NOAEL Studies
Preservative
Triclocarban NOAEL Studies
INCI: TRICLOCARBAN
CAS: 101-20-2
Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.
ECHA 14 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ECHA | LOAEL | 200 | mg/kg bw/day | rat | oral: feed | - | developmental toxicity | dossier=b3710a60-6080-4ff3-a7c3-2f0958c328ed.i6z; document=2b765eea-3427-4727-bd4e-854376481923_b3710a60-6080-4ff3-a7c3-2f0958c328ed.i6d; document_key=2b765eea-3427-4727-bd4e-854376481923/b3710a60-6080-4ff3-a7c3-2f0958c328ed; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=2015; basis=reduction in number of live offspring; key_result=true; entry_uuid=4ddf244a-f307-480e-ab55-13a7a1b15f62 |
| ECHA | LOAEL | 250 | mg/kg bw/day | rat | oral: feed | - | toxicity to reproduction | dossier=b3710a60-6080-4ff3-a7c3-2f0958c328ed.i6z; document=c10e8d24-4159-428a-bad8-de178d5e5b3c_b3710a60-6080-4ff3-a7c3-2f0958c328ed.i6d; document_key=c10e8d24-4159-428a-bad8-de178d5e5b3c/b3710a60-6080-4ff3-a7c3-2f0958c328ed; document_subtype=ToxicityReproduction; literature=Name=Unnamed; ReferenceYear=2011; basis=other:; key_result=false; entry_uuid=b32ff781-c504-4aff-87c5-3d514ea77f6e |
| ECHA | LOAEL | 50 | mg/kg bw/day | rabbit | oral: gavage | - | developmental toxicity | dossier=b3710a60-6080-4ff3-a7c3-2f0958c328ed.i6z; document=505a528b-2049-4f64-a3d4-68082a4b1daa_b3710a60-6080-4ff3-a7c3-2f0958c328ed.i6d; document_key=505a528b-2049-4f64-a3d4-68082a4b1daa/b3710a60-6080-4ff3-a7c3-2f0958c328ed; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=1979; basis=body weight and weight gain; key_result=false; entry_uuid=4bf64cb5-1d70-418c-ae38-7286c434e215 |
| ECHA | LOAEL | 2500 | mg/kg bw/day | rat | oral: capsule | - | screening for reproductive / developmental toxicity | dossier=b3710a60-6080-4ff3-a7c3-2f0958c328ed.i6z; document=2930873c-3c69-4c02-884a-df846c5e6423_b3710a60-6080-4ff3-a7c3-2f0958c328ed.i6d; document_key=2930873c-3c69-4c02-884a-df846c5e6423/b3710a60-6080-4ff3-a7c3-2f0958c328ed; document_subtype=ToxicityReproduction; literature=Name=Unnamed; ReferenceYear=1973; ReportDate=1973-03-30; basis=body weight and weight gain; key_result=false; entry_uuid=f4072361-80ab-480a-abd4-ad1732810bf3 |
| ECHA | NOAEL | 500 | mg/kg bw/day | rat | oral: feed | - | developmental toxicity | dossier=b3710a60-6080-4ff3-a7c3-2f0958c328ed.i6z; document=2b765eea-3427-4727-bd4e-854376481923_b3710a60-6080-4ff3-a7c3-2f0958c328ed.i6d; document_key=2b765eea-3427-4727-bd4e-854376481923/b3710a60-6080-4ff3-a7c3-2f0958c328ed; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=2015; basis=other:; key_result=true; entry_uuid=94279545-a65a-4b00-b654-f93c64063b2f |
| ECHA | NOAEL | 25 | mg/kg bw/day | rat | oral: feed | - | chronic toxicity: oral | dossier=b3710a60-6080-4ff3-a7c3-2f0958c328ed.i6z; document=e98849df-c83c-4ac3-9448-81fda7795341_b3710a60-6080-4ff3-a7c3-2f0958c328ed.i6d; document_key=e98849df-c83c-4ac3-9448-81fda7795341/b3710a60-6080-4ff3-a7c3-2f0958c328ed; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1981; basis=other:; key_result=false; entry_uuid=08b62962-be57-40dc-b59a-be96080cd26f |
| ECHA | NOAEL | 300 | mg/kg bw/day | rat | oral: feed | - | developmental toxicity | dossier=b3710a60-6080-4ff3-a7c3-2f0958c328ed.i6z; document=9cdb8c59-e5d3-41e3-b7fd-c73fcb5d91cd_b3710a60-6080-4ff3-a7c3-2f0958c328ed.i6d; document_key=9cdb8c59-e5d3-41e3-b7fd-c73fcb5d91cd/b3710a60-6080-4ff3-a7c3-2f0958c328ed; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=1983; basis=body weight and weight gain; key_result=false; entry_uuid=fa40e2bd-fcf5-4ae1-b529-66b2558e10b0 |
| ECHA | NOAEL | 150 | mg/kg bw/day | rat | oral: feed | - | three-generation reproductive toxicity | dossier=b3710a60-6080-4ff3-a7c3-2f0958c328ed.i6z; document=2a56aa92-0fb1-4934-8248-0754e1f67709_b3710a60-6080-4ff3-a7c3-2f0958c328ed.i6d; document_key=2a56aa92-0fb1-4934-8248-0754e1f67709/b3710a60-6080-4ff3-a7c3-2f0958c328ed; document_subtype=ToxicityReproduction; literature=Name=Unnamed; ReferenceYear=2011; basis=clinical signs; key_result=true; entry_uuid=75f8a85b-dba9-4f4a-8f8c-98632177f40d |
| ECHA | NOAEL | 50 | mg/kg bw/day | rat | oral: feed | - | three-generation reproductive toxicity | dossier=b3710a60-6080-4ff3-a7c3-2f0958c328ed.i6z; document=2a56aa92-0fb1-4934-8248-0754e1f67709_b3710a60-6080-4ff3-a7c3-2f0958c328ed.i6d; document_key=2a56aa92-0fb1-4934-8248-0754e1f67709/b3710a60-6080-4ff3-a7c3-2f0958c328ed; document_subtype=ToxicityReproduction; literature=Name=Unnamed; ReferenceYear=2011; basis=sexual maturation; key_result=true; entry_uuid=9444f8d3-59ae-4198-a3e7-08c47f6faab9 |
| ECHA | NOAEL | 75 | mg/kg bw/day | rat | oral: feed | - | sub-chronic toxicity: oral | dossier=b3710a60-6080-4ff3-a7c3-2f0958c328ed.i6z; document=97058f98-7b34-46f0-b0e5-8698ae83ed72_b3710a60-6080-4ff3-a7c3-2f0958c328ed.i6d; document_key=97058f98-7b34-46f0-b0e5-8698ae83ed72/b3710a60-6080-4ff3-a7c3-2f0958c328ed; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=2005; basis=other:; key_result=false; entry_uuid=572bfaeb-0f38-40bc-b4b9-7a803a212e85 |
