Is Thiram safe in cosmetics?
Thiram has a safety rating of "POOR" in our database. EU status: prohibited. US status: permitted. 10 toxicological study endpoint(s) are available in our database.
Thiram
Also known as: Tetramethylthiouram disulfide, Thioperoxydicarbonic diamide ([(H2N)C(S)]2S2), N,N,N',N'-tetramethyl-, Thioperoxydicarbonic diamide ([(H2N)C(S)]2S2), tetramethyl-, Methane, 1,1',1'',1'''-[dithiobis(carbonothioylnitrilo)]tetrakis-, Disulfide, bis(dimethylthiocarbamoyl) (+14 more)
INCI: THIRAM (TETRAMETHYLTHIURAM DISULFIDE) — NO COSMETIC INCI ASSIGNMENT
Thiram (CAS 137-26-8) is a cosmetic cosmetic ingredient functioning as Fungicide / pesticide (agricultural use); rubber vulcanization accelerator. NOAEL 0.6 mg/kg bw/day (PDF-verified against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: prohibited. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 137-26-8 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
Thiram is prohibited in EU cosmetics but has active industrial GHS classifications (H302, H332, H315, H317, H319, H373, H400, H410).
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Fungicide / pesticide (agricultural use); rubber vulcanization accelerator
Safety Rating
POOR
Chemistry & Identifiers
IUPAC Name
dimethylcarbamothioylsulfanyl N,N-dimethylcarbamodithioate
InChIKey
KUAZQDVKQLNFPE-UHFFFAOYSA-N
Regulatory Status
EU EU Status
prohibited
US US Status
permitted
US Notes
Not permitted in cosmetics; EPA-regulated pesticide. FDA would consider adulterated if found in cosmetic products
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Thiram.
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
10 study endpoints found for Thiram. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =3.8 mg/kg bw/day | oral | rat (Sprague Dawley (SD) rat; Crl: CD(SD)IGS BR) | DNT | ToxRefDB_ToxRefDB_v3_pod.csv |
| NOAEL | =3.8 mg/kg bw/day | oral | rat (Sprague Dawley (SD) rat; Crl: CD(SD)IGS BR) | DNT | ToxRefDB_ToxRefDB_v3_pod.csv |
| NOAEL | =0.6 mg/kg bw/day | oral | Dog | chronic | ToxValDB_ECHA_IUCLID |
| NOAEL | =2.34 mg/kg bw/day | oral | Rat | chronic | ToxValDB_ECHA_IUCLID |
| NOAEL | =2.775 mg/kg bw/day | oral | Mouse | chronic | ToxValDB_ECHA_IUCLID |
| NOAEL | =4.8 mg/kg bw/day | oral | Rat | subchronic | ToxValDB_ECHA_IUCLID |
| NOAEL | =29.55 mg/kg bw/day | oral | Mouse | subchronic | ToxValDB_ECHA_IUCLID |
| NOAEL | =55.5 mg/kg bw/day | oral | Mouse | chronic | ToxValDB_ECHA_IUCLID |
| NOAEL | =111 mg/kg bw/day | oral | Mouse | chronic | ToxValDB_ECHA_IUCLID |
| NOAEL | =300 mg/kg bw/day | dermal | Rabbit | short-term | ToxValDB_ECHA_IUCLID |
GHS Hazard Classification
Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.
Short-term Exposure Effects
The substance is irritating to the eyes, skin and respiratory tract.
Long-term Exposure Effects
Repeated or prolonged contact may cause skin sensitization. The substance may have effects on the thyroid and liver.
Routes of Exposure
The substance can be absorbed into the body by inhalation of its aerosol and by ingestion.
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for Thiram across SCCS product categories, with measured dermal absorption where available.
IARC Carcinogenicity
International Agency for Research on Cancer (WHO) monograph evaluation.
IARC Group
3
Volume
Sup 7, 53
Evaluation Year
1990
EU CLP Annex VI Harmonized Classification
Legally binding harmonized classification per Regulation (EC) No 1272/2008 (CLP) Annex VI.
