Timonacic

INCI: TIMONACIC (SYNONYM: THIAZOLIDINE-4-CARBOXYLIC ACID / THIOPROLINE)

CAS Number
444-27-9 (racemic); 45521-09-3 (S-isomer)
Function
Antioxidant, hair conditioning agent, keratin-binding agent
Safety Rating
GOOD

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status restricted
๐Ÿ‡บ๐Ÿ‡ธ US Status restricted
US Notes Not specifically restricted; FDA UNII assigned (E5913T3IBL); permitted in cosmetics under general FDCA provisions

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
moderate
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

No CIR final safety assessment published; primarily studied as pharmaceutical/nutraceutical; ensure cosmetic-grade purity โ‰ฅ98%

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Concern Level: Low

Frequently Asked Questions

Is Timonacic safe in cosmetics?

No CIR final safety assessment published; primarily studied as pharmaceutical/nutraceutical; ensure cosmetic-grade purity โ‰ฅ98% The EU classifies Timonacic as "restricted". Safety rating: GOOD.

Is Timonacic allowed in the EU?

Timonacic EU regulatory status: restricted. This is based on EU Regulation 1223/2009 and its amendments.

What does Timonacic do in cosmetics?

Timonacic functions as: Antioxidant, hair conditioning agent, keratin-binding agent. It is classified as a cosmetic ingredient in our database. CAS number: 444-27-9 (racemic); 45521-09-3 (S-isomer).

What is the Margin of Safety for Timonacic?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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