Trifluoroacetic Acid (TFA)
INCI: TRIFLUOROACETIC ACID
Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
1 study endpoint found for Trifluoroacetic Acid (TFA). NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| LOAEL | 0.05 mg/L air | other | code:3544 | inhalation | REACH |
GHS Hazard Classification
Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.
Expert Verdict
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Frequently Asked Questions
Is Trifluoroacetic Acid (TFA) safe in cosmetics?
:-- The EU classifies Trifluoroacetic Acid (TFA) as "permitted". Safety rating: POOR. 1 toxicological study endpoint(s) are available in our database.
Is Trifluoroacetic Acid (TFA) allowed in the EU?
Trifluoroacetic Acid (TFA) EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Trifluoroacetic Acid (TFA) do in cosmetics?
Trifluoroacetic Acid (TFA) functions as: pH adjuster. It is classified as a cosmetic ingredient in our database. CAS number: 76-05-1.
What is the Margin of Safety for Trifluoroacetic Acid (TFA)?
adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Trifluoroacetic Acid (TFA)?
The NOAEL (No Observed Adverse Effect Level) for Trifluoroacetic Acid (TFA) is 0.05 mg/L air based on a inhalation study via other route in code:3544. Source: REACH.
Is Trifluoroacetic Acid (TFA) classified as hazardous under GHS?
Trifluoroacetic Acid (TFA) carries a GHS signal word of "DANGER". Hazard statements: Causes severe skin burns and eye damage Causes damage to respiratory tract if inhaled Harmful to aquatic life. This classification is based on the ILO/WHO International Chemical Safety Card and ECHA C&L inventory data. Note: GHS classification applies to the pure substance — at cosmetic use concentrations, hazard thresholds may not be met.
Compliance Tools
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Related Ingredients
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