NOAEL Studies Cosmetic Ingredient

Trifluoroacetic Acid (TFA) NOAEL Studies

INCI: TRIFLUOROACETIC ACID

CAS: 76-05-1

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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EFSA 10 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
EFSA NOAEL =9.9 mg/kg bw/day Rat oral: unspecified 90 days subchronic EFSA - 2016 - OutputID 2825 - organ weights - hepatotoxicity - Peer review of the pesticide risk assessment of the active substance flurtamone - doi:10.2903/j.efsa.2016.4498
EFSA NOAEL =10 mg/kg bw/day Rat oral: unspecified 90 days subchronic EFSA - 2017 - OutputID 2986 - organ weights - systemic - Updated peer review of the pesticide risk assessment of the active substance flurtamone - doi:10.2903/j.efsa.2017.4976
EFSA NOAEL =43 mg/kg bw/day Rat oral: unspecified 14 days short-term toxicity EFSA - 2016 - OutputID 2825 - other - Peer review of the pesticide risk assessment of the active substance flurtamone - doi:10.2903/j.efsa.2016.4498
EFSA NOEL =98 mg/kg bw/day Rat - - chronic/long term toxicity EFSA - 2016 - OutputID 2825 - Peer review of the pesticide risk assessment of the active substance flurtamone - doi:10.2903/j.efsa.2016.4498
EFSA ADI =0.05 mg/kg bw/day Consumers - - ADI EFSA - 2016 - OutputID 2825 - Consumers - Peer review of the pesticide risk assessment of the active substance flurtamone - doi:10.2903/j.efsa.2016.4498
EFSA ARfD =0.05 mg/kg bw/day Consumers - - ARfD EFSA - 2016 - OutputID 2825 - Consumers - Peer review of the pesticide risk assessment of the active substance flurtamone - doi:10.2903/j.efsa.2016.4498
EFSA NOAEL =9.9 mg/kg bw/day Rat oral subchronic; 90 days subchronic LONG_REF=EFSA (2016). Peer review of the pesticide risk assessment of the active substance flurtamone. doi:10.2903/j.efsa.2016.4498.; TITLE=Peer review of the pesticide risk assessment of the active substance flurtamone; AUTHOR=EFSA; DOI=doi:10.2903/j.efsa.2016.4498; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65201d30e4b0f0a60ddd1165; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://zenodo.org/record/5076033#.Y9fEoXbMI2z; YEAR=2016; ORIGINAL_YEAR=2016; TOXICOLOGICAL_EFFECT=organ weight; TOXICOLOGICAL_EFFECT_CATEGORY=organ weight; STUDY_GROUP=EFSA_dup_-_15624947_15624955:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_5cfbfca6855814f038b58c7544638554
EFSA NOAEL =10 mg/kg bw/day Rat oral subchronic; 90 days subchronic LONG_REF=EFSA (2017). Updated peer review of the pesticide risk assessment of the active substance flurtamone. doi:10.2903/j.efsa.2017.4976.; TITLE=Updated peer review of the pesticide risk assessment of the active substance flurtamone; AUTHOR=EFSA; DOI=doi:10.2903/j.efsa.2017.4976; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65201d30e4b0f0a60ddd1165; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://zenodo.org/record/5076033#.Y9fEoXbMI2z; YEAR=2017; ORIGINAL_YEAR=2017; TOXICOLOGICAL_EFFECT=organ weight; TOXICOLOGICAL_EFFECT_CATEGORY=organ weight; STUDY_GROUP=EFSA_dup_-_15624947_15624955:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_615989e5c342e5304e954494ade3ee54
EFSA NOAEL =43 mg/kg bw/day Rat oral short-term; 14 days short-term LONG_REF=EFSA (2016). Peer review of the pesticide risk assessment of the active substance flurtamone. doi:10.2903/j.efsa.2016.4498.; TITLE=Peer review of the pesticide risk assessment of the active substance flurtamone; AUTHOR=EFSA; DOI=doi:10.2903/j.efsa.2016.4498; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65201d30e4b0f0a60ddd1165; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://zenodo.org/record/5076033#.Y9fEoXbMI2z; YEAR=2016; ORIGINAL_YEAR=2016; TOXICOLOGICAL_EFFECT=other; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=EFSA:15624948:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_3061d82031bc7bbe60f550e5bd2230dc
