NOAEL Studies Fragrance

Tonalide NOAEL Studies

INCI: ACETYL HEXAMETHYL TETRALIN

CAS: 1506-02-1

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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NTP_ICE_acute_oral 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_acute_oral LD50 =570 mg/kg bw Rat oral acute Rat Acute Oral Toxicity NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_3936; row=12469; data_type=In Vivo; mixture=Chemical; chemical_name=6-Acetyl-1,1,2,4,4,7-hexamethyltetralin; preferred_name=Tonalide; dtxsid=DTXSID7041544; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7041544; source_file=acute_oral.xlsx
NTP_ICE_acute_oral LD50 =964 mg/kg bw Rat oral acute Rat Acute Oral Toxicity OECD eChemPortal (undated); record_id=acute_oral_3940; row=12470; data_type=In Vivo; mixture=Chemical; chemical_name=6-Acetyl-1,1,2,4,4,7-hexamethyltetralin; preferred_name=Tonalide; dtxsid=DTXSID7041544; url=https://www.echemportal.org/echemportal/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7041544; source_file=acute_oral.xlsx
NTP_ICE_acute_oral LD50 =920 mg/kg bw Rat oral acute Rat Acute Oral Toxicity OECD eChemPortal (undated); record_id=acute_oral_3938; row=12471; data_type=In Vivo; mixture=Chemical; chemical_name=6-Acetyl-1,1,2,4,4,7-hexamethyltetralin; preferred_name=Tonalide; dtxsid=DTXSID7041544; url=https://www.echemportal.org/echemportal/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7041544; source_file=acute_oral.xlsx
NTP_ICE_acute_oral LD50 =1150 mg/kg bw Rat oral acute Rat Acute Oral Toxicity OECD eChemPortal (undated); record_id=acute_oral_3942; row=12472; data_type=In Vivo; mixture=Chemical; chemical_name=6-Acetyl-1,1,2,4,4,7-hexamethyltetralin; preferred_name=Tonalide; dtxsid=DTXSID7041544; url=https://www.echemportal.org/echemportal/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7041544; source_file=acute_oral.xlsx
NTP_ICE_endocrine 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_endocrine AC50 13.5672114060306 uM - - - ERPathway2016; ER Pathway Model, Antagonist sheet=Integrated_approaches; excel_row=15564; RecordID=ERPathway2016_294; DatasetName=ERPathway2016; DTXSID=DTXSID7041544; Assay=ER Pathway Model, Antagonist; Endpoint=AC50; Response=13.5672114060306; Response_Unit=uM; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7041544
NTP_ICE_endocrine ACC 5.31979312584713 uM - - - ERPathway2016; ER Pathway Model, Antagonist sheet=Integrated_approaches; excel_row=15565; RecordID=ERPathway2016_294; DatasetName=ERPathway2016; DTXSID=DTXSID7041544; Assay=ER Pathway Model, Antagonist; Endpoint=ACC; Response=5.31979312584713; Response_Unit=uM; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7041544
NTP_ICE_endocrine Model Score 0 unitless - - - ARPathway2016; AR Pathway Model, Antagonist sheet=Integrated_approaches; excel_row=15560; RecordID=ARPathway2016_993; DatasetName=ARPathway2016; DTXSID=DTXSID7041544; Assay=AR Pathway Model, Antagonist; Endpoint=Model Score; Response=0; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7041544
NTP_ICE_endocrine Model Score 0.0388 unitless - - - ERPathway2016; ER Pathway Model, Agonist sheet=Integrated_approaches; excel_row=15566; RecordID=ERPathway2016_294; DatasetName=ERPathway2016; DTXSID=DTXSID7041544; Assay=ER Pathway Model, Agonist; Endpoint=Model Score; Response=0.0388; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7041544
NTP_ICE_skin_sensitization 3 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_skin_sensitization Incidence of positive responses 0 % Human Dermal - In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test sheet=Data_invivo; excel_row=6084; Record_ID=skin_sensitization_invivo_1395; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Mixture=Chemical; DTXSID=DTXSID7041544; Assay=Human Repeat Insult Patch Test; Endpoint=Incidence of positive responses; Response=0; Response_Unit=%; Species=Human; Route=Dermal; Reference=RIFM 1998; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Api et al. 2017; 28300631; 10.1016/j.fct.2017.03.019; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7041544
NTP_ICE_skin_sensitization Induction dose per skin area 11811 ug/cm2 Human Dermal - In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test sheet=Data_invivo; excel_row=6082; Record_ID=skin_sensitization_invivo_1395; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Mixture=Chemical; DTXSID=DTXSID7041544; Assay=Human Repeat Insult Patch Test; Endpoint=Induction dose per skin area; Response=11811; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=RIFM 1998; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Api et al. 2017; 28300631; 10.1016/j.fct.2017.03.019; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7041544