| ECHA | NOAEL | 100 | mg/kg bw/day | rat | oral: feed | - | developmental toxicity | dossier=b3710a60-6080-4ff3-a7c3-2f0958c328ed.i6z; document=fed49333-84f4-47ab-971a-19d01e29912a_b3710a60-6080-4ff3-a7c3-2f0958c328ed.i6d; document_key=fed49333-84f4-47ab-971a-19d01e29912a/b3710a60-6080-4ff3-a7c3-2f0958c328ed; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=1979; basis=body weight and weight gain; key_result=false; entry_uuid=72ad32d8-0679-4618-8729-cbfb5e16c663 |
| ECHA | NOAEL | 200 | mg/kg bw/day | rat | oral: feed | - | one-generation reproductive toxicity | dossier=b3710a60-6080-4ff3-a7c3-2f0958c328ed.i6z; document=0988a8e5-992e-4aac-919d-444984c2a147_b3710a60-6080-4ff3-a7c3-2f0958c328ed.i6d; document_key=0988a8e5-992e-4aac-919d-444984c2a147/b3710a60-6080-4ff3-a7c3-2f0958c328ed; document_subtype=ToxicityReproduction; literature=Name=Unnamed; ReferenceYear=2015; basis=food consumption and compound intake; key_result=false; entry_uuid=e41429db-f0b6-4e26-ab5a-40de98d85364 |
| ECHA | NOAEL | 250 | mg/kg bw/day | rabbit | oral: gavage | - | developmental toxicity | dossier=b3710a60-6080-4ff3-a7c3-2f0958c328ed.i6z; document=505a528b-2049-4f64-a3d4-68082a4b1daa_b3710a60-6080-4ff3-a7c3-2f0958c328ed.i6d; document_key=505a528b-2049-4f64-a3d4-68082a4b1daa/b3710a60-6080-4ff3-a7c3-2f0958c328ed; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=1979; basis=reduction in number of live offspring; key_result=false; entry_uuid=f8097bff-c080-4979-9bd5-eb4c567ab1a6 |
| ECHA | NOEL | 200 | mg/kg bw/day | rat | oral: feed | - | two-generation reproductive toxicity | dossier=b3710a60-6080-4ff3-a7c3-2f0958c328ed.i6z; document=3543613a-4f96-481e-ba62-87bd2e8f1c99_b3710a60-6080-4ff3-a7c3-2f0958c328ed.i6d; document_key=3543613a-4f96-481e-ba62-87bd2e8f1c99/b3710a60-6080-4ff3-a7c3-2f0958c328ed; document_subtype=ToxicityReproduction; literature=Name=Unnamed; ReferenceYear=1979; basis=other:; key_result=false; entry_uuid=87c29761-03f4-47e6-91b6-9648b7e7aab8 |
NTP ICE acute oral 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE acute oral | LD50 | >34600 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | record_id=acute_oral_145; row=7317; data_type=In Vivo; mixture=Chemical; chemical_name=Triclocarban; preferred_name=Triclocarban; dtxsid=DTXSID4026214; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4026214; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID4026214; source_file=acute_oral.xlsx |
| NTP ICE acute oral | LD50 | >2000 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | record_id=acute_oral_142; row=7318; data_type=In Vivo; mixture=Chemical; chemical_name=Triclocarban; preferred_name=Triclocarban; dtxsid=DTXSID4026214; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4026214; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID4026214; source_file=acute_oral.xlsx |
NTP ICE adme parameters 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE adme parameters | Clint | 38.4 | uL/min/10^6 cells | Rat | - | - | Measured; httk, Rat Hepatic Intrinsic Clearance | sheet=Data; excel_row=1737; Record_ID=adme_parameters_1112; Data_Type=Measured; DTXSID=DTXSID4026214; Assay=httk, Rat Hepatic Intrinsic Clearance; Endpoint=Clint; Response=38.4; Response_Unit=ul/min/10^6 cells; Species=Rat; Reference=httk2.3.1, Black 2021; URL=https://cran.r-project.org/web/packages/httk/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4026214; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID4026214 |
| NTP ICE adme parameters | Clint | 9.45 | uL/min/10^6 cells | Human | - | - | Measured; httk, Human Hepatic Intrinsic Clearance | sheet=Data; excel_row=1738; Record_ID=adme_parameters_1112; Data_Type=Measured; DTXSID=DTXSID4026214; Assay=httk, Human Hepatic Intrinsic Clearance; Endpoint=Clint; Response=9.45; Response_Unit=ul/min/10^6 cells; Species=Human; Reference=httk2.3.1, Black 2021; URL=https://cran.r-project.org/web/packages/httk/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4026214; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID4026214 |
NTP ICE endocrine 5 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE endocrine | AC50 | 1.63486318612577 | uM | - | - | - | ARPathway2016; AR Pathway Model, Agonist | sheet=Integrated_approaches; excel_row=15746; RecordID=ARPathway2016_1; DatasetName=ARPathway2016; DTXSID=DTXSID4026214; Assay=AR Pathway Model, Agonist; Endpoint=AC50; Response=1.63486318612577; Response_Unit=uM; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4026214; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID4026214 |
