NOAEL Studies Cosmetic Ingredient

Trimethylamine Oxide NOAEL Studies

INCI: TRIMETHYLAMINE OXIDE

CAS: 1184-78-7

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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ToxValDB_ECHA_IUCLID 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_ECHA_IUCLID NOAEL =300 mg/kg bw/day Rat oral - reproduction developmental QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaa64e4b0a7c65d1b5aa1; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/25104/7/9/2?documentUUID=ac40b02a-4db6-4bde-a39d-a3f04f7d3529; YEAR=2017; ORIGINAL_YEAR=2017; TOXICOLOGICAL_EFFECT=P0: reproductive function (oestrous cycle)|P0: reproductive function (sperm measures)|P0: reproductive performance; TOXICOLOGICAL_EFFECT_CATEGORY=reproduction; STUDY_GROUP=ECHA IUCLID:15855736:M/F:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_6247c68869b8948c8854f25098d9d368
ToxValDB_ECHA_IUCLID NOAEL =150 mg/kg bw/day Rat oral - reproduction developmental QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaa64e4b0a7c65d1b5aa1; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/25104/7/9/2?documentUUID=ac40b02a-4db6-4bde-a39d-a3f04f7d3529; YEAR=2017; ORIGINAL_YEAR=2017; STUDY_GROUP=ECHA IUCLID:15856497:F:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_ca15b191fddcae92e02f8bac9d08486d
ToxValDB_GESTIS_DNEL 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_GESTIS_DNEL DNEL systemic =0.6 mg/m3 Human inhalation - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15635459:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_b630fe0edae416105ab794e446ff9fcc
openFDA substances 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier FLD0K1SJ1A UNII - - - chemical {"approval_status":null,"molecular_formula":"C3H9NO","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"FLD0K1SJ1A"}
openFDA substances FDA UNII substance identifier FLD0K1SJ1A UNII - - - chemical {"approval_status":null,"molecular_formula":"C3H9NO","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"FLD0K1SJ1A"}
openFDA substances FDA UNII substance identifier FLD0K1SJ1A UNII - - - chemical {"approval_status":null,"molecular_formula":"C3H9NO","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"FLD0K1SJ1A"}
openFDA substances FDA UNII substance identifier FLD0K1SJ1A UNII - - - chemical {"approval_status":null,"molecular_formula":"C3H9NO","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"FLD0K1SJ1A"}