NTP_ICE_skin_sensitization Relative reliability score 4 unitless Human Dermal - In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test sheet=Data_invivo; excel_row=6088; Record_ID=skin_sensitization_invivo_1395; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Mixture=Chemical; DTXSID=DTXSID7041544; Assay=Human Repeat Insult Patch Test; Endpoint=Relative reliability score; Response=4; Response_Unit=Unitless; Species=Human; Route=Dermal; Reference=RIFM 1998; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Api et al. 2017; 28300631; 10.1016/j.fct.2017.03.019; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7041544
ToxValDB_ECHA_IUCLID 13 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_ECHA_IUCLID NOAEL >=20 mg/kg bw/day Rat oral - developmental QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7d1c1e4b0a7c65d23005f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/12808/7/9/3?documentUUID=403cf8b8-39ca-40c8-867d-6bba204143ae; YEAR=1997; ORIGINAL_YEAR=1997; STUDY_GROUP=ECHA IUCLID_dup_Developmental Toxicity Teratogenicity_15820588_15824594:-:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_c3b709026dfc4888e6537c661df128ec
ToxValDB_ECHA_IUCLID NOAEL >=20 mg/kg bw/day Rat oral - developmental QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7d1c1e4b0a7c65d230063; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/12808/7/9/3?documentUUID=403cf8b8-39ca-40c8-867d-6bba204143ae; YEAR=1997; ORIGINAL_YEAR=1997; STUDY_GROUP=ECHA IUCLID:15820738:-:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_45db428b049ebb3b53fe838616bdab08
ToxValDB_ECHA_IUCLID NOAEL =15 mg/kg bw/day Rabbit oral - developmental QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eac00e4b0a7c65d1bce26; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/12808/7/9/3?documentUUID=403cf8b8-39ca-40c8-867d-6bba204143ae; YEAR=1997; ORIGINAL_YEAR=1997; TOXICOLOGICAL_EFFECT=fetus: fetal/pup body weight changes|fetus: visceral malformations; TOXICOLOGICAL_EFFECT_CATEGORY=development; STUDY_GROUP=ECHA IUCLID:15823708:M/F:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_87db391c17d432034921855750351be3
ToxValDB_ECHA_IUCLID NOAEL >=50 mg/kg bw/day Rat oral - developmental QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eac00e4b0a7c65d1bce28; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/12808/7/9/3?documentUUID=403cf8b8-39ca-40c8-867d-6bba204143ae; YEAR=1997; ORIGINAL_YEAR=1997; STUDY_GROUP=ECHA IUCLID_dup_Developmental Toxicity Teratogenicity_15820588_15824594:-:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_9a1289022e93b7536da3d5d3e09bbb5e
ToxValDB_ECHA_IUCLID NOAEL >=10 mg/kg bw/day Rat dermal - subchronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/67c61f82e4b096bca877dc67; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/12808/7/6/4?documentUUID=403cf8b8-39ca-40c8-867d-6bba204143ae; YEAR=1997; ORIGINAL_YEAR=1997; STUDY_GROUP=ECHA IUCLID:15826867:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_327ccdc219362a9f84e66ef1f02d00f4
ToxValDB_ECHA_IUCLID NOAEL =300 ppm Rat oral short-term; 14 days short-term QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7cad7e4b0a7c65d223c11; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/12808/7/6/2?documentUUID=403cf8b8-39ca-40c8-867d-6bba204143ae; YEAR=1997; ORIGINAL_YEAR=1997; TOXICOLOGICAL_EFFECT=liver: gross pathology|organ weights and organ / body weight ratios; TOXICOLOGICAL_EFFECT_CATEGORY=gross pathology|organ weight; STUDY_GROUP=ECHA IUCLID:15833521:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_4040ab169180e9009d10b82024f94565
ToxValDB_ECHA_IUCLID NOAEL =5 mg/kg bw/day Rat oral subchronic; 13 weeks subchronic QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eadd4e4b0a7c65d1c6270; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/12808/7/6/2?documentUUID=403cf8b8-39ca-40c8-867d-6bba204143ae; YEAR=1997; ORIGINAL_YEAR=1997; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15837428_15849277:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_702f2643102b4f54892737113be1fc62
ToxValDB_ECHA_IUCLID NOAEL =100 ppm Rat oral - reproduction developmental QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c8dae4b0a7c65d21a68b; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/12808/7/9/2?documentUUID=403cf8b8-39ca-40c8-867d-6bba204143ae; YEAR=1997; ORIGINAL_YEAR=1997; TOXICOLOGICAL_EFFECT=P0: body weight and weight gain|P0: food consumption and compound intake|P0: organ weights and organ / body weight ratios|P0: gross pathology|P0: histopathology: non-neoplastic; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|food and/or water consumption|gross pathology|nonneoplastic histopathology|organ weight; STUDY_GROUP=ECHA IUCLID_dup_Toxicity Reproduction_15855152_15855182_15856027_15856051:M/F:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_62666afaaa7e5fc53855a01bde208e0e