EFSA NOEL =98 mg/kg bw/day Rat oral - chronic LONG_REF=EFSA (2016). Peer review of the pesticide risk assessment of the active substance flurtamone. doi:10.2903/j.efsa.2016.4498.; TITLE=Peer review of the pesticide risk assessment of the active substance flurtamone; AUTHOR=EFSA; DOI=doi:10.2903/j.efsa.2016.4498; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65201d30e4b0f0a60ddd1165; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://zenodo.org/record/5076033#.Y9fEoXbMI2z; YEAR=2016; ORIGINAL_YEAR=2016; STUDY_GROUP=EFSA:15624949:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_4271cba567955eb3aad3a1871110ca8c
NTP ICE acute inhalation 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP ICE acute inhalation LC50 10 mg/L - Inhalation - In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity sheet=Data; excel_row=5373; Record_ID=acute_inhalation_1003; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID9041578; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=10; Response_Unit=mg/L; Reference=ChemIDplus; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9041578
NTP ICE acute oral 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP ICE acute oral LD50 =200 mg/kg bw Rat oral acute Rat Acute Oral Toxicity NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_10090; row=16202; data_type=In Vivo; mixture=Chemical; chemical_name=Acetic acid, trifluoro-; preferred_name=Trifluoroacetic acid; dtxsid=DTXSID9041578; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9041578; source_file=acute_oral.xlsx
NTP ICE skin irritation 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP ICE skin irritation Breakthrough Time 4.5 min - Dermal - In Vitro; Corrositex sheet=Data_invitro; excel_row=6233; Record_ID=skin_irritation_invitro_182; Data_Type=In Vitro; Concentration=99; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID9041578; Assay=Corrositex; Endpoint=Breakthrough Time; Response=4.5; Response_Unit=min; Reference=Gordon et al. 1994; Not available; Not available; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9041578
ECHA 7 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ECHA LEL ~300 mg/m3 Rat inhalation - acute QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059759e4b063812d6fa6de; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/18986/7/3/3?documentUUID=948c3b48-7e1c-4023-9993-d82b075264fd; YEAR=1992; ORIGINAL_YEAR=1992; STUDY_GROUP=ECHA IUCLID_dup_Acute Toxicity Inhalation_15797131_15799460_15799461:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_728be81829abc32c6a4809535bf31a79
ECHA LEL >=327.7 mg/m3 Rat inhalation - acute QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059759e4b063812d6fa6de; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/18986/7/3/3?documentUUID=948c3b48-7e1c-4023-9993-d82b075264fd; YEAR=1992; ORIGINAL_YEAR=1992; STUDY_GROUP=ECHA IUCLID_dup_Acute Toxicity Inhalation_15797131_15799460_15799461:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_9f84f8ba1d15f9fdbdf34d0f18c39752
ECHA LEL <=344.1 mg/m3 Rat inhalation - acute QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059759e4b063812d6fa6de; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/18986/7/3/3?documentUUID=948c3b48-7e1c-4023-9993-d82b075264fd; YEAR=1992; ORIGINAL_YEAR=1992; STUDY_GROUP=ECHA IUCLID_dup_Acute Toxicity Inhalation_15797131_15799460_15799461:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_b37a6db9c6103b2173732726fc9b0313
ECHA LEL =500 mg/kg bw/day Rat oral - acute QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6605975fe4b063812d6fa6ed; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/18986/7/3/2?documentUUID=3dfb49eb-0a68-471e-a921-b28d6142c8ac; YEAR=2001; ORIGINAL_YEAR=2001; STUDY_GROUP=ECHA IUCLID_dup_Acute Toxicity Oral_15804422_15805042:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_e49950e1655a6ce4945b3d88c996d5e3
