Is Trifluoroacetyl Tripeptide-2 safe in cosmetics?
Trifluoroacetyl Tripeptide-2 has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted.
Good
Cosmetic Ingredient
Trifluoroacetyl Tripeptide-2
INCI: TRIFLUOROACETYL TRIPEPTIDE-2
Trifluoroacetyl Tripeptide-2 (CAS 64577-63-5) is a cosmetic cosmetic ingredient functioning as Skin Conditioning, Skin Protecting (anti-aging peptide, marketed as "Progeline"). EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database.
View industrial chemical safety profile for CAS 64577-63-5 →
Auto-generated CPSR Part A draft with source citations
Function
Skin Conditioning, Skin Protecting (anti-aging peptide, marketed as "Progeline")
Safety Rating
GOOD
Chemistry & Identifiers
IUPAC Name
(2S)-2-[[(2S)-3-(4-hydroxyphenyl)-2-[[(2S)-3-methyl-2-[(2,2,2-trifluoroacetyl)amino]butanoyl]amino]propanoyl]amino]-3-methylbutanoic acid
InChIKey
SAVSLMGBKQKUAV-JYJNAYRXSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Permitted in cosmetics; no specific restrictions
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Trifluoroacetyl Tripeptide-2.
Calculate MoS for your specific formulation with the MoS Calculator.
Additional Ingredient Properties
1 property record from structured ingredient metadata.
peptide
{"cas_number": "64577-63-5", "trade_name": "Progeline", "peptide_sequence_amino_acids": "TFA-Val-Gly-Val", "peptide_length_residues": "3", "molecular_weight_daltons": "399.3", "peptide_class": "enzyme_inhibitor", "mechanism_of_action": "Inhibits progerin synthesis, MMP inhibition, elastase inhibition", "target_protein_or_receptor": "Progerin/MMPs/elastase", "collagen_stimulation_type": "I", "colla…
Expert Verdict
Expert safety assessment and concern-level summary for Trifluoroacetyl Tripeptide-2.
Frequently Asked Questions
Is Trifluoroacetyl Tripeptide-2 allowed in the EU?
Trifluoroacetyl Tripeptide-2 EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Trifluoroacetyl Tripeptide-2 do in cosmetics?
Trifluoroacetyl Tripeptide-2 functions as: Skin Conditioning, Skin Protecting (anti-aging peptide, marketed as "Progeline"). It is classified as a cosmetic ingredient in our database. CAS number: 64577-63-5.
Compliance Tools
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Ingredient Decoder
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Substance Compliance
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MoS Calculator
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Heavy Metal Limits
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Moderate
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