-glucose|organ weight-kidney-absolute|pathology gross-lymph node-discolored|hematology-erythrocyte (rbc) count differential-erythrocyte (rbc)|pathology gross-liver-foci|organ weight-kidney-relative to brain weight; dose_level=2; study_year=1991; study_citation=Kehoe, D. (1991) 104-Week Combined Chronic Toxicity and Carcino- genicity Study with Thiram in Rats: Lab Project Number: HLA 6111 113. Unpublished study prepared by Hazleton Labs America, Inc. 2513 p.; dsstox_substance_id=DTXSID5021332; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | LEL | =1.6 | mg/kg bw/day | rat (Sprague Dawley (SD) rat; Crl: CD(SD)IGS BR) | oral | 3 GD (gestation day) to 1 Generation | DNT | study_id=776296; toxval_study_source_id=studyid776296_Adult_F0_F_systemic; toxval_effect_list=in life observation-food consumption-food consumption|in life observation-body weight-body weight|in life observation-body weight-body weight gain; dose_level=1; study_year=2005; study_citation=Fulcher, S.M. (2005) Thiram: developmental neurotoxicity study in the CD rat by dietary administration. Huntingdon Life Sciences, Ltd., Wooley Road, Alconbury, Huntingdon, Cambridgeshire, PE28 4HS, England. Laboratory study no. PFX/004; January 18, 2005. MRID 46455201. Piccirillo, V. (2008) Response to Data Evaluation Record for Developmental Neurotoxicity Study in Rats With Thiram (MRID 46455201). Huntingdon Life Sciences, Ltd., Wo'oley Road, Alconbury, Huntingdon, Cambridgeshire, PE28 4HS, England. Project Number: 2008/1, PFX/004, PFX004/042634; January 1, 2008. MRID 47429501. Stannard, D. (2010) Thiram: Morphometric Examination of Brains Derived from a Developmental Neurotoxicity Study in the CD Rat. Huntingdon Life Sciences, Eye Research Center, Eye, Suffolk, IP23 7PX, UK. Project Number: SMJ000l, PFX/004/042634. MRID 48291001.; dsstox_substance_id=DTXSID5021332; admin_method=Diet; vehicle=diet; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | LOAEL | =7.34 | mg/kg bw/day | dog (beagle; beagle) | oral | 0 day to 90 day | SUB | study_id=3542; toxval_study_source_id=studyid3542_Adult_F0_F_systemic; toxval_effect_list=hematology-hemoglobin (hgb)-hemoglobin (hgb)|clinical chemistry-cholesterol-cholesterol|hematology-mean corpuscular (cell) volume (mcv)-mean corpuscular (cell) volume (mcv)|in life observation-food consumption-food consumption|clinical chemistry-albumin-albumin|hematology-erythrocyte (rbc) count differential-erythrocyte (rbc)|clinical chemistry-protein-protein|clinical chemistry-calcium-calcium|hematology-hematocrit (hct)-hematocrit (hct)|hematology-mean corpuscular hemoglobin (mch)-mean corpuscular hemoglobin (mch); dose_level=2; study_year=1990; study_citation=Kehoe, D. (1990) 13-Week Toxicity Study with Thiram in Dogs: Lab Project Number: HLA 6111-121: 90-017. Unpublished study prepar- ed Hazleton Laboratories America, Inc. 237 p.; dsstox_substance_id=DTXSID5021332; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | LOAEL | =7.01 | mg/kg bw/day | dog (beagle; beagle) | oral | 0 day to 90 day | SUB | study_id=3542; toxval_study_source_id=studyid3542_Adult_F0_M_systemic; toxval_effect_list=in life observation-food consumption-food consumption|hematology-platelet-platelet|clinical chemistry-cholesterol-cholesterol|in life observation-body weight-body weight|clinical chemistry-calcium-calcium|hematology-erythrocyte (rbc) count differential-erythrocyte (rbc)|hematology-mean corpuscular (cell) volume (mcv)-mean corpuscular (cell) volume (mcv)|hematology-hematocrit (hct)-hematocrit (hct)|hematology-hemoglobin (hgb)-hemoglobin (hgb)|clinical chemistry-albumin-albumin|hematology-mean corpuscular hemoglobin (mch)-mean corpuscular hemoglobin (mch)|clinical chemistry-protein-protein; dose_level=2; study_year=1990; study_citation=Kehoe, D. (1990) 13-Week Toxicity Study with Thiram in Dogs: Lab Project Number: HLA 6111-121: 90-017. Unpublished study prepar- ed Hazleton Laboratories America, Inc. 237 p.; dsstox_substance_id=DTXSID5021332; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | LOAEL | =15 | mg/kg bw/day | rat (sprague dawley; Sprague Dawley (CD)) | oral | 6 GD to 15 GD | DEV | study_id=3546; toxval_study_source_id=studyid3546_Fetal_Fetal_MF_developmental; toxval_effect_list=developmental malformation-bone-short supernumerary|developmental malformation-bone-incomplete ossification; dose_level=2; study_year=1988; study_citation=Tesh, J.; McAnulty, P.; Willoughby, C.; et al. (1988) Thiram: Teratology Study in the Rat: 87/TRK002/179. Unpublished study prepared by Life Science Research. 91 p.; dsstox_substance_id=DTXSID5021332; admin_method=Gavage/Intubation; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | LOAEL | =2.54 | mg/kg bw/day | dog (beagle; beagle) | oral | 0 week to 52 week | CHR | study_id=3550; toxval_study_source_id=studyid3550_Adult_F0_F_systemic; toxval_effect_list=clinical chemistry-cholesterol-cholesterol|clinical chemistry-albumin-albumin|organ weight-liver-relative to body weight|clinical chemistry-protein-protein; dose_level=2; study_year=1991; study_citation=Kehoe, D. (1991) 52-Week Dietary Chronic Toxicity Study with Thiram in Dogs: Final Report: Lab Project Number: HLA 6111-112. Unpublished study prepared by Hazleton Laboratories America, Inc. 545 p.; dsstox_substance_id=DTXSID5021332; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | LOAEL | =8.9 | mg/kg bw/day | rat (sprague dawley; CD(SD)BR) | oral | 0 day to 104 week | CHR | study_id=3552; toxval_study_source_id=studyid3552_Adult_F0_F_systemic; toxval_effect_list=hematology-mean corpuscular (cell) volume (mcv)-mean corpuscular (cell) volume (mcv)|hematology-hemoglobin (hgb)-hemoglobin (hgb)|hematology-mean corpuscular hemoglobin concentration (mchc)-mean corpuscular hemoglobin concentration (mchc)|pathology microscopic-liver-hyperplasia|hematology-erythrocyte (rbc) count differential-erythrocyte (rbc)|in life observation-body weight-body weight gain|clinical chemistry-urea nitrogen-urea nitrogen|hematology-hematocrit (hct)-hematocrit (hct); dose_level=2; study_year=1991; study_citation=Kehoe, D. (1991) 104-Week Combined Chronic Toxicity and Carcino- genicity Study with Thiram in Rats: Lab Project Number: HLA 6111 113. Unpublished study prepared by Hazleton Labs America, Inc. 2513 p.; dsstox_substance_id=DTXSID5021332; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | LOAEL | =6.6 | mg/kg bw/day | rat (Sprague Dawley (SD) rat; Crl: CD(SD)IGS BR) | oral | 3 GD (gestation day) to 1 Generation | DNT | study_id=776296; toxval_study_source_id=studyid776296_Adult_F0_F_neurological; toxval_effect_list=detailed clin obs: dam lactation #2-convulsive behavior-tremors|detailed clin obs: dam lactation #2-unusual behavior or appearance-rearing activity|detailed clin obs: dam lactation #2-autonomic function-palpebral closure (ptosis)|detailed clin obs: dam lactation #2-unusual behavior or appearance-activity; dose_level=3; study_year=2005; study_citation=Fulcher, S.M. (2005) Thiram: developmental neurotoxicity study in the CD rat by dietary administration. Huntingdon Life Sciences, Ltd., Wooley Road, Alconbury, Huntingdon, Cambridgeshire, PE28 4HS, England. Laboratory study no. PFX/004; January 18, 2005. MRID 46455201. Piccirillo, V. (2008) Response to Data Evaluation Record for Developmental Neurotoxicity Study in Rats With Thiram (MRID 46455201). Huntingdon Life Sciences, Ltd., Wo'oley Road, Alconbury, Huntingdon, Cambridgeshire, PE28 4HS, England. Project Number: 2008/1, PFX/004, PFX004/042634; January 1, 2008. MRID 