Signal Word
Warning
Pictograms
Harmful / IrritantHealth HazardEnvironmental Hazard
Hazard Class and Category
Acute Tox. 4 *; Acute Tox. 4 *; STOT RE 2 *; Skin Irrit. 2; Eye Irrit. 2; Skin Sens. 1; Aquatic Acute 1; Aquatic Chronic 1
Hazard Statements
- H332 Harmful if inhaled
- H302 Harmful if swallowed
- H373 **
- H315 Causes skin irritation
- H319 Causes serious eye irritation
- H317 May cause an allergic skin reaction
- H400 Very toxic to aquatic life
- H410 Very toxic to aquatic life with long lasting effects
Specific Concentration Limits / M-factors
M = 10
Inserted via ATP: CLP00
Sensitization AOP Dashboard
Adverse Outcome Pathway data across 5 assays (DPRA, KeratinoSens, hCLAT, LLNA, NESIL) aggregated from public sources.
DPRA Cys %
99.75%
DPRA Lys %
4.25%
KeratinoSens IC50
26.8 µM
hCLAT CV75
11.5 µg/mL
LLNA EC3
5.2%
NESIL
15517 µg/cm²
LLNA: Moderate (1B)
GHS: 1B
Human: positive
Source: LLNA: Gerberick et al. (2005); DPRA: Jaworska 2011 [DOI:10.1002/jat.2869] | Nukada et al. 2013 [DOI:10.1016/j.tiv.2012.11.006]; KS: Natsch et al. 2011 [DOI:10.1021/tx2003678] | Joint Research Centre of the European Union 2014; hCLAT: Ashikaga et al. 2010 [DOI:10.1177/026119291003800403] | Sakaguchi et al. 2010 [DOI:10.1016/j.tiv.2010.05.012]; HPPT: [27] Kligman AM (1966): https://doi.org/10.1038/jid.1966.160
HRIPT Human Patch Test Studies
5 human repeat insult patch tests aggregated from dermatological literature.
| Test Type | N | Sensitized | Dose µg/cm² | NESIL µg/cm² | Potency |
|---|---|---|---|---|---|
| HMT | - | 0 | 6206.9 | - | - |
| HMT | - | 0 | 6206.9 | - | - |
| HMT | - | 0 | 15517.24 | - | - |
| HMT | - | 0 | 15517.24 | - | - |
| OECD_DA_Human | - | 0 | - | - | 1B (Weak sensitizer) |
Endocrine Disruptor Evidence (Expanded)
Cross-referenced EDC classifications, mechanism data, and dose-response evidence from EDLists, SIN List, and cosmetic-specific detail sources.
SIN List ED: Endocrine Disruptor
Cosmetic relevance: none
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
100 - 1,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Hazard classification: Restricted (Annex XVII)
Expanded Jurisdictional Detail
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
ASEAN Cosmetic Directive (II)
Ref: 354
JPKR Japan/Korea Cosmetics
Japan (Restricted): max 0.50
Additional Jurisdictional Restrictions (4)
| Jurisdiction | Status | Max % | Product Type |
|---|---|---|---|
| JP | restricted | 0.50% (wash-away); 0.30% (leave-on) | Wash-away: 0.50% | Leave-on: 0.30% |
| CA | banned | - | - |
| KR | prohibited | - | - |
| KR | prohibited | - | - |
Expanded Dermal Absorption Data
Cross-database dermal penetration: EPA Dryad physics-based, Roberts Mendeley permeation, and SCCS-aggregated measured values.
