NOAEL Studies Cosmetic Ingredient

TIN NOAEL Studies

CAS: 7440-31-5

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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ATSDR_toxval_ATSDR_MRLs.xlsx 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ATSDR_toxval_ATSDR_MRLs.xlsx NOAEL =32 mg/kg/day Rat (Wistar; M/F) oral subchronic; 13 weeks subchronic ATSDR MRLs; row_hash=0949944aa9fb07be; source_hash=ToxValhc_56898a71d2080974af7e63a851150c43; raw_endpoint_type=NOAEL; raw_endpoint_subtype=; raw_value=32; raw_unit=mg/kg/day; method=diet; effect=hematological; effect_category=hematology; file=toxval_ATSDR_MRLs.xlsx; long_ref=De Groot AP, Feron VJ, Til HP. 1973. Short-term toxicity studies on some salts and oxides of tin in rats. Food Cosmet Toxicol 11:19-30.; stored_source_record=https://clowder.edap-cluster.com/files/6568f4f4e4b063812d585817
INCHEM_WHO_cicads_cicads_cicad65 10 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
INCHEM_WHO_cicads_cicads_cicad65 LOAEL =264 mg/kg diet - oral - Acute toxicity document_id=cicads_cicads_cicad65; title=Tin and Inorganic Tin Compounds (Cicads 65, 2005); path=mirror/documents/cicads/cicads/cicad65.htm; row_hash=a5fe919c1733af59; raw_unit=mg/kg food; context=Of the two recent studies on the acute gastrointestinal effects of tin, one showed a LOAEL of approximately 66 mg of tin (264 mg/kg food).
INCHEM_WHO_cicads_cicads_cicad65 LOAEL =264 mg/kg diet - oral - Acute toxicity document_id=cicads_cicads_cicad65; title=Tin and Inorganic Tin Compounds (Cicads 65, 2005); path=mirror/documents/cicads/cicads/cicad65.htm; row_hash=a5fe919c1733af59; raw_unit=mg/kg food; context=Of the two recent studies on the acute gastrointestinal effects of tin, one showed a LOAEL of approximately 66 mg of tin (264 mg/kg food).
INCHEM_WHO_cicads_cicads_cicad65 NOAEL =30 mg/kg bw/day Rat oral - Toxicology study document_id=cicads_cicads_cicad65; title=Tin and Inorganic Tin Compounds (Cicads 65, 2005); path=mirror/documents/cicads/cicads/cicad65.htm; row_hash=367cf74db7615a41; raw_unit=mg/kg body weight per day; context=In rats, the NOAEL was 1000 mg/kg diet, equivalent to 30 mg/kg body weight per day; at the higher dose, survival was decreased in the males.
INCHEM_WHO_cicads_cicads_cicad65 NOAEL =30 mg/kg bw Rat - - Toxicology study document_id=cicads_cicads_cicad65; title=Tin and Inorganic Tin Compounds (Cicads 65, 2005); path=mirror/documents/cicads/cicads/cicad65.htm; row_hash=ce8210b58e33fb5d; raw_unit=mg/kg; context=Dans cette étude, les NOAEL (dose sans effet nocif observé) étaient de 30 mg/kg de poids corporel par jour pour le rat et de 130 mg/kg de poids corporel par jour pour la souris, avec une diminution de la survie aux doses les plus élevées.
INCHEM_WHO_cicads_cicads_cicad65 NOAEL =30 mg/kg bw/day Rat oral - Toxicology study document_id=cicads_cicads_cicad65; title=Tin and Inorganic Tin Compounds (Cicads 65, 2005); path=mirror/documents/cicads/cicads/cicad65.htm; row_hash=367cf74db7615a41; raw_unit=mg/kg body weight per day; context=In rats, the NOAEL was 1000 mg/kg diet, equivalent to 30 mg/kg body weight per day; at the higher dose, survival was decreased in the males.
INCHEM_WHO_cicads_cicads_cicad65 NOAEL =30 mg/kg bw Rat - - Toxicology study document_id=cicads_cicads_cicad65; title=Tin and Inorganic Tin Compounds (Cicads 65, 2005); path=mirror/documents/cicads/cicads/cicad65.htm; row_hash=ce8210b58e33fb5d; raw_unit=mg/kg; context=Dans cette étude, les NOAEL (dose sans effet nocif observé) étaient de 30 mg/kg de poids corporel par jour pour le rat et de 130 mg/kg de poids corporel par jour pour la souris, avec une diminution de la survie aux doses les plus élevées.
INCHEM_WHO_cicads_cicads_cicad65 NOAEL =130 mg/kg bw/day Mouse oral - Toxicology study document_id=cicads_cicads_cicad65; title=Tin and Inorganic Tin Compounds (Cicads 65, 2005); path=mirror/documents/cicads/cicads/cicad65.htm; row_hash=f939fe5b55a0e0b5; raw_unit=mg/kg body weight per day; context=Female mice were normal at 1000 mg/kg diet (NOAEL 130 mg/kg body weight per day), but survival was reduced at 270 mg/kg body weight per day (NTP, 1982).
INCHEM_WHO_cicads_cicads_cicad65 NOAEL =130 mg/kg bw/day Mouse oral - Toxicology study document_id=cicads_cicads_cicad65; title=Tin and Inorganic Tin Compounds (Cicads 65, 2005); path=mirror/documents/cicads/cicads/cicad65.htm; row_hash=f939fe5b55a0e0b5; raw_unit=mg/kg body weight per day; context=Female mice were normal at 1000 mg/kg diet (NOAEL 130 mg/kg body weight per day), but survival was reduced at 270 mg/kg body weight per day (NTP, 1982).
