NOAEL Studies UV Filter / Sunscreen

TriAsorB NOAEL Studies

INCI: PHENYLENE BIS-DIPHENYLTRIAZINE

CAS: 55514-22-2

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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SCCS Opinion 8 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
SCCS Opinion NOAEL =48.5 % rat oral 2-week repeated dose toxicity p.36
SCCS Opinion NOAEL =54 mg/kg bw/day - inhalation 14-day NOAEL study p.41
SCCS Opinion NOAEL =80 mg/kg bw rat dermal 90 day irritation p.73
SCCS Opinion NOAEL =464 mg/kg bw/day rat oral prenatal developmental toxicity p.52
SCCS Opinion NOAEL =464 mg/kg bw/d - oral developmental reproductive toxicity p.67
SCCS Opinion NOAEL =485 mg/kg/day rat oral 13 weeks repeated dose toxicity p.36
SCCS Opinion NOAEL =1000 mg/kg bw/day - - Developmental repeated dose toxicity p.36
SCCS Opinion NOAEL =1000 mg/kg/day - - - NOAEL study p.50
ECHA 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ECHA NOEL =1000 mg/kg bw/day Rat oral short-term; 5 days short-term QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7cb54e4b0a7c65d225bce; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/6106/7/6/2?documentUUID=4b4753c6-29c3-4692-aadf-22c699e4c870; YEAR=2012; ORIGINAL_YEAR=2012; STUDY_GROUP=ECHA IUCLID:15839320:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_4179f756f5efa114acc49834735cf108
Regulatory source 14 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
Regulatory source - 54 mg/kg bw/day - inhalation 14-day - p.41
Regulatory source - 1000 mg/kg/day - - - - p.50
Regulatory source - 1000 mg/kg/day rat oral 4-week - p.66
Regulatory source developmental toxicity 464 mg/kg bw/day rat oral prenatal developmental toxicity p.52
Regulatory source developmental toxicity 1000 mg/kg bw/day - - prenatal developmental toxicity p.52
Regulatory source irritation 80 mg/kg bw rat dermal 90 day irritation p.73
Regulatory source repeated dose toxicity 48.5 % rat oral 2-week repeated dose toxicity p.36
Regulatory source repeated dose toxicity 54 mg/kg bw/day rat inhalation subacute repeated dose toxicity p.66
Regulatory source repeated dose toxicity 485 mg/kg/day rat oral 13 weeks repeated dose toxicity p.36
Regulatory source repeated dose toxicity 1000 mg/kg bw/day - - Developmental repeated dose toxicity p.36
Regulatory source repeated dose toxicity 1000 mg/kg/day rat oral 13-week repeated dose toxicity p.66
Regulatory source repeated dose toxicity 1000 mg/kg/day rat oral developmental repeated dose toxicity p.66
Regulatory source reproductive toxicity 464 mg/kg bw/d - oral developmental reproductive toxicity p.67
Regulatory source reproductive toxicity 1000 mg/kg/day rat - Developmental reproductive toxicity p.51