| NTP ICE endocrine | ACC | 1.50338250094856 | uM | - | - | - | ARPathway2016; AR Pathway Model, Agonist | sheet=Integrated_approaches; excel_row=15747; RecordID=ARPathway2016_1; DatasetName=ARPathway2016; DTXSID=DTXSID4026214; Assay=AR Pathway Model, Agonist; Endpoint=ACC; Response=1.50338250094856; Response_Unit=uM; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4026214; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID4026214 |
| NTP ICE endocrine | Model Score | 0.0248 | unitless | - | - | - | ARPathway2016; AR Pathway Model, Antagonist | sheet=Integrated_approaches; excel_row=15748; RecordID=ARPathway2016_1; DatasetName=ARPathway2016; DTXSID=DTXSID4026214; Assay=AR Pathway Model, Antagonist; Endpoint=Model Score; Response=0.0248; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4026214; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID4026214 |
| NTP ICE endocrine | Model Score | 0.0194 | unitless | - | - | - | ARPathway2016; AR Pathway Model, Agonist | sheet=Integrated_approaches; excel_row=15749; RecordID=ARPathway2016_1; DatasetName=ARPathway2016; DTXSID=DTXSID4026214; Assay=AR Pathway Model, Agonist; Endpoint=Model Score; Response=0.0194; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4026214; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID4026214 |
| NTP ICE endocrine | Model Score | 0 | unitless | - | - | - | ERPathway2016; ER Pathway Model, Agonist | sheet=Integrated_approaches; excel_row=15752; RecordID=ERPathway2016_568; DatasetName=ERPathway2016; DTXSID=DTXSID4026214; Assay=ER Pathway Model, Agonist; Endpoint=Model Score; Response=0; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4026214; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID4026214 |
NTP ICE skin sensitization 4 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE skin sensitization | Incidence of positive responses | 0 | % | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test | sheet=Data_invivo; excel_row=1597; Record_ID=skin_sensitization_invivo_529; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=1.5; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID4026214; Assay=Human Repeat Insult Patch Test; Endpoint=Incidence of positive responses; Response=0; Response_Unit=%; Species=Human; Route=Dermal; Reference=Marzulli and Maibach 1974; 4459237; 10.1016/0015-6264(74)90367-8; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4026214; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID4026214 |
| NTP ICE skin sensitization | Induction dose per skin area | 1046 | ug/cm2 | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test | sheet=Data_invivo; excel_row=1596; Record_ID=skin_sensitization_invivo_529; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=1.5; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID4026214; Assay=Human Repeat Insult Patch Test; Endpoint=Induction dose per skin area; Response=1046; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Marzulli and Maibach 1974; 4459237; 10.1016/0015-6264(74)90367-8; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4026214; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID4026214 |
| NTP ICE skin sensitization | Induction dose per skin area | 6975 | ug/cm2 | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test | sheet=Data_invivo; excel_row=1600; Record_ID=skin_sensitization_invivo_530; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=10.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID4026214; Assay=Human Repeat Insult Patch Test; Endpoint=Induction dose per skin area; Response=6975; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Marzulli and Maibach 1974; 4459237; 10.1016/0015-6264(74)90367-8; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4026214; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID4026214 |
| NTP ICE skin sensitization | Relative reliability score | 2 | unitless | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test | sheet=Data_invivo; excel_row=1599; Record_ID=skin_sensitization_invivo_529; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=1.5; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID4026214; Assay=Human Repeat Insult Patch Test; Endpoint=Relative reliability score; Response=2; Response_Unit=Unitless; Species=Human; Route=Dermal; Reference=Marzulli and Maibach 1974; 4459237; 10.1016/0015-6264(74)90367-8; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4026214; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID4026214 |
SCCS Opinion 86 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| SCCS Opinion | NOAEL | =0.0006 | - | - | oral | - | NOAEL study | p.55 |
| SCCS Opinion | NOAEL | =0.0321 | mg/kg bw/d | - | oral | chronic | NOAEL study | p.33 |
| SCCS Opinion | NOAEL | <0.2 | % | rat | oral | developmental | reproductive toxicity | p.23 |
| SCCS Opinion | NOAEL | =0.2 | % | - | - | - | NOAEL study | p.22 |
| SCCS Opinion | NOAEL | =0.25 | % | - | oral | developmental | reproductive toxicity | p.23 |
