NOAEL Studies Cosmetic Ingredient

TRIMETHYLBENZOYL DIPHENYLPHOSPHINE OXIDE NOAEL Studies

CAS: 75980-60-8

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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CIR Safety Assessment 5 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
CIR Safety Assessment NOAEL =50 mg/kg bw/d rat oral Subchronic repeated dose toxicity 4; 1; 3, p.5
CIR Safety Assessment NOAEL =60 mg/kg bw/d rat oral 20 d developmental toxicity 4; 150; (22, p.6
CIR Safety Assessment NOAEL =100 mg/kg bw/d rat oral 90-d repeated dose toxicity 0; 5; 3, p.6
CIR Safety Assessment NOAEL =150 mg/kg bw/d rat oral 90-d repeated dose toxicity 90; (10; 99, p.6
CIR Safety Assessment NOAEL =200 mg/kg bw/d - - - developmental toxicity 200; 600; 1, p.14
NTP ICE acute oral 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP ICE acute oral LD50 >5000 mg/kg bw Rat oral acute Rat Acute Oral Toxicity record_id=acute_oral_11345; row=7977; data_type=In Vivo; mixture=Chemical; chemical_name=Diphenyl(2,4,6-trimethylbenzoyl)phosphine oxide; preferred_name=Diphenyl(2,4,6-trimethylbenzoyl)phosphine oxide; dtxsid=DTXSID4052502; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4052502; source_file=acute_oral.xlsx
SCCS Opinion 3 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
SCCS Opinion NOAEL =0.033 mg/kg bw/day rat oral 90 day repeated dose toxicity p.26
SCCS Opinion NOAEL =50 mg/kg bw/day rat oral 28-day repeated dose toxicity p.13
SCCS Opinion NOAEL =100 mg/kg bw/day rat - - NOAEL study p.18
ToxValDB EPA TSCA 8e 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB EPA TSCA 8e LEL =500 mg/kg bw/day Rat oral short-term (developmental); 15 days reproduction developmental STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/68c96d15e4b02565fc7d3269; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://chemview.epa.gov; SUBSOURCE_URL=https://chemview.epa.gov/chemview/proxy?filename=090225268023f445_8EHQ-16-20230_Section 8 (e)_N_2075 No Confidentiality Letter CDX.pdf; TOXICOLOGICAL_EFFECT=P0: decreased body weight; STUDY_GROUP=EPA TSCA 8e:15957445:F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_82e5987ccc21599ba8ba8a7516788d98
ToxValDB GESTIS DNEL 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB GESTIS DNEL DNEL systemic =0.822 mg/m3 Human inhalation - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15631554:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_798c61a3798dbdbb148f0aec7291f219
Regulatory source 18 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
Regulatory source developmental toxicity 60 mg/kg bw/d rat oral 20 d developmental toxicity p.6
Regulatory source developmental toxicity >100 mg/kg bw/d rabbit oral 20 d developmental toxicity p.6
Regulatory source developmental toxicity 200 mg/kg bw/d - - - developmental toxicity p.14
Regulatory source repeated dose toxicity 50 mg/kg bw/d rat oral Subchronic repeated dose toxicity p.5
Regulatory source repeated dose toxicity 100 mg/kg bw/d rat oral 90-d repeated dose toxicity p.6
Regulatory source repeated dose toxicity 150 mg/kg bw/d rat oral 90-d repeated dose toxicity p.6
Regulatory source - 100 mg/kg bw/day rat - - - p.18
Regulatory source - 100 mg/kg bw/day rat - 91 days - p.27
Regulatory source repeated dose toxicity =0.033 mg/kg bw/day rat oral 90 day repeated dose toxicity p.26
Regulatory source repeated dose toxicity 50 mg/kg bw/day rat oral 28-day repeated dose toxicity p.13
Regulatory source repeated dose toxicity 50 mg/kg bw/day rat oral 28 days repeated dose toxicity p.14
Regulatory source repeated dose toxicity 50 % rat oral 90 day repeated dose toxicity p.26
Regulatory source repeated dose toxicity 50 mg/kg bw/day rat oral 90 day repeated dose toxicity p.26
Regulatory source repeated dose toxicity 50 mg/kg bw/day rabbit oral 28-day repeated dose toxicity p.27
Regulatory source repeated dose toxicity 50 mg/kg bw/day mouse oral 28-day repeated dose toxicity p.27
Regulatory source repeated dose toxicity 100 mg/kg bw/day rat oral 90 day repeated dose toxicity p.26
Regulatory source repeated dose toxicity 100 mg/kg bw/day mouse oral 28-day repeated dose toxicity p.27
Regulatory source repeated dose toxicity 100 mg/kg bw/day mouse oral 90-day repeated dose toxicity p.27
openFDA substances 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier B9EIM2D97X UNII - - - chemical -