NOAEL Studies
Antioxidant
Tocopherol NOAEL Studies
INCI: TOCOPHEROL
CAS: 59-02-9
Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.
EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx | NOAEL | =540 | mg/day | Human | - | - | study with volunteers | EFSA FEEDAP - 2010 - OutputID 178 - haematology - hemopoietic - Scientific Opinion on the safety and efficacy of vitamin E as a feed additive for all animal species - doi:10.2903/j.efsa.2010.1635 |
NTP_ICE_skin_sensitization 5 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_skin_sensitization | CD86, EC150 | >200 | ug/mL | - | Dermal | - | In Vitro; CE_USENSE2018; U-SENS | sheet=Data_invitro; excel_row=8699; Record_ID=skin_sensitization_invitro_2409; Data_Type=In Vitro; Internal_Data_Source=CE_USENSE2018; Mixture=Chemical; DTXSID=DTXSID0026339; Assay=U-SENS; Endpoint=CD86, EC150; Response_Modifier=>; Reported_Response_Modifier=>; Reported_Response=200; Reported_Response_Unit=ug/mL; Response=200; Response_Unit=ug/mL; Reference=Piroird et al. 2015; 25820135; 10.1016/j.tiv.2015.03.009; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0026339 |
| NTP_ICE_skin_sensitization | CV75 | >1000 | ug/mL | - | Dermal | - | In Vitro; CE_hCLAT2018; h-CLAT | sheet=Data_invitro; excel_row=2382; Record_ID=skin_sensitization_invitro_579; Data_Type=In Vitro; Internal_Data_Source=CE_hCLAT2018; Mixture=Chemical; DTXSID=DTXSID0026339; Assay=h-CLAT; Endpoint=CV75; Response_Modifier=>; Reported_Response_Modifier=>; Reported_Response=1000; Reported_Response_Unit=ug/mL; Response=1000; Response_Unit=ug/mL; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0026339 |
| NTP_ICE_skin_sensitization | EC1.5 | 114.6 | uM | - | Dermal | - | In Vitro; CE_KeratinoSense2018; KeratinoSens | sheet=Data_invitro; excel_row=6095; Record_ID=skin_sensitization_invitro_1447; Data_Type=In Vitro; Internal_Data_Source=CE_KeratinoSense2018; Mixture=Chemical; DTXSID=DTXSID0026339; Assay=KeratinoSens; Endpoint=EC1.5; Reported_Response=114.6; Reported_Response_Unit=uM; Response=114.6; Response_Unit=uM; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0026339 |
| NTP_ICE_skin_sensitization | EC3 | >2000 | uM | - | Dermal | - | In Vitro; CE_KeratinoSense2018; KeratinoSens | sheet=Data_invitro; excel_row=6096; Record_ID=skin_sensitization_invitro_1447; Data_Type=In Vitro; Internal_Data_Source=CE_KeratinoSense2018; Mixture=Chemical; DTXSID=DTXSID0026339; Assay=KeratinoSens; Endpoint=EC3; Response_Modifier=>; Reported_Response_Modifier=>; Reported_Response=2000; Reported_Response_Unit=uM; Response=2000; Response_Unit=uM; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0026339 |
| NTP_ICE_skin_sensitization | Imax | 2.09 | ratio | - | Dermal | - | In Vitro; CE_KeratinoSense2018; KeratinoSens | sheet=Data_invitro; excel_row=6098; Record_ID=skin_sensitization_invitro_1447; Data_Type=In Vitro; Internal_Data_Source=CE_KeratinoSense2018; Mixture=Chemical; DTXSID=DTXSID0026339; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=2.09; Reported_Response_Unit=Unitless; Response=2.09; Response_Unit=Ratio; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0026339 |
ToxValDB_ECHA_IUCLID 10 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_ECHA_IUCLID | LOAEL | =500 | mg/kg bw/day | Rat | oral | chronic; 104 weeks | chronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7ca1be4b0a7c65d220566; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/en/registration-dossier/-/registered-dossier/30433?documentUUID=672abcc8-8d17-44a5-a1db-9951805a33c2; YEAR=1981; ORIGINAL_YEAR=1981; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15847805_15848147:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_8515bb460e5d514559a02582dd3be4c8 |
| ToxValDB_ECHA_IUCLID | LOAEL | =125 | mg/kg bw/day | Rat | oral | subchronic; 90 days | subchronic | QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669ead64e4b0a7c65d1c3f50; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/en/registration-dossier/-/registered-dossier/25435?documentUUID=1b5482f2-44a9-41c3-a01c-c9ebf5a4b820; YEAR=2002; ORIGINAL_YEAR=2002; STUDY_GROUP=ECHA IUCLID:15848045:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_627d3186af718468a5ea8073054af082 |
| ToxValDB_ECHA_IUCLID | LOAEL | =21 | mg/kg bw/day | Rat | oral | - | reproduction developmental | QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaa99e4b0a7c65d1b6a67; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/en/registration-dossier/-/registered-dossier/25435?documentUUID=1b5482f2-44a9-41c3-a01c-c9ebf5a4b820; YEAR=2002; ORIGINAL_YEAR=2002; STUDY_GROUP=ECHA IUCLID:15861691:F:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_0549c3f660feefe125d8cfc6e5d87d02 |