ECHA NOAEL =25 mg/kg bw/day Rat oral - reproduction developmental QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eab5ae4b0a7c65d1b9db0; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/18986/7/9/2?documentUUID=3dfb49eb-0a68-471e-a921-b28d6142c8ac; YEAR=2001; ORIGINAL_YEAR=2001; STUDY_GROUP=ECHA IUCLID_dup_Toxicity Reproduction_15862989_15862990:M:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_50a0cf77a595740d318409f715740079
ECHA NOAEL =150 mg/kg bw/day Rat oral - reproduction developmental QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eac62e4b0a7c65d1bee67; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/18986/7/9/3?documentUUID=948c3b48-7e1c-4023-9993-d82b075264fd; YEAR=1992; ORIGINAL_YEAR=1992; STUDY_GROUP=ECHA IUCLID_dup_Developmental Toxicity Teratogenicity_15823247_15823613_15823712:F:-maternal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_06fa23bb24340a45963ae6848dff021e
ECHA NOEL =1000 mg/kg bw/day Rat oral - reproduction developmental QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eab5ae4b0a7c65d1b9db3; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/18986/7/9/2?documentUUID=948c3b48-7e1c-4023-9993-d82b075264fd; YEAR=1992; ORIGINAL_YEAR=1992; STUDY_GROUP=ECHA IUCLID_dup_Toxicity Reproduction_15859639_15862988:M/F:F1-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_15b834e24240e417ae0d8b0def32b8e3
ToxValDB GESTIS DNEL 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB GESTIS DNEL DNEL local =2.67 mg/m3 Human inhalation - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15635393:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_028e87eb512f032f818bffef8d9b9d37
Regulatory source 8 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
Regulatory source LOAEL =37 mg/kg bw/day Rat oral subchronic; 38 days reproduction developmental LONG_REF=Unnamed Report (2012b) (ECHA Summary); AUTHOR=ECHA; EXTERNAL_SOURCE_ID_DESC=HERO ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759a9cce4b0a7c65d37b3bd; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://ehp.niehs.nih.gov/doi/full/10.1289/EHP10343; TOXICOLOGICAL_EFFECT=P0: Immune: Spleen: Spleen, Increased Extramedullary Hematopoiesis; TOXICOLOGICAL_EFFECT_CATEGORY=nonneoplastic histopathology; STUDY_GROUP=PFAS 150 SEM v2_dup_-_15863651_15863746_15863865_15863869_15864036_15864057_15864062_15864066:M:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_3c4cc8e72e1c084855e79b68dd250736
Regulatory source LOAEL =112.5 mg/kg bw/day Rat oral subchronic; 38 days reproduction developmental LONG_REF=Unnamed Report (2012b) (ECHA Summary); AUTHOR=ECHA; EXTERNAL_SOURCE_ID_DESC=HERO ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759a9cce4b0a7c65d37b3bd; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://ehp.niehs.nih.gov/doi/full/10.1289/EHP10343; TOXICOLOGICAL_EFFECT=P0: Endocrine: Blood: Glucose (GLU)|P0: General Toxicity: Whole Body: Body Weight Change|P0: General Toxicity: Whole Body: Body Weight, Absolute|P0: General Toxicity: Whole Body: Clinical Observations|P0: Hematologic: Blood: Hemoglobin (HGB)|P0: Hematologic: Blood: Inorganic Phosphorous (PHOS)|P0: Hepatic: Liver: Albumin (A)|P0: Hepatic: Liver: Hepatocellular Hypertrophy, Centrilobular|P0: Hepatic: Liver: Liver Weight, Absolute|P0: Hepatic: Liver: Liver Weight, Relative|P0: Immune: Spleen: Spleen, Increased Extramedullary Hematopoiesis|P0: Other Systems: Eye: Ophthalmology|P0: Other Systems: Whole Body: Chloride (CL)|P0: Reproductive: Whole Body: Fertility Index|P0: Urinary: Blood: Calcium (CA)|P0: Urinary: Kidney: Kidney Weight, Absolute|P0: Urinary: Kidney: Kidney Weight, Relative|P0: Whole Body: Whole Body: Functional Observation Battery (FOB)|P0: Whole Body: Whole Body: Motor Activity; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical chemistry|clinical signs|gross pathology|hematology|neurobehavior|nonneoplastic histopathology|organ weight|reproduction; STUDY_GROUP=PFAS 150 SEM v2_dup_-_15863651_15863746_15863865_15863869_15864036_15864057_15864062_15864066:M:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_419fdaf8f2c1b1eced3e1395c66acfc0
