NOAEL Studies Cosmetic Ingredient

Toluene-2,5-Diamine NOAEL Studies

INCI: TOLUENE-2,5-DIAMINE

CAS: 95-70-5

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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COSMOS DB 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
COSMOS DB LOAEL 20 mg/kg bw/day rat oral 90 day Subchronic SCCS; SA 91-day toxicity study of toluene-2,5-diamine sulfate (WR 23005, A005) administeredby oral gavage to rats with a 28-dayrecovery period. Study Number VKA00169,Charles River, Spencerville, Ohio, USA
COSMOS DB NOAEL 10 mg/kg bw/day rat oral 90 day Subchronic SCCS; SA 91-day toxicity study of toluene-2,5-diamine sulfate (WR 23005, A005) administeredby oral gavage to rats with a 28-dayrecovery period. Study Number VKA00169,Charles River, Spencerville, Ohio, USA
IARC Monographs 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
IARC Monographs IARC carcinogenicity classification 3 IARC group - - 1987 IARC Monographs -
NTP ICE acute oral 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP ICE acute oral LD50 =102 mg/kg bw Rat oral acute Rat Acute Oral Toxicity NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_11737; row=10482; data_type=In Vivo; mixture=Chemical; chemical_name=2-Methyl-1,4-benzenediamine; preferred_name=2-Methyl-1,4-benzenediamine; dtxsid=DTXSID6029123; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6029123; source_file=acute_oral.xlsx
NTP ICE cancer 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP ICE cancer IARC group 3 unitless - - - WOE; IARC Carcinogenicity sheet=Data; excel_row=7216; Record_ID=cancer_5117; Data_Type=WOE; Formulation_Name=2-Methyl-1,4-benzenediamine; Mixture=Chemical; DTXSID=DTXSID6029123; Assay=IARC Carcinogenicity; Endpoint=IARC group; Response=3; Response_Unit=Unitless; URL=http://publications.iarc.fr/34; http://publications.iarc.fr/139; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6029123
NTP ICE skin sensitization 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP ICE skin sensitization EC3 0.2 % Mouse Dermal - In Vivo; LLNAdb2013; LLNA sheet=Data_invivo; excel_row=13082; Record_ID=skin_sensitization_invivo_3077; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID6029123; Assay=LLNA; Endpoint=EC3; Response=0.2; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Gerberick et al. 2005; 16536334; Not available; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6029123
SCCS Opinion 19 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
SCCS Opinion NOAEL =0.39 mg/kg bw rat oral 90-day dermal absorption p.62
SCCS Opinion NOAEL =0.67 mg/kg rat oral 90-day dermal absorption p.60
SCCS Opinion NOAEL =0.97 mg/kg rat oral 90-day dermal absorption p.50
SCCS Opinion NOAEL =2.5 mg/kg bw/day rat oral 12-week NOAEL study p.28
SCCS Opinion NOAEL =2.5 mg/kg rat oral 90-day dermal absorption p.50
SCCS Opinion NOAEL =2.5 mg/kg bw rat dermal 90-day carcinogenicity p.53
SCCS Opinion NOAEL =2.5 mg/kg bw/d rat oral 12-week NOAEL study p.32
SCCS Opinion NOAEL =6.9 mg/kg bw/d rat oral 90-day dermal absorption p.62
SCCS Opinion NOAEL =10 µg/cm rat - subchronic repeated dose toxicity (ref. 62), p.50
SCCS Opinion NOAEL =10 mg/kg bw/d - - 3-day NOAEL study p.33
SCCS Opinion NOAEL =10 mg/kg rat oral 91-day dermal absorption p.59
SCCS Opinion NOAEL =10 mg/kg bw/day rat - - NOAEL study p.62
SCCS Opinion NOAEL =20 mg/kg bw/d rat oral 90-day reproductive toxicity p.61
SCCS Opinion NOAEL =45 mg/kg rabbit oral - reproductive toxicity p.42
SCCS Opinion NOAEL =45 mg/kg bw/d rabbit oral - reproductive toxicity p.48
SCCS Opinion NOAEL =45 mg/kg rat oral 90-day reproductive toxicity p.61
SCCS Opinion NOAEL =50 mg/kg bw/d rat oral - NOAEL study p.43
SCCS Opinion NOAEL =60 mg/kg bw/d - - - NOAEL study p.31
SCCS Opinion NOAEL =69 % rat oral 90-day dermal absorption p.60
ToxValDB GESTIS DNEL 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB GESTIS DNEL DNEL systemic =0.27 mg/m3 Human inhalation - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15633466:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_e6205e107c3cfce8b3b03fb33ec3dd62
