NOAEL Studies
Cosmetic Ingredient
Tricresyl Phosphate NOAEL Studies
INCI: TRICRESYL PHOSPHATE
CAS: 1330-78-5
Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.
INCHEM_WHO_ehc_ehc_ehc110 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| INCHEM_WHO_ehc_ehc_ehc110 | NOEL | =0.1 | mg/L | - | - | 2-week | Reproductive toxicity | document_id=ehc_ehc_ehc110; title=Tricresyl phosphate (EHC 110, 1990); path=mirror/documents/ehc/ehc/ehc110.htm; row_hash=4371cc2a823e30ed; raw_unit=mg/litre; context=There are limited data on the acute toxicity of TCP to aquatic invertebrates: the 48-h LC 50 for Daphnia is 5.6 ng/litre; the 24-h LC 50 for nematodes is 400 ng/litre; the 2-week NOEL for Daphnia (mortality, growth, reproduction) is 0.1 mg/litre. |
| INCHEM_WHO_ehc_ehc_ehc110 | NOEL | =0.1 | mg/L | - | - | 2-week | Reproductive toxicity | document_id=ehc_ehc_ehc110; title=Tricresyl phosphate (EHC 110, 1990); path=mirror/documents/ehc/ehc/ehc110.htm; row_hash=4371cc2a823e30ed; raw_unit=mg/litre; context=There are limited data on the acute toxicity of TCP to aquatic invertebrates: the 48-h LC 50 for Daphnia is 5.6 ng/litre; the 24-h LC 50 for nematodes is 400 ng/litre; the 2-week NOEL for Daphnia (mortality, growth, reproduction) is 0.1 mg/litre. |
NTP_ICE_cancer 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_cancer | Top dose | 250 | ppm | Mouse | Gavage; Dosed feed | - | In Vivo; NTP Carcinogenicity | sheet=Data; excel_row=4607; Record_ID=cancer_6629; Data_Type=In Vivo; Formulation_Name=Tricresyl Phosphate; Mixture=Chemical; DTXSID=DTXSID4021391; Assay=NTP Carcinogenicity; Endpoint=Top dose; Response=250; Response_Unit=ppm; Species=Mouse; Strain=B6C3F1; Sex=Male; Route=Gavage; Dosed feed; Reference=TR-433; URL=https://ntp.niehs.nih.gov/publications/reports/tr/400s/tr433/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4021391; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID4021391 |
| NTP_ICE_cancer | Top dose | 600 | ppm | Rat | Gavage; Dosed feed | - | In Vivo; NTP Carcinogenicity | sheet=Data; excel_row=4609; Record_ID=cancer_6630; Data_Type=In Vivo; Formulation_Name=Tricresyl Phosphate; Mixture=Chemical; DTXSID=DTXSID4021391; Assay=NTP Carcinogenicity; Endpoint=Top dose; Response=600; Response_Unit=ppm; Species=Rat; Strain=F344/N; Sex=Male; Route=Gavage; Dosed feed; Reference=TR-433; URL=https://ntp.niehs.nih.gov/publications/reports/tr/400s/tr433/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4021391; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID4021391 |
NTP_ICE_endocrine 4 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_endocrine | AC50 | 41.6901401012661 | uM | - | - | - | ARPathway2016; AR Pathway Model, Agonist | sheet=Integrated_approaches; excel_row=16160; RecordID=ARPathway2016_59; DatasetName=ARPathway2016; DTXSID=DTXSID4021391; Assay=AR Pathway Model, Agonist; Endpoint=AC50; Response=41.6901401012661; Response_Unit=uM; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4021391; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID4021391 |
| NTP_ICE_endocrine | ACC | 95.4400224840921 | uM | - | - | - | ARPathway2016; AR Pathway Model, Agonist | sheet=Integrated_approaches; excel_row=16161; RecordID=ARPathway2016_59; DatasetName=ARPathway2016; DTXSID=DTXSID4021391; Assay=AR Pathway Model, Agonist; Endpoint=ACC; Response=95.4400224840921; Response_Unit=uM; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4021391; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID4021391 |