47429501. Stannard, D. (2010) Thiram: Morphometric Examination of Brains Derived from a Developmental Neurotoxicity Study in the CD Rat. Huntingdon Life Sciences, Eye Research Center, Eye, Suffolk, IP23 7PX, UK. Project Number: SMJ000l, PFX/004/042634. MRID 48291001.; dsstox_substance_id=DTXSID5021332; admin_method=Diet; vehicle=diet; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | NEL | >0 | mg/kg bw/day | dog (beagle; beagle) | oral | 0 day to 90 day | SUB | study_id=3542; toxval_study_source_id=studyid3542_Adult_F0_F_systemic; toxval_effect_list=in life observation-clinical signs-emesis|clinical chemistry-calcium-calcium|clinical chemistry-protein-protein|hematology-mean corpuscular hemoglobin concentration (mchc)-mean corpuscular hemoglobin concentration (mchc)|hematology-hematocrit (hct)-hematocrit (hct)|hematology-mean corpuscular hemoglobin (mch)-mean corpuscular hemoglobin (mch)|clinical chemistry-cholesterol-cholesterol|hematology-hemoglobin (hgb)-hemoglobin (hgb)|in life observation-food consumption-food consumption|clinical chemistry-albumin-albumin|hematology-mean corpuscular (cell) volume (mcv)-mean corpuscular (cell) volume (mcv)|hematology-erythrocyte (rbc) count differential-erythrocyte (rbc)|hematology-platelet-platelet|in life observation-body weight-body weight; dose_level=0; study_year=1990; study_citation=Kehoe, D. (1990) 13-Week Toxicity Study with Thiram in Dogs: Lab Project Number: HLA 6111-121: 90-017. Unpublished study prepar- ed Hazleton Laboratories America, Inc. 237 p.; dsstox_substance_id=DTXSID5021332; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | NEL | =1.6 | mg/kg bw/day | rat (sprague dawley; Sprague Dawley (CD)) | oral | 90 days (premating) to 2 generation | MGR | study_id=3549; toxval_study_source_id=studyid3549_Adult_F0_F_systemic; toxval_effect_list=pathology microscopic-pituitary gland-angiectasis|in life observation-body weight-body weight|in life observation-body weight-body weight gain|in life observation-food consumption-food consumption; dose_level=1; study_year=1997; study_citation=Turck, P. (1997) Two Generation Reproduction/Fertility Study in Rats with Thiram: Lab Project Number: 399-180. Unpublished study prepared by MPI Research. 1579 p.; dsstox_substance_id=DTXSID5021332; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | NEL | =4.2 | mg/kg bw/day | rat (sprague dawley; Sprague Dawley (CD)) | oral | 90 days (premating) to 2 generation | MGR | study_id=3549; toxval_study_source_id=studyid3549_Adult_F0_M_systemic; toxval_effect_list=pathology microscopic-prostate-inflammation|in life observation-food consumption-food consumption; dose_level=2; study_year=1997; study_citation=Turck, P. (1997) Two Generation Reproduction/Fertility Study in Rats with Thiram: Lab Project Number: 399-180. Unpublished study prepared by MPI Research. 1579 p.; dsstox_substance_id=DTXSID5021332; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | NEL | =1.8 | mg/kg bw/day | rat (sprague dawley; Sprague Dawley (CD)) | oral | 90 days (premating) to 2 generation | MGR | study_id=3549; toxval_study_source_id=studyid3549_Adult_F1_F_systemic; toxval_effect_list=in life observation-body weight-body weight gain; dose_level=1; study_year=1997; study_citation=Turck, P. (1997) Two Generation Reproduction/Fertility Study in Rats with Thiram: Lab Project Number: 399-180. Unpublished study prepared by MPI Research. 1579 p.; dsstox_substance_id=DTXSID5021332; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | NEL | =1.7 | mg/kg bw/day | rat (sprague dawley; Sprague Dawley (CD)) | oral | 90 days (premating) to 2 generation | MGR | study_id=3549; toxval_study_source_id=studyid3549_Juvenile_F1_M_systemic; toxval_effect_list=in life observation-body weight-offspring (pup) weight|in life observation-body weight-offspring (pup) weight gain; dose_level=1; study_year=1997; study_citation=Turck, P. (1997) Two Generation Reproduction/Fertility Study in Rats with Thiram: Lab Project Number: 399-180. Unpublished study prepared by MPI Research. 1579 p.; dsstox_substance_id=DTXSID5021332; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | NEL | =3.1 | mg/kg bw/day | mouse (cd1; Crl:CD-1(ICR)BR) | oral | 0 day to 97 week | CHR | study_id=3551; toxval_study_source_id=studyid3551_Adult_F0_F_systemic; toxval_effect_list=pathology microscopic-skin-inflammation|in life observation-body weight-body weight|pathology microscopic-stomach-hyperkeratosis|hematology-hematocrit (hct)-hematocrit (hct)|hematology-hemoglobin (hgb)-hemoglobin (hgb)|pathology microscopic-spleen-pigmentation|hematology-erythrocyte (rbc) count differential-erythrocyte (rbc)|pathology microscopic-urinary bladder-[other]|in life observation-body weight-body weight gain|hematology-platelet-platelet|pathology microscopic-skin-necrosis|pathology microscopic-eye-atrophy; dose_level=1; study_year=1992; study_citation=Trutter, J. (1992) Oncogenicity Study in Mice with Thiram: Lab Project Number: 798-223. Unpublished study prepared by Hazleton Washington, Inc. 2965 p.; dsstox_substance_id=DTXSID5021332; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | NEL | =2.5 | mg/kg bw/day | mouse (cd1; Crl:CD-1(ICR)BR) | oral | 0 day to 97 week | CHR | study_id=3551; toxval_study_source_id=studyid3551_Adult_F0_M_systemic; toxval_effect_list=pathology microscopic-urinary bladder-[other]|pathology microscopic-skin-inflammation|hematology-mean corpuscular hemoglobin concentration (mchc)-mean corpuscular hemoglobin concentration (mchc)|in life observation-body weight-body weight gain|pathology microscopic-eye-atrophy|pathology microscopic-stomach-hyperkeratosis|pathology microscopic-skin-necrosis|in life observation-body weight-body weight; dose_level=1; study_year=1992; study_citation=Trutter, J. (1992) Oncogenicity Study in Mice with Thiram: Lab Project Number: 798-223. Unpublished study prepared by Hazleton Washington, Inc. 2965 p.; dsstox_substance_id=DTXSID5021332; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | NEL | =1.5 | mg/kg bw/day | rat (sprague dawley; CD(SD)BR) | oral | 0 day to 104 week | CHR | study_id=3552; toxval_study_source_id=studyid3552_Adult_F0_M_systemic; toxval_effect_list=organ weight-kidney-relative to brain weight|pathology gross-liver-foci|hematology-erythrocyte (rbc) count differential-erythrocyte (rbc)|clinical chemistry-glucose-glucose|organ weight-kidney-absolute|pathology gross-lymph node-discolored|hematology-mean corpuscular (cell) volume (mcv)-mean corpuscular (cell) volume (mcv)|pathology gross-kidney-discolored|pathology microscopic-pancreas-atrophy|in life observation-body weight-body weight gain|pathology microscopic-pancreas-steatosis|pathology microscopic-pancreas-infiltration cellular; dose_level=1; study_year=1991; study_citation=Kehoe, D. (1991) 104-Week Combined Chronic Toxicity and Carcino- genicity Study with Thiram in Rats: Lab Project Number: HLA 6111 113. Unpublished study prepared by Hazleton Labs America, Inc. 2513 p.; dsstox_substance_id=DTXSID5021332; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | NOAEL | =3.8 | mg/kg bw/day | rat (Sprague Dawley (SD) rat; Crl: CD(SD)IGS BR) | oral | 3 GD (gestation day) to 1 Generation | DNT | study_id=776296; toxval_study_source_id=studyid776296_Adult_F0_F_neurological; toxval_effect_list=detailed clin obs: dam lactation #2-autonomic function-palpebral closure (ptosis)|detailed clin obs: dam lactation #2-convulsive behavior-tremors|detailed clin obs: dam lactation #2-unusual behavior or appearance-rearing activity|detailed clin obs: dam lactation #2-unusual behavior or appearance-activity; dose_level=2; study_year=2005; study_citation=Fulcher, S.M. (2005) Thiram: developmental neurotoxicity study in the CD rat by dietary administration. Huntingdon Life Sciences, Ltd., Wooley Road, Alconbury, Huntingdon, Cambridgeshire, PE28 4HS, England. Laboratory study no. PFX/004; January 18, 2005. MRID 46455201. Piccirillo, V. (2008) Response to Data Evaluation Record for Developmental Neurotoxicity Study in Rats With Thiram (MRID 46455201). Huntingdon Life Sciences, Ltd., Wo'oley Road, Alconbury, Huntingdon, Cambridgeshire, PE28 4HS, England. Project Number: 2008/1, PFX/004, PFX004/042634; January 1, 2008. MRID 47429501. Stannard, D. (2010) Thiram: Morphometric Examination of Brains Derived from a Developmental Neurotoxicity Study in the CD Rat. Huntingdon Life Sciences, Eye Research Center, Eye, Suffolk, IP23 7PX, UK. Project Number: SMJ000l, PFX/004/042634. MRID 48291001.; dsstox_substance_id=DTXSID5021332; admin_method=Diet; vehicle=diet; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