Regulatory source LOAEL =153.6 mg/kg bw/day Rat oral subchronic; 90 days subchronic LONG_REF=ECHA. (2019). Registration dossier: Trifluoroacetic acid (CASRN: 76-05-1): Repeated dose toxicity: oral: 001 Key | Experimental result.; TITLE=Registration dossier: Trifluoroacetic acid (CASRN: 76-05-1): Repeated dose toxicity: oral: 001 Key; AUTHOR=ECHA; EXTERNAL_SOURCE_ID=6298442; EXTERNAL_SOURCE_ID_DESC=HERO ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759a9cce4b0a7c65d37b3bd; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://ehp.niehs.nih.gov/doi/full/10.1289/EHP10343; TOXICOLOGICAL_EFFECT=Cardiovascular: Heart: Aorta Histopathology|Cardiovascular: Heart: Heart Weight, Absolute|Cardiovascular: Heart: Heart Weight, Relative|Endocrine: Adrenal: Adrenal Gland Histopathology|Endocrine: Adrenal: Adrenal Gland Weight, Absolute|Endocrine: Adrenal: Adrenal Gland Weight, Relative|Endocrine: Blood: Glucose (GLU)|Endocrine: Blood: Triglycerides (TRIG)|Endocrine: Multiple Organs: Urobilinogen, Urine|Endocrine: Pituitary: Pituitary Gland Histopathology|Endocrine: Pituitary: Pituitary Gland Weight, Absolute|Endocrine: Pituitary: Pituitary Gland Weight, Relative|Endocrine: Serum: Cholesterol (CHOL), Total|Endocrine: Thyroid/Parathyroid: Thyroid/Parathyroid Gland Histopathology|Endocrine: Thyroid: Thyroid Gland Weight, Absolute|Endocrine: Thyroid: Thyroid Gland Weight, Relative|General Toxicity: Whole Body: Body Weight Change|General Toxicity: Whole Body: Body Weight, Absolute|General Toxicity: Whole Body: Clinical Observations|General Toxicity: Whole Body: Feed Consumption, Absolute|General Toxicity: Whole Body: Mortality|Hematologic: Blood: Hematocrit (HCT)|Hematologic: Blood: Hemoglobin (HGB)|Hematologic: Blood: Inorganic Phosphorous (PHOS)|Hematologic: Blood: Mean Corpuscular Hemoglobin (MCH)|Hematologic: Blood: Mean Corpuscular Hemoglobin Concentration (MCHC)|Hematologic: Blood: Mean Corpuscular Volume (MCV)|Hematologic: Blood: Platelets (PLT)|Hematologic: Blood: Prothrombin Time (PT)|Hematologic: Blood: Red Blood Cell (RBC)|Hematologic: Blood: Reticulocytes|Hematologic: Bone Marrow: Bone Marrow Histopathology|Hepatic: Liver: Alanine Aminotransferase (ALT)|Hepatic: Liver: Albumin (A)|Hepatic: Liver: Alkaline Phosphatase (ALP)|Hepatic: Liver: Aspartate Aminotransferase (AST)|Hepatic: Liver: Hepatocellular Hypertrophy|Hepatic: Liver: Liver Weight, Absolute|Hepatic: Liver: Liver Weight, Relative|Hepatic: Liver: Total Bilirubin (TBILI)|Immune: Blood: White Blood Cell (WBC)|Immune: Blood: White Blood Cell (WBC) Differential|Immune: Lymph Node: Lymph Node, Mesenteric Histopathology|Immune: Lymph Node: Lymph Node, Submaxillary Histopathology|Immune: Spleen: Spleen Histopathology|Immune: Spleen: Spleen Weight, Absolute|Immune: Spleen: Spleen Weight, Relative|Immune: Thymus: Thymus Histopathology|Immune: Thymus: Thymus Weight, Absolute|Immune: Thymus: Thymus Weight, Relative|Nervous: Brain: Brain Histopathology|Nervous: Brain: Brain Weight, Absolute|Nervous: Brain: Brain Weight, Relative|Nervous: PNS: Grip Strength|Nervous: PNS: Sensory Reactions|Nervous: Sciatic Nerve: Sciatic Nerve Histopathology|Nervous: Spinal Cord: Spinal Cord Histopathology|Other Systems: Bone: Articular Surface Histopathology|Other Systems: Bone: Sternum Histopathology|Other Systems: Esophagus: Esophagus Histopathology|Other Systems: Eye: Eye Histopathology|Other Systems: Eye: Ophthalmology|Other Systems: Harderian Gland: Harderian Gland Histopathology|Other Systems: Large Intestine: Large Intestine, Cecum Histopathology|Other Systems: Large Intestine: Large Intestine, Colon Histopathology|Other Systems: Large Intestine: Large Intestine, Rectum Histopathology|Other Systems: Lung: Lung Histopathology|Other Systems: Muscle: Skeletal Muscle Histopathology|Other Systems: Pancreas: Pancreas Histopathology|Other Systems: Salivary Glands: Salivary Gland, Submaxillary Histopathology|Other Systems: Skin: Skin Histopathology|Other Systems: Small Intestine: Small Intestine, Duodenum Histopathology|Other Systems: Small Intestine: Small Intestine, Ileum Histopathology|Other Systems: Small Intestine: Small Intestine, Jejunum Histopathology|Other Systems: Stomach: Stomach Histopathology|Other Systems: Tongue: Tongue Histopathology|Other Systems: Trachea: Trachea Histopathology|Other Systems: Whole Body: Chloride (CL)|Other Systems: Whole Body: Gamma-Glutamyl Transferase (GGT)|Other Systems: Whole Body: Potassium (K)|Other Systems: Whole Body: Total Protein (TP)|Reproductive: Mammary Gland: Mammary Gland Histopathology|Reproductive: Ovary: Ovary Histopathology|Reproductive: Ovary: Ovary Weight, Absolute|Reproductive: Ovary: Ovary Weight, Relative|Reproductive: Uterus: Uterus Weight, Absolute|Reproductive: Uterus: Uterus Weight, Relative|Reproductive: Uterus: Uterus, Cervix Histopathology|Reproductive: Vagina: Vagina Histopathology|Urinary: Blood: Calcium (CA)|Urinary: Blood: Sodium (NA)|Urinary: Kidney: Bilirubin|Urinary: Kidney: Creatinine (CREAT)|Urinary: Kidney: Ketone Levels|Urinary: Kidney: Kidney Histopathology|Urinary: Kidney: Kidney Weight, Absolute|Urinary: Kidney: Kidney Weight, Relative|Urinary: Kidney: Occult Blood, Urine|Urinary: Kidney: Urea|Urinary: Kidney: Urinary Protein|Urinary: Kidney: Urine Appearance|Urinary: Kidney: Urine pH|Urinary: Kidney: Urine Volume|Urinary: Urinary Bladder: Urinary Bladder Histopathology|Whole Body: Whole Body: Functional Observation Battery (FOB)|Whole Body: Whole Body: Motor Activity; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical chemistry|clinical signs|food and/or water consumption|gross pathology|hematology|mortality/survival|neurobehavior|nonneoplastic histopathology|organ weight|urinalysis; STUDY_GROUP=PFAS 150 SEM v2_dup_-_15863654_15863753_15863871_15864028_15864039_15864068_15864168:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_05597438405ce731c983a3033abaecb5
Regulatory source NOAEL =15.36 mg/kg bw/day Rat oral subchronic; 90 days subchronic LONG_REF=ECHA. (2019). Registration dossier: Trifluoroacetic acid (CASRN: 76-05-1): Repeated dose toxicity: oral: 001 Key | Experimental result.; TITLE=Registration dossier: Trifluoroacetic acid (CASRN: 76-05-1): Repeated dose toxicity: oral: 001 Key; AUTHOR=ECHA; EXTERNAL_SOURCE_ID=6298442; EXTERNAL_SOURCE_ID_DESC=HERO ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759a9cce4b0a7c65d37b3bd; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://ehp.niehs.nih.gov/doi/full/10.1289/EHP10343; TOXICOLOGICAL_EFFECT=Cardiovascular: Heart: Aorta Histopathology|Cardiovascular: Heart: Heart Weight, Absolute|Cardiovascular: Heart: Heart Weight, Relative|Endocrine: Adrenal: Adrenal Gland Histopathology|Endocrine: Adrenal: Adrenal Gland Weight, Absolute|Endocrine: Adrenal: Adrenal Gland Weight, Relative|Endocrine: Blood: Glucose (GLU)|Endocrine: Blood: Triglycerides (TRIG)|Endocrine: Multiple Organs: Urobilinogen, Urine|Endocrine: Pituitary: Pituitary Gland Histopathology|Endocrine: Pituitary: Pituitary Gland Weight, Absolute|Endocrine: Pituitary: Pituitary Gland Weight, Relative|Endocrine: Serum: Cholesterol (CHOL), Total|Endocrine: Thyroid/Parathyroid: Thyroid/Parathyroid Gland Histopathology|Endocrine: Thyroid: Thyroid Gland Weight, Absolute|Endocrine: Thyroid: Thyroid Gland Weight, Relative|General Toxicity: Whole Body: Body Weight Change|General Toxicity: Whole Body: Body Weight, Absolute|General Toxicity: Whole Body: Clinical Observations|General Toxicity: Whole Body: Feed Consumption, Absolute|General Toxicity: Whole Body: Mortality|Hematologic: Blood: Hematocrit (HCT)|Hematologic: Blood: Hemoglobin (HGB)|Hematologic: Blood: Inorganic Phosphorous (PHOS)|Hematologic: Blood: Mean Corpuscular Hemoglobin (MCH)|Hematologic: Blood: Mean Corpuscular Hemoglobin Concentration (MCHC)|Hematologic: Blood: Mean Corpuscular Volume (MCV)|Hematologic: Blood: Platelets (PLT)|Hematologic: Blood: Prothrombin Time (PT)|Hematologic: Blood: Red Blood Cell (RBC)|Hematologic: Blood: Reticulocytes|Hematologic: Bone Marrow: Bone Marrow Histopathology|Hepatic: Liver: Alanine Aminotransferase (ALT)|Hepatic: Liver: Albumin (A)|Hepatic: Liver: Alkaline Phosphatase (ALP)|Hepatic: Liver: Aspartate Aminotransferase (AST)|Hepatic: Liver: Hepatocellular Hypertrophy|Hepatic: Liver: Liver Weight, Absolute|Hepatic: Liver: Liver Weight, Relative|Hepatic: Liver: Total Bilirubin (TBILI)|Immune: Blood: White Blood Cell (WBC)|Immune: Blood: White Blood Cell (WBC) Differential|Immune: Lymph Node: Lymph Node, Mesenteric Histopathology|Immune: Lymph Node: Lymph Node, Submaxillary Histopathology|Immune: Spleen: Spleen Histopathology|Immune: Spleen: Spleen Weight, Absolute|Immune: Spleen: Spleen Weight, Relative|Immune: Thymus: Thymus Histopathology|Immune: Thymus: Thymus Weight, Absolute|Immune: Thymus: Thymus Weight, Relative|Nervous: Brain: Brain Histopathology|Nervous: Brain: Brain Weight, Absolute|Nervous: Brain: Brain Weight, Relative|Nervous: PNS: Grip Strength|Nervous: PNS: Sensory Reactions|Nervous: Sciatic Nerve: Sciatic Nerve Histopathology|Nervous: Spinal Cord: Spinal Cord Histopathology|Other Systems: Bone: Articular Surface Histopathology|Other Systems: Bone: Sternum Histopathology|Other Systems: Esophagus: Esophagus Histopathology|Other Systems: Eye: Eye Histopathology|Other Systems: Eye: Ophthalmology|Other Systems: Harderian Gland: Harderian Gland Histopathology|Other Systems: Large Intestine: Large Intestine, Cecum Histopathology|Other Systems: Large Intestine: Large Intestine, Colon Histopathology|Other Systems: Large Intestine: Large Intestine, Rectum Histopathology|Other Systems: Lung: Lung Histopathology|Other Systems: Muscle: Skeletal Muscle Histopathology|Other Systems: Pancreas: Pancreas Histopathology|Other Systems: Salivary Glands: Salivary Gland, Submaxillary Histopathology|Other Systems: Skin: Skin Histopathology|Other Systems: Small Intestine: Small Intestine, Duodenum Histopathology|Other Systems: Small Intestine: Small Intestine, Ileum Histopathology|Other Systems: Small Intestine: Small Intestine, Jejunum Histopathology|Other Systems: Stomach: Stomach Histopathology|Other Systems: Tongue: Tongue Histopathology|Other Systems: Trachea: Trachea Histopathology|Other Systems: Whole Body: Chloride (CL)|Other Systems: Whole Body: Gamma-Glutamyl Transferase (GGT)|Other Systems: Whole Body: Potassium (K)|Other Systems: Whole Body: Total Protein (TP)|Reproductive: Mammary Gland: Mammary Gland Histopathology|Reproductive: Ovary: Ovary Histopathology|Reproductive: Ovary: Ovary Weight, Absolute|Reproductive: Ovary: Ovary Weight, Relative|Reproductive: Uterus: Uterus Weight, Absolute|Reproductive: Uterus: Uterus Weight, Relative|Reproductive: Uterus: Uterus, Cervix Histopathology|Reproductive: Vagina: Vagina Histopathology|Urinary: Blood: Calcium (CA)|Urinary: Blood: Sodium (NA)|Urinary: Kidney: Bilirubin|Urinary: Kidney: Creatinine (CREAT)|Urinary: Kidney: Ketone Levels|Urinary: Kidney: Kidney Histopathology|Urinary: Kidney: Kidney Weight, Absolute|Urinary: Kidney: Kidney Weight, Relative|Urinary: Kidney: Occult Blood, Urine|Urinary: Kidney: Urea|Urinary: Kidney: Urinary Protein|Urinary: Kidney: Urine Appearance|Urinary: Kidney: Urine pH|Urinary: Kidney: Urine Volume|Urinary: Urinary Bladder: Urinary Bladder Histopathology|Whole Body: Whole Body: Functional Observation Battery (FOB)|Whole Body: Whole Body: Motor Activity; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical chemistry|clinical signs|food and/or water consumption|gross pathology|hematology|mortality/survival|neurobehavior|nonneoplastic histopathology|organ weight|urinalysis; STUDY_GROUP=PFAS 150 SEM v2_dup_-_15863654_15863753_15863871_15864028_15864039_15864068_15864168:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_252e11a8a85c0b03262557833f1ec383