| NTP_ICE_endocrine | Model Score | 0.0171 | unitless | - | - | - | ARPathway2016; AR Pathway Model, Antagonist | sheet=Integrated_approaches; excel_row=16162; RecordID=ARPathway2016_59; DatasetName=ARPathway2016; DTXSID=DTXSID4021391; Assay=AR Pathway Model, Antagonist; Endpoint=Model Score; Response=0.0171; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4021391; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID4021391 |
| NTP_ICE_endocrine | Model Score | 0 | unitless | - | - | - | ARPathway2016; AR Pathway Model, Agonist | sheet=Integrated_approaches; excel_row=16163; RecordID=ARPathway2016_59; DatasetName=ARPathway2016; DTXSID=DTXSID4021391; Assay=AR Pathway Model, Agonist; Endpoint=Model Score; Response=0; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4021391; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID4021391 |
ToxRefDB_ToxRefDB_v3_pod.csv 3 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxRefDB_ToxRefDB_v3_pod.csv | LEL | =8 | mg/kg bw/day | mouse (b6c3f1; B6C3F1) | oral | 0 day to 105 week | CHR | study_id=7406; toxval_study_source_id=studyid7406_Adult_F0_F_cholinesterase; toxval_effect_list=cholinesterase-cholinesterase-cholinesterase (che); dose_level=1; study_year=1994; study_citation=(1994) TOXICOLOGY AND CARCINOGENESIS STUDIES OF TRICRESYL PHOSPHATE (CAS NO. 1330-78-5) IN F344/N RATS AND B6C3F1 MICE (GAVAGE AND FEED STUDIES). NTP TR 433, NIH Publication No. 94-3164. (Chronic mouse); dsstox_substance_id=DTXSID4021391; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | LEL | =7 | mg/kg bw/day | mouse (b6c3f1; B6C3F1) | oral | 0 day to 105 week | CHR | study_id=7406; toxval_study_source_id=studyid7406_Adult_F0_M_cholinesterase; toxval_effect_list=cholinesterase-cholinesterase-cholinesterase (che); dose_level=1; study_year=1994; study_citation=(1994) TOXICOLOGY AND CARCINOGENESIS STUDIES OF TRICRESYL PHOSPHATE (CAS NO. 1330-78-5) IN F344/N RATS AND B6C3F1 MICE (GAVAGE AND FEED STUDIES). NTP TR 433, NIH Publication No. 94-3164. (Chronic mouse); dsstox_substance_id=DTXSID4021391; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | NEL | >0 | mg/kg bw/day | mouse (b6c3f1; B6C3F1) | oral | 0 day to 105 week | CHR | study_id=7406; toxval_study_source_id=studyid7406_Adult_F0_F_cholinesterase; toxval_effect_list=cholinesterase-cholinesterase-cholinesterase (che); dose_level=0; study_year=1994; study_citation=(1994) TOXICOLOGY AND CARCINOGENESIS STUDIES OF TRICRESYL PHOSPHATE (CAS NO. 1330-78-5) IN F344/N RATS AND B6C3F1 MICE (GAVAGE AND FEED STUDIES). NTP TR 433, NIH Publication No. 94-3164. (Chronic mouse); dsstox_substance_id=DTXSID4021391; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
ToxValDB_ATSDR_MRLs 4 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_ATSDR_MRLs | BMDL (10) | =3.72 | mg/kg bw/day | Rat | oral | chronic; 104 weeks | chronic | LONG_REF=NTP. 1994. Toxicology and carcinogenesis studies of tricresyl phosphate (CAS No. 1330- 78-5) in F344/N rats and B6C3F1 mice (gavage and feed studies). Program NT. TR 433.; TITLE=Toxicology and carcinogenesis studies of tricresyl phosphate (CAS No. 1330- 78-5) in F344/N rats and B6C3F1 mice (gavage and feed studies); AUTHOR=NTP; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6568f4f4e4b063812d5857dd; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.atsdr.cdc.gov/ToxProfiles/tp202.pdf; TOXICOLOGICAL_EFFECT=reproductive; TOXICOLOGICAL_EFFECT_CATEGORY=reproduction; STUDY_GROUP=ATSDR MRLs:15447868:M/F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_ce949fe79a4a94869e83248e123acf4b |