| SCCS Opinion | NOAEL | =0.4 | mg/kg | - | - | - | reproductive toxicity | p.77 |
| SCCS Opinion | NOAEL | =0.5 | - | - | - | - | NOAEL study | p.58 |
| SCCS Opinion | NOAEL | =1 | mg/kg bw/day | rat | oral | - | NOAEL study | Ref.: Stoker 2010, p.26 |
| SCCS Opinion | NOAEL | =1.5 | % | human | oral | subchronic | repeated dose toxicity | p.36 |
| SCCS Opinion | NOAEL | =1.5 | mg/kg bw/day | rat | oral | - | NOAEL study | Ref.: Costa 2020a In the Costa et al, p.23 |
| SCCS Opinion | NOAEL | =2 | - | - | dermal | - | NOAEL study | p.56 |
| SCCS Opinion | NOAEL | =3 | mg/kg bw/day | mouse | - | - | NOAEL study | Ref.: Mandal 2020 Raj et al, p.28 |
| SCCS Opinion | NOAEL | =4.69 | mg/kg bw/day | mouse | - | 8 months | reproductive toxicity | p.27 |
| SCCS Opinion | NOAEL | =5 | mg/kg bw/day | rat | oral | - | NOAEL study | p.79 |
| SCCS Opinion | NOAEL | =6 | - | - | - | - | genotoxicity | p.21 |
| SCCS Opinion | NOAEL | =6.75 | mg/kg bw/d | rat | oral | chronic | NOAEL study | p.33 |
| SCCS Opinion | NOAEL | =6.75 | mg/kg bw/day | rat | oral | 2-year | NOAEL study | p.48 |
| SCCS Opinion | NOAEL | =8 | mg/kg | rat | oral | 2-year | NOAEL study | p.25 |
| SCCS Opinion | NOAEL | =8 | mg/kg bw/day | rat | - | - | NOAEL study | Ref.: Pernoncini 2018 3, p.26 |
| SCCS Opinion | NOAEL | =8 | - | human | - | - | NOAEL study | p.80 |
| SCCS Opinion | NOAEL | =8 | mg/kg bw/d | mouse | - | - | NOAEL study | p.73 |
| SCCS Opinion | NOAEL | =9.375 | mg/kg bw/day | rat | - | 20-day | repeated dose toxicity | p.31 |
| SCCS Opinion | NOAEL | =9.4 | mg/kg bw/day | rat | - | - | NOAEL study | Ref.: Pernoncini 2018 3, p.26 |
| SCCS Opinion | NOAEL | =10 | mg/kg bw/day | rat | oral | 28 days | NOAEL study | p.28 |
| SCCS Opinion | NOAEL | =12 | mg/kg bw/d | rat | oral | 13-week | repeated dose toxicity | p.16 |
| SCCS Opinion | NOAEL | =12 | mg/kg bw/day | rat | oral | 8 weeks | NOAEL study | p.30 |
| SCCS Opinion | NOAEL | =24 | - | - | oral | - | NOAEL study | p.55 |
| SCCS Opinion | NOAEL | =25 | mg/kg bw/d | rat | oral | Subchronic | repeated dose toxicity | p.19 |
| SCCS Opinion | NOAEL | =25 | mg/kg bw/day | rat | - | 28 weeks | reproductive toxicity | p.25 |
| SCCS Opinion | NOAEL | =25 | - | - | oral | - | NOAEL study | p.56 |
| SCCS Opinion | NOAEL | =26 | - | - | dermal | - | NOAEL study | p.57 |
| SCCS Opinion | NOAEL | =27 | % | rat | oral | chronic | NOAEL study | p.33 |
| SCCS Opinion | NOAEL | =27 | - | - | - | - | NOAEL study | p.58 |
| SCCS Opinion | NOAEL | =28 | - | - | oral | - | NOAEL study | p.58 |
| SCCS Opinion | NOAEL | =30 | mg/kg bw/d | rat | oral | subchronic | repeated dose toxicity | p.16 |
| SCCS Opinion | NOAEL | =37.5 | mg/kg/day | rat | oral | 8-months | NOAEL study | p.73 |
| SCCS Opinion | NOAEL | =48 | mg/kg bw/d | rat | oral | 95-week | repeated dose toxicity | p.16 |
| SCCS Opinion | NOAEL | =50 | mg/kg bw | - | - | 2-year | reproductive toxicity | p.25 |
| SCCS Opinion | NOAEL | =56 | - | - | oral | - | NOAEL study | p.56 |
| SCCS Opinion | NOAEL | =65 | % | rat | oral | 90 days | developmental toxicity | p.26 |
| SCCS Opinion | NOAEL | =65 | mg/kg bw/d | rat | dermal | 1-year | repeated dose toxicity | p.16 |
| SCCS Opinion | NOAEL | =69 | - | - | - | - | NOAEL study | p.69 |
| SCCS Opinion | NOAEL | =70 | - | - | - | - | NOAEL study | p.70 |
| SCCS Opinion | NOAEL | =71 | - | - | - | - | NOAEL study | p.71 |
| SCCS Opinion | NOAEL | =72 | - | - | - | - | NOAEL study | p.72 |
| SCCS Opinion | NOAEL | =73 | - | - | - | - | NOAEL study | p.73 |
| SCCS Opinion | NOAEL | =74 | - | - | - | - | NOAEL study | p.74 |
| SCCS Opinion | NOAEL | =75 | mg/kg bw/d | rat | oral | Subchronic | repeated dose toxicity | p.19 |
| SCCS Opinion | NOAEL | =75 | mg/kg bw/d | rat | - | developmental | reproductive toxicity | p.15 |
| SCCS Opinion | NOAEL | =75 | - | - | - | - | NOAEL study | p.75 |
| SCCS Opinion | NOAEL | =76 | - | - | - | - | NOAEL study | p.76 |
| SCCS Opinion | NOAEL | =77 | - | - | - | - | NOAEL study | p.77 |
| SCCS Opinion | NOAEL | =78 | - | - | - | - | NOAEL study | p.78 |
| SCCS Opinion | NOAEL | =79 | - | - | - | - | NOAEL study | p.79 |
| SCCS Opinion | NOAEL | =80 | - | - | - | - | NOAEL study | p.80 |
| SCCS Opinion | NOAEL | =95 | mg/kg/day | - | - | developmental | reproductive toxicity | p.23 |
| SCCS Opinion | NOAEL | =100 | mg/kg | - | - | developmental | reproductive toxicity | p.23 |
| SCCS Opinion | NOAEL | =100 | % | - | oral | 10 years | NOAEL study | p.55 |
| SCCS Opinion | NOAEL | =100 | mg/kg/d | mouse | - | 12 week | NOAEL study | p.74 |
| SCCS Opinion | NOAEL | =100 | mg/kg | rat | oral | 31 days | NOAEL study | p.75 |
| SCCS Opinion | NOAEL | =125 | mg/kg | - | - | developmental | reproductive toxicity | p.23 |
| SCCS Opinion | NOAEL | =187.5 | mg/kg bw/d | rat | oral | - | NOAEL study | p.69 |