INCHEM_WHO_cicads_cicads_cicad65 NOAEL =180 mg/kg bw/day Mouse - - Toxicology study document_id=cicads_cicads_cicad65; title=Tin and Inorganic Tin Compounds (Cicads 65, 2005); path=mirror/documents/cicads/cicads/cicad65.htm; row_hash=3f2d1d51c3172eff; raw_unit=mg/kg body weight per day; context=The male mice showed no effects (NOAEL 180 mg/kg body weight per day).
INCHEM_WHO_cicads_cicads_cicad65 NOAEL =180 mg/kg bw/day Mouse - - Toxicology study document_id=cicads_cicads_cicad65; title=Tin and Inorganic Tin Compounds (Cicads 65, 2005); path=mirror/documents/cicads/cicads/cicad65.htm; row_hash=3f2d1d51c3172eff; raw_unit=mg/kg body weight per day; context=The male mice showed no effects (NOAEL 180 mg/kg body weight per day).
ToxValDB_ATSDR_MRLs 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_ATSDR_MRLs MRL =0.3 mg/kg bw/day Human oral - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/674e166be4b0a7c65d36ea5d; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://wwwn.cdc.gov/TSP/MRLS/mrlsListing.aspx; YEAR=2005; ORIGINAL_YEAR=2005; TOXICOLOGICAL_EFFECT=hematological in male/female rats; STUDY_GROUP=ATSDR MRLs:15447247:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_ea87069a2d5e7bd284e17a6f9d46b166
ToxValDB_ATSDR_MRLs NOAEL =32 mg/kg bw/day Rat oral subchronic; 13 weeks subchronic LONG_REF=De Groot AP, Feron VJ, Til HP. 1973. Short-term toxicity studies on some salts and oxides of tin in rats. Food Cosmet Toxicol 11:19-30.; TITLE=Short-term toxicity studies on some salts and oxides of tin in rats; AUTHOR=De Groot AP; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6568f4f4e4b063812d585817; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.atsdr.cdc.gov/ToxProfiles/tp55.pdf; TOXICOLOGICAL_EFFECT=hematological; TOXICOLOGICAL_EFFECT_CATEGORY=hematology; STUDY_GROUP=ATSDR MRLs:15447815:M/F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_56898a71d2080974af7e63a851150c43
ToxValDB_ECHA_IUCLID 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_ECHA_IUCLID NOAEL =1000 mg/kg bw/day Rat oral - developmental GUIDELINE=OECD Guideline 414 (Prenatal Developmental Toxicity Study); QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eac62e4b0a7c65d1bed71; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15457/7/9/3?documentUUID=cc18f7bf-c57e-4fc8-ad22-cec697ad9b22; YEAR=2008; ORIGINAL_YEAR=2008; STUDY_GROUP=ECHA IUCLID_dup_Developmental Toxicity Teratogenicity_15820762_15821442:M/F:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_94cd4e94778c42b23068e1d464af0ed5
ToxValDB_ECHA_IUCLID NOEL >1000 mg/kg bw/day Rat oral short-term; 14 days short-term QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7cbc7e4b0a7c65d227796; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15457/7/6/2?documentUUID=cc18f7bf-c57e-4fc8-ad22-cec697ad9b22; YEAR=2008; ORIGINAL_YEAR=2008; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15833386_15843060:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_a548ec7642a1865138654340ee83899c
ToxValDB_GESTIS_DNEL 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_GESTIS_DNEL DNEL systemic =71 mg/m3 Human inhalation - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15635248:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_cf4da9d9b6cc5f0b10861fdaba49893b
ToxValDB_RSL 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_RSL RfD =0.6 mg/kg bw/day Human oral - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759b87ce4b0a7c65d37b4e2; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/risk/regional-screening-levels-rsls-generic-tables; STUDY_GROUP=RSL:15659235:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_b5d59601062a2b278599eb098f0f5abe
openFDA substances 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier 387GMG9FH5 UNII - - - chemical {"approval_status":null,"molecular_formula":"Sn","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"387GMG9FH5"}
openFDA substances FDA UNII substance identifier 387GMG9FH5 UNII - - - chemical {"approval_status":null,"molecular_formula":"Sn","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"387GMG9FH5"}
openFDA substances FDA UNII substance identifier 387GMG9FH5 UNII - - - chemical {"approval_status":null,"molecular_formula":"Sn","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"387GMG9FH5"}
openFDA substances FDA UNII substance identifier 387GMG9FH5 UNII - - - chemical {"approval_status":null,"molecular_formula":"Sn","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"387GMG9FH5"}