ToxValDB AU DWG 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB AU DWG | NOEL | =0.4 | mg/kg bw/day | Dog | oral | chronic; 2 years | chronic | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/68c82db5e4b02565fc7d237c; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.nhmrc.gov.au; SUBSOURCE_URL=https://www.nhmrc.gov.au/sites/default/files/documents/attachments/publications/Australian_Drinking_Water_Guidelines_ADWG_V3-8_Sep2022.pdf; TOXICOLOGICAL_EFFECT=neurological disturbances, anaemia and changes in the liver; STUDY_GROUP=AU DWG:15951776:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_3418a97c60dd5a7e534fc96f6523b768 |
ToxValDB ECOTOX 12 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB ECOTOX | LOEL | =1 | mmol/kg | Mouse | oral | acute; 1 days | acute | LONG_REF=Toxicol. Lett.42(1): 87-98 Borg,K., and H. Tjalve Effect of Thiram and Dithiocarbamate Pesticides on the Gastrointestinal Absorption and Distribution of Nickel in Mice 1988; TITLE=Effect of Thiram and Dithiocarbamate Pesticides on the Gastrointestinal Absorption and Distribution of Nickel in Mice; AUTHOR=Borg,K., and H. Tjalve; DOI=10.1016/0378-4274(88)90106-3; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=90179; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1988; ORIGINAL_YEAR=1988; TOXICOLOGICAL_EFFECT=Biochemistry: Nickel content; STUDY_GROUP=ECOTOX:15605694:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=ccaef8edfd8ec15b83da2e2c8768c857 |
| ToxValDB ECOTOX | LOEL | =25 | mg/kg bw/day | Mouse | injection | short-term; 2 days | short-term | LONG_REF=Teratog. Carcinog. Mutagen.12(3): 97-112 Crebelli,R., A. Zijno, L. Conti, B. Crochi, P. Leopardi, F. Marcon, L. Renzi, and A. Carere Further In Vitro and In Vivo Mutagenicity Assays with Thiram and Ziram Fungicides: Bacterial Reversion Assays and Mouse Micronucleus Test 1992; TITLE=Further In Vitro and In Vivo Mutagenicity Assays with Thiram and Ziram Fungicides: Bacterial Reversion Assays and Mouse Micronucleus Test; AUTHOR=Crebelli,R., A. Zijno, L. Conti, B. Crochi, P. Leopardi, F. Marcon, L. Renzi, and A. Carere; DOI=10.1002/tcm.1770120302; QUALITY=Control type: Multiple control types; EXTERNAL_SOURCE_ID=99049; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1992; ORIGINAL_YEAR=1992; TOXICOLOGICAL_EFFECT=Cell(s): Polychromatic cells; STUDY_GROUP=ECOTOX_dup_EPA ORD_15594976_15594977_15596212_15607992:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=fb34e74e94c486d49fb7f1bf6e4ecf54 |
| ToxValDB ECOTOX | LOEL | =50 | ul/org | Mouse | dermal | short-term; 18 days | short-term | LONG_REF=Toxicology176(1-2): 123-134 De Jong,W.H., M. Tentij, S.W. Spiekstra, R.J. Vandebriel, and H. Van Loveren Determination of the Sensitising Activity of the Rubber Contact Sensitisers TMTD, ZDMC, MBT and DEA in a Modified Local Lymph Node Assay and the Effect of Sodium Dodecyl Sulfate Pretreatment on Local Lymph Node Response 2002; TITLE=Determination of the Sensitising Activity of the Rubber Contact Sensitisers TMTD, ZDMC, MBT and DEA in a Modified Local Lymph Node Assay and the Effect of Sodium Dodecyl Sulfate Pretreatment on Local Lymph Node Response; AUTHOR=De Jong,W.H., M. Tentij, S.W. Spiekstra, R.J. Vandebriel, and H. Van Loveren; DOI=10.1016/s0300-483x(02)00131-2; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=99302; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2002; ORIGINAL_YEAR=2002; TOXICOLOGICAL_EFFECT=Cell(s): Number of cells|Histology: Proliferation|Morphology: Weight; TOXICOLOGICAL_EFFECT_CATEGORY=nonneoplastic histopathology|other; STUDY_GROUP=ECOTOX:15594832:M/F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=4e4c92acdbe6b0dd46089db4031e8f9e |
| ToxValDB ECOTOX | LOEL | =76 | mL/454 g diet | Mouse | oral | short-term; 4 days | short-term | LONG_REF=Int. Biodeterior. Biodegrad.45:169-174 Nolte,D.L., and J.P. Barnett A Repellent to Reduce Mouse Damage to Longleaf Pine Seed 2000; TITLE=A Repellent to Reduce Mouse Damage to Longleaf Pine Seed; AUTHOR=Nolte,D.L., and J.P. Barnett; DOI=10.1016/S0964-8305(00)00060-3; QUALITY=Control type: Baseline control |::| Control type: Concurrent control; EXTERNAL_SOURCE_ID=74471; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2000; ORIGINAL_YEAR=2000; TOXICOLOGICAL_EFFECT=Avoidance: Food avoidance; TOXICOLOGICAL_EFFECT_CATEGORY=food and/or water consumption; STUDY_GROUP=ECOTOX:15605086:unknown:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=2eb5f8208a8bca04f0e00551af4ad9c8 |
| ToxValDB ECOTOX | NOEL | =10 | mg/kg bw/day | Mouse | oral | chronic; 547.92 days | chronic | LONG_REF=J. Natl. Cancer Inst.42:1101-1114 Innes,J.R.M., B.M. Ulland, M.G. Valerio, L. Petrucelli, L. Fishbein, E.R. Hart, A.J. Pallotta, R.R. Bates, H.L. Falk, J Bioassay of Pesticides and Industrial Chemicals for Tumorigenicity in Mice: A Preliminary Note 1969; TITLE=Bioassay of Pesticides and Industrial Chemicals for Tumorigenicity in Mice: A Preliminary Note; AUTHOR=Innes,J.R.M., B.M. Ulland, M.G. Valerio, L. Petrucelli, L. Fishbein, E.R. Hart, A.J. Pallotta, R.R. Bates, H.L. Falk, J; QUALITY=Control type: Multiple entries; EXTERNAL_SOURCE_ID=71346; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1969; ORIGINAL_YEAR=1969; TOXICOLOGICAL_EFFECT=Injury: Tumor induction; TOXICOLOGICAL_EFFECT_CATEGORY=cancer; STUDY_GROUP=ECOTOX:15611931:unknown:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=9bc8d73f3fcbc419ee2ee58aa7d545c0 |
| ToxValDB ECOTOX | NOEL | =12.5 | mg/kg bw/day | Mouse | injection | short-term; 2 days | short-term | LONG_REF=Teratog. Carcinog. Mutagen.12(3): 97-112 Crebelli,R., A. Zijno, L. Conti, B. Crochi, P. Leopardi, F. Marcon, L. Renzi, and A. Carere Further In Vitro and In Vivo Mutagenicity Assays with Thiram and Ziram Fungicides: Bacterial Reversion Assays and Mouse Micronucleus Test 1992; TITLE=Further In Vitro and In Vivo Mutagenicity Assays with Thiram and Ziram Fungicides: Bacterial Reversion Assays and Mouse Micronucleus Test; AUTHOR=Crebelli,R., A. Zijno, L. Conti, B. Crochi, P. Leopardi, F. Marcon, L. Renzi, and A. Carere; DOI=10.1002/tcm.1770120302; QUALITY=Control type: Multiple control types; EXTERNAL_SOURCE_ID=99049; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1992; ORIGINAL_YEAR=1992; TOXICOLOGICAL_EFFECT=Cell(s): Polychromatic cells; STUDY_GROUP=ECOTOX_dup_EPA ORD_15594976_15594977_15596212_15607992:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=f24b2917b921e7f5b8bfbd9ff52aaed1 |