| SCCS Opinion | NOAEL | =200 | mg/kg | rat | oral | 10 days | NOAEL study | p.75 |
| SCCS Opinion | NOAEL | =250 | mg/kg bw/d | rat | oral | Sub-chronic | repeated dose toxicity | p.20 |
| SCCS Opinion | NOAEL | =250 | mg/kg bw/d | rat | oral | 2-year | repeated dose toxicity | p.15 |
| SCCS Opinion | NOAEL | =280 | mg/kg/day | - | oral | developmental | reproductive toxicity | p.23 |
| SCCS Opinion | NOAEL | =300 | mg/kg/day | - | - | developmental | reproductive toxicity | p.23 |
| SCCS Opinion | NOAEL | =300 | mg/kg/d | rat | oral | - | NOAEL study | p.70 |
| SCCS Opinion | NOAEL | =300 | - | - | - | - | NOAEL study | p.70 |
| SCCS Opinion | NOAEL | =300 | mg/kg | rat | oral | Developmental | reproductive toxicity | p.71 |
| SCCS Opinion | NOAEL | =320 | mg/kg bw/day | rat | oral | - | NOAEL study | p.79 |
| SCCS Opinion | NOAEL | =450 | - | human | - | - | NOAEL study | p.80 |
| SCCS Opinion | NOAEL | =600 | mg/kg bw/d | rat | - | 8 weeks | reproductive toxicity | p.71 |
| SCCS Opinion | NOAEL | =750 | mg/kg bw/d | rat | oral | 12 week | NOAEL study | p.74 |
| SCCS Opinion | NOAEL | >1000 | mg/kg bw/d | rat | oral | Subchronic | repeated dose toxicity | p.19 |
| SCCS Opinion | NOAEL | >1000 | mg/kg bw | rat | oral | 5 days | NOAEL study | Ref.: 19 Triclocarban (purity 98, p.20 |
| SCCS Opinion | NOAEL | =1000 | ppm | rat | oral | developmental | reproductive toxicity | p.23 |
| SCCS Opinion | NOAEL | =1000 | ppm | rat | - | developmental | reproductive toxicity | p.15 |
| SCCS Opinion | NOAEL | =1643 | - | - | - | - | NOAEL study | p.57 |
| SCCS Opinion | NOAEL | =3000 | ppm | rat | oral | developmental | reproductive toxicity | p.23 |
| SCCS Opinion | NOAEL | =3000 | ppm | rat | - | developmental | reproductive toxicity | p.15 |
| SCCS Opinion | NOAEL | =4000 | mg/kg bw/day | mouse | oral | 14 days | NOAEL study | p.78 |
| SCCS Opinion | NOAEL | =5000 | mg/kg | rat | oral | subchronic | repeated dose toxicity | p.16 |
| SCCS Opinion | NOAEL | =6750 | - | - | - | - | NOAEL study | p.55 |
| SCCS Opinion | NOAEL | =10000 | ppm | rat | oral | Chronic | repeated dose toxicity | p.20 |
| SCCS Opinion | NOAEL | =unclear:icant differences (compared to control group) are largely limited to the highest tested dose. No apical effects on reproductive performance were reported in these studies. The SCCS considers that the hormonal/behavioural parameters evaluated in both female and male offspring following maternal exposure of Wistar rat to triclocarban are sensitive paramaters that may be indicative of an endocrine activity, but that as such as they are not directly linked to an adverse effect and therefore cannot be used to derive a NOAEL/LOAEL. | - | rat | - | - | reproductive toxicity | p.23 |
ToxValDB GESTIS DNEL 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB GESTIS DNEL | DNEL systemic | =2.47 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15635353:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_f4dd391cdd318be83d00205ce1f3a1c8 |
ToxValDB HPVIS 6 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB HPVIS | LOAEL | =75 | mg/kg bw/day | Rat | oral | chronic; 24 months | chronic | LONG_REF="A 24-Month DietaryToxicity/Carcinogenicity Study of TCC in Rats", Monsanto 1981, Bio/dynamics Project # 77-l 785, BDN-77-280.; TITLE=A 24-Month DietaryToxicity/Carcinogenicity Study of TCC in Rats; AUTHOR=Monsanto; QUALITY=2; EXTERNAL_SOURCE_ID=63724; EXTERNAL_SOURCE_ID_DESC=HPVIS ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/63861d6de4b04f6bb1480596; RECORD_SOURCE_LEVEL=Extraction document; STUDY_GROUP=HPVIS_dup_HPVIS Mammalian Repeat Dose_15640267_15640292:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_d38809656dd15c2218812487cdac7a2b |
| ToxValDB HPVIS | NOAEL | =75 | mg/kg bw/day | Rat | oral | subchronic; 8 weeks | subchronic | LONG_REF=Monsanto, 1985, Hazleton Laboratries Report # 241-180; TITLE=Monsanto, 1985, Hazleton Laboratries Report # 241-180; AUTHOR=Monsanto; QUALITY=3; EXTERNAL_SOURCE_ID=64244; EXTERNAL_SOURCE_ID_DESC=HPVIS ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/63861d6de4b04f6bb1480596; RECORD_SOURCE_LEVEL=Extraction document; STUDY_GROUP=HPVIS:15639496:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_92d975fb1ffd54184420a0ecb6808f60 |
| ToxValDB HPVIS | NOAEL | =25 | mg/kg bw/day | Rat | oral | short-term; 30 days | short-term | LONG_REF=Monsanto, 1960, Younger Laboratories Project# Y-60-39; TITLE=Monsanto, 1960, Younger Laboratories Project# Y-60-39; AUTHOR=Monsanto; QUALITY=2; EXTERNAL_SOURCE_ID=61100; EXTERNAL_SOURCE_ID_DESC=HPVIS ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/63861d6de4b04f6bb1480596; RECORD_SOURCE_LEVEL=Extraction document; YEAR=1960; ORIGINAL_YEAR=1960; STUDY_GROUP=HPVIS_dup_HPVIS Mammalian Repeat Dose_15639703_15640030:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_e2005d82eded26e2e9057893bfcaa93a |