| ToxValDB_ATSDR_MRLs | BMDL (10) | =2.12 | mg/kg bw/day | Rat | oral | chronic; 104 weeks | chronic | LONG_REF=NTP. 1994. Toxicology and carcinogenesis studies of tricresyl phosphate (CAS No. 1330- 78-5) in F344/N rats and B6C3F1 mice (gavage and feed studies). Program NT. TR 433.; TITLE=Toxicology and carcinogenesis studies of tricresyl phosphate (CAS No. 1330- 78-5) in F344/N rats and B6C3F1 mice (gavage and feed studies); AUTHOR=NTP; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6568f4f4e4b063812d5857dd; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.atsdr.cdc.gov/ToxProfiles/tp202.pdf; TOXICOLOGICAL_EFFECT=reproductive; TOXICOLOGICAL_EFFECT_CATEGORY=reproduction; STUDY_GROUP=ATSDR MRLs:15447869:M/F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_bd85c369553301b2b94c9c9774cf3707 |
| ToxValDB_ATSDR_MRLs | MRL | =0.04 | mg/kg bw/day | Human | oral | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/674e166be4b0a7c65d36ea5d; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://wwwn.cdc.gov/TSP/MRLS/mrlsListing.aspx; YEAR=2012; ORIGINAL_YEAR=2012; TOXICOLOGICAL_EFFECT=reproductive in male/female rats; STUDY_GROUP=ATSDR MRLs_dup_-_15447289_15447290:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_b214af22c7c0059578146de7d6a31cc2 |
| ToxValDB_ATSDR_MRLs | MRL | =0.02 | mg/kg bw/day | Human | oral | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/674e166be4b0a7c65d36ea5d; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://wwwn.cdc.gov/TSP/MRLS/mrlsListing.aspx; YEAR=2012; ORIGINAL_YEAR=2012; TOXICOLOGICAL_EFFECT=reproductive in male/female rats; STUDY_GROUP=ATSDR MRLs_dup_-_15447289_15447290:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_b3bb1f533b2d2d57f3218bddecf53da0 |
ToxValDB_ECHA_IUCLID 7 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_ECHA_IUCLID | LOAEL | =20 | mg/kg bw/day | Rat | oral | - | developmental | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eabdde4b0a7c65d1bc299; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/16010/7/9/3?documentUUID=2b204d86-0225-4a9d-a816-55fb51981c73; TOXICOLOGICAL_EFFECT=fetus: fetal/pup body weight changes; TOXICOLOGICAL_EFFECT_CATEGORY=development; STUDY_GROUP=ECHA IUCLID:15821548:M/F:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_c477f8eb531850d9cd894bb3eaadc25e |
| ToxValDB_ECHA_IUCLID | LOAEL | =62.5 | mg/kg bw/day | Mouse | oral | - | reproduction developmental | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaa8be4b0a7c65d1b65f0; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/16010/7/9/2?documentUUID=2b204d86-0225-4a9d-a816-55fb51981c73; STUDY_GROUP=ECHA IUCLID:15857632:M/F:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_de9963f6516b2df8d0d9dc74d7a69c6e |
| ToxValDB_ECHA_IUCLID | NOAEL | =300 | mg/m3 | Rat | inhalation | - | repeat dose other | GUIDELINE=OECD Guideline 424 (Neurotoxicity Study in Rodents); QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c85ae4b0a7c65d218143; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/16010/7/10/1?documentUUID=2b204d86-0225-4a9d-a816-55fb51981c73; TOXICOLOGICAL_EFFECT=body weight and weight gain; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=ECHA IUCLID:15825691:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_07e7457c7b97fd395b8f990b3b01fafe |