| ToxValDB ECOTOX | NOEL | =25 | mg/kg bw/day | Mouse | injection | acute; 1 days | acute | LONG_REF=Teratog. Carcinog. Mutagen.12(3): 97-112 Crebelli,R., A. Zijno, L. Conti, B. Crochi, P. Leopardi, F. Marcon, L. Renzi, and A. Carere Further In Vitro and In Vivo Mutagenicity Assays with Thiram and Ziram Fungicides: Bacterial Reversion Assays and Mouse Micronucleus Test 1992; TITLE=Further In Vitro and In Vivo Mutagenicity Assays with Thiram and Ziram Fungicides: Bacterial Reversion Assays and Mouse Micronucleus Test; AUTHOR=Crebelli,R., A. Zijno, L. Conti, B. Crochi, P. Leopardi, F. Marcon, L. Renzi, and A. Carere; DOI=10.1002/tcm.1770120302; QUALITY=Control type: Multiple control types; EXTERNAL_SOURCE_ID=99049; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1992; ORIGINAL_YEAR=1992; TOXICOLOGICAL_EFFECT=Cell(s): Polychromatic cells; STUDY_GROUP=ECOTOX_dup_EPA ORD_15596604_15599023_15609795_15609796:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=0de1ccecb035bdda920efdf305bb566e |
| ToxValDB ECOTOX | NOEL | =37.5 | mg/kg bw/day | Mouse | injection | short-term; 2 days | short-term | LONG_REF=Teratog. Carcinog. Mutagen.12(3): 97-112 Crebelli,R., A. Zijno, L. Conti, B. Crochi, P. Leopardi, F. Marcon, L. Renzi, and A. Carere Further In Vitro and In Vivo Mutagenicity Assays with Thiram and Ziram Fungicides: Bacterial Reversion Assays and Mouse Micronucleus Test 1992; TITLE=Further In Vitro and In Vivo Mutagenicity Assays with Thiram and Ziram Fungicides: Bacterial Reversion Assays and Mouse Micronucleus Test; AUTHOR=Crebelli,R., A. Zijno, L. Conti, B. Crochi, P. Leopardi, F. Marcon, L. Renzi, and A. Carere; DOI=10.1002/tcm.1770120302; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=99049; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1992; ORIGINAL_YEAR=1992; TOXICOLOGICAL_EFFECT=Cell(s): Polychromatic cells|Cell(s): Polychromatic cells, micronucleated; TOXICOLOGICAL_EFFECT_CATEGORY=nonneoplastic histopathology; STUDY_GROUP=ECOTOX_dup_EPA ORD_15594976_15594977_15596212_15607992:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=3a9c98231fec70f81126969008162427 |
| ToxValDB ECOTOX | NOEL | =50 | mg/kg bw/day | Mouse | injection | acute; 1 days | acute | LONG_REF=Teratog. Carcinog. Mutagen.12(3): 97-112 Crebelli,R., A. Zijno, L. Conti, B. Crochi, P. Leopardi, F. Marcon, L. Renzi, and A. Carere Further In Vitro and In Vivo Mutagenicity Assays with Thiram and Ziram Fungicides: Bacterial Reversion Assays and Mouse Micronucleus Test 1992; TITLE=Further In Vitro and In Vivo Mutagenicity Assays with Thiram and Ziram Fungicides: Bacterial Reversion Assays and Mouse Micronucleus Test; AUTHOR=Crebelli,R., A. Zijno, L. Conti, B. Crochi, P. Leopardi, F. Marcon, L. Renzi, and A. Carere; DOI=10.1002/tcm.1770120302; QUALITY=Control type: Multiple control types; EXTERNAL_SOURCE_ID=99049; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1992; ORIGINAL_YEAR=1992; TOXICOLOGICAL_EFFECT=Cell(s): Polychromatic cells, micronucleated; TOXICOLOGICAL_EFFECT_CATEGORY=nonneoplastic histopathology; STUDY_GROUP=ECOTOX_dup_EPA ORD_15596604_15599023_15609795_15609796:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=4874ab26437ec2a74945282c3aaa7197 |
| ToxValDB ECOTOX | NOEL | =80 | mg/kg bw/day | Rat | injection | short-term; 5 days | short-term | LONG_REF=Arch. Toxicol.8:77-79 Komulainen,H., and K. Savolainen Effect of Dithiocarbamate Fungicides and Thiurams on 3H-Haloperidol Binding in Rat Brain 1985; TITLE=Effect of Dithiocarbamate Fungicides and Thiurams on 3H-Haloperidol Binding in Rat Brain; AUTHOR=Komulainen,H., and K. Savolainen; DOI=10.1007/978-3-642-69928-3_8; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=90501; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1985; ORIGINAL_YEAR=1985; TOXICOLOGICAL_EFFECT=Biochemistry: Protein binding; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ECOTOX:15599546:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=a76d61c06246f5004256399de43d537b |
| ToxValDB ECOTOX | NOEL | =250 | mg/kg bw/day | Mouse | oral | short-term; 1.25 days | short-term | LONG_REF=Mutat. Res.48(2): 225-236 Seiler,J.P. Nitrosation In Vitro and In Vivo by Sodium Nitrite, and Mutagenicity of Nitrogenous Pesticides 1977; TITLE=Nitrosation In Vitro and In Vivo by Sodium Nitrite, and Mutagenicity of Nitrogenous Pesticides; AUTHOR=Seiler,J.P.; DOI=10.1016/0027-5107(77)90164-6; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=88676; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1977; ORIGINAL_YEAR=1977; TOXICOLOGICAL_EFFECT=Cell(s): Polychromatic cells, micronucleated; TOXICOLOGICAL_EFFECT_CATEGORY=nonneoplastic histopathology; STUDY_GROUP=ECOTOX:15609136:M/F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=03144c9447194fdcee7e5302dfd13404 |
| ToxValDB ECOTOX | NOEL | =366.7 | mg/kg bw/day | Mouse | injection | short-term; 2 days | short-term | LONG_REF=Mutat. Res.518(2): 145-150 Grisolia,C.K. A Comparison Between Mouse and Fish Micronucleus Test Using Cyclophosphamide, Mitomycin C and Various Pesticides 2002; TITLE=A Comparison Between Mouse and Fish Micronucleus Test Using Cyclophosphamide, Mitomycin C and Various Pesticides; AUTHOR=Grisolia,C.K.; DOI=10.1016/s1383-5718(02)00086-4; QUALITY=Control type: Multiple control types; EXTERNAL_SOURCE_ID=74478; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2002; ORIGINAL_YEAR=2002; TOXICOLOGICAL_EFFECT=Cell(s): Polychromatic cells; STUDY_GROUP=ECOTOX:15606416:M/F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=8344a78ba71d20d4dcaa6f19b2ca3a72 |
ToxValDB EPA OPP 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB EPA OPP | PAD (RfD) | =0.014 | mg/kg bw/day | Human | oral | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/63d99625e4b02a0c3a37c5d8; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/sdwa/2021-human-health-benchmarks-pesticides; YEAR=2021; ORIGINAL_YEAR=2021; STUDY_GROUP=EPA OPP_dup_HHBP_15790228_15790230:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_693e7e84b82389d2671019141b726f52 |
| ToxValDB EPA OPP | PAD (RfD) | =0.015 | mg/kg bw/day | Human | oral | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/63d99625e4b02a0c3a37c5d8; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/sdwa/2021-human-health-benchmarks-pesticides; YEAR=2021; ORIGINAL_YEAR=2021; STUDY_GROUP=EPA OPP_dup_HHBP_15790228_15790230:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_b997a0afacd7db6a1e70308df4ffe0af |
ToxValDB GESTIS DNEL 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB GESTIS DNEL | DNEL systemic | =0.118 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15635243:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_cb8f47db92215504b43a784a65c4819d |
ToxValDB HPVIS 3 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB HPVIS | NOAEL | ~2.5 | mg/kg bw/day | Rat | oral | subchronic; 90 days | subchronic | LONG_REF=HLA 6111-110 (1988)Posting date of document from which data were extracted for entry into HPVIS: July 25, 2003.; QUALITY=1; EXTERNAL_SOURCE_ID=61975; EXTERNAL_SOURCE_ID_DESC=HPVIS ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/63861d6de4b04f6bb1480596; RECORD_SOURCE_LEVEL=Extraction document; YEAR=1982; ORIGINAL_YEAR=1982; STUDY_GROUP=HPVIS:15639828:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_e29623f43b7ca213d3e0bcc90f1dc6bf |