| ToxValDB HPVIS | NOAEL | >1000 | mg/kg bw/day | Rat | oral | short-term; 30 days | short-term | LONG_REF=Monsanto, 1960, Younger Laboratories Project# Y-60-39; TITLE=Monsanto, 1960, Younger Laboratories Project# Y-60-39; AUTHOR=Monsanto; QUALITY=2; EXTERNAL_SOURCE_ID=63467; EXTERNAL_SOURCE_ID_DESC=HPVIS ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/63861d6de4b04f6bb1480596; RECORD_SOURCE_LEVEL=Extraction document; YEAR=1960; ORIGINAL_YEAR=1960; STUDY_GROUP=HPVIS_dup_HPVIS Mammalian Repeat Dose_15639703_15640030:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_c7e8ccc643d320574762069ec3d589bf |
| ToxValDB HPVIS | NOAEL | >3000 | ppm | Rat | oral | - | reproduction developmental | LONG_REF=Monsanto, 1983, Bio/dynamics Project # 79-2398 (BD-79-058).; TITLE=Monsanto, 1983, Bio/dynamics Project # 79-2398 (BD-79-058); AUTHOR=Monsanto; QUALITY=2; EXTERNAL_SOURCE_ID=58770; EXTERNAL_SOURCE_ID_DESC=HPVIS ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/63861d6de4b04f6bb1480590; RECORD_SOURCE_LEVEL=Extraction document; STUDY_GROUP=HPVIS:15642559:F:-maternal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_9ba0734f62c89f7fd2ed1d82bdbf1e3d |
| ToxValDB HPVIS | NOAEL | =1000 | ppm | Rat | oral | - | reproduction developmental | LONG_REF=Monsanto, 1983, Bio/dynamics Project # 79-2398 (BD-79-058); TITLE=Monsanto, 1983, Bio/dynamics Project # 79-2398 (BD-79-058); AUTHOR=Monsanto; QUALITY=2; EXTERNAL_SOURCE_ID=65229 |::| 65618; EXTERNAL_SOURCE_ID_DESC=HPVIS ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/63861d6de4b04f6bb1480598; RECORD_SOURCE_LEVEL=Extraction document; YEAR=1979; ORIGINAL_YEAR=1979; STUDY_GROUP=HPVIS:15643144:-:F1offspring; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_5f36623aa21399c5bf49d59015def247 |
ToxValDB MN MDH HHBW 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB MN MDH HHBW | NOAEL | =25 | mg/kg bw/day | Rat | oral | - | repeat dose other | LONG_REF=European Commission (EC) - Health & Consumer Protection Directorate-General. (2005). "Scientific Committee on Consumer Products (SCCP) Opinion on Triclocarban. COLIPA n P29. SCCP/0851/04.", from http://ec.europa.eu/health/ph_risk/committees/04_sccp/docs/sccp_o_016.pdf.; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/68c98af0e4b02565fc7d4de3; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.health.state.mn.us/communities/environment/risk/guidance/gw/table.html; SUBSOURCE_URL=https://www.health.state.mn.us/communities/environment/risk/docs/guidance/gw/triclocarbansumm.pdf; YEAR=1981; ORIGINAL_YEAR=1981; TOXICOLOGICAL_EFFECT=Testicular degeneration, anemia, increased liver and spleen weights, microscopic changes in spleen, bone marrow, liver and kidney; STUDY_GROUP=MN MDH HHBW:15952952:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_e3a71e06983a79cb78c075c12b25fa66 |
Regulatory source 127 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| Regulatory source | - | 0.0006 | - | - | oral | - | - | p.55 |
| Regulatory source | - | 0.0321 | mg/kg bw/d | - | oral | chronic | - | p.33 |
| Regulatory source | - | =0.2 | % | - | - | - | - | p.22 |
| Regulatory source | - | 0.5 | - | - | - | - | - | p.58 |
| Regulatory source | - | 1 | mg/kg bw/day | rat | oral | - | - | p.26 |
| Regulatory source | - | 1.5 | mg/kg bw/day | rat | oral | - | - | p.23 |
| Regulatory source | - | 2 | - | - | dermal | - | - | p.56 |
| Regulatory source | - | =3 | mg/kg bw/day | mouse | - | - | - | p.28 |
| Regulatory source | - | 5 | mg/kg bw/day | rat | oral | - | - | p.79 |
| Regulatory source | - | =6.75 | mg/kg bw/d | rat | oral | chronic | - | p.33 |
| Regulatory source | - | 6.75 | mg/kg bw/day | rat | oral | 2-year | - | p.48 |
| Regulatory source | - | 8 | mg/kg | rat | oral | 2-year | - | p.25 |
| Regulatory source | - | =8 | mg/kg bw/day | rat | oral | 3-day | - | p.25 |
| Regulatory source | - | =8 | mg/kg bw/day | rat | - | - | - | p.26 |
| Regulatory source | - | =8 | mg/kg bw/day | rat | oral | 8 weeks | - | p.30 |
| Regulatory source | - | 8 | mg/kg bw/day | - | oral | 10 years | - | p.55 |
| Regulatory source | - | 8 | mg/kg bw/d | rat | oral | 8-months | - | p.73 |
| Regulatory source | - | 8 | mg/kg | rat | - | 10 weeks | - | p.76 |
| Regulatory source | - | 8 | - | human | - | - | - | p.80 |
| Regulatory source | - | 8 | - | - | - | - | - | p.56 |
| Regulatory source | - | 8 | - | - | oral | - | - | p.56 |
| Regulatory source | - | 8 | mg/kg bw/d | mouse | - | - | - | p.73 |
| Regulatory source | - | 9.4 | mg/kg bw/day | rat | - | - | - | p.26 |
| Regulatory source | - | =10 | mg/kg bw/day | rat | oral | 28 days | - | p.28 |
| Regulatory source | - | 12 | mg/kg bw/day | rat | oral | 8 weeks | - | p.30 |
| Regulatory source | - | 24 | - | - | oral | - | - | p.55 |