| ToxValDB_ECHA_IUCLID | NOAEL | =1000 | mg/m3 | Rat | inhalation | - | repeat dose other | GUIDELINE=OECD Guideline 424 (Neurotoxicity Study in Rodents); QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c85ae4b0a7c65d218143; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/16010/7/10/1?documentUUID=2b204d86-0225-4a9d-a816-55fb51981c73; STUDY_GROUP=ECHA IUCLID:15825692:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_19f6311d08016e369beb3b8477b41a01 |
| ToxValDB_ECHA_IUCLID | NOAEL | =2000 | mg/kg bw/day | Chicken | oral | - | repeat dose other | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c85ae4b0a7c65d218151; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/16010/7/10/1?documentUUID=2b204d86-0225-4a9d-a816-55fb51981c73; STUDY_GROUP=ECHA IUCLID:15825832:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_93f9aff933224cd8ce39c64dc61b052d |
| ToxValDB_ECHA_IUCLID | NOAEL | =1000 | mg/kg bw/day | Rat | oral | subchronic; 3 months | subchronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669ead34e4b0a7c65d1c314c; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/16010/7/6/2?documentUUID=2b204d86-0225-4a9d-a816-55fb51981c73; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15831389_15834636:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_1e89a1c4177f3d63b38bd361f1bc6022 |
| ToxValDB_ECHA_IUCLID | NOEL | =30 | mg/kg bw/day | Rat | oral | subchronic; 3 months | subchronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eadece4b0a7c65d1c692b; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/2204/7/6/2?documentUUID=99c3641c-7c92-445e-b2e1-a7d3058b8a91; YEAR=2010; ORIGINAL_YEAR=2010; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15831389_15834636:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_5968e3f76e2bdb0768730171a2886a5c |
ToxValDB_ECOTOX 3 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_ECOTOX | LOEL | =2000 | ppm | Mouse | oral | chronic; 120 days | reproduction developmental | LONG_REF=Reprod. Toxicol.12(4): 489-494 Chapin,R.E., R.A. Sloane, and J.K. Haseman Reproductive Endpoints in General Toxicity Studies: Are they Predictive? 1998; TITLE=Reproductive Endpoints in General Toxicity Studies: Are they Predictive?; AUTHOR=Chapin,R.E., R.A. Sloane, and J.K. Haseman; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=116723; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1998; ORIGINAL_YEAR=1998; TOXICOLOGICAL_EFFECT=Growth: Weight|Reproduction: Abnormal|Reproduction: Motility|Reproduction: Sperm cell counts|Morphology: Weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|other|reproduction; STUDY_GROUP=ECOTOX_dup_EPA ORD_15612488_15612514:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; Source overall passed QC, and this record was expert reviewed and revised from ECOTOX source; QC_STATUS=pass; SOURCE_HASH=e71c1b60c775b721eb844e68d675d35e |
| ToxValDB_ECOTOX | NOEL | =0.1 | % | Mouse | oral | chronic; 361 days | chronic | LONG_REF=Fundam. Appl. Toxicol.39(1): 1-10 Bolon,B., T.J. Bucci, A.R. Warbritton, J.J. Chen, D.R. Mattison, and J.J. Heindel Differential Follicle Counts as a Screen for Chemically Induced Ovarian Toxicity in Mice: Results from Continuous Breeding Bioassays 1997; TITLE=Differential Follicle Counts as a Screen for Chemically Induced Ovarian Toxicity in Mice: Results from Continuous Breeding Bioassays; AUTHOR=Bolon,B., T.J. Bucci, A.R. Warbritton, J.J. Chen, D.R. Mattison, and J.J. Heindel; DOI=10.1006/faat.1997.2338; QUALITY=Control type: Multiple control types; EXTERNAL_SOURCE_ID=151647; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1997; ORIGINAL_YEAR=1997; TOXICOLOGICAL_EFFECT=Reproduction: Number of ovarian follicles; TOXICOLOGICAL_EFFECT_CATEGORY=reproduction; STUDY_GROUP=ECOTOX:15599868:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=f894c55afeb96ff86536c1e6f8c0d695 |