| ToxValDB HPVIS | NOAEL | =5 | mg/kg bw/day | Rabbit | oral | short-term; 14 days | reproduction developmental | LONG_REF=LSR 87/TRK 004/541 (1988)Posting date of document from which data were extracted for entry into HPVIS: July 25, 2003.; QUALITY=1; EXTERNAL_SOURCE_ID=59944; EXTERNAL_SOURCE_ID_DESC=HPVIS ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/63861d6de4b04f6bb1480590; RECORD_SOURCE_LEVEL=Extraction document; YEAR=1988; ORIGINAL_YEAR=1988; STUDY_GROUP=HPVIS:15642914:F:-maternal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_7c8655204d490c478c27cc38b37fdb9e |
| ToxValDB HPVIS | NOAEL | =7.5 | mg/kg bw/day | Rat | oral | short-term; 10 days | developmental | LONG_REF=Thiram Task Force, 1987Posting date of document from which data were extracted for entry into HPVIS: July 25, 2003.; QUALITY=2; EXTERNAL_SOURCE_ID=58346; EXTERNAL_SOURCE_ID_DESC=HPVIS ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/63861d6de4b04f6bb1480590; RECORD_SOURCE_LEVEL=Extraction document; YEAR=1987; ORIGINAL_YEAR=1987; STUDY_GROUP=HPVIS:15642417:F:F1offspring; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_dcf77757deefbf1b0e82e28df33347cd |
ToxValDB IRIS 3 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB IRIS | LEL | =15 | mg/kg bw/day | Rat | oral | chronic; 2 years | chronic | LONG_REF=E.I. duPont de Nemours & Co., Inc. 1954. MRID. No. 0045162. HED Doc. No. 004550. Available from EPA. Write to FOI, EPA, Washington, DC 20460.; AUTHOR=E.I. duPont de Nemours & Co., Inc; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/652e8a35e4b045b9ff7a542d; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/iris; SUBSOURCE_URL=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=267; TOXICOLOGICAL_EFFECT=neurotoxicity; TOXICOLOGICAL_EFFECT_CATEGORY=nonneoplastic histopathology; STUDY_GROUP=IRIS_dup_IRIS Summary_15644769_15644771:M/F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_f70f1eb808c5d7349799b1f207cb879d |
| ToxValDB IRIS | NOEL | =5 | mg/kg bw/day | Rat | oral | chronic; 2 years | chronic | LONG_REF=E.I. duPont de Nemours & Co., Inc. 1954. MRID. No. 0045162. HED Doc. No. 004550. Available from EPA. Write to FOI, EPA, Washington, DC 20460.; AUTHOR=E.I. duPont de Nemours & Co., Inc; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/652e8a35e4b045b9ff7a542d; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/iris; SUBSOURCE_URL=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=267; TOXICOLOGICAL_EFFECT=neurotoxicity; TOXICOLOGICAL_EFFECT_CATEGORY=nonneoplastic histopathology; STUDY_GROUP=IRIS_dup_IRIS Summary_15644769_15644771:M/F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_aa6138f13f03ff074b2dfe3675d3ddc3 |
| ToxValDB IRIS | RfD | =0.005 | mg/kg bw/day | Human | oral | - | Toxicity Value | LONG_REF=E.I. duPont de Nemours & Co., Inc. 1954. MRID. No. 0045162. HED Doc. No. 004550. Available from EPA. Write to FOI, EPA, Washington, DC 20460.; AUTHOR=E.I. duPont de Nemours & Co., Inc; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/652e8a35e4b045b9ff7a542d; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/iris; SUBSOURCE_URL=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=267; TOXICOLOGICAL_EFFECT=Neurotoxicity in male/female rats; STUDY_GROUP=IRIS:15645482:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_6a36ced23cca8bf6a386b20a402f136d |
ToxValDB RSL 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB RSL | RfD | =0.006 | mg/kg bw/day | Human | oral | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759b87ce4b0a7c65d37b4e2; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/risk/regional-screening-levels-rsls-generic-tables; STUDY_GROUP=RSL:15663807:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_3911e6e1405e290bea642788b8b361a4 |
ToxValDB ToxRefDB 22 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB ToxRefDB | LEL | =0.9 | mg/kg bw/day | Dog | oral | chronic; 52 weeks | chronic | LONG_REF=Kehoe, D. (1991) 52-Week Dietary Chronic Toxicity Study with Thiram in Dogs: Final Report: Lab Project Number: HLA 6111-112. Unpublished study prepared by Hazleton Laboratories America, Inc. 545 p.; TITLE=52-Week Dietary Chronic Toxicity Study with Thiram in Dogs: Final Report: Lab Project Number: HLA 6111-112; AUTHOR=Kehoe, D; EXTERNAL_SOURCE_ID=3550; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1991; ORIGINAL_YEAR=1991; TOXICOLOGICAL_EFFECT=systemic: hematology-mean corpuscular (cell) volume (mcv)-mean corpuscular (cell) volume (mcv)|systemic: hematology-mean corpuscular hemoglobin (mch)-mean corpuscular hemoglobin (mch)|systemic: clinical chemistry-albumin-albumin|systemic: clinical chemistry-cholesterol-cholesterol|systemic: organ weight-liver-relative to body weight|systemic: clinical chemistry-protein-protein; TOXICOLOGICAL_EFFECT_CATEGORY=clinical chemistry|hematology|organ weight; STUDY_GROUP=ToxRefDB_dup_-_15702566_15702567_15702568:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_1fda1665314c8292ade9e771bed0c31a |
| ToxValDB ToxRefDB | LEL | =1.8 | mg/kg bw/day | Rat | oral | chronic; 104 weeks | chronic | LONG_REF=Kehoe, D. (1991) 104-Week Combined Chronic Toxicity and Carcino- genicity Study with Thiram in Rats: Lab Project Number: HLA 6111 113. Unpublished study prepared by Hazleton Labs America, Inc. 2513 p.; TITLE=104-Week Combined Chronic Toxicity and Carcino- genicity Study with Thiram in Rats: Lab Project Number: HLA 6111 113; AUTHOR=Kehoe, D; EXTERNAL_SOURCE_ID=3552; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1991; ORIGINAL_YEAR=1991; TOXICOLOGICAL_EFFECT=systemic: pathology microscopic-spleen-hematopoietic cell proliferation|systemic: hematology-mean corpuscular hemoglobin concentration (mchc)-mean corpuscular hemoglobin concentration (mchc)|systemic: hematology-mean corpuscular (cell) volume (mcv)-mean corpuscular (cell) volume (mcv)|systemic: hematology-hemoglobin (hgb)-hemoglobin (hgb)|systemic: hematology-erythrocyte (rbc) count differential-erythrocyte (rbc)|systemic: hematology-hematocrit (hct)-hematocrit (hct)|systemic: clinical chemistry-urea nitrogen-urea nitrogen|systemic: pathology microscopic-liver-hyperplasia|systemic: pathology microscopic-thyroid gland-hyperplasia|systemic: in life observation-body weight-body weight gain|systemic: pathology gross-adrenal gland-cyst|systemic: pathology microscopic-pancreas-steatosis|systemic: pathology microscopic-pancreas-infiltration cellular|systemic: organ weight-ovary-relative to brain weight|systemic: organ weight-ovary-absolute|systemic: clinical chemistry-glucose-glucose|systemic: pathology microscopic-liver-hematopoietic cell proliferation; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical chemistry|gross pathology|hematology|nonneoplastic histopathology|organ weight; STUDY_GROUP=ToxRefDB_dup_-_15702579_15702580_15702581:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_7e4c31addd126e86131a0866394ae65a |