| Regulatory source | - | 25 | mg/kg bw/d | rat | oral | chronic | - | p.33 |
| Regulatory source | - | 25 | mg/kg bw/day | rat | - | 2-year | - | p.34 |
| Regulatory source | - | 25 | mg/kg bw/day | rat | oral | 2-year | - | p.48 |
| Regulatory source | - | 25 | - | - | oral | - | - | p.56 |
| Regulatory source | - | 26 | - | - | dermal | - | - | p.57 |
| Regulatory source | - | 27 | % | rat | oral | chronic | - | p.33 |
| Regulatory source | - | 27 | - | - | - | - | - | p.58 |
| Regulatory source | - | 28 | - | - | oral | - | - | p.58 |
| Regulatory source | - | 37.5 | mg/kg/day | rat | oral | 8-months | - | p.73 |
| Regulatory source | - | 37.5 | mg/kg | rat | oral | 8-months | - | p.73 |
| Regulatory source | - | 56 | - | - | oral | - | - | p.56 |
| Regulatory source | - | 69 | - | - | - | - | - | p.69 |
| Regulatory source | - | 70 | - | - | - | - | - | p.70 |
| Regulatory source | - | 71 | - | - | - | - | - | p.71 |
| Regulatory source | - | 72 | - | - | - | - | - | p.72 |
| Regulatory source | - | 73 | - | - | - | - | - | p.73 |
| Regulatory source | - | 74 | - | - | - | - | - | p.74 |
| Regulatory source | - | 75 | mg/kg bw/d | rat | oral | 23 months | - | p.21 |
| Regulatory source | - | 75 | mg/kg bw/d | rat | oral | 8-week | - | p.34 |
| Regulatory source | - | 75 | - | - | - | - | - | p.75 |
| Regulatory source | - | 76 | - | - | - | - | - | p.76 |
| Regulatory source | - | 77 | - | - | - | - | - | p.77 |
| Regulatory source | - | 78 | - | - | - | - | - | p.78 |
| Regulatory source | - | 79 | - | - | - | - | - | p.79 |
| Regulatory source | - | 80 | - | - | - | - | - | p.80 |
| Regulatory source | - | 100 | % | - | oral | 10 years | - | p.55 |
| Regulatory source | - | 100 | % | - | - | - | - | p.55 |
| Regulatory source | - | 100 | mg/kg/d | mouse | - | 12 week | - | p.74 |
| Regulatory source | - | =100 | mg/kg | rat | oral | 31 days | - | p.75 |
| Regulatory source | - | 187.5 | mg/kg bw/d | rat | oral | - | - | p.69 |
| Regulatory source | - | 200 | mg/kg | rat | oral | 10 days | - | p.75 |
| Regulatory source | - | 200 | mg/kg/day | rat | oral | 10 days | - | p.75 |
| Regulatory source | - | 200 | mg/kg bw/day | rat | oral | 31 days | - | p.78 |
| Regulatory source | - | 200 | mg/kg | rat | - | 8 weeks | - | p.71 |
| Regulatory source | - | 300 | mg/kg/d | rat | oral | - | - | p.70 |
| Regulatory source | - | 300 | - | - | - | - | - | p.70 |
| Regulatory source | - | 320 | mg/kg bw/day | rat | oral | - | - | p.79 |
| Regulatory source | - | 450 | - | human | - | - | - | p.80 |
| Regulatory source | - | 600 | mg/kg bw/d | rat | - | - | - | p.71 |
| Regulatory source | - | 750 | mg/kg bw/d | rat | oral | 12 week | - | p.74 |
| Regulatory source | - | 750 | mg/kg bw/d | rat | oral | 60-day | - | p.74 |
| Regulatory source | - | >1000 | mg/kg bw | rat | oral | 5 days | - | p.20 |
| Regulatory source | - | 1643 | - | - | - | - | - | p.57 |
| Regulatory source | - | 4000 | mg/kg bw/day | mouse | oral | 14 days | - | p.78 |
| Regulatory source | - | 6750 | - | - | - | - | - | p.55 |
| Regulatory source | - | 10000 | ppm | rat | - | Chronic | - | p.20 |
| Regulatory source | carcinogenicity | 10000 | ppm | rat | oral | 6 months | carcinogenicity | p.21 |
| Regulatory source | developmental toxicity | 65 | % | rat | oral | 90 days | developmental toxicity | p.26 |
| Regulatory source | genotoxicity | 6 | - | - | - | - | genotoxicity | p.21 |
| Regulatory source | irritation | 12 | mg/kg bw/day | rat | oral | - | irritation | p.59 |
| Regulatory source | repeated dose toxicity | 1.5 | % | human | oral | subchronic | repeated dose toxicity | p.36 |
| Regulatory source | repeated dose toxicity | 8 | mg/kg bw/day | rat | - | 20-day | repeated dose toxicity | p.31 |
| Regulatory source | repeated dose toxicity | 9.375 | mg/kg bw/day | rat | - | 20-day | repeated dose toxicity | p.31 |
| Regulatory source | repeated dose toxicity | 12 | mg/kg bw/d | rat | oral | 13-week | repeated dose toxicity | p.16 |
| Regulatory source | repeated dose toxicity | 12 | mg/kg bw/day | rat | - | 20-day | repeated dose toxicity | p.31 |
| Regulatory source | repeated dose toxicity | =25 | mg/kg bw/d | rat | oral | Subchronic | repeated dose toxicity | p.19 |
| Regulatory source | repeated dose toxicity | 25 | mg/kg bw/d | rat | dermal | 2-year | repeated dose toxicity | p.36 |
| Regulatory source | repeated dose toxicity | 30 | mg/kg bw/d | rat | oral | subchronic | repeated dose toxicity | p.16 |
| Regulatory source | repeated dose toxicity | 48 | mg/kg bw/d | rat | oral | 95-week | repeated dose toxicity | p.16 |
| Regulatory source | repeated dose toxicity | 65 | mg/kg bw/d | rat | dermal | 1-year | repeated dose toxicity | p.16 |
| Regulatory source | repeated dose toxicity | =75 | mg/kg bw/d | rat | oral | Subchronic | repeated dose toxicity | p.19 |