ToxValDB RSL 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB RSL RfD =0.0002 mg/kg bw/day Human oral - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759b87ce4b0a7c65d37b4e2; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/risk/regional-screening-levels-rsls-generic-tables; STUDY_GROUP=RSL:15659282:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_f7d43f2605898519a9d34c9ce2c3bd93
ToxValDB RSL RfD =0.002 mg/kg bw/day Human oral - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759b87ce4b0a7c65d37b4e2; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/risk/regional-screening-levels-rsls-generic-tables; STUDY_GROUP=RSL:15663813:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_e9b93cf51c5be60f6da04cf341449402
Regulatory source 43 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
Regulatory source - 2.5 mg/kg bw/day rat oral 12-week - p.28
Regulatory source - 2.5 mg/kg rat oral - - p.48
Regulatory source - 2.5 mg/kg bw/d rat oral 12-week - p.32
Regulatory source - 2.5 mg/kg bw/d rat oral 28-day - p.33
Regulatory source - 2.5 mg/kg bw rat oral - - p.60
Regulatory source - 10 mg/kg bw/d - - 3-day - p.33
Regulatory source - 10 mg/kg bw/d - oral 28-day - p.34
Regulatory source - 10 mg/kg rat oral 91-day - p.59
Regulatory source - 10 mg/kg bw rat oral 91-day - p.61
Regulatory source - 10 mg/kg bw/day rat oral 91 day - p.62
Regulatory source - 10 mg/kg bw/day rat - - - p.62
Regulatory source - 50 mg/kg bw/d rat oral - - p.43
Regulatory source - 50 mg/kg bw/d rat - - - p.43
Regulatory source - 60 mg/kg bw/d - - - - p.31
Regulatory source carcinogenicity 2.5 mg/kg bw/day rat oral 90-day carcinogenicity p.51
Regulatory source carcinogenicity 2.5 mg/kg bw rat dermal 90-day carcinogenicity p.53
Regulatory source carcinogenicity 10 mg/kg bw/d rat oral 90-day carcinogenicity p.63
Regulatory source carcinogenicity 69 % rat oral 90-day carcinogenicity p.63
Regulatory source dermal absorption =0.39 mg/kg bw rat oral 90-day dermal absorption p.62
Regulatory source dermal absorption =0.67 mg/kg rat oral 90-day dermal absorption p.60
Regulatory source dermal absorption =0.97 mg/kg rat oral 90-day dermal absorption p.50
Regulatory source dermal absorption =2.5 mg/kg rat oral 90-day dermal absorption p.50
Regulatory source dermal absorption =6.9 mg/kg bw/d rat oral 90-day dermal absorption p.62
Regulatory source dermal absorption 10 mg/kg rat oral 91-day dermal absorption p.59
Regulatory source dermal absorption =10 mg/kg rat oral 90-day dermal absorption p.60
Regulatory source dermal absorption =10 mg/kg bw/d rat oral 90-day dermal absorption p.62
Regulatory source dermal absorption 69 % rat oral 90-day dermal absorption p.60
Regulatory source genotoxicity 10 mg/kg bw/d - oral 28-day genotoxicity p.34
Regulatory source repeated dose toxicity 2.5 mg/kg rat - subchronic repeated dose toxicity p.50
Regulatory source repeated dose toxicity 10 µg/cm rat - subchronic repeated dose toxicity p.50
Regulatory source repeated dose toxicity 60 mg/kg bw/d rat oral Sub-chronic repeated dose toxicity p.31
Regulatory source reproductive toxicity 10 mg/kg bw/d rat oral 90-day reproductive toxicity p.61
Regulatory source reproductive toxicity 10 mg/kg bw/d rabbit oral 90-day reproductive toxicity p.63
Regulatory source reproductive toxicity 20 mg/kg bw/d rat oral 90-day reproductive toxicity p.61
Regulatory source reproductive toxicity 20 mg/kg bw/d rabbit oral 90-day reproductive toxicity p.63
Regulatory source reproductive toxicity 45 mg/kg rabbit oral - reproductive toxicity p.42
Regulatory source reproductive toxicity 45 mg/kg rat oral 12-week reproductive toxicity p.51
Regulatory source reproductive toxicity 45 mg/kg bw/d rabbit oral - reproductive toxicity p.48
Regulatory source reproductive toxicity 45 mg/kg rat oral 90-day reproductive toxicity p.61
Regulatory source reproductive toxicity 45 mg/kg bw/d rabbit oral 90-day reproductive toxicity p.63
Regulatory source reproductive toxicity 50 mg/kg bw/d rat oral 12-week reproductive toxicity p.51
Regulatory source reproductive toxicity 50 mg/kg bw/d rat oral 90-day reproductive toxicity p.61
Regulatory source reproductive toxicity 50 mg/kg bw/d rabbit oral 90-day reproductive toxicity p.63
openFDA substances 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier 24JO8Z0RJU UNII - - - chemical -