NOAEL Studies Cosmetic Ingredient

Trimethyl Hydroxypentyl Isobutyrate NOAEL Studies

INCI: TRIMETHYL HYDROXYPENTYL ISOBUTYRATE

CAS: 25265-77-4

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

Back to parent ingredient page
NTP_ICE_acute_oral 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_acute_oral LD50 =3200 mg/kg bw Rat oral acute Rat Acute Oral Toxicity record_id=acute_oral_4628; row=8968; data_type=In Vivo; mixture=Chemical; chemical_name=2,2,4-Trimethyl-1,3-pentanediol monoisobutyrate; preferred_name=Texanol; dtxsid=DTXSID5027857; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5027857; source_file=acute_oral.xlsx
ToxValDB_DOE_Protective_Action_Criteria 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_DOE_Protective_Action_Criteria LEL =27537.8 mg/m3 Human inhalation - acute LONG_REF=U.S. Department of Energy (DOE) Protective Action Criteria (PAC). 2023. PAC Chemical Database. Updated 11 October 2023. Available: https://edms3.energy.gov/pac/ (Accessed November 16, 2023); TITLE=U.S. Department of Energy (DOE) Protective Action Criteria (PAC) Chemical Database; AUTHOR=U.S. Department of Energy; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65428efee4b045b9ff7cc432; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://edms3.energy.gov/pac/TeelDocs; YEAR=2011; ORIGINAL_YEAR=2011; STUDY_GROUP=DOE Protective Action Criteria:15520725:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_6854b31242c0226c9599d0bf1089faad
ToxValDB_ECHA_IUCLID 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_ECHA_IUCLID NOAEL =1000 mg/kg bw/day Rabbit oral - reproduction developmental QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eac0de4b0a7c65d1bd1a9; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14126/7/9/3?documentUUID=8b004f0f-f06f-4def-bf2b-9320e25acb03; YEAR=1992; ORIGINAL_YEAR=1992; TOXICOLOGICAL_EFFECT=maternal: body weight and weight gain|maternal: changes in number of pregnant|maternal: changes in pregnancy duration|maternal: clinical signs; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical signs|reproduction; STUDY_GROUP=ECHA IUCLID:15823344:F:-maternal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_3218917b61ebbf6a1c24c2b6de260b7c
ToxValDB_ECHA_IUCLID NOAEL =300 mg/kg bw/day Rat oral subchronic; 90 days subchronic QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eadede4b0a7c65d1c696a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14126/7/6/2?documentUUID=8b004f0f-f06f-4def-bf2b-9320e25acb03; YEAR=1992; ORIGINAL_YEAR=1992; TOXICOLOGICAL_EFFECT=histopathology: nonneoplastic; TOXICOLOGICAL_EFFECT_CATEGORY=nonneoplastic histopathology; STUDY_GROUP=ECHA IUCLID:15847884:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_d70318dd4dde2f59ca2e7c68f7a942e8
ToxValDB_ECHA_IUCLID NOEL >15 mg/kg bw/day Rat oral short-term; 28 days short-term QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eadede4b0a7c65d1c6974; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14126/7/6/2?documentUUID=8b004f0f-f06f-4def-bf2b-9320e25acb03; YEAR=1992; ORIGINAL_YEAR=1992; STUDY_GROUP=ECHA IUCLID:15847390:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_695d7509124bbd8588cc1f61c4fe9a10
ToxValDB_ECHA_IUCLID NOEL >150 mg/kg bw/day Rat oral short-term; 28 days short-term QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eadede4b0a7c65d1c6974; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14126/7/6/2?documentUUID=8b004f0f-f06f-4def-bf2b-9320e25acb03; YEAR=1992; ORIGINAL_YEAR=1992; STUDY_GROUP=ECHA IUCLID:15849066:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_c3bdaf7e45f212da65f2be38c026bc30
ToxValDB_GESTIS_DNEL 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_GESTIS_DNEL DNEL systemic =123.42 mg/m3 Human inhalation - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15635505:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_9152a6eae7d5713b3519200b3db731ac
ToxValDB_TX_TCEQ 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_TX_TCEQ NOAEL (ADJ) =1035.4 mg/m3 Rat inhalation short-term; 15 days short-term LONG_REF=O'Donoghue, JL. 1984. Basic toxicity of texanol ester-alcohol. Unpublished study performed by the Toxicological Sciences Laboratory for Eastman Kodak Company. Eastman Kodak Company. Report date: 10-12-84.; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/68c993f9e4b02565fc7d5abf; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.tceq.texas.gov; SUBSOURCE_URL=https://www.tceq.texas.gov/downloads/toxicology/dsd/final/texanol.pdf; YEAR=2008 Accessible 2013; ORIGINAL_YEAR=2008 Accessible 2013; STUDY_GROUP=TX TCEQ:15954691:M/F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_497d41dd19a3e3f237902a7b4004260c
ToxValDB_TX_TCEQ NOAEL (ADJ) =1.3358 mg/m3 Rat oral subchronic; 51 days subchronic LONG_REF=Faber, WD and RS Hosenfeld. 1992. Combined repeated dose and reproductive/developmental toxicity study in the rat. Unpublished study performed by the Toxicological Sciences Laboratory for Eastman Kodak Company. Eastman Kodak Company, TX-92-57. Report date: 8-24-92; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/68c993f9e4b02565fc7d5abf; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.tceq.texas.gov; SUBSOURCE_URL=https://www.tceq.texas.gov/downloads/toxicology/dsd/final/texanol.pdf; YEAR=2008 Accessible 2013; ORIGINAL_YEAR=2008 Accessible 2013; STUDY_GROUP=TX TCEQ:15954692:M/F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_a08cea25a4ea4be383d7cc866d6a857d
openFDA substances 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier ID6ZZH846Y UNII - - - mixture {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"mixture","unii_code":"ID6ZZH846Y"}
openFDA substances FDA UNII substance identifier ID6ZZH846Y UNII - - - mixture {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"mixture","unii_code":"ID6ZZH846Y"}
openFDA substances FDA UNII substance identifier ID6ZZH846Y UNII - - - mixture {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"mixture","unii_code":"ID6ZZH846Y"}
openFDA substances FDA UNII substance identifier ID6ZZH846Y UNII - - - mixture {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"mixture","unii_code":"ID6ZZH846Y"}