Regulatory source NOAEL =37.5 mg/kg bw/day Rat oral subchronic; 38 days reproduction developmental LONG_REF=Unnamed Report (2012b) (ECHA Summary); AUTHOR=ECHA; EXTERNAL_SOURCE_ID_DESC=HERO ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759a9cce4b0a7c65d37b3bd; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://ehp.niehs.nih.gov/doi/full/10.1289/EHP10343; TOXICOLOGICAL_EFFECT=P0: Endocrine: Blood: Glucose (GLU)|P0: General Toxicity: Whole Body: Body Weight Change|P0: General Toxicity: Whole Body: Body Weight, Absolute|P0: General Toxicity: Whole Body: Clinical Observations|P0: Hematologic: Blood: Hemoglobin (HGB)|P0: Hematologic: Blood: Inorganic Phosphorous (PHOS)|P0: Hepatic: Liver: Albumin (A)|P0: Hepatic: Liver: Hepatocellular Hypertrophy, Centrilobular|P0: Hepatic: Liver: Liver Weight, Absolute|P0: Hepatic: Liver: Liver Weight, Relative|P0: Immune: Spleen: Spleen, Increased Extramedullary Hematopoiesis|P0: Other Systems: Eye: Ophthalmology|P0: Other Systems: Whole Body: Chloride (CL)|P0: Reproductive: Whole Body: Fertility Index|P0: Urinary: Blood: Calcium (CA)|P0: Urinary: Kidney: Kidney Weight, Absolute|P0: Urinary: Kidney: Kidney Weight, Relative|P0: Whole Body: Whole Body: Functional Observation Battery (FOB)|P0: Whole Body: Whole Body: Motor Activity; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical chemistry|clinical signs|gross pathology|hematology|neurobehavior|nonneoplastic histopathology|organ weight|reproduction; STUDY_GROUP=PFAS 150 SEM v2_dup_-_15863651_15863746_15863865_15863869_15864036_15864057_15864062_15864066:M:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_f4f40d7a0a2dc5e43abcf02e48f40c2d
Regulatory source NOAEL =75 mg/kg bw/day Rat oral short-term (developmental); 14 days reproduction developmental LONG_REF=Unnamed Report (2010a) (ECHA Summary); AUTHOR=ECHA; EXTERNAL_SOURCE_ID_DESC=HERO ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759a9cce4b0a7c65d37b3bd; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://ehp.niehs.nih.gov/doi/full/10.1289/EHP10343; TOXICOLOGICAL_EFFECT=P0: Developmental: Placenta: Placenta Weight, Absolute|P0: Developmental: Uterus: Implantation|P0: Developmental: Uterus: Resorptions, Mean/Litter|P0: Developmental: Whole Body: No. Male Pups per No. of Pups Sexed|P0: General Toxicity: Whole Body: Clinical Observations|P0: General Toxicity: Whole Body: Maternal Body Weight|P0: General Toxicity: Whole Body: Maternal Body Weight, Corrected|P0: Hepatic: Liver: Liver Weight, Absolute|P0: Reproductive: Ovary: Corpora Lutea|P0: Reproductive: Uterus: Uterine Weight, Gravid|P0: Reproductive: Whole Body: Length of Gestation|P0: Reproductive: Whole Body: No. of Pregnancies|P0: Urinary: Kidney: Kidney Weight, Absolute; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical signs|development|organ weight|reproduction; STUDY_GROUP=PFAS 150 SEM v2_dup_-_15863653_15863752_15863868_15864035_15864065:F:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_0c03120b4f19c14d94d04a0e50cac311