| ToxValDB_ECOTOX | NOEL | =0.2 | % | Mouse | oral | chronic; 294 days | chronic | LONG_REF=Fundam. Appl. Toxicol.39(1): 1-10 Bolon,B., T.J. Bucci, A.R. Warbritton, J.J. Chen, D.R. Mattison, and J.J. Heindel Differential Follicle Counts as a Screen for Chemically Induced Ovarian Toxicity in Mice: Results from Continuous Breeding Bioassays 1997; TITLE=Differential Follicle Counts as a Screen for Chemically Induced Ovarian Toxicity in Mice: Results from Continuous Breeding Bioassays; AUTHOR=Bolon,B., T.J. Bucci, A.R. Warbritton, J.J. Chen, D.R. Mattison, and J.J. Heindel; DOI=10.1006/faat.1997.2338; QUALITY=Control type: Multiple control types; EXTERNAL_SOURCE_ID=151647; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1997; ORIGINAL_YEAR=1997; TOXICOLOGICAL_EFFECT=Reproduction: Number of ovarian follicles; TOXICOLOGICAL_EFFECT_CATEGORY=reproduction; STUDY_GROUP=ECOTOX:15609617:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=3c398b3b9dd56e1bcc72958df2baa1d0 |
ToxValDB_EPA_TSCA_8e 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_EPA_TSCA_8e | NEL | =1000 | mg/m3 | Rat | inhalation | subchronic; 90 days | subchronic | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/68c96d15e4b02565fc7d3269; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://chemview.epa.gov; SUBSOURCE_URL=https://chemview.epa.gov/chemview/proxy?filename=8EHQ-18-21393_378194.pdf; TOXICOLOGICAL_EFFECT=no toxicologically significant effects observed; STUDY_GROUP=EPA TSCA 8e:15957699:F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_17a1e37c7f28aa3d98560717d1f15fa7 |
ToxValDB_GESTIS_DNEL 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_GESTIS_DNEL | DNEL systemic | =0.18 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15634494:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_f2c89ee5c0a3af31fe149be24183104d |
ToxValDB_HESS 5 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_HESS | NOAEL | =200 | mg/kg bw/day | Rat | oral | short-term; 28 days | short-term | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/60da0dd1e4b0a676289dd86a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.nite.go.jp/en/chem/qsar/hess_update-e.html; TOXICOLOGICAL_EFFECT=Clinical Observation: Locomotor activity decrease, Salivation|Blood Chemistry: Ch E decrease; TOXICOLOGICAL_EFFECT_CATEGORY=clinical chemistry|clinical signs; STUDY_GROUP=HESS_dup_-_15638754_15638755:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_4d0dd0417da798a27ca2c6c6c70f2165 |
| ToxValDB_HESS | NOEL | <40 | mg/kg bw/day | Rat | oral | short-term; 28 days | short-term | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/60da0dd1e4b0a676289dd86a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.nite.go.jp/en/chem/qsar/hess_update-e.html; TOXICOLOGICAL_EFFECT=Clinical Observation: Locomotor activity decrease, Salivation|Blood Chemistry: Ch E decrease; TOXICOLOGICAL_EFFECT_CATEGORY=clinical chemistry|clinical signs; STUDY_GROUP=HESS_dup_-_15638754_15638755:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_2cb06bd4ed0fc85ea9e1f7eab187738c |