| ToxValDB_ECHA_IUCLID | NOAEL | =2000 | mg/kg bw/day | Rat | oral | - | chronic | QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c80fe4b0a7c65d2165cc; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/en/registration-dossier/-/registered-dossier/30433?documentUUID=7ebe7685-4160-4698-ba04-bd916f6625a2; YEAR=1991; ORIGINAL_YEAR=1991; STUDY_GROUP=ECHA IUCLID:15820323:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_1d1ef282f0a2783393892ceab5184fdd |
| ToxValDB_ECHA_IUCLID | NOAEL | =1600 | mg/kg bw/day | Rat | oral | - | developmental | QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eabe9e4b0a7c65d1bc648; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/en/registration-dossier/-/registered-dossier/25435?documentUUID=1b5482f2-44a9-41c3-a01c-c9ebf5a4b820; YEAR=2002; ORIGINAL_YEAR=2002; STUDY_GROUP=ECHA IUCLID:15823339:M/F:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_68a0b9375ef0cc44405a338bc82305ba |
| ToxValDB_ECHA_IUCLID | NOAEL | =1028 | mg/kg bw/day | Rat | oral | - | developmental | QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7d23ee4b0a7c65d232346; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/en/registration-dossier/-/registered-dossier/30433?documentUUID=672abcc8-8d17-44a5-a1db-9951805a33c2; YEAR=1981; ORIGINAL_YEAR=1981; STUDY_GROUP=ECHA IUCLID_dup_Developmental Toxicity Teratogenicity_15824354_15824355:M/F:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_51906b183616044bed744bf86eef6737 |
| ToxValDB_ECHA_IUCLID | NOAEL | =180 | mg/kg bw/day | Rat | oral | subchronic; 90 days | subchronic | QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7cc1be4b0a7c65d229001; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/en/registration-dossier/-/registered-dossier/30433?documentUUID=672abcc8-8d17-44a5-a1db-9951805a33c2; YEAR=1981; ORIGINAL_YEAR=1981; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15848163_15848246_15848632_15848937:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_817cd33f3db1ea3671dd1556dbe42ad0 |
| ToxValDB_ECHA_IUCLID | NOAEL | =1086 | mg/kg bw/day | Rat | oral | subchronic; 90 days | subchronic | QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7cae5e4b0a7c65d223f4b; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/en/registration-dossier/-/registered-dossier/30433?documentUUID=672abcc8-8d17-44a5-a1db-9951805a33c2; YEAR=1981; ORIGINAL_YEAR=1981; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15848163_15848246_15848632_15848937:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_bb8614b5177639fe6ef6b3b02f3e3653 |
| ToxValDB_ECHA_IUCLID | NOEL | =550 | mg/kg bw/day | Mouse | oral | - | chronic | QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669ea9e4e4b0a7c65d1b346c; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/en/registration-dossier/-/registered-dossier/25435?documentUUID=1b5482f2-44a9-41c3-a01c-c9ebf5a4b820; YEAR=2002; ORIGINAL_YEAR=2002; STUDY_GROUP=ECHA IUCLID:15820143:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_c25a12f12e15d83ca86e0acc25951d5a |
| ToxValDB_ECHA_IUCLID | NOEL | >1028 | mg/kg bw/day | Rat | oral | - | reproduction developmental | QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eabe9e4b0a7c65d1bc646; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/en/registration-dossier/-/registered-dossier/25435?documentUUID=1b5482f2-44a9-41c3-a01c-c9ebf5a4b820; YEAR=2002; ORIGINAL_YEAR=2002; STUDY_GROUP=ECHA IUCLID_dup_Developmental Toxicity Teratogenicity_15824351_15824352_15824353:F:-maternal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_25d7ad2f8cc313beb114ce6e17a21a0c |
ToxValDB_ECOTOX 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_ECOTOX | NOEL | =50 | mg/kg bw/day | Rat | injection | subchronic; 35 days | subchronic | LONG_REF=Pestic. Biochem. Physiol.93(3): 127-132 Garg,D.P., A.K. Bansal, A. Malhotra, R. Kiran, and D.K. Dhawan Methomyl Induced Hematological and Biochemical Alterations - Protection by Vitamin E 2009; TITLE=Methomyl Induced Hematological and Biochemical Alterations - Protection by Vitamin E; AUTHOR=Garg,D.P., A.K. Bansal, A. Malhotra, R. Kiran, and D.K. Dhawan; DOI=10.1016/j.pestbp.2009.01.001; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=118558; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2009; ORIGINAL_YEAR=2009; TOXICOLOGICAL_EFFECT=Biochemistry: Glutathione (reduced glutathione)|Biochemistry: Hemoglobin|Cell(s): Basophil|Cell(s): Eosinophil|Cell(s): Leukocytes|Cell(s): Lymphocyte|Cell(s): Neutrophil|Cell(s): Red blood cell|Enzyme(s): Catalase|Enzyme(s): Glutathione peroxidase|Enzyme(s): Glutathione S-transferase|Enzyme(s): Superoxide dismutase (SOD) enzyme activity|Physiology: Lipid peroxidation; TOXICOLOGICAL_EFFECT_CATEGORY=enzyme activity|hematology|other; STUDY_GROUP=ECOTOX_dup_EPA ORD_15594620_15598159:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=0c381b17813411c352d63f4b538d1551 |