Regulatory source NOAEL =375 mg/kg bw/day Rat oral subchronic; 38 days reproduction developmental LONG_REF=Unnamed Report (2012b) (ECHA Summary); AUTHOR=ECHA; EXTERNAL_SOURCE_ID_DESC=HERO ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759a9cce4b0a7c65d37b3bd; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://ehp.niehs.nih.gov/doi/full/10.1289/EHP10343; TOXICOLOGICAL_EFFECT=P0: General Toxicity: Whole Body: Body Weight Change|P0: General Toxicity: Whole Body: Body Weight, Absolute|P0: General Toxicity: Whole Body: Clinical Observations|P0: Other Systems: Eye: Ophthalmology|P0: Other Systems: Whole Body: Chloride (CL)|P0: Reproductive: Whole Body: Fertility Index|P0: Whole Body: Whole Body: Functional Observation Battery (FOB)|P0: Whole Body: Whole Body: Motor Activity; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical chemistry|clinical signs|gross pathology|neurobehavior|reproduction; STUDY_GROUP=PFAS 150 SEM v2_dup_-_15863651_15863746_15863865_15863869_15864036_15864057_15864062_15864066:M:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_14722f000337c076dad8df12d328dc93
Regulatory source NOAEL =1536 mg/kg bw/day Rat oral subchronic; 90 days subchronic LONG_REF=ECHA. (2019). Registration dossier: Trifluoroacetic acid (CASRN: 76-05-1): Repeated dose toxicity: oral: 001 Key | Experimental result.; TITLE=Registration dossier: Trifluoroacetic acid (CASRN: 76-05-1): Repeated dose toxicity: oral: 001 Key; AUTHOR=ECHA; EXTERNAL_SOURCE_ID=6298442; EXTERNAL_SOURCE_ID_DESC=HERO ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759a9cce4b0a7c65d37b3bd; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://ehp.niehs.nih.gov/doi/full/10.1289/EHP10343; TOXICOLOGICAL_EFFECT=Cardiovascular: Heart: Aorta Histopathology|Cardiovascular: Heart: Heart Weight, Absolute|Cardiovascular: Heart: Heart Weight, Relative|Immune: Blood: White Blood Cell (WBC)|Immune: Blood: White Blood Cell (WBC) Differential|Immune: Lymph Node: Lymph Node, Mesenteric Histopathology|Immune: Lymph Node: Lymph Node, Submaxillary Histopathology|Immune: Spleen: Spleen Histopathology|Immune: Spleen: Spleen Weight, Absolute|Immune: Spleen: Spleen Weight, Relative|Immune: Thymus: Thymus Histopathology|Immune: Thymus: Thymus Weight, Absolute|Immune: Thymus: Thymus Weight, Relative|Other Systems: Bone: Articular Surface Histopathology|Other Systems: Bone: Sternum Histopathology|Other Systems: Esophagus: Esophagus Histopathology|Other Systems: Eye: Eye Histopathology|Other Systems: Eye: Ophthalmology|Other Systems: Harderian Gland: Harderian Gland Histopathology|Other Systems: Large Intestine: Large Intestine, Cecum Histopathology|Other Systems: Large Intestine: Large Intestine, Colon Histopathology|Other Systems: Large Intestine: Large Intestine, Rectum Histopathology|Other Systems: Lung: Lung Histopathology|Other Systems: Muscle: Skeletal Muscle Histopathology|Other Systems: Salivary Glands: Salivary Gland, Submaxillary Histopathology|Other Systems: Skin: Skin Histopathology|Other Systems: Small Intestine: Small Intestine, Duodenum Histopathology|Other Systems: Small Intestine: Small Intestine, Ileum Histopathology|Other Systems: Small Intestine: Small Intestine, Jejunum Histopathology|Other Systems: Stomach: Stomach Histopathology|Other Systems: Tongue: Tongue Histopathology|Other Systems: Trachea: Trachea Histopathology|Other Systems: Whole Body: Chloride (CL)|Other Systems: Whole Body: Gamma-Glutamyl Transferase (GGT)|Other Systems: Whole Body: Potassium (K)|Other Systems: Whole Body: Total Protein (TP)|Reproductive: Mammary Gland: Mammary Gland Histopathology|Reproductive: Ovary: Ovary Histopathology|Reproductive: Ovary: Ovary Weight, Absolute|Reproductive: Ovary: Ovary Weight, Relative|Reproductive: Uterus: Uterus Weight, Absolute|Reproductive: Uterus: Uterus Weight, Relative|Reproductive: Uterus: Uterus, Cervix Histopathology|Reproductive: Vagina: Vagina Histopathology; TOXICOLOGICAL_EFFECT_CATEGORY=clinical chemistry|gross pathology|hematology|nonneoplastic histopathology|organ weight; STUDY_GROUP=PFAS 150 SEM v2_dup_-_15863654_15863753_15863871_15864028_15864039_15864068_15864168:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_46b180deb913ff6a789113ef8c4108a4
openFDA substances 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier E5R8Z4G708 UNII - - - chemical -