| ToxValDB_HESS | NOEL | <50 | mg/kg bw/day | Rat | oral | subchronic; 13 weeks | subchronic | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/60da0df7e4b0a676289deb3e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.nite.go.jp/en/chem/qsar/hess_update-e.html; TOXICOLOGICAL_EFFECT=Body Weight Changes: decrease|Hematology: Hct decrease, Hgb decrease, RBC decrease|Blood Chemistry: Ch E decrease|Absolute Organ Weight: Liver increase, Right kidney increase, Left testis decrease, Thymus decrease|Relative Organ Weight: Liver increase, Right kidney increase, Left testis decrease, Thymus decrease|Histopathology: Adrenals-Cytoplasmic Vacuolization/Cortex Ovary-Interstitial cell hypertrophy Testis-Seminiferous tubule atrophy; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical chemistry|hematology|nonneoplastic histopathology|organ weight; STUDY_GROUP=HESS:15638756:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_371be2a00a5a6b7500fef618a9ec09bc |
| ToxValDB_HESS | NOEL | <86.4 | mg/kg bw/day | Rat | oral | subchronic; 13 weeks | subchronic | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/60da0df7e4b0a676289deb21; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.nite.go.jp/en/chem/qsar/hess_update-e.html; TOXICOLOGICAL_EFFECT=Clinical Observation: Emaciation|Body Weight Changes: decrease|Food Consumption: decrease|Hematology: Hct decrease, RBC decrease, Hgb decrease, Plt increase, Ret increase|Blood Chemistry: Ch E decrease|Absolute Organ Weight: Liver increase, Right testis decrease|Relative Organ Weight: Liver increase, Right testis decrease|Histopathology: Adrenal-Cytoplasmic vacuolization/Cortex Ovary-Interstitial cell hyperplasia Ovary-Interstitium inflammation Kidney/papilla-Edema Kidney/papilla- Necrosis Pituitary-Basophilic hypertrophy Testis -Tubules atrophy; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical chemistry|clinical signs|food and/or water consumption|hematology|nonneoplastic histopathology|organ weight; STUDY_GROUP=HESS:15638757:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_786649b0931e07f244ae88f743211f2d |
| ToxValDB_HESS | NOEL | =65 | mg/kg bw/day | Rat | oral | subchronic; 13 weeks | subchronic | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/60da0df7e4b0a676289deb21; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.nite.go.jp/en/chem/qsar/hess_update-e.html; TOXICOLOGICAL_EFFECT=Clinical Observation: Emaciation|Body Weight Changes: decrease|Food Consumption: decrease|Hematology: Hct decrease, RBC decrease, Hgb decrease, Plt increase, Ret increase|Blood Chemistry: Ch E decrease|Absolute Organ Weight: Liver increase, Right testis decrease|Relative Organ Weight: Liver increase, Right testis decrease|Histopathology: Adrenal-Cytoplasmic vacuolization/Cortex Ovary-Interstitial cell hyperplasia Ovary-Interstitium inflammation Kidney/papilla-Edema Kidney/papilla- Necrosis Pituitary-Basophilic hypertrophy Testis -Tubules atrophy; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical chemistry|clinical signs|food and/or water consumption|hematology|nonneoplastic histopathology|organ weight; STUDY_GROUP=HESS:15639030:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_a76f3cda83b1c4eedc30308a7c5b5022 |
ToxValDB_HPVIS 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_HPVIS | LOAEL | =0.5 | % diet | Rat | oral | short-term; 28 days | short-term | LONG_REF=Foster D. Snell, Inc. 28-Day Oral Administration in Rats. Conducted for FMC Corporation. 1976.; TITLE=28-Day Oral Administration in Rats. Conducted for FMC Corporation; AUTHOR=Foster D. Snell, Inc; QUALITY=2; EXTERNAL_SOURCE_ID=64344; EXTERNAL_SOURCE_ID_DESC=HPVIS ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/63861d6de4b04f6bb1480596; RECORD_SOURCE_LEVEL=Extraction document; YEAR=1976; ORIGINAL_YEAR=1976; TOXICOLOGICAL_EFFECT_CATEGORY=multiple; STUDY_GROUP=HPVIS_dup_HPVIS Mammalian Repeat Dose_15639871_15640154:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_ccd7c5ef5c44d98d08b706b1a8c5450c |