ToxValDB_ECHA_IUCLID NOAEL =150 ppm Rat oral - reproduction developmental QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c8dae4b0a7c65d21a6a1; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/12808/7/9/2?documentUUID=403cf8b8-39ca-40c8-867d-6bba204143ae; YEAR=1997; ORIGINAL_YEAR=1997; TOXICOLOGICAL_EFFECT=P0: organ weights and organ / body weight ratios|P0: gross pathology; TOXICOLOGICAL_EFFECT_CATEGORY=gross pathology|organ weight; STUDY_GROUP=ECHA IUCLID_dup_Toxicity Reproduction_15855152_15855182_15856027_15856051:M/F:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_6f03f78fda09a66b5a536ea216ac1f42
ToxValDB_ECHA_IUCLID NOAEL >=300 ppm Rat oral - reproduction developmental QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c8dae4b0a7c65d21a68b; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/12808/7/9/2?documentUUID=403cf8b8-39ca-40c8-867d-6bba204143ae; YEAR=1997; ORIGINAL_YEAR=1997; STUDY_GROUP=ECHA IUCLID_dup_Toxicity Reproduction_15855152_15855182_15856027_15856051:M/F:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_0006e63dd56bc8f7e571e9c309bf18cb
ToxValDB_ECHA_IUCLID NOAEL >600 ppm Rat oral - reproduction developmental QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c8dae4b0a7c65d21a6a1; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/12808/7/9/2?documentUUID=403cf8b8-39ca-40c8-867d-6bba204143ae; YEAR=1997; ORIGINAL_YEAR=1997; STUDY_GROUP=ECHA IUCLID_dup_Toxicity Reproduction_15855152_15855182_15856027_15856051:M/F:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_c0fea6f8468fe3b7c8ac5b993a417bd5
ToxValDB_ECHA_IUCLID NOEL =1.5 mg/kg bw/day Rat oral subchronic; 90 days subchronic QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eadd4e4b0a7c65d1c626c; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/12808/7/6/2?documentUUID=403cf8b8-39ca-40c8-867d-6bba204143ae; YEAR=1997; ORIGINAL_YEAR=1997; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15847245_15849058:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_09f4c55d142a7944e12c946f40ed198f
ToxValDB_ECHA_IUCLID NOEL =10 mg/kg bw/day Rat oral short-term; 28 days short-term QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eadd4e4b0a7c65d1c627c; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/12808/7/6/2?documentUUID=403cf8b8-39ca-40c8-867d-6bba204143ae; YEAR=1997; ORIGINAL_YEAR=1997; STUDY_GROUP=ECHA IUCLID:15849278:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_5f4dfd2096eb5887b2b108829a9c9f36
ToxValDB_GESTIS_DNEL 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_GESTIS_DNEL DNEL systemic =0.175 mg/m3 Human inhalation - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15635118:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_43343abc2fda1c88f9b03739b7fef2c2
ToxValDB_MN_MDH_HHBW 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_MN_MDH_HHBW NOAEL =5 mg/kg bw/day Rat oral subchronic subchronic LONG_REF=Api, A.M., R.L. Smith, S. Pipino, T. Marczylo, F. De Matteis. (2004). "Evaluation of the oral subchronic toxicity of AHTN (7-Acetyl-1,1,3,4,4,6-hexamethyl-1,2,3,4-tetrahydronaphthalene) in the rat." Food and Chemical Toxicology. 42:791-801; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/68c98af0e4b02565fc7d4e6d; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.health.state.mn.us/communities/environment/risk/guidance/gw/table.html; SUBSOURCE_URL=https://www.health.state.mn.us/communities/environment/risk/docs/guidance/gw/ahtn.pdf; YEAR=2004; ORIGINAL_YEAR=2004; TOXICOLOGICAL_EFFECT=Effects on various biochemical liver parameters including increased A/G ratio, reductions in plasma glucose, cholesterol, and plasma triglyceride; STUDY_GROUP=MN MDH HHBW:15952717:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_8fe4636751ad5354eaf48936e6ff6499
openFDA substances 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier 360Q8Z01IP UNII - - - chemical {"approval_status":null,"molecular_formula":"C18H26O","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"360Q8Z01IP"}
openFDA substances FDA UNII substance identifier 360Q8Z01IP UNII - - - chemical {"approval_status":null,"molecular_formula":"C18H26O","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"360Q8Z01IP"}
openFDA substances FDA UNII substance identifier 360Q8Z01IP UNII - - - chemical {"approval_status":null,"molecular_formula":"C18H26O","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"360Q8Z01IP"}
openFDA substances FDA UNII substance identifier 360Q8Z01IP UNII - - - chemical {"approval_status":null,"molecular_formula":"C18H26O","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"360Q8Z01IP"}