| ToxValDB ToxRefDB | LEL | =2.26 | mg/kg bw/day | Dog | oral | subchronic; 90 days | subchronic | LONG_REF=Kehoe, D. (1990) 13-Week Toxicity Study with Thiram in Dogs: Lab Project Number: HLA 6111-121: 90-017. Unpublished study prepar- ed Hazleton Laboratories America, Inc. 237 p.; TITLE=13-Week Toxicity Study with Thiram in Dogs: Lab Project Number: HLA 6111-121: 90-017; AUTHOR=Kehoe, D; EXTERNAL_SOURCE_ID=3542; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1990; ORIGINAL_YEAR=1990; TOXICOLOGICAL_EFFECT=systemic: clinical chemistry-cholesterol-cholesterol|systemic: hematology-mean corpuscular hemoglobin (mch)-mean corpuscular hemoglobin (mch)|systemic: clinical chemistry-protein-protein|systemic: clinical chemistry-albumin-albumin|systemic: hematology-hemoglobin (hgb)-hemoglobin (hgb)|systemic: in life observation-body weight-body weight|systemic: hematology-hematocrit (hct)-hematocrit (hct)|systemic: clinical chemistry-calcium-calcium|systemic: hematology-platelet-platelet|systemic: in life observation-clinical signs-emesis|systemic: hematology-mean corpuscular (cell) volume (mcv)-mean corpuscular (cell) volume (mcv)|systemic: hematology-erythrocyte (rbc) count differential-erythrocyte (rbc)|systemic: in life observation-food consumption-food consumption|systemic: hematology-mean corpuscular hemoglobin concentration (mchc)-mean corpuscular hemoglobin concentration (mchc); TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical chemistry|clinical signs|food and/or water consumption|hematology; STUDY_GROUP=ToxRefDB_dup_-_15702532_15702533_15702534:M:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_172a81f62317fefa461707d1c80f2441 |
| ToxValDB ToxRefDB | LEL | =2.35 | mg/kg bw/day | Dog | oral | subchronic; 90 days | subchronic | LONG_REF=Kehoe, D. (1990) 13-Week Toxicity Study with Thiram in Dogs: Lab Project Number: HLA 6111-121: 90-017. Unpublished study prepar- ed Hazleton Laboratories America, Inc. 237 p.; TITLE=13-Week Toxicity Study with Thiram in Dogs: Lab Project Number: HLA 6111-121: 90-017; AUTHOR=Kehoe, D; EXTERNAL_SOURCE_ID=3542; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1990; ORIGINAL_YEAR=1990; TOXICOLOGICAL_EFFECT=systemic: clinical chemistry-cholesterol-cholesterol|systemic: hematology-hemoglobin (hgb)-hemoglobin (hgb)|systemic: clinical chemistry-protein-protein|systemic: hematology-erythrocyte (rbc) count differential-erythrocyte (rbc)|systemic: in life observation-clinical signs-emesis|systemic: hematology-hematocrit (hct)-hematocrit (hct)|systemic: clinical chemistry-calcium-calcium|systemic: hematology-mean corpuscular (cell) volume (mcv)-mean corpuscular (cell) volume (mcv)|systemic: clinical chemistry-albumin-albumin|systemic: hematology-mean corpuscular hemoglobin (mch)-mean corpuscular hemoglobin (mch)|systemic: in life observation-food consumption-food consumption|systemic: hematology-mean corpuscular hemoglobin concentration (mchc)-mean corpuscular hemoglobin concentration (mchc)|systemic: in life observation-body weight-body weight|systemic: hematology-platelet-platelet; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical chemistry|clinical signs|food and/or water consumption|hematology; STUDY_GROUP=ToxRefDB_dup_-_15702529_15702530_15702531:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_e02033e71d6f8f0437d234d22def0f5f |
| ToxValDB ToxRefDB | LEL | =4.7 | mg/kg bw/day | Rat | oral | chronic (developmental) | reproduction developmental | LONG_REF=Turck, P. (1997) Two Generation Reproduction/Fertility Study in Rats with Thiram: Lab Project Number: 399-180. Unpublished study prepared by MPI Research. 1579 p.; TITLE=Two Generation Reproduction/Fertility Study in Rats with Thiram: Lab Project Number: 399-180; AUTHOR=Turck, P; EXTERNAL_SOURCE_ID=3549; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1997; ORIGINAL_YEAR=1997; TOXICOLOGICAL_EFFECT=systemic: in life observation-body weight-body weight gain|systemic: in life observation-food consumption-food consumption|systemic: in life observation-body weight-body weight|systemic: pathology microscopic-pituitary gland-angiectasis; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|food and/or water consumption|nonneoplastic histopathology; STUDY_GROUP=ToxRefDB_dup_-_15702540_15702541_15702542_15702543:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_4d5db3998579058abb9cb7dbae00b316 |
| ToxValDB ToxRefDB | LEL | =4.9 | mg/kg bw/day | Rat | oral | chronic (developmental) | reproduction developmental | LONG_REF=Turck, P. (1997) Two Generation Reproduction/Fertility Study in Rats with Thiram: Lab Project Number: 399-180. Unpublished study prepared by MPI Research. 1579 p.; TITLE=Two Generation Reproduction/Fertility Study in Rats with Thiram: Lab Project Number: 399-180; AUTHOR=Turck, P; EXTERNAL_SOURCE_ID=3549; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1997; ORIGINAL_YEAR=1997; TOXICOLOGICAL_EFFECT=systemic: in life observation-body weight-offspring (pup) weight|systemic: in life observation-body weight-offspring (pup) weight gain; TOXICOLOGICAL_EFFECT_CATEGORY=development; STUDY_GROUP=ToxRefDB_dup_-_15702554_15702555_15702556_15702557:M:F1juvenile; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_1f0b98231c4a5977b48fe4757c3ac834 |
| ToxValDB ToxRefDB | LEL | =5.4 | mg/kg bw/day | Rat | oral | chronic (developmental) | reproduction developmental | LONG_REF=Turck, P. (1997) Two Generation Reproduction/Fertility Study in Rats with Thiram: Lab Project Number: 399-180. Unpublished study prepared by MPI Research. 1579 p.; TITLE=Two Generation Reproduction/Fertility Study in Rats with Thiram: Lab Project Number: 399-180; AUTHOR=Turck, P; EXTERNAL_SOURCE_ID=3549; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1997; ORIGINAL_YEAR=1997; TOXICOLOGICAL_EFFECT=systemic: in life observation-body weight-body weight gain; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=ToxRefDB_dup_-_15702546_15702547_15702548_15702549:F:F1adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_2f25cad235c439e7b0410ff4b162a591 |
| ToxValDB ToxRefDB | LEL | =7.3 | mg/kg bw/day | Rat | oral | chronic; 104 weeks | chronic | LONG_REF=Kehoe, D. (1991) 104-Week Combined Chronic Toxicity and Carcino- genicity Study with Thiram in Rats: Lab Project Number: HLA 6111 113. Unpublished study prepared by Hazleton Labs America, Inc. 2513 p.; TITLE=104-Week Combined Chronic Toxicity and Carcino- genicity Study with Thiram in Rats: Lab Project Number: HLA 6111 113; AUTHOR=Kehoe, D; EXTERNAL_SOURCE_ID=3552; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1991; ORIGINAL_YEAR=1991; TOXICOLOGICAL_EFFECT=systemic: pathology microscopic-pancreas-infiltration cellular|systemic: pathology microscopic-pancreas-steatosis|systemic: in life observation-body weight-body weight gain|systemic: pathology microscopic-pancreas-atrophy|systemic: clinical chemistry-glucose-glucose|systemic: organ weight-kidney-absolute|systemic: pathology gross-lymph node-discolored|systemic: hematology-erythrocyte (rbc) count differential-erythrocyte (rbc)|systemic: pathology gross-liver-foci|systemic: pathology gross-kidney-discolored|systemic: organ weight-kidney-relative to brain weight|systemic: hematology-mean corpuscular (cell) volume (mcv)-mean corpuscular (cell) volume (mcv); TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical chemistry|gross pathology|hematology|nonneoplastic histopathology|organ weight; STUDY_GROUP=ToxRefDB_dup_-_15702582_15702583_15702584_15702585:M:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_fcce5407c1b1177b71a93e26596414ec |
| ToxValDB ToxRefDB | LEL | =12.2 | mg/kg bw/day | Rat | oral | chronic (developmental) | reproduction developmental | LONG_REF=Turck, P. (1997) Two Generation Reproduction/Fertility Study in Rats with Thiram: Lab Project Number: 399-180. Unpublished study prepared by MPI Research. 1579 p.; TITLE=Two Generation Reproduction/Fertility Study in Rats with Thiram: Lab Project Number: 399-180; AUTHOR=Turck, P; EXTERNAL_SOURCE_ID=3549; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1997; ORIGINAL_YEAR=1997; TOXICOLOGICAL_EFFECT=systemic: pathology microscopic-prostate-inflammation|systemic: in life observation-food consumption-food consumption; TOXICOLOGICAL_EFFECT_CATEGORY=food and/or water consumption|nonneoplastic histopathology; STUDY_GROUP=ToxRefDB_dup_-_15702544_15702545:M:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_5f03fdfa6b0ee108faec68acd41e9d64 |
