Trimethylamine Oxide

INCI: TRIMETHYLAMINE OXIDE

CAS Number
1184-78-7
Function
Skin-conditioning agent; humectant; protein stabilizer in cosmetic formulations
Safety Rating
GOOD

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Permitted; GRAS status in food context; no cosmetic-specific restriction

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
negligible
Sensitization
none

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Potential fish-like odor at higher concentrations; ensure anhydrous form is specified (dihydrate CAS differs: 62637-93-8)

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Concern Level: Low

Regulatory Flags

fda_food_additive

Frequently Asked Questions

Is Trimethylamine Oxide safe in cosmetics?

Potential fish-like odor at higher concentrations; ensure anhydrous form is specified (dihydrate CAS differs: 62637-93-8) The EU classifies Trimethylamine Oxide as "permitted". Safety rating: GOOD.

Is Trimethylamine Oxide allowed in the EU?

Trimethylamine Oxide EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Trimethylamine Oxide do in cosmetics?

Trimethylamine Oxide functions as: Skin-conditioning agent; humectant; protein stabilizer in cosmetic formulations. It is classified as a cosmetic ingredient in our database. CAS number: 1184-78-7.

What is the Margin of Safety for Trimethylamine Oxide?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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