Good Cosmetic Ingredient NOAEL Data

Trilaurylamine

INCI: TRILAURYLAMINE

CAS Number
102-87-4
Function
Antistatic agent (reduces static charges on hair surfaces)
Safety Rating
GOOD

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status restricted
๐Ÿ‡บ๐Ÿ‡ธ US Status restricted
US Notes Permitted for cosmetic use; not specifically restricted by FDA; no OTC drug monograph listing

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
low
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

7 study endpoints found for Trilaurylamine. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
NOAEL 10 mg/kg bw/day oral rat Subchronic COSMOS_DB
NOAEL 10 mg/kg bw/day oral rat Subchronic COSMOS_DB
NOAEL 5 mg/kg bw/day oral dog Subchronic COSMOS_DB
NOAEL 200 ppm oral dog Subchronic COSMOS_DB
dose_tested 10 mg/kg bw/day oral rat Subchronic COSMOS_DB
dose_tested 10 mg/kg bw/day oral rat Subchronic COSMOS_DB
dose_tested 5 mg/kg bw/day oral dog Subchronic COSMOS_DB

Expert Verdict

Nitrosamine formation risk โ€” secondary amine impurities can react with nitrosating agents to form potentially carcinogenic nitrosamines; strict purity and formulation controls required

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Concern Level: Moderate

Regulatory Flags

fda_food_additive

Frequently Asked Questions

Is Trilaurylamine safe in cosmetics?

Nitrosamine formation risk โ€” secondary amine impurities can react with nitrosating agents to form potentially carcinogenic nitrosamines; strict purity and formulation controls required The EU classifies Trilaurylamine as "restricted". Safety rating: GOOD. 7 toxicological study endpoint(s) are available in our database.

Is Trilaurylamine allowed in the EU?

Trilaurylamine EU regulatory status: restricted. This is based on EU Regulation 1223/2009 and its amendments.

What does Trilaurylamine do in cosmetics?

Trilaurylamine functions as: Antistatic agent (reduces static charges on hair surfaces). It is classified as a cosmetic ingredient in our database. CAS number: 102-87-4.

What is the Margin of Safety for Trilaurylamine?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

What is the NOAEL for Trilaurylamine?

The NOAEL (No Observed Adverse Effect Level) for Trilaurylamine is 10 mg/kg bw/day based on a Subchronic study via oral route in rat. A total of 7 study endpoints are available. Source: COSMOS_DB.

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