| ToxValDB ToxRefDB | LEL | =24 | mg/kg bw/day | Mouse | oral | chronic; 97 weeks | chronic | LONG_REF=Trutter, J. (1992) Oncogenicity Study in Mice with Thiram: Lab Project Number: 798-223. Unpublished study prepared by Hazleton Washington, Inc. 2965 p.; TITLE=Oncogenicity Study in Mice with Thiram: Lab Project Number: 798-223; AUTHOR=Trutter, J; EXTERNAL_SOURCE_ID=3551; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1992; ORIGINAL_YEAR=1992; TOXICOLOGICAL_EFFECT=systemic: pathology microscopic-skin-necrosis|systemic: pathology microscopic-skin-inflammation|systemic: pathology microscopic-eye-atrophy|systemic: in life observation-body weight-body weight gain|systemic: hematology-mean corpuscular hemoglobin concentration (mchc)-mean corpuscular hemoglobin concentration (mchc)|systemic: in life observation-body weight-body weight|systemic: pathology microscopic-urinary bladder-[other]|systemic: pathology microscopic-stomach-hyperkeratosis; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|hematology|nonneoplastic histopathology; STUDY_GROUP=ToxRefDB_dup_-_15702575_15702576_15702577_15702578:M:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_a907fed8a11788c2b0319a2ab12b0f40 |
| ToxValDB ToxRefDB | LEL | =57 | mg/kg bw/day | Mouse | oral | chronic; 97 weeks | chronic | LONG_REF=Trutter, J. (1992) Oncogenicity Study in Mice with Thiram: Lab Project Number: 798-223. Unpublished study prepared by Hazleton Washington, Inc. 2965 p.; TITLE=Oncogenicity Study in Mice with Thiram: Lab Project Number: 798-223; AUTHOR=Trutter, J; EXTERNAL_SOURCE_ID=3551; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1992; ORIGINAL_YEAR=1992; TOXICOLOGICAL_EFFECT=systemic: in life observation-body weight-body weight gain|systemic: hematology-platelet-platelet|systemic: pathology microscopic-stomach-hyperkeratosis|systemic: pathology microscopic-eye-atrophy|systemic: pathology microscopic-skin-inflammation|systemic: pathology microscopic-spleen-pigmentation|systemic: hematology-erythrocyte (rbc) count differential-erythrocyte (rbc)|systemic: pathology microscopic-urinary bladder-[other]|systemic: in life observation-body weight-body weight|systemic: pathology microscopic-skin-necrosis|systemic: hematology-hemoglobin (hgb)-hemoglobin (hgb)|systemic: hematology-hematocrit (hct)-hematocrit (hct); TOXICOLOGICAL_EFFECT_CATEGORY=body weight|hematology|nonneoplastic histopathology; STUDY_GROUP=ToxRefDB_dup_-_15702571_15702572_15702573_15702574:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_0d04a8f6fdcad36c2255d0028b4d1b06 |
| ToxValDB ToxRefDB | LOAEL | =2.54 | mg/kg bw/day | Dog | oral | chronic; 52 weeks | chronic | LONG_REF=Kehoe, D. (1991) 52-Week Dietary Chronic Toxicity Study with Thiram in Dogs: Final Report: Lab Project Number: HLA 6111-112. Unpublished study prepared by Hazleton Laboratories America, Inc. 545 p.; TITLE=52-Week Dietary Chronic Toxicity Study with Thiram in Dogs: Final Report: Lab Project Number: HLA 6111-112; AUTHOR=Kehoe, D; EXTERNAL_SOURCE_ID=3550; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1991; ORIGINAL_YEAR=1991; TOXICOLOGICAL_EFFECT=systemic: clinical chemistry-albumin-albumin|systemic: clinical chemistry-cholesterol-cholesterol|systemic: organ weight-liver-relative to body weight|systemic: clinical chemistry-protein-protein; TOXICOLOGICAL_EFFECT_CATEGORY=clinical chemistry|organ weight; STUDY_GROUP=ToxRefDB_dup_-_15702566_15702567_15702568:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_f954c0714817e7ad873592a768d99377 |
| ToxValDB ToxRefDB | LOAEL | =7.01 | mg/kg bw/day | Dog | oral | subchronic; 90 days | subchronic | LONG_REF=Kehoe, D. (1990) 13-Week Toxicity Study with Thiram in Dogs: Lab Project Number: HLA 6111-121: 90-017. Unpublished study prepar- ed Hazleton Laboratories America, Inc. 237 p.; TITLE=13-Week Toxicity Study with Thiram in Dogs: Lab Project Number: HLA 6111-121: 90-017; AUTHOR=Kehoe, D; EXTERNAL_SOURCE_ID=3542; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1990; ORIGINAL_YEAR=1990; TOXICOLOGICAL_EFFECT=systemic: hematology-erythrocyte (rbc) count differential-erythrocyte (rbc)|systemic: in life observation-food consumption-food consumption|systemic: hematology-platelet-platelet|systemic: hematology-mean corpuscular (cell) volume (mcv)-mean corpuscular (cell) volume (mcv)|systemic: clinical chemistry-cholesterol-cholesterol|systemic: hematology-mean corpuscular hemoglobin (mch)-mean corpuscular hemoglobin (mch)|systemic: in life observation-body weight-body weight|systemic: hematology-hematocrit (hct)-hematocrit (hct)|systemic: hematology-hemoglobin (hgb)-hemoglobin (hgb)|systemic: clinical chemistry-calcium-calcium|systemic: clinical chemistry-protein-protein|systemic: clinical chemistry-albumin-albumin; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical chemistry|food and/or water consumption|hematology; STUDY_GROUP=ToxRefDB_dup_-_15702532_15702533_15702534:M:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_ee7305999a0e4a0032c921e443e5409e |
| ToxValDB ToxRefDB | LOAEL | =7.34 | mg/kg bw/day | Dog | oral | subchronic; 90 days | subchronic | LONG_REF=Kehoe, D. (1990) 13-Week Toxicity Study with Thiram in Dogs: Lab Project Number: HLA 6111-121: 90-017. Unpublished study prepar- ed Hazleton Laboratories America, Inc. 237 p.; TITLE=13-Week Toxicity Study with Thiram in Dogs: Lab Project Number: HLA 6111-121: 90-017; AUTHOR=Kehoe, D; EXTERNAL_SOURCE_ID=3542; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1990; ORIGINAL_YEAR=1990; TOXICOLOGICAL_EFFECT=systemic: hematology-erythrocyte (rbc) count differential-erythrocyte (rbc)|systemic: hematology-hemoglobin (hgb)-hemoglobin (hgb)|systemic: clinical chemistry-cholesterol-cholesterol|systemic: clinical chemistry-protein-protein|systemic: hematology-hematocrit (hct)-hematocrit (hct)|systemic: clinical chemistry-calcium-calcium|systemic: hematology-mean corpuscular hemoglobin (mch)-mean corpuscular hemoglobin (mch)|systemic: hematology-mean corpuscular (cell) volume (mcv)-mean corpuscular (cell) volume (mcv)|systemic: in life observation-food consumption-food consumption|systemic: clinical chemistry-albumin-albumin; TOXICOLOGICAL_EFFECT_CATEGORY=clinical chemistry|food and/or water consumption|hematology; STUDY_GROUP=ToxRefDB_dup_-_15702529_15702530_15702531:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_09900eb5c06dea2ea9faceb8b1d75ff7 |
| ToxValDB ToxRefDB | LOAEL | =8.9 | mg/kg bw/day | Rat | oral | chronic; 104 weeks | chronic | LONG_REF=Kehoe, D. (1991) 104-Week Combined Chronic Toxicity and Carcino- genicity Study with Thiram in Rats: Lab Project Number: HLA 6111 113. Unpublished study prepared by Hazleton Labs America, Inc. 2513 p.; TITLE=104-Week Combined Chronic Toxicity and Carcino- genicity Study with Thiram in Rats: Lab Project Number: HLA 6111 113; AUTHOR=Kehoe, D; EXTERNAL_SOURCE_ID=3552; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1991; ORIGINAL_YEAR=1991; TOXICOLOGICAL_EFFECT=systemic: hematology-mean corpuscular (cell) volume (mcv)-mean corpuscular (cell) volume (mcv)|systemic: hematology-mean corpuscular hemoglobin concentration (mchc)-mean corpuscular hemoglobin concentration (mchc)|systemic: clinical chemistry-urea nitrogen-urea nitrogen|systemic: pathology microscopic-liver-hyperplasia|systemic: in life observation-body weight-body weight gain|systemic: hematology-hematocrit (hct)-hematocrit (hct)|systemic: hematology-erythrocyte (rbc) count differential-erythrocyte (rbc)|systemic: hematology-hemoglobin (hgb)-hemoglobin (hgb); TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical chemistry|hematology|nonneoplastic histopathology; STUDY_GROUP=ToxRefDB_dup_-_15702579_15702580_15702581:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_c045a6e894047ac14ec87a19cb4f4cf5 |