| ToxValDB_HPVIS | NOAEL | =0.1 | % diet | Rat | oral | short-term; 28 days | short-term | LONG_REF=Foster D. Snell, Inc. 28-Day Oral Administration in Rats. Conducted for FMC Corporation. 1976.; TITLE=28-Day Oral Administration in Rats. Conducted for FMC Corporation; AUTHOR=Foster D. Snell, Inc; QUALITY=2; EXTERNAL_SOURCE_ID=62256; EXTERNAL_SOURCE_ID_DESC=HPVIS ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/63861d6de4b04f6bb1480596; RECORD_SOURCE_LEVEL=Extraction document; YEAR=1976; ORIGINAL_YEAR=1976; STUDY_GROUP=HPVIS_dup_HPVIS Mammalian Repeat Dose_15639871_15640154:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_bdcf4d4831725a3e9acae5d85ed81ff7 |
ToxValDB_ToxRefDB 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_ToxRefDB | LEL | =8 | mg/kg bw/day | Mouse | oral | chronic; 105 weeks | chronic | LONG_REF=(1994) TOXICOLOGY AND CARCINOGENESIS STUDIES OF TRICRESYL PHOSPHATE (CAS NO. 1330-78-5) IN F344/N RATS AND B6C3F1 MICE (GAVAGE AND FEED STUDIES). NTP TR 433, NIH Publication No. 94-3164. (Chronic mouse); TITLE=TOXICOLOGY AND CARCINOGENESIS STUDIES OF TRICRESYL PHOSPHATE (CAS NO. 1330-78-5) IN F344/N RATS AND B6C3F1 MICE (GAVAGE AND FEED STUDIES); AUTHOR=NTP; EXTERNAL_SOURCE_ID=7406; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1994; ORIGINAL_YEAR=1994; TOXICOLOGICAL_EFFECT=cholinesterase: cholinesterase-cholinesterase-cholinesterase (che); TOXICOLOGICAL_EFFECT_CATEGORY=neurotransmitter; STUDY_GROUP=ToxRefDB_dup_-_15712590_15712591:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_c678054b5c45e7b1c2234c4aab4c7c58 |
| ToxValDB_ToxRefDB | LEL | =7 | mg/kg bw/day | Mouse | oral | chronic; 105 weeks | chronic | LONG_REF=(1994) TOXICOLOGY AND CARCINOGENESIS STUDIES OF TRICRESYL PHOSPHATE (CAS NO. 1330-78-5) IN F344/N RATS AND B6C3F1 MICE (GAVAGE AND FEED STUDIES). NTP TR 433, NIH Publication No. 94-3164. (Chronic mouse); TITLE=TOXICOLOGY AND CARCINOGENESIS STUDIES OF TRICRESYL PHOSPHATE (CAS NO. 1330-78-5) IN F344/N RATS AND B6C3F1 MICE (GAVAGE AND FEED STUDIES); AUTHOR=NTP; EXTERNAL_SOURCE_ID=7406; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1994; ORIGINAL_YEAR=1994; TOXICOLOGICAL_EFFECT=cholinesterase: cholinesterase-cholinesterase-cholinesterase (che); TOXICOLOGICAL_EFFECT_CATEGORY=neurotransmitter; STUDY_GROUP=ToxRefDB_dup_-_15712592_15712593:M:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_845dd7dff7ae873e6c12b5fddb48a3ca |
openFDA substances 4 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| openFDA substances | FDA UNII substance identifier | 512641US16 | UNII | - | - | - | mixture | {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"mixture","unii_code":"512641US16"} |
| openFDA substances | FDA UNII substance identifier | 512641US16 | UNII | - | - | - | mixture | {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"mixture","unii_code":"512641US16"} |
| openFDA substances | FDA UNII substance identifier | 512641US16 | UNII | - | - | - | mixture | {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"mixture","unii_code":"512641US16"} |
| openFDA substances | FDA UNII substance identifier | 512641US16 | UNII | - | - | - | mixture | {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"mixture","unii_code":"512641US16"} |