Good Cosmetic Ingredient NOAEL Data Sensitization Data

TRIETHYLENE GLYCOL DIMETHACRYLATE

CAS Number
109-16-0
Function
Nail Conditioning
Safety Rating
GOOD

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status Permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status restricted
US Notes CIR: SQ - IJT 24(Suppl 5):53-100, 2005

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Toxicological Studies

7 study endpoints found for TRIETHYLENE GLYCOL DIMETHACRYLATE. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
NOAEL 1000 mg/kg bw/day oral rat oral REACH
NOAEL 100 mg/kg bw/day dermal code:3543 dermal REACH
LOAEL 500 mg/kg bw/day dermal code:3543 dermal REACH
NOAEL 1522 mg/kg bw/day oral rat oral REACH
LOAEL 100 mg/kg bw/day dermal code:3543 dermal REACH
NOAEL 1522 mg/kg bw/day oral rat oral REACH
NOAEL 100 mg/kg bw/day dermal code:3543 dermal REACH

Sensitization Profile

Contact sensitization data for TRIETHYLENE GLYCOL DIMETHACRYLATE based on clinical patch test studies and IFRA standards.

Sensitization Rate
low
Allergen Class
other
EU Allergen Listed
no
Patch Test Positive Rate
0.3%
Cross-reactivity Group
acrylate-group
Reaction Type
contact-dermatitis

Source: IVDK; ESSCA

Expert Verdict

TRIETHYLENE GLYCOL DIMETHACRYLATE is listed in the EU CosIng database with functions: Nail Conditioning It is permitted in the EU without specific restrictions.

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Concern Level: Low

Regulatory Flags

cosing-sourced eu-permitted needs-enrichment

Frequently Asked Questions

Is TRIETHYLENE GLYCOL DIMETHACRYLATE safe in cosmetics?

TRIETHYLENE GLYCOL DIMETHACRYLATE is listed in the EU CosIng database with functions: Nail Conditioning It is permitted in the EU without specific restrictions. The EU classifies TRIETHYLENE GLYCOL DIMETHACRYLATE as "Permitted". Safety rating: GOOD. 7 toxicological study endpoint(s) are available in our database.

Is TRIETHYLENE GLYCOL DIMETHACRYLATE allowed in the EU?

TRIETHYLENE GLYCOL DIMETHACRYLATE EU regulatory status: Permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does TRIETHYLENE GLYCOL DIMETHACRYLATE do in cosmetics?

TRIETHYLENE GLYCOL DIMETHACRYLATE functions as: Nail Conditioning. It is classified as a cosmetic ingredient in our database. CAS number: 109-16-0.

What is the NOAEL for TRIETHYLENE GLYCOL DIMETHACRYLATE?

The NOAEL (No Observed Adverse Effect Level) for TRIETHYLENE GLYCOL DIMETHACRYLATE is 1000 mg/kg bw/day based on a oral study via oral route in rat. A total of 7 study endpoints are available. Source: REACH.

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