| ToxValDB ToxRefDB | LOAEL | =15 | mg/kg bw/day | Rat | oral | short-term (developmental); 10 days | developmental | LONG_REF=Tesh, J.; McAnulty, P.; Willoughby, C.; et al. (1988) Thiram: Teratology Study in the Rat: 87/TRK002/179. Unpublished study prepared by Life Science Research. 91 p.; TITLE=Thiram: Teratology Study in the Rat: 87/TRK002/179; AUTHOR=Tesh, J.; McAnulty, P.; Willoughby, C.; et al; EXTERNAL_SOURCE_ID=3546; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1988; ORIGINAL_YEAR=1988; TOXICOLOGICAL_EFFECT=developmental: developmental malformation-bone-incomplete ossification|developmental: developmental malformation-bone-short supernumerary; TOXICOLOGICAL_EFFECT_CATEGORY=development; STUDY_GROUP=ToxRefDB_dup_-_15702537_15702538_15702539:M/F:fetusfetal; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_7dd1cd690f6a00e50612fff600e17ce7 |
| ToxValDB ToxRefDB | NEL | =1.6 | mg/kg bw/day | Rat | oral | chronic (developmental) | reproduction developmental | LONG_REF=Turck, P. (1997) Two Generation Reproduction/Fertility Study in Rats with Thiram: Lab Project Number: 399-180. Unpublished study prepared by MPI Research. 1579 p.; TITLE=Two Generation Reproduction/Fertility Study in Rats with Thiram: Lab Project Number: 399-180; AUTHOR=Turck, P; EXTERNAL_SOURCE_ID=3549; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1997; ORIGINAL_YEAR=1997; TOXICOLOGICAL_EFFECT=systemic: in life observation-body weight-body weight gain|systemic: in life observation-food consumption-food consumption|systemic: pathology microscopic-pituitary gland-angiectasis|systemic: in life observation-body weight-body weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|food and/or water consumption|nonneoplastic histopathology; STUDY_GROUP=ToxRefDB_dup_-_15702540_15702541_15702542_15702543:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_10f960d3ad1de1ab80d433995d8f7d98 |
| ToxValDB ToxRefDB | NEL | =1.7 | mg/kg bw/day | Rat | oral | chronic (developmental) | reproduction developmental | LONG_REF=Turck, P. (1997) Two Generation Reproduction/Fertility Study in Rats with Thiram: Lab Project Number: 399-180. Unpublished study prepared by MPI Research. 1579 p.; TITLE=Two Generation Reproduction/Fertility Study in Rats with Thiram: Lab Project Number: 399-180; AUTHOR=Turck, P; EXTERNAL_SOURCE_ID=3549; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1997; ORIGINAL_YEAR=1997; TOXICOLOGICAL_EFFECT=systemic: in life observation-body weight-offspring (pup) weight gain|systemic: in life observation-body weight-offspring (pup) weight; TOXICOLOGICAL_EFFECT_CATEGORY=development; STUDY_GROUP=ToxRefDB_dup_-_15702554_15702555_15702556_15702557:M:F1juvenile; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_2613d6d33b35aff5fda3f1063cd37680 |
| ToxValDB ToxRefDB | NEL | =1.8 | mg/kg bw/day | Rat | oral | chronic (developmental) | reproduction developmental | LONG_REF=Turck, P. (1997) Two Generation Reproduction/Fertility Study in Rats with Thiram: Lab Project Number: 399-180. Unpublished study prepared by MPI Research. 1579 p.; TITLE=Two Generation Reproduction/Fertility Study in Rats with Thiram: Lab Project Number: 399-180; AUTHOR=Turck, P; EXTERNAL_SOURCE_ID=3549; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1997; ORIGINAL_YEAR=1997; TOXICOLOGICAL_EFFECT=systemic: in life observation-body weight-body weight gain; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=ToxRefDB_dup_-_15702546_15702547_15702548_15702549:F:F1adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_e6f61234b6276c54cf698eed574b82a2 |
| ToxValDB ToxRefDB | NEL | =2.5 | mg/kg bw/day | Mouse | oral | chronic; 97 weeks | chronic | LONG_REF=Trutter, J. (1992) Oncogenicity Study in Mice with Thiram: Lab Project Number: 798-223. Unpublished study prepared by Hazleton Washington, Inc. 2965 p.; TITLE=Oncogenicity Study in Mice with Thiram: Lab Project Number: 798-223; AUTHOR=Trutter, J; EXTERNAL_SOURCE_ID=3551; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1992; ORIGINAL_YEAR=1992; TOXICOLOGICAL_EFFECT=systemic: in life observation-body weight-body weight gain|systemic: pathology microscopic-eye-atrophy|systemic: pathology microscopic-skin-inflammation|systemic: pathology microscopic-skin-necrosis|systemic: pathology microscopic-stomach-hyperkeratosis|systemic: pathology microscopic-urinary bladder-[other]|systemic: in life observation-body weight-body weight|systemic: hematology-mean corpuscular hemoglobin concentration (mchc)-mean corpuscular hemoglobin concentration (mchc); TOXICOLOGICAL_EFFECT_CATEGORY=body weight|hematology|nonneoplastic histopathology; STUDY_GROUP=ToxRefDB_dup_-_15702575_15702576_15702577_15702578:M:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_a4a71fbd810c3f6bfa895cc778feff4c |
| ToxValDB ToxRefDB | NEL | =3.1 | mg/kg bw/day | Mouse | oral | chronic; 97 weeks | chronic | LONG_REF=Trutter, J. (1992) Oncogenicity Study in Mice with Thiram: Lab Project Number: 798-223. Unpublished study prepared by Hazleton Washington, Inc. 2965 p.; TITLE=Oncogenicity Study in Mice with Thiram: Lab Project Number: 798-223; AUTHOR=Trutter, J; EXTERNAL_SOURCE_ID=3551; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1992; ORIGINAL_YEAR=1992; TOXICOLOGICAL_EFFECT=systemic: pathology microscopic-skin-inflammation|systemic: pathology microscopic-spleen-pigmentation|systemic: hematology-erythrocyte (rbc) count differential-erythrocyte (rbc)|systemic: pathology microscopic-urinary bladder-[other]|systemic: hematology-hematocrit (hct)-hematocrit (hct)|systemic: in life observation-body weight-body weight|systemic: hematology-hemoglobin (hgb)-hemoglobin (hgb)|systemic: in life observation-body weight-body weight gain|systemic: hematology-platelet-platelet|systemic: pathology microscopic-skin-necrosis|systemic: pathology microscopic-stomach-hyperkeratosis|systemic: pathology microscopic-eye-atrophy; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|hematology|nonneoplastic histopathology; STUDY_GROUP=ToxRefDB_dup_-_15702571_15702572_15702573_15702574:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_d8ab16dfc92fec546d0ceff7a2595f11 |
| ToxValDB ToxRefDB | NEL | =4.2 | mg/kg bw/day | Rat | oral | chronic (developmental) | reproduction developmental | LONG_REF=Turck, P. (1997) Two Generation Reproduction/Fertility Study in Rats with Thiram: Lab Project Number: 399-180. Unpublished study prepared by MPI Research. 1579 p.; TITLE=Two Generation Reproduction/Fertility Study in Rats with Thiram: Lab Project Number: 399-180; AUTHOR=Turck, P; EXTERNAL_SOURCE_ID=3549; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1997; ORIGINAL_YEAR=1997; TOXICOLOGICAL_EFFECT=systemic: pathology microscopic-prostate-inflammation|systemic: in life observation-food consumption-food consumption; TOXICOLOGICAL_EFFECT_CATEGORY=food and/or water consumption|nonneoplastic histopathology; STUDY_GROUP=ToxRefDB_dup_-_15702544_15702545:M:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_7d9d4691033ef70efa4d9bcee90d3ea5 |
openFDA substances 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| openFDA substances | FDA UNII substance identifier | 0D771IS0FH | UNII | - | - | - | chemical | - |