EPA Dryad Skin Absorption (physics-based)
MW: 240.433
LogP: 1.72962
Kp epidermis: 0.01288 cm/h
% dose epidermis: 0.44%
% dose stratum corneum: 0.41%
% dose dermis: 0.49%
Source: EPA_Dryad_Skin_Absorption_2024
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (6)
Carcinogen Classification
3, not classifiable as to its carcinogenicity to humans. (L135)
Source: Toxin and Toxin Target Database (T3DB)
Carcinogen Classification
Thiram | Group 3: Not classifiable as to its carcinogenicity to humans | Volume Sup 7: Overall Evaluations of Carcinogenicity: An Updating of IARC Monographs Volumes 1 to 42, 1987; 440 pages; ISBN 92-832-1411-0 (out of print) | Volume 53: (1991) Occupational Exposures in Insecticide Application, and Some Pesticides
Source: International Agency for Research on Cancer (IARC)
Evidence for Carcinogenicity
Cancer Classification: Not Likely to be Carcinogenic to Humans | Evaluation: There is inadequate evidence in humans for the carcinogenicity of thiram. There is inadequate evidence for the carcinogenicity of thiram in experimental animals. Overall evaluation: Thiram is not classifiable as to its carcinogenicity to humans (Group 3). | A4: Not classifiable as a human carcinogen.
Source: Hazardous Substances Data Bank (HSDB)
Endocrine Disruptors
Potential endocrine disrupting compound
Source: NORMAN Suspect List Exchange
ICSC Safety Card
0757
Source: ILO-WHO International Chemical Safety Cards (ICSCs)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Biocide
Catalyst
Chemical reaction regulator
Dispersing agent
Processing aids not otherwise specified
Regulatory List Membership (1)
FDA Indirect Food Contact Additives
Expert Verdict
Expert safety assessment and concern-level summary for Thiram.
Regulatory Flags
potential-allergen
endocrine_disruptor
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to Thiram by CAS number or substance name.
Studies
11
Lowest NOAEL
0.6 mg/kg bw/day
Highest NOAEL
1000 mg/kg bw/day
ToxValDB_ECHA_IUCLID
ToxRefDB_ToxRefDB_v3_pod.csv
Known Synonyms
Tetramethylthiouram disulfide
Thioperoxydicarbonic diamide ([(H2N)C(S)]2S2), N,N,N',N'-tetramethyl-
Thioperoxydicarbonic diamide ([(H2N)C(S)]2S2), tetramethyl-
Methane, 1,1',1'',1'''-[dithiobis(carbonothioylnitrilo)]tetrakis-
Disulfide, bis(dimethylthiocarbamoyl)
4-04-00-00242
Arasan-m
Arasan 42-S
Arasan-sf-x
Bis((dimethylamino)carbonothioyl) disulphide
Bis(dimethylthiocarbamoyl) disulphide
BRN 1725821
Caswell No. 856
Chipco thiram 75
Cyuram DS
EINECS 205-286-2
EPA Pesticide Chemical Code 079801
Fermide
Fermide 850
Chemical Function
Biocide
Processing aids not otherwise specified
Chemical reaction regulator
Catalyst
Dispersing agent
Regulatory Lists
drinking_water; Europe; manufacturing; plastic_additive
active_ingredient; agricultural; Pesticides
active_ingredient; agricultural; Pesticides
active_ingredient; agricultural; Pesticides
active_ingredient; agricultural; Pesticides
active_ingredient; agricultural; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
THIRAM
ChEMBL ID
CHEMBL120563
Max Phase
2
Frequently Asked Questions
Is Thiram allowed in the EU?
Thiram EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.
What does Thiram do in cosmetics?
Thiram functions as: Fungicide / pesticide (agricultural use); rubber vulcanization accelerator. It is classified as a cosmetic ingredient in our database. CAS number: 137-26-8.
What is the NOAEL for Thiram?
The NOAEL (No Observed Adverse Effect Level) for Thiram is =3.8 mg/kg bw/day based on a DNT study via oral route in rat (Sprague Dawley (SD) rat; Crl: CD(SD)IGS BR). A total of 10 study endpoints are available. Source: ToxRefDB_ToxRefDB_v3_pod.csv.
Is Thiram used outside cosmetics?
Thiram also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does Thiram have different safety status in cosmetics vs industrial chemicals?
Thiram is prohibited in EU cosmetics but has active industrial GHS classifications (H302, H332, H315, H317, H319, H373, H400, H410).
Compliance Tools
Check Thiram compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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