| Regulatory source | repeated dose toxicity | 250 | mg/kg bw/d | rat | oral | Sub-chronic | repeated dose toxicity | p.20 |
| Regulatory source | repeated dose toxicity | 250 | mg/kg bw/d | rat | oral | chronic | repeated dose toxicity | p.36 |
| Regulatory source | repeated dose toxicity | 250 | mg/kg bw/d | rat | oral | 2-year | repeated dose toxicity | p.15 |
| Regulatory source | repeated dose toxicity | >1000 | mg/kg bw/d | rat | oral | Subchronic | repeated dose toxicity | p.19 |
| Regulatory source | repeated dose toxicity | 5000 | mg/kg | rat | oral | subchronic | repeated dose toxicity | p.16 |
| Regulatory source | repeated dose toxicity | 10000 | ppm | rat | oral | Chronic | repeated dose toxicity | p.20 |
| Regulatory source | reproductive toxicity | 0 | - | rat | - | - | reproductive toxicity | p.23 |
| Regulatory source | reproductive toxicity | <0.2 | % | rat | oral | developmental | reproductive toxicity | p.23 |
| Regulatory source | reproductive toxicity | <0.2 | % | - | - | developmental | reproductive toxicity | p.23 |
| Regulatory source | reproductive toxicity | =0.25 | % | - | oral | developmental | reproductive toxicity | p.23 |
| Regulatory source | reproductive toxicity | 0.4 | mg/kg | - | - | - | reproductive toxicity | p.77 |
| Regulatory source | reproductive toxicity | =1 | mg/kg bw/day | rat | - | 6 weeks | reproductive toxicity | p.27 |
| Regulatory source | reproductive toxicity | 1.5 | mg/kg bw/day | - | - | - | reproductive toxicity | p.23 |
| Regulatory source | reproductive toxicity | =4.69 | mg/kg bw/day | mouse | - | 8 months | reproductive toxicity | p.27 |
| Regulatory source | reproductive toxicity | 6.75 | mg/kg bw/d | human | oral | developmental | reproductive toxicity | p.36 |
| Regulatory source | reproductive toxicity | =8 | mg/kg bw/day | rat | oral | 49-day | reproductive toxicity | p.29 |
| Regulatory source | reproductive toxicity | =8 | mg/kg bw/day | rat | oral | 10 weeks | reproductive toxicity | p.30 |
| Regulatory source | reproductive toxicity | 8 | mg/kg bw/day | rat | - | 2-year | reproductive toxicity | p.34 |
| Regulatory source | reproductive toxicity | 8 | mg/kg | rat | oral | 10 weeks | reproductive toxicity | p.76 |
| Regulatory source | reproductive toxicity | 8 | mg/kg | rat | oral | 49 day | reproductive toxicity | p.76 |
| Regulatory source | reproductive toxicity | 25 | mg/kg bw/day | rat | - | 28 weeks | reproductive toxicity | p.25 |
| Regulatory source | reproductive toxicity | 25 | mg/kg bw/day | rat | oral | 2-year | reproductive toxicity | p.59 |
| Regulatory source | reproductive toxicity | 50 | mg/kg bw | - | - | 2-year | reproductive toxicity | p.25 |
| Regulatory source | reproductive toxicity | 75 | mg/kg bw/d | rat | oral | developmental | reproductive toxicity | p.34 |
| Regulatory source | reproductive toxicity | 75 | mg/kg bw/d | rat | - | developmental | reproductive toxicity | p.15 |
| Regulatory source | reproductive toxicity | 95 | mg/kg/day | - | - | developmental | reproductive toxicity | p.23 |
| Regulatory source | reproductive toxicity | 100 | mg/kg | - | - | developmental | reproductive toxicity | p.23 |
| Regulatory source | reproductive toxicity | 125 | mg/kg | - | - | developmental | reproductive toxicity | p.23 |
| Regulatory source | reproductive toxicity | 280 | mg/kg/day | - | oral | developmental | reproductive toxicity | p.23 |
| Regulatory source | reproductive toxicity | 300 | mg/kg/day | - | - | developmental | reproductive toxicity | p.23 |
| Regulatory source | reproductive toxicity | 300 | mg/kg | rat | oral | Developmental | reproductive toxicity | p.71 |
| Regulatory source | reproductive toxicity | 600 | mg/kg bw/d | rat | - | 8 weeks | reproductive toxicity | p.71 |
| Regulatory source | reproductive toxicity | =1000 | ppm | rat | oral | developmental | reproductive toxicity | p.23 |
| Regulatory source | reproductive toxicity | >1000 | mg/kg bw/d | rat | oral | developmental | reproductive toxicity | p.23 |
| Regulatory source | reproductive toxicity | =1000 | ppm | - | - | developmental | reproductive toxicity | p.23 |
| Regulatory source | reproductive toxicity | >1000 | mg/kg | - | - | developmental | reproductive toxicity | p.23 |
| Regulatory source | reproductive toxicity | =1000 | ppm | rat | - | developmental | reproductive toxicity | p.15 |
| Regulatory source | reproductive toxicity | =3000 | ppm | rat | oral | developmental | reproductive toxicity | p.23 |
| Regulatory source | reproductive toxicity | 3000 | ppm | rat | - | developmental | reproductive toxicity | p.34 |
| Regulatory source | reproductive toxicity | =3000 | ppm | - | - | developmental | reproductive toxicity | p.23 |
openFDA substances 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| openFDA substances | FDA UNII substance identifier | BGG1Y1ED0Y | UNII | - | - | - | chemical | - |