Thiram
INCI: THIRAM (TETRAMETHYLTHIURAM DISULFIDE) — NO COSMETIC INCI ASSIGNMENT
Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
8 study endpoints found for Thiram. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 300 mg/kg bw/day | dermal | code:3484 | dermal | REACH |
| LOAEL | 300 ppm | oral | mouse | oral | REACH |
| NOAEL | 30 ppm | oral | rat | oral | REACH |
| NOAEL | 30 ppm | oral | dog | oral | REACH |
| NOAEL | 75 ppm | oral | dog | oral | REACH |
| NOAEL | 50 ppm | oral | rat | oral | REACH |
| NOAEL | 125 ppm | oral | dog | oral | REACH |
| NOAEL | 1000 mg/kg bw/day | oral | rat | oral | REACH |
GHS Hazard Classification
Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.
Expert Verdict
CMR concerns (reproductive toxicity); strong skin sensitizer; prohibited substance in EU cosmetics; banned pesticide in EU since 2019
Regulatory Flags
Frequently Asked Questions
Is Thiram safe in cosmetics?
CMR concerns (reproductive toxicity); strong skin sensitizer; prohibited substance in EU cosmetics; banned pesticide in EU since 2019 The EU classifies Thiram as "prohibited". Safety rating: POOR. 8 toxicological study endpoint(s) are available in our database.
Is Thiram allowed in the EU?
Thiram EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.
What does Thiram do in cosmetics?
Thiram functions as: Fungicide / pesticide (agricultural use); rubber vulcanization accelerator. It is classified as a cosmetic ingredient in our database. CAS number: 137-26-8.
What is the Margin of Safety for Thiram?
not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Thiram?
The NOAEL (No Observed Adverse Effect Level) for Thiram is 300 mg/kg bw/day based on a dermal study via dermal route in code:3484. A total of 8 study endpoints are available. Source: REACH.
Compliance Tools
Check Thiram compliance across multiple jurisdictions:
Related Ingredients
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