| ToxValDB_ECOTOX | NOEL | =100 | mg/kg bw/day | Rat | injection | subchronic; 48 days | subchronic | LONG_REF=Food Chem. Toxicol.47(7): 1676-1684 Ozden,S., B. Catalgol, S. Gezginci-Oktayoglu, P. Arda-Pirincci, S. Bolkent, and B. Alpertunga Methiocarb-Induced Oxidative Damage Following Subacute Exposure and the Protective Effects of Vitamin E and Taurine in Rats 2009; TITLE=Methiocarb-Induced Oxidative Damage Following Subacute Exposure and the Protective Effects of Vitamin E and Taurine in Rats; AUTHOR=Ozden,S., B. Catalgol, S. Gezginci-Oktayoglu, P. Arda-Pirincci, S. Bolkent, and B. Alpertunga; DOI=10.1016/j.fct.2009.04.018; QUALITY=Control type: Control outside of primary exposure system; EXTERNAL_SOURCE_ID=116326; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2009; ORIGINAL_YEAR=2009; TOXICOLOGICAL_EFFECT=Enzyme(s): Glutathione reductase; TOXICOLOGICAL_EFFECT_CATEGORY=enzyme activity; STUDY_GROUP=ECOTOX:15603314:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=241c99985fa5d947b6fc66bbebd407e2 |
ToxValDB_EFSA 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_EFSA | NOAEL | =540 | mg/day | Human | oral | - | epidemiologic | LONG_REF=EFSA FEEDAP (2010). Scientific Opinion on the safety and efficacy of vitamin E as a feed additive for all animal species. doi:10.2903/j.efsa.2010.1635.; TITLE=Scientific Opinion on the safety and efficacy of vitamin E as a feed additive for all animal species; AUTHOR=EFSA FEEDAP; DOI=doi:10.2903/j.efsa.2010.1635; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65201d30e4b0f0a60ddd1165; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://zenodo.org/record/5076033#.Y9fEoXbMI2z; YEAR=2010; ORIGINAL_YEAR=2010; TOXICOLOGICAL_EFFECT=hematological; TOXICOLOGICAL_EFFECT_CATEGORY=hematology; STUDY_GROUP=EFSA:15614238:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_401141af9c016dd9a8e10b4db90c2547 |
ToxValDB_WHO_JECFA_ADI 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_WHO_JECFA_ADI | ADI | >=0.15 | mg/kg | Human | oral | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/650aea37e4b0d99f5a86c066; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://apps.who.int/food-additives-contaminants-jecfa-database/; SUBSOURCE_URL=https://apps.who.int/food-additives-contaminants-jecfa-database/Home/Chemical/21; YEAR=1986; ORIGINAL_YEAR=1986; STUDY_GROUP=WHO JECFA ADI_dup_-_15715236_15715237:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_6df16265acf91852bc46629d377368d6 |
| ToxValDB_WHO_JECFA_ADI | ADI | <=2 | mg/kg | Human | oral | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/650aea37e4b0d99f5a86c066; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://apps.who.int/food-additives-contaminants-jecfa-database/; SUBSOURCE_URL=https://apps.who.int/food-additives-contaminants-jecfa-database/Home/Chemical/21; YEAR=1986; ORIGINAL_YEAR=1986; STUDY_GROUP=WHO JECFA ADI_dup_-_15715236_15715237:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_a9cac23faede3e6f6ca7e549a2c63ba5 |
openFDA substances 4 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| openFDA substances | FDA UNII substance identifier | N9PR3490H9 | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C29H50O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"N9PR3490H9"} |
| openFDA substances | FDA UNII substance identifier | N9PR3490H9 | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C29H50O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"N9PR3490H9"} |
| openFDA substances | FDA UNII substance identifier | N9PR3490H9 | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C29H50O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"N9PR3490H9"} |
| openFDA substances | FDA UNII substance identifier | N9PR3490H9 | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C29H50O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"N9PR3490H9"} |